MX2011011530A - Prceso para la preparacion de [4-(2-cloro-4-metoxi-5-metilfenil)-5 -metil-tiazolo-2il] - [2-ciclopropil-1-(3-fluoro-4-metilfenil)-eti l]-amina. - Google Patents

Prceso para la preparacion de [4-(2-cloro-4-metoxi-5-metilfenil)-5 -metil-tiazolo-2il] - [2-ciclopropil-1-(3-fluoro-4-metilfenil)-eti l]-amina.

Info

Publication number
MX2011011530A
MX2011011530A MX2011011530A MX2011011530A MX2011011530A MX 2011011530 A MX2011011530 A MX 2011011530A MX 2011011530 A MX2011011530 A MX 2011011530A MX 2011011530 A MX2011011530 A MX 2011011530A MX 2011011530 A MX2011011530 A MX 2011011530A
Authority
MX
Mexico
Prior art keywords
methyl
preparation
thiazolo
cyclopropyl
fluoro
Prior art date
Application number
MX2011011530A
Other languages
English (en)
Inventor
Zsolt Parkanyl
Janos Fazekas
Peter Miskolczi
Annamaria Molnar
Bela Agai
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2011011530A publication Critical patent/MX2011011530A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/02—Thiocyanates
    • C07C331/04—Thiocyanates having sulfur atoms of thiocyanate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F216/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F216/12—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an ether radical
    • C08F216/14—Monomers containing only one unsaturated aliphatic radical
    • C08F216/1466—Monomers containing sulfur
    • C08F216/1483—Monomers containing sulfur and nitrogen

Abstract

El objeto de la presente invención es un nuevo proceso para la preparación de [4-(2-cloro-4-metoxi-5-metilfenil)-5-metil- tiazolo-2-il]-[2-ciclopropil-1 -(3-fluoro4-metilfenil)-etil]-amina de fórmula (I) (ver fórmula (I)) y los nuevos intermediarios del proceso de preparación.
MX2011011530A 2009-04-30 2010-04-26 Prceso para la preparacion de [4-(2-cloro-4-metoxi-5-metilfenil)-5 -metil-tiazolo-2il] - [2-ciclopropil-1-(3-fluoro-4-metilfenil)-eti l]-amina. MX2011011530A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0900267A HUP0900267A2 (en) 2009-04-30 2009-04-30 Process for preparing of thiazole amines and intermediates thereof
PCT/HU2010/000047 WO2010125414A1 (en) 2009-04-30 2010-04-26 Process for the preparation of [4-(2-chloro-4-methoxy-5-methylphenyl)-5-methyl-thiazolo-2-yl]-[2-cyclopropyl-1-(3-fluoro-4-methylphenyl)-ethyl]-amine

Publications (1)

Publication Number Publication Date
MX2011011530A true MX2011011530A (es) 2011-11-18

Family

ID=89988941

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011011530A MX2011011530A (es) 2009-04-30 2010-04-26 Prceso para la preparacion de [4-(2-cloro-4-metoxi-5-metilfenil)-5 -metil-tiazolo-2il] - [2-ciclopropil-1-(3-fluoro-4-metilfenil)-eti l]-amina.

Country Status (19)

Country Link
US (1) US8314249B2 (es)
EP (1) EP2424848B1 (es)
JP (1) JP5608221B2 (es)
KR (1) KR20120014005A (es)
CN (1) CN102414185B (es)
AR (1) AR076478A1 (es)
AU (1) AU2010243362B2 (es)
BR (1) BRPI1014627A2 (es)
CA (1) CA2760384A1 (es)
HU (1) HUP0900267A2 (es)
IL (1) IL216017A0 (es)
IN (1) IN2011KN04192A (es)
MX (1) MX2011011530A (es)
MY (1) MY152269A (es)
RU (1) RU2523793C2 (es)
SG (1) SG175829A1 (es)
TW (1) TWI461413B (es)
UY (1) UY32594A (es)
WO (1) WO2010125414A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8943551B2 (en) * 2008-08-14 2015-01-27 Microsoft Corporation Cloud-based device information storage
HUP0900267A2 (en) 2009-04-30 2011-03-28 Sanofi Aventis Process for preparing of thiazole amines and intermediates thereof
EP3096756A1 (en) 2014-01-21 2016-11-30 Neurocrine Biosciences, Inc. Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia
US10207974B1 (en) 2017-12-05 2019-02-19 Chevron Phillips Chemical Company Lp Synthesis of gamma dicarbonyl and pyrrole compounds
AU2019393256A1 (en) * 2018-12-07 2021-07-29 Neurocrine Biosciences, Inc. CRF1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia
WO2021062246A1 (en) * 2019-09-27 2021-04-01 Neurocrine Biosciences, Inc. Crf receptor antagonists and methods of use
JP2023531164A (ja) 2020-06-10 2023-07-21 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 先天性副腎過形成を処置するためのｃｒｆ１受容体アンタゴニスト

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB823251A (en) 1955-07-02 1959-11-11 Thomae Gmbh Dr K Improvements in or relating to preparations containing benzoxathiol derivatives for the care of hair and skin
US3222248A (en) * 1961-12-12 1965-12-07 Stauffer Chemical Co Method of controlling microorganisms by means of organic thiocyanates
US3433803A (en) 1966-12-01 1969-03-18 Olin Mathieson Substituted imino-1,3-oxathiols and their preparation
HRP921128B1 (en) 1991-10-30 1998-10-31 Sandor Garaczy Novel process for the preparation of 4-methyl-5(2-chloroethyl)-thiazole and analogues thereof
JPH1036360A (ja) 1996-02-21 1998-02-10 Kuraray Co Ltd ２−クロロ−５−クロロメチル−１，３−チアゾールの製造方法
FR2796380B3 (fr) * 1999-07-15 2001-08-17 Sanofi Synthelabo Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant
HUP0900267A2 (en) 2009-04-30 2011-03-28 Sanofi Aventis Process for preparing of thiazole amines and intermediates thereof

Also Published As

Publication number Publication date
WO2010125414A8 (en) 2011-04-07
CN102414185A (zh) 2012-04-11
AU2010243362B2 (en) 2015-07-30
CN102414185B (zh) 2014-02-26
SG175829A1 (en) 2011-12-29
WO2010125414A1 (en) 2010-11-04
UY32594A (es) 2010-11-30
IN2011KN04192A (es) 2015-10-02
US8314249B2 (en) 2012-11-20
BRPI1014627A2 (pt) 2015-08-25
KR20120014005A (ko) 2012-02-15
CA2760384A1 (en) 2010-11-04
AR076478A1 (es) 2011-06-15
IL216017A0 (en) 2012-01-31
EP2424848B1 (en) 2013-03-13
JP5608221B2 (ja) 2014-10-15
TWI461413B (zh) 2014-11-21
RU2011148584A (ru) 2013-06-10
EP2424848A1 (en) 2012-03-07
TW201105640A (en) 2011-02-16
HUP0900267A2 (en) 2011-03-28
AU2010243362A1 (en) 2011-11-17
US20120083608A1 (en) 2012-04-05
MY152269A (en) 2014-09-15
JP2012525368A (ja) 2012-10-22
HU0900267D0 (en) 2009-07-28
RU2523793C2 (ru) 2014-07-27

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