BRPI1013387A2 - biomarcadores relacionados à resistência à insulina e métodos de uso dos mesmos - Google Patents

biomarcadores relacionados à resistência à insulina e métodos de uso dos mesmos

Info

Publication number
BRPI1013387A2
BRPI1013387A2 BRPI1013387-9A BRPI1013387A BRPI1013387A2 BR PI1013387 A2 BRPI1013387 A2 BR PI1013387A2 BR PI1013387 A BRPI1013387 A BR PI1013387A BR PI1013387 A2 BRPI1013387 A2 BR PI1013387A2
Authority
BR
Brazil
Prior art keywords
content item
wcd
marker
service provider
content
Prior art date
Application number
BRPI1013387-9A
Other languages
English (en)
Portuguese (pt)
Inventor
Fu Hu Yun
Chirila Costel
Alexander Danny
Milburn Michael
W. Mitchell Matthew
Gall Walter
A. Lawton Kay
Original Assignee
Metabolon, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolon, Inc. filed Critical Metabolon, Inc.
Publication of BRPI1013387A2 publication Critical patent/BRPI1013387A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
BRPI1013387-9A 2009-03-31 2010-03-31 biomarcadores relacionados à resistência à insulina e métodos de uso dos mesmos BRPI1013387A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16533609P 2009-03-31 2009-03-31
US61/165,336 2009-03-31
US16657209P 2009-04-03 2009-04-03
US61/166,572 2009-04-03
PCT/US2010/029399 WO2010114897A1 (en) 2009-03-31 2010-03-31 Biomarkers related to insulin resistance and methods using the same

Publications (1)

Publication Number Publication Date
BRPI1013387A2 true BRPI1013387A2 (pt) 2019-04-16

Family

ID=42828685

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1013387-9A BRPI1013387A2 (pt) 2009-03-31 2010-03-31 biomarcadores relacionados à resistência à insulina e métodos de uso dos mesmos

Country Status (6)

Country Link
US (1) US20120122981A1 (cg-RX-API-DMAC7.html)
EP (1) EP2414535A4 (cg-RX-API-DMAC7.html)
JP (1) JP2012522989A (cg-RX-API-DMAC7.html)
CN (1) CN102449161A (cg-RX-API-DMAC7.html)
BR (1) BRPI1013387A2 (cg-RX-API-DMAC7.html)
WO (1) WO2010114897A1 (cg-RX-API-DMAC7.html)

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EP2172775A4 (en) * 2007-06-25 2010-12-01 Ajinomoto Kk METHOD OF EVALUATING VISCERAL GREASE ACCUMULATION
MX341954B (es) 2007-07-17 2016-09-08 Metabolon Inc Biomarcadores para prediabetes, enfermedades cardiovasculares y otros transtornos relacionados con sindrome metabolico, y metodos de uso de los mismos.
US10215765B2 (en) 2010-09-15 2019-02-26 Quest Diagnostics Investments Incorporated Detection of vitamins A and E by tandem mass spectrometry
WO2012058298A1 (en) * 2010-10-26 2012-05-03 Mayo Foundation For Medical Education And Research Biomarkers of reduced insulin action
KR101303825B1 (ko) * 2011-06-02 2013-09-05 연세대학교 산학협력단 혈장 대사체를 이용한 제2형 당뇨병 진단 키트
WO2013002381A1 (ja) 2011-06-30 2013-01-03 味の素株式会社 脂肪性肝疾患の評価方法、脂肪性肝疾患評価装置、脂肪性肝疾患評価方法、脂肪性肝疾患評価プログラム、脂肪性肝疾患評価システム、情報通信端末装置、および脂肪性肝疾患の予防・改善物質の探索方法
EP2756095A4 (en) * 2011-09-14 2015-07-22 Metabolon Inc BIOMARKERS RELATED TO INSULIN RESISTANCE AND METHOD OF USE THEREOF
EP2642295A1 (en) * 2012-03-22 2013-09-25 Nestec S.A. 1-O-alkyl-2-acylglycerophosphocholine (PC-O) 40:1 as biomarker for healthy ageing
EP2642293A1 (en) 2012-03-22 2013-09-25 Nestec S.A. 9-oxo-octadecadienoic acid (9-oxo-HODE)as as biomarker for healthy ageing
US9928345B2 (en) 2012-06-08 2018-03-27 Liposciences, Inc. Multiple-marker risk parameters predictive of conversion to diabetes
US9361429B2 (en) 2012-06-08 2016-06-07 Liposcience, Inc. Multi-parameter diabetes risk evaluations
US9470771B2 (en) 2012-06-08 2016-10-18 Liposcience, Inc. NMR measurements of NMR biomarker GlycA
EP2883058B1 (en) * 2012-08-13 2018-01-03 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Biomarkers for type 2 diabetes
US20140324460A1 (en) * 2012-09-26 2014-10-30 Health Diagnostic Laboratory, Inc. Method for determining and managing total cardiodiabetes risk
EP2939024B1 (en) 2012-12-26 2021-04-28 Quest Diagnostics Investments Incorporated C peptide detection by mass spectrometry
EP2943789A1 (en) * 2013-01-11 2015-11-18 Health Diagnostic Laboratory, Inc. Method of detection of occult pancreatic beta cell dysfunction in normoglycemic patients
ES2669620T3 (es) 2013-01-31 2018-05-28 Metabolon, Inc. Biomarcadores relacionados con el avance de la resistencia a la insulina y métodos que lo utilizan
US20140278121A1 (en) * 2013-03-13 2014-09-18 Robust for Life, Inc. Systems and methods for network-based calculation and reporting of metabolic risk
EP3041402A4 (en) * 2013-09-04 2017-08-23 Joseph Michael Lawless Kelly Methods and systems for the detection of disease
WO2015157407A1 (en) * 2014-04-08 2015-10-15 Metabolon, Inc. Small molecule biochemical profiling of individual subjects for disease diagnosis and health assessment
JP6051258B2 (ja) * 2015-04-15 2016-12-27 ライオン株式会社 脂質異常症への罹患しやすさを試験する方法
JP6051257B2 (ja) * 2015-04-15 2016-12-27 ライオン株式会社 脂質異常症への罹患しやすさを試験する方法
JP6873490B2 (ja) * 2015-10-18 2021-05-19 ジア，ウェイ 糖尿病関連バイオマーカーおよび糖尿病関連状態の処置
GB201522302D0 (en) 2015-12-17 2016-02-03 Mars Inc Food product for regulating lipid metabolites
CN106093430A (zh) * 2016-06-06 2016-11-09 上海阿趣生物科技有限公司 可用于检测糖尿病的标志物及其用途
CN108318573B (zh) * 2016-08-16 2020-11-13 北京毅新博创生物科技有限公司 检测胰岛素抵抗的质谱模型的制备方法
CN106442770B (zh) * 2016-09-05 2019-01-18 南京医科大学 与特发性男性不育相关的精浆代谢小分子标志物及其检测方法和应用
CN106908605B (zh) * 2017-01-22 2019-02-22 中国人民解放军军事医学科学院基础医学研究所 eLtaS蛋白作为预防和治疗胰岛素抵抗相关疾病的药物靶点的应用
EP3901631A3 (en) * 2017-08-17 2021-12-29 Société des Produits Nestlé S.A. Markers in prepuberty for childhood-prediabetes
CN108623655B (zh) * 2018-05-15 2020-09-01 浙江省农业科学院 改善胰岛素抵抗的二肽el及其用途
CN109298084A (zh) * 2018-07-23 2019-02-01 上海市东方医院 用于检测血清或者血浆中油酸浓度的试剂盒及其制备方法和应用
CN112740045A (zh) * 2018-09-27 2021-04-30 雀巢产品有限公司 在儿童期和青年期发展成胰岛素抗性的风险的标志物
CN110887808A (zh) * 2019-10-28 2020-03-17 广东省测试分析研究所（中国广州分析测试中心） 一种红外光谱技术快速检测阿卡波糖发酵过程中的糖源含量的方法
CN112903885B (zh) * 2019-12-03 2022-05-06 中国科学院大连化学物理研究所 一种筛查糖尿病的联合型代谢标志物的应用及其试剂盒
CN213980949U (zh) 2020-08-27 2021-08-17 康明斯电力公司 用于发电机组的系统
CN112461986B (zh) * 2021-02-03 2021-06-08 首都医科大学附属北京友谊医院 一种用于评估空腹血糖受损和2型糖尿病患病风险的整合生物标志物体系
EP3922990B1 (en) 2021-03-28 2024-05-08 MS Ekspert Sp. z o.o. System for automatic changing and sealing of disposable chromatographic columns in high-performance liquid chromatography; measurement method and its application in the analysis of biomarker of rare disease
CN113929762B (zh) * 2021-12-16 2022-04-26 清华大学 3-羟基丁酰化和/或3-羟基戊酰化修饰胰岛素及其应用
CN117159717A (zh) * 2023-09-28 2023-12-05 广东省人民医院 Slc25a33在制备预防或治疗葡萄糖代谢相关疾病的药物中的应用

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WO1997031103A1 (en) * 1996-02-20 1997-08-28 Kyowa Hakko Kogyo Co., Ltd. Method for determining 1,5-anhydroglucitol
WO2002098355A2 (en) * 2001-06-01 2002-12-12 Clingenix, Inc. Methods and reagents for diagnosis and treatment of insulin resistance and related conditions
US7425545B2 (en) * 2001-07-25 2008-09-16 Isis Pharmaceuticals, Inc. Modulation of C-reactive protein expression
AU2008219700B2 (en) * 2007-02-22 2014-05-29 Health Diagnostic Laboratory, Inc. Metabolic markers of diabetic conditions and methods of use thereof
MX341954B (es) * 2007-07-17 2016-09-08 Metabolon Inc Biomarcadores para prediabetes, enfermedades cardiovasculares y otros transtornos relacionados con sindrome metabolico, y metodos de uso de los mismos.

Also Published As

Publication number Publication date
EP2414535A4 (en) 2012-12-26
WO2010114897A1 (en) 2010-10-07
CN102449161A (zh) 2012-05-09
EP2414535A1 (en) 2012-02-08
JP2012522989A (ja) 2012-09-27
US20120122981A1 (en) 2012-05-17

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]