BRPI0909547A2 - vacina combinada de sarampo - hpv, vetor e hospedero - Google Patents
vacina combinada de sarampo - hpv, vetor e hospederoInfo
- Publication number
- BRPI0909547A2 BRPI0909547A2 BRPI0909547-0A BRPI0909547A BRPI0909547A2 BR PI0909547 A2 BRPI0909547 A2 BR PI0909547A2 BR PI0909547 A BRPI0909547 A BR PI0909547A BR PI0909547 A2 BRPI0909547 A2 BR PI0909547A2
- Authority
- BR
- Brazil
- Prior art keywords
- hpv
- vaccines
- combined
- vector
- measles
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A61K39/165—Mumps or measles virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55533—IL-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18441—Use of virus, viral particle or viral elements as a vector
- C12N2760/18443—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/101—Plasmid DNA for bacteria
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
Abstract
"vacina combinada de sarampo - hpv, vetor e hospedeiro" a presente invenção refere-se a vacinas combinadas contra o sarampo e o vírus de papiloma humano (hpv). em particular, a invenção refere-se a vetores do vírus de sarampo recombinante contendo ácido nucléico heterólogo codificando antígenos simples ou variados derivados a partir de hpv, preferivelmente, o antígeno principal cápside l1, o antígeno secundário cápside l2, as onco proteínas do gene anterior e6 e do gene anterior e7 do tipo hpv 16, e opcionalmente dos tipos 18, 6 e 11. em uma primeira realização, vacinas profiláticas são geradas expressando antígenos de hpv, preferivelmente l1 e/ou l2 de tal maneira que as mesmas induzem uma imune resposta potente e duradoura em mamíferos, preferivelmente em seres humanos, para proteger contra a infecção causada por hpv e mv. em outra realização as vacinas terapêuticas são geradas expressando as proteínas e6 e e7, e opcionalmente l1 e l2, de tal maneira que as mesmas induzem imunes respostas fortes que resolverão as infecções persistentes de hpv num estágio mais cedo ou mais tarde, incluindo o carcinoma cervical induzido por hpv. em uma realização preferida, as vacinas combinadas são de fácil produção em uma grande escala e podem ser distribuídas com um custo baixo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1113/MUM2008 | 2008-05-26 | ||
IN1113MU2008 | 2008-05-26 | ||
PCT/IN2009/000302 WO2010079505A2 (en) | 2008-05-26 | 2009-05-26 | Combined measles-human papilloma vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0909547A2 true BRPI0909547A2 (pt) | 2019-03-06 |
Family
ID=42316922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0909547-0A BRPI0909547A2 (pt) | 2008-05-26 | 2009-05-26 | vacina combinada de sarampo - hpv, vetor e hospedero |
Country Status (13)
Country | Link |
---|---|
US (1) | US9623098B2 (pt) |
EP (1) | EP2280728B1 (pt) |
JP (1) | JP5726727B2 (pt) |
CN (2) | CN102099053A (pt) |
AR (1) | AR071910A1 (pt) |
AU (1) | AU2009336562B2 (pt) |
BR (1) | BRPI0909547A2 (pt) |
CA (1) | CA2722847C (pt) |
EA (1) | EA027784B1 (pt) |
ES (1) | ES2565846T3 (pt) |
TW (1) | TWI561244B (pt) |
WO (1) | WO2010079505A2 (pt) |
ZA (1) | ZA201007595B (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2000240471A1 (en) | 2000-03-31 | 2001-10-15 | Northern Research And Engineering Corporation | Solid-fueled power generation system with carbon dioxide sequestration and method therefor |
EP2110382A1 (en) | 2002-06-20 | 2009-10-21 | Institut Pasteur | Infectious cDNA of an improved vaccine strain of measles virus, use for immunogenic compositions |
EP1375670B1 (en) * | 2002-06-20 | 2013-06-12 | Institut Pasteur | Recombinant measles viruses expressing epitopes of antigens of RNA viruses and use of the recombinant viruses for the preparation of vaccine compositions |
CA2432738A1 (en) | 2003-02-26 | 2004-08-26 | Philippe Despres | New dengue and west nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications |
KR101616572B1 (ko) * | 2009-05-05 | 2016-05-11 | 카딜라 핼쓰캐어 리미티드 | 홍역-말라리아 조합 백신 |
EP3443982A1 (en) * | 2011-10-12 | 2019-02-20 | The Trustees of the University of Pennsylvania | Vaccines for human papilloma virus and methods for using the same |
WO2013074501A1 (en) * | 2011-11-14 | 2013-05-23 | Crucell Holland B.V. | Heterologous prime-boost immunization using measles virus-based vaccines |
US20150224181A1 (en) | 2012-09-14 | 2015-08-13 | The United States Of America As Represented By The Secretary Department Of Health And Human Se | Brachyury protein, non-poxvirus non-yeast vectors encoding brachyury protein, and their use |
MX2015011484A (es) | 2013-03-12 | 2016-02-03 | Univ Pennsylvania | Vacunas mejoradas para el virus de papiloma humano y metodos para utilizarlas. |
CN105801704B (zh) * | 2014-12-31 | 2020-06-02 | 艾托金生物医药(苏州)有限公司 | 一种具有抗宫颈癌细胞活性的重组疫苗构建方法及应用 |
CN104830869B (zh) * | 2015-04-30 | 2018-06-01 | 武汉凯德维斯生物技术有限公司 | 与宫颈癌发生相关的hpv整合的基因位点及其应用 |
JP7048482B2 (ja) | 2015-08-03 | 2022-04-05 | アメリカ合衆国 | Brachyury欠失変異体、Brachyury欠失変異体をコードする非酵母ベクター、及びそれらの使用 |
RU2681174C1 (ru) * | 2018-07-12 | 2019-03-04 | Закрытое акционерное общество научно-производственная компания "Комбиотех" | Способ получения рекомбинантной вакцины для профилактики папилломавирусной инфекции человека, рекомбинантная вакцина |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9113809D0 (en) | 1991-06-26 | 1991-08-14 | Cancer Res Campaign Tech | Papillomavirus l2 protein |
ATE234925T1 (de) | 1991-07-19 | 2003-04-15 | Univ Queensland | Impfstoffe gegen papillomavirus |
ATE380871T1 (de) | 1992-06-25 | 2007-12-15 | Univ Georgetown | Papillomavirus vakzine |
US5437951A (en) | 1992-09-03 | 1995-08-01 | The United States Of America As Represented By The Department Of Health And Human Services | Self-assembling recombinant papillomavirus capsid proteins |
DE69434383T2 (de) | 1993-03-09 | 2005-11-24 | The University Of Rochester | Herstellung von menschlichem papillomavirus hüllprotein und virus-ähnlichen teilchen |
DE69510207T3 (de) | 1995-08-09 | 2007-02-15 | Schweiz. Serum- & Impfinstitut Bern | Verfahren zur Herstellung von infektiösen minussträngigen RNA-Viren |
ES2273482T3 (es) * | 1998-03-09 | 2007-05-01 | Glaxosmithkline Biologicals S.A. | Composiciones de vacunas combinadas. |
HU228473B1 (en) * | 1998-10-16 | 2013-03-28 | Smithkline Beecham Biolog | Adjuvant systems and vaccines |
GB0110431D0 (en) * | 2001-04-27 | 2001-06-20 | Glaxosmithkline Biolog Sa | Novel compounds |
EP1375670B1 (en) * | 2002-06-20 | 2013-06-12 | Institut Pasteur | Recombinant measles viruses expressing epitopes of antigens of RNA viruses and use of the recombinant viruses for the preparation of vaccine compositions |
KR101114784B1 (ko) | 2002-11-12 | 2012-02-27 | 예일 유니버시티 | 아데노바이러스 벡터 백신 |
CA2432738A1 (en) * | 2003-02-26 | 2004-08-26 | Philippe Despres | New dengue and west nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications |
MY139500A (en) * | 2003-11-12 | 2009-10-30 | Merck Sharp & Dohme | Optimized expression of hpv 58 l1 in yeast |
US9034343B2 (en) * | 2005-01-12 | 2015-05-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Attenuated human parainfluenza virus, methods and uses thereof |
-
2009
- 2009-05-26 JP JP2011511167A patent/JP5726727B2/ja active Active
- 2009-05-26 TW TW098117618A patent/TWI561244B/zh not_active IP Right Cessation
- 2009-05-26 AR ARP090101881A patent/AR071910A1/es unknown
- 2009-05-26 CN CN2009801194069A patent/CN102099053A/zh active Pending
- 2009-05-26 BR BRPI0909547-0A patent/BRPI0909547A2/pt not_active Application Discontinuation
- 2009-05-26 EA EA201071366A patent/EA027784B1/ru not_active IP Right Cessation
- 2009-05-26 AU AU2009336562A patent/AU2009336562B2/en not_active Ceased
- 2009-05-26 CN CN201610737988.9A patent/CN106377767A/zh active Pending
- 2009-05-26 EP EP09828417.7A patent/EP2280728B1/en active Active
- 2009-05-26 US US12/993,693 patent/US9623098B2/en not_active Expired - Fee Related
- 2009-05-26 WO PCT/IN2009/000302 patent/WO2010079505A2/en active Application Filing
- 2009-05-26 CA CA2722847A patent/CA2722847C/en not_active Expired - Fee Related
- 2009-05-26 ES ES09828417.7T patent/ES2565846T3/es active Active
-
2010
- 2010-10-25 ZA ZA2010/07595A patent/ZA201007595B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2722847A1 (en) | 2010-07-15 |
CN106377767A (zh) | 2017-02-08 |
US9623098B2 (en) | 2017-04-18 |
TW201010718A (en) | 2010-03-16 |
JP5726727B2 (ja) | 2015-06-03 |
EP2280728B1 (en) | 2016-03-02 |
WO2010079505A2 (en) | 2010-07-15 |
TWI561244B (en) | 2016-12-11 |
CN102099053A (zh) | 2011-06-15 |
ZA201007595B (en) | 2011-09-28 |
US20110129493A1 (en) | 2011-06-02 |
AU2009336562B2 (en) | 2012-12-20 |
JP2011524863A (ja) | 2011-09-08 |
EP2280728A2 (en) | 2011-02-09 |
WO2010079505A3 (en) | 2010-11-04 |
AR071910A1 (es) | 2010-07-21 |
ES2565846T3 (es) | 2016-04-07 |
AU2009336562A1 (en) | 2010-07-15 |
EA027784B1 (ru) | 2017-09-29 |
CA2722847C (en) | 2019-12-17 |
EA201071366A1 (ru) | 2011-06-30 |
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