WO2007098718A8 - Antígenos vacunales quiméricos contra el virus de la influenza aviar - Google Patents

Antígenos vacunales quiméricos contra el virus de la influenza aviar

Info

Publication number
WO2007098718A8
WO2007098718A8 PCT/CU2007/000009 CU2007000009W WO2007098718A8 WO 2007098718 A8 WO2007098718 A8 WO 2007098718A8 CU 2007000009 W CU2007000009 W CU 2007000009W WO 2007098718 A8 WO2007098718 A8 WO 2007098718A8
Authority
WO
WIPO (PCT)
Prior art keywords
chimeric
antigens
influenza virus
avian influenza
vaccine
Prior art date
Application number
PCT/CU2007/000009
Other languages
English (en)
French (fr)
Other versions
WO2007098718A1 (es
Inventor
Ramos Oliberto Sanchez
Alonso Jorge Roberto Toledo
Archer Damarys Diaz
Baile Nancy Elena Figueroa
Molto Maria Pilar Rodriguez
Nordelo Carlos Guillermo Borroto
Original Assignee
Ct Ingenieria Genetica Biotech
Ramos Oliberto Sanchez
Alonso Jorge Roberto Toledo
Archer Damarys Diaz
Baile Nancy Elena Figueroa
Molto Maria Pilar Rodriguez
Borroto Nordelo Carlos Guiller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Ingenieria Genetica Biotech, Ramos Oliberto Sanchez, Alonso Jorge Roberto Toledo, Archer Damarys Diaz, Baile Nancy Elena Figueroa, Molto Maria Pilar Rodriguez, Borroto Nordelo Carlos Guiller filed Critical Ct Ingenieria Genetica Biotech
Priority to EP07711103A priority Critical patent/EP1997831A1/en
Priority to MX2008011143A priority patent/MX2008011143A/es
Priority to AU2007219571A priority patent/AU2007219571A1/en
Priority to CA002638832A priority patent/CA2638832A1/en
Priority to JP2008556645A priority patent/JP2009528305A/ja
Priority to US12/280,568 priority patent/US20090324644A1/en
Priority to BRPI0708383-1A priority patent/BRPI0708383A2/pt
Publication of WO2007098718A1 publication Critical patent/WO2007098718A1/es
Publication of WO2007098718A8 publication Critical patent/WO2007098718A8/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/605—MHC molecules or ligands thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención describe antígenos vacunales quiméricos contra el virus de la Influenza Aviar (IA). Dichos antígenos vacunales están basados en subunidades virales que están acopladas a moléculas proteicas estimuladoras del sistema inmune, tanto celular como humoral. Los antígenos quiméricos pueden ser producidos en sistemas de expresión que garantizan un correcto plegamiento tridimensional de las moléculas quiméricas que constituyen la base de la presente invención. Las composiciones vacunales que contienen dichos antígenos quiméricos inducen una respuesta inmune potente y temprana tanto en las aves como en los mamíferos vacunados, estimulando altos títulos de anticuerpos inhibidores de la hemaglutación y una potente respuesta celular específica contra el antígeno viral. Los antígenos quiméricos, así como las composiciones vacunales resultantes son aplicables a la esfera de la salud humana y animal, como vacunas para uso preventivo.
PCT/CU2007/000009 2006-02-28 2007-02-28 Antígenos vacunales quiméricos contra el virus de la influenza aviar WO2007098718A1 (es)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP07711103A EP1997831A1 (en) 2006-02-28 2007-02-28 Chimeric vaccine antigens against the avian influenza virus
MX2008011143A MX2008011143A (es) 2006-02-28 2007-02-28 Antigenos vacunales quimericos contra el virus de la influenza aviar.
AU2007219571A AU2007219571A1 (en) 2006-02-28 2007-02-28 Chimeric vaccine antigens against the avian influenza virus
CA002638832A CA2638832A1 (en) 2006-02-28 2007-02-28 Chimeric vaccine antigens against the avian influenza virus
JP2008556645A JP2009528305A (ja) 2006-02-28 2007-02-28 鳥インフルエンザウイルスに対するキメラワクチン抗原
US12/280,568 US20090324644A1 (en) 2006-02-28 2007-02-28 Chimeric vaccine antigens against the avian influenza virus
BRPI0708383-1A BRPI0708383A2 (pt) 2006-02-28 2007-02-28 antìgeno vacinal quimérico contra o vìrus da influenza aviário e composição de vacina capaz de produzir uma resposta imune protetora contra vìrus da influenza aviária em aves e em mamìferos

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU2006-0051 2006-02-28
CU20060051A CU23576A1 (es) 2006-02-28 2006-02-28 Antígenos vacunales quiméricos contra el virus de la influenza aviar

Publications (2)

Publication Number Publication Date
WO2007098718A1 WO2007098718A1 (es) 2007-09-07
WO2007098718A8 true WO2007098718A8 (es) 2008-12-18

Family

ID=40130782

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CU2007/000009 WO2007098718A1 (es) 2006-02-28 2007-02-28 Antígenos vacunales quiméricos contra el virus de la influenza aviar

Country Status (14)

Country Link
US (1) US20090324644A1 (es)
EP (1) EP1997831A1 (es)
JP (1) JP2009528305A (es)
KR (1) KR20080113217A (es)
CN (1) CN101421302A (es)
AR (1) AR059647A1 (es)
AU (1) AU2007219571A1 (es)
BR (1) BRPI0708383A2 (es)
CA (1) CA2638832A1 (es)
CL (1) CL2007000526A1 (es)
CU (1) CU23576A1 (es)
MX (1) MX2008011143A (es)
RU (1) RU2008138535A (es)
WO (1) WO2007098718A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5480812B2 (ja) * 2007-11-01 2014-04-23 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー アイメリアに対する免疫応答を強化する組成物および方法
JP2012525134A (ja) * 2009-04-30 2012-10-22 サイトス バイオテクノロジー アーゲー インフルエンザ赤血球凝集素の組成物とその使用
TW201738562A (zh) * 2009-05-28 2017-11-01 亞培生物股份有限公司 體外病原體檢驗技術
KR101262300B1 (ko) * 2009-10-06 2013-05-20 헬릭스 주식회사 형질전환 식물 유래의 고병원성 조류독감 바이러스 단백질 백신 및 그 제조방법
US9795661B2 (en) 2009-11-16 2017-10-24 The United States Of America As Represented By The Secretary Of The Navy TH1/TH2 polarizing vaccines
EA033538B1 (ru) 2013-03-15 2019-10-31 Univ Arkansas Композиции и способы усиления иммунного ответа на кишечные патогены
KR101582490B1 (ko) 2014-04-14 2016-01-19 아이디바이오 주식회사 인플루엔자 바이러스의 다중 아형에 대한 교차 면역반응을 형성하는 신규한 재조합 바이러스 백신
MX2018013331A (es) 2016-05-03 2019-06-10 Univ Arkansas Vector de vacuna de levadura que incluye polipeptidos inmunoestimuladores y antigenicos y metodos para su uso.
KR101964044B1 (ko) * 2018-03-14 2019-04-02 인제대학교 산학협력단 재조합 아데노바이러스를 이용한 다가형 인플루엔자 생백신 플랫폼
CN112679586A (zh) * 2020-12-28 2021-04-20 乾元浩生物股份有限公司 H5、h7亚型禽流感病毒基因工程亚单位疫苗及其制备方法与应用
CN114106113B (zh) * 2021-11-13 2024-04-19 江苏南农高科技股份有限公司 一种表达猪细小病毒vp2蛋白的重组杆状病毒、制备方法及应用

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* Cited by examiner, † Cited by third party
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US5762939A (en) 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
ES2370937T3 (es) 1993-09-13 2011-12-23 Protein Sciences Corporation Un método para producir vacunas antigripales polivalentes a base de hemaglutinina.
US20020136722A1 (en) * 1997-06-18 2002-09-26 Heath Andrew William Vaccination method
CU23102A1 (es) * 2002-10-21 2005-12-20 Ct Ingenieria Genetica Biotech Método para la producción de proteínas recombinantes en la glándula mamaria de mamíferos no transgénicos
CA2628837C (en) * 2005-11-07 2018-11-27 Sidney Kimmel Cancer Center Cd40 ligand fusion protein vaccine

Also Published As

Publication number Publication date
MX2008011143A (es) 2008-09-08
KR20080113217A (ko) 2008-12-29
US20090324644A1 (en) 2009-12-31
CN101421302A (zh) 2009-04-29
CA2638832A1 (en) 2007-09-07
CL2007000526A1 (es) 2009-03-27
AR059647A1 (es) 2008-04-16
CU23576A1 (es) 2010-09-30
BRPI0708383A2 (pt) 2011-05-24
RU2008138535A (ru) 2010-04-10
WO2007098718A1 (es) 2007-09-07
AU2007219571A1 (en) 2007-09-07
EP1997831A1 (en) 2008-12-03
JP2009528305A (ja) 2009-08-06

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