BRPI0919827B8 - processos para aumentar o rendimento de uma reação de peguilação de r-methug-csf processo para a produção em escala grama de peg- r-methug-csf - Google Patents
processos para aumentar o rendimento de uma reação de peguilação de r-methug-csf processo para a produção em escala grama de peg- r-methug-csfInfo
- Publication number
- BRPI0919827B8 BRPI0919827B8 BRPI0919827A BRPI0919827A BRPI0919827B8 BR PI0919827 B8 BRPI0919827 B8 BR PI0919827B8 BR PI0919827 A BRPI0919827 A BR PI0919827A BR PI0919827 A BRPI0919827 A BR PI0919827A BR PI0919827 B8 BRPI0919827 B8 BR PI0919827B8
- Authority
- BR
- Brazil
- Prior art keywords
- csf
- methug
- yield
- increasing
- peg
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2261MU2008 | 2008-10-20 | ||
PCT/IN2009/000262 WO2010089756A2 (en) | 2008-10-20 | 2009-05-04 | An improved process for pegylation of proteins |
Publications (4)
Publication Number | Publication Date |
---|---|
BRPI0919827A2 BRPI0919827A2 (pt) | 2016-02-10 |
BRPI0919827A8 BRPI0919827A8 (pt) | 2018-04-17 |
BRPI0919827B1 BRPI0919827B1 (pt) | 2020-04-07 |
BRPI0919827B8 true BRPI0919827B8 (pt) | 2021-05-25 |
Family
ID=42542457
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0919827A BRPI0919827B8 (pt) | 2008-10-20 | 2009-05-04 | processos para aumentar o rendimento de uma reação de peguilação de r-methug-csf processo para a produção em escala grama de peg- r-methug-csf |
Country Status (7)
Country | Link |
---|---|
US (1) | US8586710B2 (pt) |
EP (1) | EP2337794B1 (pt) |
BR (1) | BRPI0919827B8 (pt) |
CA (1) | CA2741209C (pt) |
MX (1) | MX2011004195A (pt) |
RU (1) | RU2472806C1 (pt) |
WO (1) | WO2010089756A2 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014176309A1 (en) | 2013-04-23 | 2014-10-30 | Nizyme, Inc. | Methods and compositions for treating diseases |
US20200237923A1 (en) * | 2015-10-14 | 2020-07-30 | The Johns Hopkins University | Protein bioconjugation method |
USD849464S1 (en) | 2017-09-19 | 2019-05-28 | Whirlpool Corporation | Coffee maker |
WO2020140021A2 (en) * | 2018-12-28 | 2020-07-02 | Coherus Biosciences, Inc. | Process for producing, isolating, and purifying modified recombinant proteins |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990006952A1 (en) * | 1988-12-22 | 1990-06-28 | Kirin-Amgen, Inc. | Chemically modified granulocyte colony stimulating factor |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
JP2004510751A (ja) | 2000-10-05 | 2004-04-08 | アレス トレーディング ソシエテ アノニム | 位置選択的液相ペグ化 |
EP1835938B1 (en) * | 2004-12-27 | 2013-08-07 | Baxter International Inc. | Polymer-von willebrand factor-conjugates |
EP2630972B1 (en) * | 2006-07-25 | 2017-08-30 | Lipoxen Technologies Limited | N-terminal polysialylation |
WO2008051383A2 (en) * | 2006-10-19 | 2008-05-02 | Amgen Inc. | Use of alcohol co-solvents to improve pegylation reaction yields |
WO2008055972A2 (en) * | 2006-11-09 | 2008-05-15 | Novo Nordisk A/S | N-terminal pegylated prolactin receptor molecules |
-
2009
- 2009-05-04 EP EP09839569.2A patent/EP2337794B1/en not_active Not-in-force
- 2009-05-04 WO PCT/IN2009/000262 patent/WO2010089756A2/en active Application Filing
- 2009-05-04 MX MX2011004195A patent/MX2011004195A/es active IP Right Grant
- 2009-05-04 RU RU2011120170/04A patent/RU2472806C1/ru active
- 2009-05-04 US US13/123,558 patent/US8586710B2/en active Active
- 2009-05-04 BR BRPI0919827A patent/BRPI0919827B8/pt not_active IP Right Cessation
- 2009-05-04 CA CA2741209A patent/CA2741209C/en active Active
Also Published As
Publication number | Publication date |
---|---|
RU2472806C1 (ru) | 2013-01-20 |
US20110196134A1 (en) | 2011-08-11 |
BRPI0919827B1 (pt) | 2020-04-07 |
WO2010089756A3 (en) | 2010-12-16 |
US8586710B2 (en) | 2013-11-19 |
WO2010089756A2 (en) | 2010-08-12 |
EP2337794A2 (en) | 2011-06-29 |
EP2337794B1 (en) | 2013-07-31 |
MX2011004195A (es) | 2011-09-27 |
BRPI0919827A8 (pt) | 2018-04-17 |
RU2011120170A (ru) | 2012-11-27 |
BRPI0919827A2 (pt) | 2016-02-10 |
CA2741209C (en) | 2016-12-20 |
CA2741209A1 (en) | 2010-08-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B15K | Others concerning applications: alteration of classification |
Ipc: C07K 14/535 (2006.01), A61K 47/60 (2017.01) |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B25D | Requested change of name of applicant approved |
Owner name: USV PRIVATE LIMITED (IN) |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 07/04/2020, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 04/05/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 14A ANUIDADE. |
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B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2721 DE 28-02-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |