MX2011008542A - Molecula de acido nucleico de un racimo biosintetico que codifica sintasas peptidicas no ribosomales y usos de la misma. - Google Patents

Molecula de acido nucleico de un racimo biosintetico que codifica sintasas peptidicas no ribosomales y usos de la misma.

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Publication number
MX2011008542A
MX2011008542A MX2011008542A MX2011008542A MX2011008542A MX 2011008542 A MX2011008542 A MX 2011008542A MX 2011008542 A MX2011008542 A MX 2011008542A MX 2011008542 A MX2011008542 A MX 2011008542A MX 2011008542 A MX2011008542 A MX 2011008542A
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MX
Mexico
Prior art keywords
nucleic acid
acid molecule
ribosomal peptide
encoding non
cluster encoding
Prior art date
Application number
MX2011008542A
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English (en)
Inventor
Philipp Krastel
Esther Schmitt
Brigitta-Maria Liechty
Charles Moore
Original Assignee
Novartis Ag
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Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2011008542A publication Critical patent/MX2011008542A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales

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  • Life Sciences & Earth Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
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  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se refiere a la provisión de un polinucleótido que comprende uno o más fragmentos funcionales de un racimo biosintético de genes involucrado en la producción de un compuesto de la fórmula (I) o (I'). La presente invención también proporciona un método para la preparación de un compuesto de la fórmula (I) o (I'), o de las fórmulas (II) a (VII), (Xl) a (XIV), y (XVII), y (XVIII). Más aún, en la presente invención también se proporciona el uso de este compuesto como una composición farmacéutica.
MX2011008542A 2009-02-13 2010-02-11 Molecula de acido nucleico de un racimo biosintetico que codifica sintasas peptidicas no ribosomales y usos de la misma. MX2011008542A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15251709P 2009-02-13 2009-02-13
US21994009P 2009-06-24 2009-06-24
PCT/EP2010/051696 WO2010092109A2 (en) 2009-02-13 2010-02-11 Nucleic acid molecule of a biosynthetic cluster encoding non ribosomal peptide synthases and uses thereof

Publications (1)

Publication Number Publication Date
MX2011008542A true MX2011008542A (es) 2011-09-01

Family

ID=42021648

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MX2011008542A MX2011008542A (es) 2009-02-13 2010-02-11 Molecula de acido nucleico de un racimo biosintetico que codifica sintasas peptidicas no ribosomales y usos de la misma.

Country Status (11)

Country Link
US (1) US20120034650A1 (es)
EP (1) EP2396344A2 (es)
JP (1) JP2012517801A (es)
KR (1) KR20110118811A (es)
CN (1) CN102369211B (es)
AU (1) AU2010212851B2 (es)
BR (1) BRPI1007983A2 (es)
CA (1) CA2751831A1 (es)
EA (1) EA020118B1 (es)
MX (1) MX2011008542A (es)
WO (1) WO2010092109A2 (es)

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EP2577779B1 (en) 2010-05-28 2014-06-04 Basf Se Use of expanded graphite in lithium/sulphur batteries
CN109563528B (zh) * 2016-04-14 2022-10-18 灿盛制药荷兰公司 真核nrps催化过程中的mbth样蛋白
CN111601894B (zh) * 2018-01-16 2024-05-14 花王株式会社 M23a家族蛋白酶的制造方法
CN113278601B (zh) * 2021-05-17 2022-07-08 浙江工业大学 一种腺苷酰化蛋白a6突变体及其编码基因与应用
CN115312121B (zh) * 2022-09-29 2023-03-24 北京齐碳科技有限公司 靶基因位点检测方法、装置、设备及计算机存储介质
CN117384924B (zh) * 2023-12-11 2024-06-25 中国农业科学院生物技术研究所 一种基于酶结构域拆分的多肽生物合成方法

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Also Published As

Publication number Publication date
CA2751831A1 (en) 2010-08-19
WO2010092109A3 (en) 2010-11-18
EA201101179A1 (ru) 2012-04-30
BRPI1007983A2 (pt) 2019-09-24
CN102369211A (zh) 2012-03-07
AU2010212851A1 (en) 2011-08-18
EP2396344A2 (en) 2011-12-21
JP2012517801A (ja) 2012-08-09
KR20110118811A (ko) 2011-11-01
EA020118B1 (ru) 2014-08-29
AU2010212851B2 (en) 2012-12-13
US20120034650A1 (en) 2012-02-09
CN102369211B (zh) 2015-04-29
WO2010092109A2 (en) 2010-08-19

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