BRPI1011428B1 - mecanismo de ajuste de dose para uso com um dispositivo de administração de fármaco e dispositivo de administração de fármaco - Google Patents
mecanismo de ajuste de dose para uso com um dispositivo de administração de fármaco e dispositivo de administração de fármaco Download PDFInfo
- Publication number
- BRPI1011428B1 BRPI1011428B1 BRPI1011428-9A BRPI1011428A BRPI1011428B1 BR PI1011428 B1 BRPI1011428 B1 BR PI1011428B1 BR PI1011428 A BRPI1011428 A BR PI1011428A BR PI1011428 B1 BRPI1011428 B1 BR PI1011428B1
- Authority
- BR
- Brazil
- Prior art keywords
- impeller
- helical groove
- dose
- stem
- adjustment mechanism
- Prior art date
Links
- 238000012377 drug delivery Methods 0.000 title claims abstract description 101
- 230000007246 mechanism Effects 0.000 title claims abstract description 101
- 239000003814 drug Substances 0.000 claims description 14
- 230000036961 partial effect Effects 0.000 claims description 14
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- JUFFVKRROAPVBI-PVOYSMBESA-N chembl1210015 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N[C@H]1[C@@H]([C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@]3(O[C@@H](C[C@H](O)[C@H](O)CO)[C@H](NC(C)=O)[C@@H](O)C3)C(O)=O)O2)O)[C@@H](CO)O1)NC(C)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 JUFFVKRROAPVBI-PVOYSMBESA-N 0.000 description 76
- 108010011459 Exenatide Proteins 0.000 description 45
- 229960001519 exenatide Drugs 0.000 description 45
- 230000008901 benefit Effects 0.000 description 27
- 101000976075 Homo sapiens Insulin Proteins 0.000 description 21
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 description 20
- 210000000078 claw Anatomy 0.000 description 16
- 230000008878 coupling Effects 0.000 description 11
- 238000010168 coupling process Methods 0.000 description 11
- 238000005859 coupling reaction Methods 0.000 description 11
- 238000013461 design Methods 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
- 230000002829 reductive effect Effects 0.000 description 11
- 230000010287 polarization Effects 0.000 description 10
- 238000000465 moulding Methods 0.000 description 9
- 150000003839 salts Chemical class 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 7
- 238000002347 injection Methods 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- 238000010276 construction Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 206010012601 diabetes mellitus Diseases 0.000 description 5
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 5
- 230000000717 retained effect Effects 0.000 description 5
- 229920006351 engineering plastic Polymers 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- -1 Gonadorrelina Chemical compound 0.000 description 3
- 238000001647 drug administration Methods 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 239000003055 low molecular weight heparin Substances 0.000 description 3
- 229940127215 low-molecular weight heparin Drugs 0.000 description 3
- 229940126601 medicinal product Drugs 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 208000004476 Acute Coronary Syndrome Diseases 0.000 description 2
- 208000002249 Diabetes Complications Diseases 0.000 description 2
- 206010012689 Diabetic retinopathy Diseases 0.000 description 2
- 108010088406 Glucagon-Like Peptides Proteins 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 150000001447 alkali salts Chemical class 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000011321 prophylaxis Methods 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000012453 solvate Substances 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 108010037003 Buserelin Proteins 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 206010014522 Embolism venous Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000006771 Gonadotropins Human genes 0.000 description 1
- 108010086677 Gonadotropins Proteins 0.000 description 1
- 108010069236 Goserelin Proteins 0.000 description 1
- BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 description 1
- 102000002265 Human Growth Hormone Human genes 0.000 description 1
- 108010000521 Human Growth Hormone Proteins 0.000 description 1
- 239000000854 Human Growth Hormone Substances 0.000 description 1
- 108010024118 Hypothalamic Hormones Proteins 0.000 description 1
- 102000015611 Hypothalamic Hormones Human genes 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 108010021717 Nafarelin Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 102000006877 Pituitary Hormones Human genes 0.000 description 1
- 108010047386 Pituitary Hormones Proteins 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 208000001435 Thromboembolism Diseases 0.000 description 1
- 108010050144 Triptorelin Pamoate Proteins 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- 150000001241 acetals Chemical class 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- CUWODFFVMXJOKD-UVLQAERKSA-N buserelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 CUWODFFVMXJOKD-UVLQAERKSA-N 0.000 description 1
- 229960002719 buserelin Drugs 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229960000610 enoxaparin Drugs 0.000 description 1
- 239000002622 gonadotropin Substances 0.000 description 1
- 229960002913 goserelin Drugs 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 239000000960 hypophysis hormone Substances 0.000 description 1
- 229940043650 hypothalamic hormone Drugs 0.000 description 1
- 239000000601 hypothalamic hormone Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 239000004026 insulin derivative Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- RWHUEXWOYVBUCI-ITQXDASVSA-N nafarelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C=C2C=CC=CC2=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 RWHUEXWOYVBUCI-ITQXDASVSA-N 0.000 description 1
- 229960002333 nafarelin Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229960004532 somatropin Drugs 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- BENFXAYNYRLAIU-QSVFAHTRSA-N terlipressin Chemical compound NCCCC[C@@H](C(=O)NCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CN)CSSC1 BENFXAYNYRLAIU-QSVFAHTRSA-N 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 208000004043 venous thromboembolism Diseases 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2403—Ampoule inserted into the ampoule holder
- A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2485—Ampoule holder connected to rest of syringe
- A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2485—Ampoule holder connected to rest of syringe
- A61M2005/2492—Ampoule holder connected to rest of syringe via snap connection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M2005/3152—Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31556—Accuracy improving means
- A61M5/31558—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31573—Accuracy improving means
- A61M5/31575—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T74/00—Machine element or mechanism
- Y10T74/19—Gearing
- Y10T74/19642—Directly cooperating gears
- Y10T74/19698—Spiral
- Y10T74/19702—Screw and nut
- Y10T74/19721—Thread geometry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T74/00—Machine element or mechanism
- Y10T74/19—Gearing
- Y10T74/19949—Teeth
- Y10T74/19953—Worm and helical
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Feeding Of Articles To Conveyors (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18285609P | 2009-06-01 | 2009-06-01 | |
| EP09009047 | 2009-07-10 | ||
| PCT/EP2010/057486 WO2010139640A1 (en) | 2009-06-01 | 2010-05-28 | Spindle for a drug delivery device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI1011428A2 BRPI1011428A2 (pt) | 2016-03-15 |
| BRPI1011428B1 true BRPI1011428B1 (pt) | 2019-11-19 |
Family
ID=42224739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1011428-9A BRPI1011428B1 (pt) | 2009-06-01 | 2010-05-28 | mecanismo de ajuste de dose para uso com um dispositivo de administração de fármaco e dispositivo de administração de fármaco |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10034982B2 (enExample) |
| EP (1) | EP2437821B1 (enExample) |
| JP (1) | JP5903042B2 (enExample) |
| CN (1) | CN102448524B (enExample) |
| AR (1) | AR076894A1 (enExample) |
| AU (1) | AU2010255815B2 (enExample) |
| BR (1) | BRPI1011428B1 (enExample) |
| CA (1) | CA2761505C (enExample) |
| DK (1) | DK2437821T3 (enExample) |
| ES (1) | ES2649863T3 (enExample) |
| HU (1) | HUE035737T2 (enExample) |
| IL (1) | IL216430A (enExample) |
| MY (1) | MY161517A (enExample) |
| NO (1) | NO2437821T3 (enExample) |
| PL (1) | PL2437821T3 (enExample) |
| RU (1) | RU2551933C2 (enExample) |
| SG (1) | SG176080A1 (enExample) |
| TW (1) | TWI587885B (enExample) |
| WO (1) | WO2010139640A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1476210B1 (en) | 2002-02-11 | 2008-09-24 | Antares Pharma, Inc. | Intradermal injector |
| PT1850892T (pt) | 2005-01-24 | 2019-02-08 | Antares Pharma Inc | Injector a jacto com seringa pré-cheia |
| WO2007131013A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Two-stage reconstituting injector |
| WO2007131025A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Injector with adjustable dosing |
| ES2752152T3 (es) | 2008-03-10 | 2020-04-03 | Antares Pharma Inc | Dispositivo de seguridad para inyector |
| EP2318075B1 (en) | 2008-08-05 | 2019-05-22 | Antares Pharma, Inc. | Multiple dosage injector |
| DE102008042299A1 (de) * | 2008-09-23 | 2010-04-01 | Robert Bosch Gmbh | Schraubgetriebe |
| US8257319B2 (en) | 2009-06-01 | 2012-09-04 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device inner housing having helical spline |
| EP2292286A1 (en) * | 2009-09-07 | 2011-03-09 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for a medication delivery device and medication delivery device |
| JP5703299B2 (ja) * | 2009-09-07 | 2015-04-15 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬物送達デバイスのための駆動機構 |
| DK2482889T3 (en) * | 2009-09-30 | 2016-05-17 | Sanofi Aventis Deutschland | ACCOMMODATION drug delivery device |
| EP2482896A1 (en) * | 2009-09-30 | 2012-08-08 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for a drug delivery device and reset member for a drive mechanism |
| WO2011039205A2 (en) * | 2009-09-30 | 2011-04-07 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device and drive member for a drug delivery device |
| TW201127435A (en) * | 2009-09-30 | 2011-08-16 | Sanofi Aventis Deutschland | Drive mechanism for a drug delivery device |
| CN103547303B (zh) | 2011-03-25 | 2015-11-25 | 赛诺菲-安万特德国有限公司 | 给药装置 |
| AR086255A1 (es) * | 2011-05-06 | 2013-11-27 | Sanofi Aventis Deutschland | Conjunto para un dispositivo de administracion de farmacos y dispositivo de administracion de farmacos |
| EP2720738B1 (en) * | 2011-06-17 | 2016-01-20 | Sanofi-Aventis Deutschland GmbH | Cartridge holder assembly for drug delivery devices |
| EP2731644B1 (en) | 2011-07-15 | 2019-02-20 | Sanofi-Aventis Deutschland GmbH | Drug delivery device with electro-mechanic drive mechanism |
| US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
| EP2732245B1 (en) * | 2011-07-15 | 2019-12-25 | Sanofi-Aventis Deutschland GmbH | A drug delivery device |
| US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
| JP6296979B2 (ja) * | 2011-07-15 | 2018-03-20 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬物送達デバイス |
| JP6230530B2 (ja) * | 2011-07-15 | 2017-11-15 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬物送達デバイス |
| WO2013074507A2 (en) * | 2011-11-14 | 2013-05-23 | Regenerative Sciences, Llc | Suspended particle delivery systems and methods |
| JP6214549B2 (ja) | 2011-12-08 | 2017-10-18 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬剤送達デバイス用の駆動アセンブリおよび駆動アセンブリを備える薬剤送達デバイス |
| US9486583B2 (en) | 2012-03-06 | 2016-11-08 | Antares Pharma, Inc. | Prefilled syringe with breakaway force feature |
| JP6457383B2 (ja) | 2012-04-06 | 2019-01-23 | アンタレス・ファーマ・インコーポレーテッド | テストステロン組成物の針支援式ジェット注入投与 |
| WO2013169800A1 (en) | 2012-05-07 | 2013-11-14 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
| CN104918648B (zh) | 2013-01-15 | 2017-12-15 | 赛诺菲-安万特德国有限公司 | 具有光学剂量编码解码系统的笔型药物注射装置 |
| EP3369446B1 (en) | 2013-01-15 | 2021-09-01 | Sanofi-Aventis Deutschland GmbH | Pen-type drug injection device and optical dose value decoding system with additional sensor to distinguish between dose dialling and dose delivery mode |
| EP2945673B1 (en) | 2013-01-15 | 2018-12-05 | Sanofi-Aventis Deutschland GmbH | A decoding system |
| PT3659647T (pt) | 2013-02-11 | 2024-03-27 | Antares Pharma Inc | Dispositivo de injeção a jato auxiliado por agulha tendo força de gatilho reduzida |
| ES2742046T3 (es) | 2013-03-11 | 2020-02-12 | Antares Pharma Inc | Inyector de dosis con sistema de piñón |
| EP2968776B1 (en) | 2013-03-13 | 2019-06-12 | Sanofi-Aventis Deutschland GmbH | Assembly for a drug delivery device and drug delivery device with such an assembly |
| CN105658264B (zh) * | 2013-09-03 | 2019-09-13 | 赛诺菲 | 用于药物输送装置的活塞杆以及包括活塞杆的药物输送装置 |
| US10478565B2 (en) * | 2013-11-15 | 2019-11-19 | Sanofi-Aventis Deutschland Gmbh | Assembly for a drug delivery device and drug delivery device |
| CN106573109A (zh) * | 2014-07-01 | 2017-04-19 | 赛诺菲 | 药物输送装置 |
| US20180132979A1 (en) | 2015-05-29 | 2018-05-17 | 3M Innovative Properties Company | A dental material dispensing device and a method of dispensing a dental material |
| EP3325052B1 (en) * | 2015-07-23 | 2020-02-19 | 3M Innovative Properties Company | A device comprising a plunger assembly, a method of assembling the device and a method of making the plunger assembly |
| WO2017041971A1 (en) * | 2015-09-09 | 2017-03-16 | Sanofi | Piston rod |
| EP3598990A1 (en) | 2018-07-23 | 2020-01-29 | Sanofi | Drug delivery device and assembly method for a drug delivery device |
| EP3836989A1 (en) * | 2018-09-08 | 2021-06-23 | Shaily Engineering Plastics Limited | Injection device |
| RU2695625C1 (ru) * | 2019-02-18 | 2019-07-24 | Общество с ограниченной ответственностью «НЭКСТ БИО» | Инъекционное устройство |
| GB201908810D0 (en) * | 2019-06-19 | 2019-07-31 | Ondosis Ab | Delivery device for drug pellets |
| GB2586004B (en) * | 2019-06-21 | 2022-03-16 | Shaily Eng Plastics Ltd | Injector pen assembly |
Family Cites Families (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US533575A (en) | 1895-02-05 | wilkens | ||
| US3302462A (en) | 1964-05-25 | 1967-02-07 | Dow Chemical Co | Pipetting device with stop mechanism |
| DE3715258C2 (de) | 1987-05-08 | 1996-10-31 | Haselmeier Wilhelm Fa | Injektionsgerät |
| GB8713810D0 (en) | 1987-06-12 | 1987-07-15 | Hypoguard Uk Ltd | Measured dose dispensing device |
| US5226895A (en) | 1989-06-05 | 1993-07-13 | Eli Lilly And Company | Multiple dose injection pen |
| GB9007113D0 (en) | 1990-03-29 | 1990-05-30 | Sams Bernard | Dispensing device |
| US5226896A (en) | 1990-04-04 | 1993-07-13 | Eli Lilly And Company | Dose indicating injection pen |
| AU641206B2 (en) | 1991-01-22 | 1993-09-16 | Eli Lilly And Company | Multiple dose injection pen |
| DE4112259A1 (de) | 1991-04-15 | 1992-10-22 | Medico Dev Investment Co | Injektionsgeraet |
| CA2109087A1 (en) | 1991-04-22 | 1992-10-23 | Nils Goran Helldin | A syringe, including a rod and a piston |
| EP0525525B1 (de) | 1991-07-24 | 1995-05-03 | Medico Development Investment Company | Injektor |
| DK175491D0 (da) | 1991-10-18 | 1991-10-18 | Novo Nordisk As | Apparat |
| US5279586A (en) | 1992-02-04 | 1994-01-18 | Becton, Dickinson And Company | Reusable medication delivery pen |
| US5271527A (en) | 1992-04-02 | 1993-12-21 | Habley Medical Technology Corporation | Reusable pharmaceutical dispenser with full stroke indicator |
| US5423752A (en) * | 1992-07-31 | 1995-06-13 | Habley Medical Technology Corporation | Variable proportion dispenser with cartridge replacement assembly |
| US5300041A (en) | 1992-06-01 | 1994-04-05 | Habley Medical Technology Corporation | Dose setting and repeating syringe |
| US5391157A (en) | 1992-10-20 | 1995-02-21 | Eli Lilly And Company | End of dose indicator |
| US5378233A (en) | 1992-11-18 | 1995-01-03 | Habley Medical Technology Corporation | Selected dose pharmaceutical dispenser |
| US5320609A (en) | 1992-12-07 | 1994-06-14 | Habley Medical Technology Corporation | Automatic pharmaceutical dispensing syringe |
| DE9301334U1 (de) | 1993-02-01 | 1993-04-01 | Ing. Lang & Menke Gmbh, 5870 Hemer | Federscheibe zum Spielausgleich bei Kugellagern |
| FR2701211B1 (fr) | 1993-02-08 | 1995-05-24 | Aguettant Lab | Instrument doseur, notamment d'injection |
| US5383865A (en) | 1993-03-15 | 1995-01-24 | Eli Lilly And Company | Medication dispensing device |
| US5411377A (en) | 1993-03-17 | 1995-05-02 | Houser; Michael P. | Mass displacement wave energy conversion system |
| US5584815A (en) | 1993-04-02 | 1996-12-17 | Eli Lilly And Company | Multi-cartridge medication injection device |
| ZA941881B (en) | 1993-04-02 | 1995-09-18 | Lilly Co Eli | Manifold medication injection apparatus and method |
| DK170604B1 (da) | 1993-12-07 | 1995-11-13 | Niels Erik Holm Aps | Doseringsenhed til dosering af afmålte mængder af en væske |
| US5514097A (en) | 1994-02-14 | 1996-05-07 | Genentech, Inc. | Self administered injection pen apparatus and method |
| US5792117A (en) | 1994-07-22 | 1998-08-11 | Raya Systems, Inc. | Apparatus for optically determining and electronically recording injection doses in syringes |
| US5582598A (en) | 1994-09-19 | 1996-12-10 | Becton Dickinson And Company | Medication delivery pen with variable increment dose scale |
| CA2213682C (en) | 1995-03-07 | 2009-10-06 | Eli Lilly And Company | Recyclable medication dispensing device |
| AU1860697A (en) | 1995-09-08 | 1997-07-28 | Visionary Medical Products Corporation | Pen-type injector drive mechanism |
| US5674204A (en) | 1995-09-19 | 1997-10-07 | Becton Dickinson And Company | Medication delivery pen cap actuated dose delivery clutch |
| US5688251A (en) | 1995-09-19 | 1997-11-18 | Becton Dickinson And Company | Cartridge loading and priming mechanism for a pen injector |
| WO1998001172A1 (de) | 1996-07-05 | 1998-01-15 | Disetronic Licensing Ag | Injektionsgerät zum injizieren von flüssigkeit |
| US5851079A (en) | 1996-10-25 | 1998-12-22 | The Procter & Gamble Company | Simplified undirectional twist-up dispensing device with incremental dosing |
| AU8333298A (en) | 1997-07-14 | 1999-02-10 | Novo Nordisk A/S | Cylinder ampoule |
| DE19730999C1 (de) | 1997-07-18 | 1998-12-10 | Disetronic Licensing Ag | Dosierknopfsicherung an einer Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts |
| US5921966A (en) | 1997-08-11 | 1999-07-13 | Becton Dickinson And Company | Medication delivery pen having an improved clutch assembly |
| CZ297361B6 (cs) | 1998-01-30 | 2006-11-15 | Novo Nordisk A/S | Injekcní stríkacka |
| US5961495A (en) | 1998-02-20 | 1999-10-05 | Becton, Dickinson And Company | Medication delivery pen having a priming mechanism |
| US6221053B1 (en) | 1998-02-20 | 2001-04-24 | Becton, Dickinson And Company | Multi-featured medication delivery pen |
| US6248095B1 (en) | 1998-02-23 | 2001-06-19 | Becton, Dickinson And Company | Low-cost medication delivery pen |
| DE29818721U1 (de) | 1998-10-21 | 2000-03-02 | Medico Development Investment Co., Ascona | Injektionsgerät |
| DE19900827C1 (de) | 1999-01-12 | 2000-08-17 | Disetronic Licensing Ag | Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts |
| DE19900792C1 (de) | 1999-01-12 | 2000-06-15 | Disetronic Licensing Ag | Vorrichtung zur Verabreichung eines injizierbaren Produkts |
| DE29900482U1 (de) | 1999-01-14 | 2000-08-31 | Medico Development Investment Co., Ascona | Injektionsgerät |
| SE9901366D0 (sv) | 1999-04-16 | 1999-04-16 | Pharmacia & Upjohn Ab | Injector device and method for its operation |
| ATE318157T1 (de) * | 1999-08-05 | 2006-03-15 | Becton Dickinson Co | Stiftförmige medikamentenabgabevorrichtung |
| TW453884B (en) | 1999-09-16 | 2001-09-11 | Novo Nordisk As | Dose setting limiter |
| GB0007071D0 (en) | 2000-03-24 | 2000-05-17 | Sams Bernard | One-way clutch mechanisms and injector devices |
| US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
| CN1268405C (zh) | 2000-10-09 | 2006-08-09 | 伊莱利利公司 | 用于甲状旁腺激素给药的笔式装置 |
| US6899699B2 (en) | 2001-01-05 | 2005-05-31 | Novo Nordisk A/S | Automatic injection device with reset feature |
| EP2258425B1 (en) | 2001-05-16 | 2013-01-30 | Eli Lilly and Company | Medication injector apparatus |
| EP1409046B1 (en) | 2001-07-16 | 2005-03-02 | Eli Lilly And Company | Medication dispensing apparatus configured for rotate to prime and pull/push to inject functionality |
| WO2003080160A1 (en) | 2002-03-18 | 2003-10-02 | Eli Lilly And Company | Medication dispensing apparatus with gear set for mechanical advantage |
| US20040225258A1 (en) | 2002-03-30 | 2004-11-11 | Ernest Balestracci | Tamper evident overcap for a container |
| DE10229122B4 (de) | 2002-06-28 | 2006-09-07 | Tecpharma Licensing Ag | Verabreichungsgerät mit rücksetzbarer Betätigungssperre |
| DE10239784B4 (de) | 2002-08-29 | 2004-12-30 | Tecpharma Licensing Ag | Injektions-, Infusions- oder Inhalationsvorrichtung mit Dosisanzeigevorrichtung |
| AU2003275353A1 (en) * | 2002-10-01 | 2004-04-23 | Becton, Dickinson And Company | Medication delivery pen |
| DE10302163A1 (de) | 2003-01-21 | 2004-07-29 | Tecpharma Licensing Ag | Vorrichtung zur Verabreichung einer vorgebbaren Dosis eines flüssigen Produkts |
| US7329241B2 (en) | 2003-02-14 | 2008-02-12 | Valeant Pharmaceuticals North America | Drug delivery system for administering an adjustable preset dose |
| GB0304823D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
| GB0304822D0 (en) * | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
| US9205197B2 (en) * | 2003-03-03 | 2015-12-08 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device dose setting mechanism |
| AU2003274797A1 (en) | 2003-03-05 | 2004-09-28 | 3Ip Co., Ltd. | Electronic dart game set and metod of assembling the same |
| US20040186437A1 (en) | 2003-03-20 | 2004-09-23 | Frenette Claude E. | Content-coded medical syringe, syringe set and syringe content identification method |
| GB0306642D0 (en) * | 2003-03-22 | 2003-04-30 | Dca Design Int Ltd | Improvements in and relating to an injector for a medical product |
| US6932794B2 (en) | 2003-04-03 | 2005-08-23 | Becton, Dickinson And Company | Medication delivery pen |
| PL1656170T3 (pl) | 2003-08-12 | 2019-08-30 | Eli Lilly And Company | Urządzenie do dawkowania leku z potrójnym gwintem śrubowym dla przełożenia mechanicznego |
| JP2007503944A (ja) | 2003-09-03 | 2007-03-01 | ノボ・ノルデイスク・エー／エス | ねじ山付きのロッド及びナットアセンブリ |
| DE20317377U1 (de) | 2003-11-03 | 2005-03-17 | B D Medico S A R L | Injektionsgerät |
| DE10351596B4 (de) | 2003-11-05 | 2007-10-11 | Tecpharma Licensing Ag | Autoinjektor mit variabler Dosis |
| EP1541185A1 (en) | 2003-12-08 | 2005-06-15 | Novo Nordisk A/S | Automatic syringe with priming mechanism |
| ES2710438T3 (es) | 2004-09-02 | 2019-04-25 | Sanofi Aventis Deutschland | Método de montaje de dispositivos para la administración de medicamentos |
| JP5178202B2 (ja) | 2004-12-01 | 2013-04-10 | ノボ・ノルデイスク・エー／エス | 注入装置 |
| DE102004063645A1 (de) | 2004-12-31 | 2006-07-20 | Tecpharma Licensing Ag | Vorrichtung zur dosierten Verabreichung eines fluiden Produkts mit Entkopplung für einen Behältniswechsel |
| US9457154B2 (en) | 2005-01-25 | 2016-10-04 | Novo Nordisk A/S | Injection device with an end of dose feedback mechanism |
| ATE418351T1 (de) | 2005-02-11 | 2009-01-15 | Novo Nordisk As | Injektionsvorrichtung |
| DE102005063311A1 (de) | 2005-02-23 | 2006-08-24 | Tecpharma Licensing Ag | Verabreichungsvorrichtung mit Anzeigetrommel |
| WO2006089767A1 (en) | 2005-02-28 | 2006-08-31 | Novo Nordisk A/S | Dose setting mechanism for an injection device capable of presetting a maximum dose |
| JP4979686B2 (ja) * | 2005-04-24 | 2012-07-18 | ノボ・ノルデイスク・エー／エス | 注入デバイス |
| EP1890751A1 (en) | 2005-04-24 | 2008-02-27 | Novo Nordisk A/S | An injection device with a gearbox |
| DE102005022532A1 (de) | 2005-05-17 | 2006-11-23 | Tecpharma Licensing Ag | Verabreichungsvorrichtung mit Zwangs-Priming |
| DE102005063497B4 (de) | 2005-05-24 | 2009-09-24 | Tecpharma Licensing Ag | Kunststofffeder |
| DE102005023824A1 (de) | 2005-05-24 | 2006-12-07 | Tecpharma Licensing Ag | Dosiervorrichtung für eine Injektionsvorrichtung |
| ATE499962T1 (de) | 2005-07-27 | 2011-03-15 | Novo Nordisk As | Dosismechanismus für ein injektionsgerät zur begrenzung einer dosiseinstellung entsprechend der verbleibenden arzneimenge |
| EP1965846A1 (en) | 2005-12-08 | 2008-09-10 | Eli Lilly And Company | Dose indicating assembly of a pharmaceutical injection device |
| DE102005060928A1 (de) | 2005-12-20 | 2007-06-28 | Tecpharma Licensing Ag | Injektionsvorrichtung mit axial überlappendem Dosier- oder Anzeigeglied |
| DE102006038123C5 (de) | 2006-08-14 | 2012-05-03 | Tecpharma Licensing Ag | Injektionsvorrichtung mit Mechanikverriegelung |
| DE102007001432A1 (de) * | 2006-08-14 | 2008-02-21 | Tecpharma Licensing Ag | Dosiermechaniksperrung |
| EP2076303B1 (de) | 2006-09-15 | 2018-07-18 | TecPharma Licensing AG | Injektionsgerät mit mehreren kupplungen |
| GB2443390A (en) | 2006-11-03 | 2008-05-07 | Owen Mumford Ltd | Medicine delivery apparatus |
| EP1923084A1 (en) | 2006-11-17 | 2008-05-21 | Sanofi-Aventis Deutschland GmbH | Dosing and drive mechanism for drug delivery device |
| US8740857B2 (en) | 2006-12-21 | 2014-06-03 | Novo Nordisk A/S | Syringe device |
| AU2008231897B2 (en) | 2007-03-23 | 2012-11-29 | Novo Nordisk A/S | An injection device comprising a locking nut |
| DE102007019124A1 (de) | 2007-04-23 | 2008-11-06 | Tecpharma Licensing Ag | Rückdrehbare Dosiervorrichtung für eine Injektionsvorrichtung |
| DE102007026083A1 (de) | 2007-05-25 | 2008-11-27 | Haselmeier S.A.R.L. | Injektionsgerät |
| US8267900B2 (en) | 2008-05-02 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Medication delivery device |
| US8647309B2 (en) | 2008-05-02 | 2014-02-11 | Sanofi-Aventis Deutschland Gmbh | Medication delivery device |
-
2010
- 2010-05-27 US US12/788,742 patent/US10034982B2/en active Active
- 2010-05-28 MY MYPI2011005290A patent/MY161517A/en unknown
- 2010-05-28 NO NO10722098A patent/NO2437821T3/no unknown
- 2010-05-28 WO PCT/EP2010/057486 patent/WO2010139640A1/en not_active Ceased
- 2010-05-28 ES ES10722098.0T patent/ES2649863T3/es active Active
- 2010-05-28 SG SG2011084118A patent/SG176080A1/en unknown
- 2010-05-28 BR BRPI1011428-9A patent/BRPI1011428B1/pt active IP Right Grant
- 2010-05-28 PL PL10722098T patent/PL2437821T3/pl unknown
- 2010-05-28 RU RU2011154332/14A patent/RU2551933C2/ru active
- 2010-05-28 AU AU2010255815A patent/AU2010255815B2/en active Active
- 2010-05-28 DK DK10722098.0T patent/DK2437821T3/en active
- 2010-05-28 US US13/375,199 patent/US9352097B2/en active Active
- 2010-05-28 JP JP2012513569A patent/JP5903042B2/ja active Active
- 2010-05-28 EP EP10722098.0A patent/EP2437821B1/en active Active
- 2010-05-28 HU HUE10722098A patent/HUE035737T2/en unknown
- 2010-05-28 CN CN201080024059.4A patent/CN102448524B/zh active Active
- 2010-05-28 TW TW099117097A patent/TWI587885B/zh active
- 2010-05-28 CA CA2761505A patent/CA2761505C/en not_active Expired - Fee Related
- 2010-05-28 AR ARP100101854A patent/AR076894A1/es active IP Right Grant
-
2011
- 2011-11-17 IL IL216430A patent/IL216430A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| MY161517A (en) | 2017-04-28 |
| US20100331790A1 (en) | 2010-12-30 |
| US10034982B2 (en) | 2018-07-31 |
| RU2011154332A (ru) | 2013-07-20 |
| JP5903042B2 (ja) | 2016-04-13 |
| NO2437821T3 (enExample) | 2018-02-10 |
| US20120160047A1 (en) | 2012-06-28 |
| AU2010255815B2 (en) | 2015-11-26 |
| CA2761505A1 (en) | 2010-12-09 |
| CN102448524B (zh) | 2014-12-24 |
| EP2437821B1 (en) | 2017-09-13 |
| AU2010255815A1 (en) | 2011-12-22 |
| SG176080A1 (en) | 2011-12-29 |
| AR076894A1 (es) | 2011-07-13 |
| PL2437821T3 (pl) | 2018-03-30 |
| TW201107005A (en) | 2011-03-01 |
| ES2649863T3 (es) | 2018-01-16 |
| CA2761505C (en) | 2018-01-23 |
| HUE035737T2 (en) | 2018-05-28 |
| JP2012528628A (ja) | 2012-11-15 |
| EP2437821A1 (en) | 2012-04-11 |
| WO2010139640A1 (en) | 2010-12-09 |
| IL216430A (en) | 2016-12-29 |
| TWI587885B (zh) | 2017-06-21 |
| BRPI1011428A2 (pt) | 2016-03-15 |
| CN102448524A (zh) | 2012-05-09 |
| IL216430A0 (en) | 2012-03-01 |
| DK2437821T3 (en) | 2018-01-02 |
| RU2551933C2 (ru) | 2015-06-10 |
| US9352097B2 (en) | 2016-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI1011428B1 (pt) | mecanismo de ajuste de dose para uso com um dispositivo de administração de fármaco e dispositivo de administração de fármaco | |
| BRPI1015142B1 (pt) | Mecanismo de ajuste de dose para um dispositivo de administração do fármaco | |
| CN102458525B (zh) | 具有可变最大剂量的给药剂量设定机构 | |
| AU2010255818B2 (en) | Drug delivery device inner housing having helical spline | |
| AU2010303051B2 (en) | Drive mechanism for a drug delivery device | |
| AU2010255813B2 (en) | Dosing mechanism for a drug delivery device | |
| BRPI1011679B1 (pt) | mecanismo de reinicialização para um dispositivo de administração de fármaco | |
| BRPI1010235B1 (pt) | Dispositivo de liberação de fármaco com uma haste do pistão melhorada | |
| BR112013006949B1 (pt) | mecanismo de acionamento para um dispositivo de liberação controlada de fármaco | |
| HK1168811A (en) | Spindle for a drug delivery device | |
| HK1168811B (en) | Spindle for a drug delivery device | |
| HK1168812A (en) | Drug delivery device inner housing having helical spline | |
| HK1168812B (en) | Drug delivery device inner housing having helical spline |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/05/2010, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/05/2010, OBSERVADAS AS CONDICOES LEGAIS |