BRPI0919753B8 - forma polimórfica de palmitoiletanolamida, composição farmacêutica para uso humano ou veterinário, método para a micronização da palmitoiletanolamida e palmitoiletanolamida ultramicronizada - Google Patents
forma polimórfica de palmitoiletanolamida, composição farmacêutica para uso humano ou veterinário, método para a micronização da palmitoiletanolamida e palmitoiletanolamida ultramicronizadaInfo
- Publication number
- BRPI0919753B8 BRPI0919753B8 BRPI0919753A BRPI0919753A BRPI0919753B8 BR PI0919753 B8 BRPI0919753 B8 BR PI0919753B8 BR PI0919753 A BRPI0919753 A BR PI0919753A BR PI0919753 A BRPI0919753 A BR PI0919753A BR PI0919753 B8 BRPI0919753 B8 BR PI0919753B8
- Authority
- BR
- Brazil
- Prior art keywords
- palmitoylethanolamide
- ultramicronized
- veterinary use
- human
- pharmaceutical composition
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61K9/1682—Processes
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- A61K9/2022—Organic macromolecular compounds
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
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- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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Abstract
composição contendo palmitoil - etano-lamida ultramicronizada. a presente invenção refere-se a uma composição para uso farmacêutico ou veterinário, compreendendo a palmitoiletanolamida. em particular, a presente invenção refere-se a uma composição farmacêutica para uso humano ou veterinário, contendo uma quantidade terapeuticamente eficiente de palmitoiletanolamida na forma ultramicronizada, em que mais do que 90% em peso da palmitoiletanolamida têm tamanhos de partícula menores do que 6 mícrons, juntamente com excipientes farmaceuticamente aceitáveis.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IT2009/000399 WO2011027373A1 (en) | 2009-09-07 | 2009-09-07 | Composition containing ultra-micronized palmitoyl - ethanolamide |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0919753A2 BRPI0919753A2 (pt) | 2015-12-08 |
BRPI0919753B1 BRPI0919753B1 (pt) | 2020-12-29 |
BRPI0919753B8 true BRPI0919753B8 (pt) | 2021-05-25 |
Family
ID=42211652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0919753A BRPI0919753B8 (pt) | 2009-09-07 | 2009-09-07 | forma polimórfica de palmitoiletanolamida, composição farmacêutica para uso humano ou veterinário, método para a micronização da palmitoiletanolamida e palmitoiletanolamida ultramicronizada |
Country Status (14)
Country | Link |
---|---|
US (2) | US8470373B2 (pt) |
EP (2) | EP2796129B1 (pt) |
JP (1) | JP5746178B2 (pt) |
KR (1) | KR101662871B1 (pt) |
CN (2) | CN102186459A (pt) |
AR (2) | AR078159A1 (pt) |
AU (1) | AU2009352080B2 (pt) |
BR (1) | BRPI0919753B8 (pt) |
CA (1) | CA2738117C (pt) |
CY (2) | CY1116695T1 (pt) |
ES (2) | ES2547133T5 (pt) |
PL (2) | PL2475352T5 (pt) |
PT (2) | PT2475352E (pt) |
WO (1) | WO2011027373A1 (pt) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
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US20110178151A1 (en) | 2008-03-04 | 2011-07-21 | Yissum Research Development Company Of The Hebrew | Compounds and methods of treating obesity |
JP5746178B2 (ja) | 2009-09-07 | 2015-07-08 | エピテック・グループ・エス.アール.エル. | 超微粉化パルミトイル−エタノールアミドを含む組成物 |
US20150202179A1 (en) * | 2012-07-20 | 2015-07-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Fatty acid derivatives for use in a method of treating depression and associated conditions |
ITMI20130354A1 (it) * | 2013-03-08 | 2014-09-09 | Again Life Italia Srl | Miscela di acidi grassi (f.a.g. fatty acids group) per uso nel trattamento di patologie infiammatorie. |
EP2921167B1 (en) | 2014-03-19 | 2016-08-17 | EPITECH GROUP S.p.A. | Pharmaceutical composition comprising palmitoylethanolamide and l-acetylcarnitine |
HUE047471T2 (hu) * | 2014-03-21 | 2020-04-28 | Epitech Group S P A | N-acil-etanolaminokat tartalmazó szemészeti, intraartikuláris vagy intravesicalis készítmények |
DK2944309T3 (da) * | 2014-05-14 | 2019-06-03 | Epitech Group S P A | Anvendelse af palmitoylethanolamid i kombination med opioider |
DK2965765T3 (da) | 2014-07-08 | 2019-07-22 | Epitech Group S P A | Anvendelse af adelmidrol til behandling af epiteldysfunktioner |
ES2641143T3 (es) | 2014-08-13 | 2017-11-07 | Epitech Group S.P.A. | Una composición farmacéutica que comprende palmitoiletanolamida y citidina-difosfocolina |
JP2015155412A (ja) * | 2015-03-03 | 2015-08-27 | エピテック・グループ・エス.アール.エル. | 超微粉化パルミトイル−エタノールアミドを含む組成物 |
NL2014464B1 (en) | 2015-03-16 | 2017-01-13 | Vanderbilt Science Holding Ltd | Composition for use in the treatment of neuropathic pain. |
EP3288553B1 (en) * | 2015-04-29 | 2022-12-28 | Scisparc Ltd | Combinations of cannabinoids and n-acylethanolamines |
WO2016183134A1 (en) * | 2015-05-12 | 2016-11-17 | Cutting Edge Medical Solutions, Llc | Palmitoylethanolamide compositions |
US10525012B2 (en) | 2015-08-11 | 2020-01-07 | Eyesiu Medicines B.V. | Pegylated lipid nanoparticle with bioactive lipophilic compound |
ITUB20153066A1 (it) * | 2015-08-11 | 2017-02-11 | Graal S R L | Composizione alimentare e/o nutraceutica contenente pea |
ITUB20154849A1 (it) * | 2015-10-30 | 2017-04-30 | Epitech Group S P A | ADELMIDROL PER L'USO NELLE PATOLOGIE CARATTERIZZATE DA INSUFFICIENTE AGONISMO DEL RECETTORE PPAR-gamma |
ES2580508B1 (es) * | 2016-04-11 | 2018-09-12 | Servicio Andaluz De Salud | Composiciones para la prevención y/o tratamiento de los trastornos por uso de alcohol. |
NL2017559B1 (en) * | 2016-09-30 | 2018-04-10 | Vanderbilt Science Holding Ltd | Method for preparing pulverized palmitoylethanolamide particles, particles obtainable by the method, and apharmaceutical or neutraceutical composition comprising saidparticles |
CN106478445A (zh) * | 2016-11-07 | 2017-03-08 | 华中药业股份有限公司 | 一种非那西丁微粉的制备方法 |
EP3417846A1 (en) | 2017-06-19 | 2018-12-26 | Gifar Srl | Food and/or nutraceutical composition |
IT201700068608A1 (it) * | 2017-06-20 | 2018-12-20 | Neilos S R L | Composizione per trattamento o prevenzione di una malattia neurodegenerativa |
MY172113A (en) * | 2017-07-05 | 2019-11-14 | Frimline Private Ltd | A pharmaceutical composition for neuropathic pain |
MY186286A (en) | 2017-09-05 | 2021-07-05 | Frimline Private Ltd | A pharmaceutical composition for improving or preventing progression of chronic kidney disease |
IT201800003912A1 (it) * | 2018-03-26 | 2019-09-26 | Innovet Italia Srl | N-palmitoil-d-glucosamina in forma micronizzata |
IT201800004439A1 (it) * | 2018-04-12 | 2019-10-12 | ASSOCIAZIONE DI CURCUMA (Curcuma longa L.), PALMITOILETANOLAMIDE (PEA) E L-TRIPTOFANO | |
US20220296540A1 (en) * | 2019-09-15 | 2022-09-22 | Celagenex Research (India) Pvt. Ltd. | Synergistic bioactive compositions for treating neurological disorders |
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US11684600B2 (en) * | 2020-03-04 | 2023-06-27 | Compact Disc Incorporated | Composition of active agents to positively affect a robust mammalian endocannabinoid system tone to better address age related discomfort |
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US5874029A (en) | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
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ES2344920T3 (es) * | 2006-03-28 | 2010-09-09 | Epitech Group S.R.L. | Composicion farmaceutica para el tratamiento de patologias provocadas por la respuesta general del sistema inmutario. |
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JP5746178B2 (ja) | 2009-09-07 | 2015-07-08 | エピテック・グループ・エス.アール.エル. | 超微粉化パルミトイル−エタノールアミドを含む組成物 |
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