BRPI0922355A2 - ácidos nucléicos, métodos para reduzir a expressão de um gene em uma célula in vitro, uso de um ácido nucléico, complexo de rna e uso do complexo de rna - Google Patents

ácidos nucléicos, métodos para reduzir a expressão de um gene em uma célula in vitro, uso de um ácido nucléico, complexo de rna e uso do complexo de rna

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Publication number
BRPI0922355A2
BRPI0922355A2 BRPI0922355A BRPI0922355A BRPI0922355A2 BR PI0922355 A2 BRPI0922355 A2 BR PI0922355A2 BR PI0922355 A BRPI0922355 A BR PI0922355A BR PI0922355 A BRPI0922355 A BR PI0922355A BR PI0922355 A2 BRPI0922355 A2 BR PI0922355A2
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BR
Brazil
Prior art keywords
rna complex
vitro
cell
methods
gene expression
Prior art date
Application number
BRPI0922355A
Other languages
English (en)
Inventor
A Polisky Barry
E Houston Michael
V Templin Michael
K Vaish Narendra
Original Assignee
Marina Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marina Biotech Inc filed Critical Marina Biotech Inc
Publication of BRPI0922355A2 publication Critical patent/BRPI0922355A2/pt
Publication of BRPI0922355A8 publication Critical patent/BRPI0922355A8/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2320/30—Special therapeutic applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints

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BRPI0922355A 2008-12-03 2009-12-03 Ácidos nucléicos, métodos para reduzir a expressão de um gene em uma célula in vitro, uso do ácido nucléico, complexo de rna e uso do complexo de rna BRPI0922355A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11962408P 2008-12-03 2008-12-03
US25208509P 2009-10-15 2009-10-15
PCT/US2009/066610 WO2010065756A2 (en) 2008-12-03 2009-12-03 Usirna complexes

Publications (2)

Publication Number Publication Date
BRPI0922355A2 true BRPI0922355A2 (pt) 2017-10-24
BRPI0922355A8 BRPI0922355A8 (pt) 2017-12-12

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BRPI0922355A BRPI0922355A8 (pt) 2008-12-03 2009-12-03 Ácidos nucléicos, métodos para reduzir a expressão de um gene em uma célula in vitro, uso do ácido nucléico, complexo de rna e uso do complexo de rna

Country Status (12)

Country Link
US (2) US9340789B2 (pt)
EP (1) EP2370577B1 (pt)
JP (3) JP5816556B2 (pt)
KR (1) KR20110097915A (pt)
CN (2) CN104673798B (pt)
AU (2) AU2009322290B2 (pt)
BR (1) BRPI0922355A8 (pt)
CA (1) CA2744093A1 (pt)
IL (1) IL212941A (pt)
SG (2) SG171879A1 (pt)
WO (1) WO2010065756A2 (pt)
ZA (1) ZA201104540B (pt)

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