BRPI0915218A2 - bloco de reação cíclica térmica em aparelhos de monitoração contínua em tempo real e uso do mesmo - Google Patents

bloco de reação cíclica térmica em aparelhos de monitoração contínua em tempo real e uso do mesmo

Info

Publication number
BRPI0915218A2
BRPI0915218A2 BRPI0915218A BRPI0915218A BRPI0915218A2 BR PI0915218 A2 BRPI0915218 A2 BR PI0915218A2 BR PI0915218 A BRPI0915218 A BR PI0915218A BR PI0915218 A BRPI0915218 A BR PI0915218A BR PI0915218 A2 BRPI0915218 A2 BR PI0915218A2
Authority
BR
Brazil
Prior art keywords
thermal cyclic
cyclic reaction
continuous monitoring
monitoring apparatus
capillary tube
Prior art date
Application number
BRPI0915218A
Other languages
English (en)
Inventor
Oh Park Han
Park Hanee
Kyu Choi Il
Original Assignee
Bioneer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41691985&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0915218(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bioneer Corp filed Critical Bioneer Corp
Publication of BRPI0915218A2 publication Critical patent/BRPI0915218A2/pt
Publication of BRPI0915218B1 publication Critical patent/BRPI0915218B1/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
    • C12M1/38—Temperature-responsive control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6467—Axial flow and illumination

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

bloco de reação cíclica térmica em aparelhos de monitorização contínua em tempo real e uso do mesmo é divulgado um aparelho de tempo real, compreendendo um bloco de reação cíclica térmica com bloco de aquecimento, que é formado de uma peça oca e dividido por uma camada isolante, e um tubo capilar por meio do qual uma amostra é fluiu internamente e/ou externamente e que é enrolada em um bloco de aquecimento, para que as diferentes temperaturas sejam transferidas e, portanto, o ciclo de reação é executado repetidamente; uma fonte de luz, um filtro passa-banda, com uma lente de condensação, um divisor de feixe, um espelho que reflete que é giratoriamente conectado com um motor de forma a transferir a luz de excitação refletida do divisor de feixe para o tubo capilar e refletem a fluorescência gerada a partir da amostra no tubo capilar, e uma parte de detecção de fluorescência.
BRPI0915218-0A 2008-06-23 2009-06-23 Bloco de reação cíclica térmica e aparelhos de monitoramento contínuo em tempo real e uso do mesmo BRPI0915218B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR20080059211 2008-06-23
KR10-2008-0059211 2008-06-23
KR1020090053677A KR101390250B1 (ko) 2008-06-23 2009-06-17 중합효소 연쇄반응 블록 및 이를 이용한 연속형 실시간 모니터링 장치
KR10-2009-0053677 2009-06-17
PCT/KR2009/003376 WO2009157695A2 (en) 2008-06-23 2009-06-23 Thermal cycling reaction block and continuous real-time monitoring apparatus using the same

Publications (2)

Publication Number Publication Date
BRPI0915218A2 true BRPI0915218A2 (pt) 2019-07-02
BRPI0915218B1 BRPI0915218B1 (pt) 2020-10-06

Family

ID=41691985

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0915218-0A BRPI0915218B1 (pt) 2008-06-23 2009-06-23 Bloco de reação cíclica térmica e aparelhos de monitoramento contínuo em tempo real e uso do mesmo

Country Status (9)

Country Link
US (1) US9205425B2 (pt)
EP (1) EP2297294B1 (pt)
JP (1) JP5284468B2 (pt)
KR (1) KR101390250B1 (pt)
CN (1) CN102083956B (pt)
AU (1) AU2009263158B2 (pt)
BR (1) BRPI0915218B1 (pt)
CA (1) CA2728203C (pt)
WO (1) WO2009157695A2 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012015165A2 (ko) * 2010-07-30 2012-02-02 나노바이오시스(주) 광 투과성 열 블록을 포함하는 pcr 장치
KR101302748B1 (ko) * 2010-09-17 2013-08-30 한국식품연구원 비접촉 가열식 유전자 증폭시스템
KR101253455B1 (ko) * 2012-06-05 2013-04-11 주식회사 진시스템 중합효소 연쇄반응 장치
WO2014035124A1 (ko) * 2012-08-30 2014-03-06 (주) 메디센서 회전형 pcr 장치 및 pcr 칩
CN104263634B (zh) * 2014-09-24 2016-08-17 中国科学技术大学 一种基于毛细管的流式聚合酶链式反应循环加热仪及加热方法
CN104730265B (zh) * 2015-03-27 2016-05-11 华南师范大学 手持式poct流式基因分析系统
EP3344394B1 (en) 2015-09-04 2021-10-20 Life Technologies Corporation Thermal isolation of reaction sites on a substrate
CN106978328A (zh) * 2016-01-15 2017-07-25 北京酷搏科技有限公司 热循环反应组件及具有其的实时检测装置
CN107446811A (zh) * 2017-07-25 2017-12-08 新疆昆泰锐生物技术有限公司 一种用于pcr的管式控温装置及包含该装置的反应仪
KR102133633B1 (ko) * 2018-04-17 2020-07-13 (주)로고스바이오시스템스 핵산증폭반응산물을 실시간으로 검출하는 장치
CN108642158A (zh) * 2018-06-19 2018-10-12 苏州雅睿生物技术有限公司 一种多通道点探测的pcr实时荧光检测系统
CN111304051B (zh) * 2020-02-20 2023-08-11 珠海黑马生物科技有限公司 一种pcr仪及使用方法

Family Cites Families (20)

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US5270183A (en) 1991-02-08 1993-12-14 Beckman Research Institute Of The City Of Hope Device and method for the automated cycling of solutions between two or more temperatures
US5207183A (en) * 1991-12-06 1993-05-04 Martha Praschnik Flea-rid and grooming apparatus and methods
DE69429038T2 (de) 1993-07-28 2002-03-21 Pe Corp Ny Norwalk Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung
US5415839A (en) * 1993-10-21 1995-05-16 Abbott Laboratories Apparatus and method for amplifying and detecting target nucleic acids
DE69519783T2 (de) * 1994-04-29 2001-06-07 Perkin Elmer Corp Verfahren und vorrichtung zur echtzeiterfassung der produkte von nukleinsäureamplifikation
GB9621357D0 (en) 1996-10-12 1996-12-04 Central Research Lab Ltd Heating apparatus
US7410793B2 (en) * 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
US6900059B1 (en) * 1999-11-26 2005-05-31 Associates Of Cape Cod, Inc. Reader for conducting assays
AU2002230592A1 (en) * 2000-10-27 2002-05-06 Molecular Devices Corporation Light detection device
AUPR707101A0 (en) * 2001-08-16 2001-09-06 Corbett Research Pty Ltd Continuous flow thermal device
US20060270026A1 (en) * 2005-05-13 2006-11-30 Applera Corporation Low-Mass Thermal Cycling Block
US8293471B2 (en) * 2004-01-28 2012-10-23 Marshall University Research Corporation Apparatus and method for a continuous rapid thermal cycle system
KR100593263B1 (ko) 2004-02-02 2006-06-26 학교법인 포항공과대학교 연속 흐름상 반응 장치
AU2004315186B2 (en) 2004-02-03 2008-03-13 Bioneer Corporation High throughput device for performing continuous-flow reactions
JP2005295877A (ja) * 2004-04-09 2005-10-27 Taiyo Yuden Co Ltd 核酸分析方法、分析装置及び分析用ディスク
KR101081316B1 (ko) * 2004-09-02 2011-11-08 (주)바이오니아 소형 실시간 모니터링 장치
DE102005027555B3 (de) * 2005-06-14 2006-10-05 Eppendorf Ag Thermocycler
EP1906172A4 (en) * 2005-07-15 2014-01-08 Olympus Corp LIGHT METER
US8124413B2 (en) * 2006-02-02 2012-02-28 Corbett Life Science Pty Ltd Thermocycler and sample port
US8124033B2 (en) * 2006-02-17 2012-02-28 Agency, Science, Technology and Research Apparatus for regulating the temperature of a biological and/or chemical sample and method of using the same

Also Published As

Publication number Publication date
CA2728203A1 (en) 2009-12-30
KR101390250B1 (ko) 2014-05-02
WO2009157695A2 (en) 2009-12-30
WO2009157695A3 (en) 2010-03-25
US9205425B2 (en) 2015-12-08
EP2297294A2 (en) 2011-03-23
CN102083956B (zh) 2013-06-26
EP2297294B1 (en) 2021-03-17
JP2011525373A (ja) 2011-09-22
JP5284468B2 (ja) 2013-09-11
US20110159579A1 (en) 2011-06-30
KR20090133079A (ko) 2009-12-31
CN102083956A (zh) 2011-06-01
CA2728203C (en) 2016-08-09
BRPI0915218B1 (pt) 2020-10-06
AU2009263158A1 (en) 2009-12-30
EP2297294A4 (en) 2016-09-07
AU2009263158B2 (en) 2014-07-24

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/10/2020, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.