BRPI0908120A2 - - Google Patents
Info
- Publication number
- BRPI0908120A2 BRPI0908120A2 BRPI0908120A BRPI0908120A2 BR PI0908120 A2 BRPI0908120 A2 BR PI0908120A2 BR PI0908120 A BRPI0908120 A BR PI0908120A BR PI0908120 A2 BRPI0908120 A2 BR PI0908120A2
- Authority
- BR
- Brazil
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3040708P | 2008-02-21 | 2008-02-21 | |
| PCT/US2009/034447 WO2009105500A1 (en) | 2008-02-21 | 2009-02-19 | Compounds that are erk inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0908120A2 true BRPI0908120A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2017-08-22 |
| BRPI0908120A8 BRPI0908120A8 (pt) | 2017-10-24 |
Family
ID=40601237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0908120A BRPI0908120A8 (pt) | 2008-02-21 | 2009-02-19 | Compostos que são inibidores de erk, composição faramacêutica e uso |
Country Status (23)
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8546404B2 (en) | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
| JP2009528280A (ja) | 2006-02-16 | 2009-08-06 | シェーリング コーポレイション | Ｅｒｋインヒビターとしてのピロリジン誘導体 |
| EP2316031B1 (en) | 2008-08-19 | 2016-09-14 | Merck Sharp & Dohme Corp. | IL-8 biomarker for monitoring cancer treatment |
| US9229008B2 (en) | 2008-08-19 | 2016-01-05 | Merck Sharp & Dohme Corp. | IL-8 level as a determinant of responsivity of a cancer to treatment |
| EP2448942B1 (en) | 2009-07-02 | 2014-09-24 | Merck Sharp & Dohme Corp. | FUSED TRICYCLIC COMPOUNDS AS mTOR INHIBITORS |
| CA2774769A1 (en) | 2009-09-30 | 2011-04-07 | Schering Corporation | Novel compounds that are erk inhibitors |
| WO2011163330A1 (en) * | 2010-06-24 | 2011-12-29 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
| WO2012036997A1 (en) * | 2010-09-16 | 2012-03-22 | Schering Corporation | Fused pyrazole derivatives as novel erk inhibitors |
| US9173396B2 (en) | 2010-10-22 | 2015-11-03 | Bayer Intellectual Property Gmbh | Heterocyclic compounds as pesticides |
| US20130330353A1 (en) * | 2010-11-16 | 2013-12-12 | Medimmune, Llc | Regimens for treatments using anti-igf antibodies |
| WO2013015918A1 (en) | 2011-07-22 | 2013-01-31 | Iowa State University Research Foundation, Inc. | Method of regioselective synthesis of substituted benzoates |
| EP2820009B1 (en) | 2012-03-01 | 2018-01-31 | Array Biopharma, Inc. | Serine/threonine kinase inhibitors |
| US20150141470A1 (en) | 2012-05-08 | 2015-05-21 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
| US9434695B2 (en) | 2012-07-18 | 2016-09-06 | Sunshine Lake Pharma Co., Ltd | Nitrogenous heterocyclic derivatives and their application in drugs |
| EP2900223B1 (en) * | 2012-09-28 | 2017-10-25 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
| BR112015006990A2 (pt) | 2012-09-28 | 2017-07-04 | Merck Sharp & Dohme | composto, composição farmacêutica, e, uso de pelo menos um composto |
| BR112015020716A2 (pt) * | 2013-03-13 | 2017-07-18 | Hoffmann La Roche | processo para a preparação de (2-(4-(2-(1-isopropil-3-metil-1h-1,2,4-triazol-5-il)-5,6-diidrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-il)-1h-pirazol-1-il)-2-metilpropanamida (i) e composto |
| US8871966B2 (en) | 2013-03-15 | 2014-10-28 | Iowa State University Research Foundation, Inc. | Regiospecific synthesis of terephthalates |
| WO2015051341A1 (en) | 2013-10-03 | 2015-04-09 | Araxes Pharma Llc | Inhibitors of erk and methods of use |
| US10428387B2 (en) | 2014-05-16 | 2019-10-01 | University Of Massachusetts | Treating chronic myelogenous leukemia (CML) |
| WO2016025639A1 (en) * | 2014-08-13 | 2016-02-18 | Celgene Avilomics Research, Inc. | Combinations of an erk inhibitor and a chemotherapeutic agent and related methods |
| WO2016095088A1 (en) * | 2014-12-15 | 2016-06-23 | Merck Sharp & Dohme Corp. | Erk inhibitors |
| WO2016095089A1 (en) | 2014-12-15 | 2016-06-23 | Merck Sharp & Dohme Corp. | Erk inhibitors |
| MX2017008077A (es) | 2014-12-18 | 2017-09-28 | Merck Sharp & Dohme | Composiciones de (s)-n-(3-(6-isopropoxipiridin-3-il)-1h-indazol-5- il)-1-(2-(4-(4-(1-metil-1h-1,2,4-triazol-3-il)fenil)-3,6-dihidrop iridin-1(2h)-il)-2-oxoetil)-3-(metiltio)pirrolidin-3-carboxamida para preparaciones farmaceuticas. |
| WO2016100152A1 (en) | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide compositions for pharmaceutical preparations |
| WO2016161160A1 (en) | 2015-04-03 | 2016-10-06 | Kalyra Pharmaceuticals, Inc. | Spirocyclic compounds |
| US20180250232A1 (en) * | 2015-09-03 | 2018-09-06 | Merck Sharp & Dohme Corp. | Process for preparing spray dried solid dispersions of (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide for pharmaceutical preparations |
| CN106432182B (zh) * | 2016-09-06 | 2019-04-30 | 铜仁学院 | 特地唑胺中间体的合成方法 |
| CN109020789B (zh) * | 2017-06-12 | 2021-08-13 | 浙江医药股份有限公司新昌制药厂 | 一种制备2-甲氧基丙烯的方法 |
| WO2021067266A1 (en) * | 2019-10-01 | 2021-04-08 | Recurium Ip Holdings, Llc | Pyrrolidinyl-based compounds |
| JP2022551309A (ja) | 2019-10-09 | 2022-12-08 | バイエル・アクチエンゲゼルシヤフト | 殺有害生物剤としての新規ヘテロアリール－トリアゾール化合物 |
| KR102823105B1 (ko) | 2019-12-06 | 2025-06-20 | 디3 바이오 (우씨) 컴퍼니, 리미티드 | Erk 억제제로서 작용하는 스피로 화합물 및 이의 응용 |
Family Cites Families (56)
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|---|---|---|---|---|
| GB2306108A (en) | 1995-10-13 | 1997-04-30 | Merck & Co Inc | Treatment of Raf-mediated cancers with imidazole derivatives |
| AU3215197A (en) | 1996-05-30 | 1998-01-05 | Merck & Co., Inc. | A method of treating cancer |
| GB2323845A (en) | 1997-03-31 | 1998-10-07 | Merck & Co Inc | MEK inhibiting lactones |
| EP1005361B1 (en) | 1997-07-18 | 2010-01-06 | Novo Nordisk Health Care AG | USE OF FVIIa OR FVIIai FOR THE TREATMENT OF ENDOTHELIAL DYSFUNKTION AND FOR THE INHIBITION OF ANGIOGENESIS RESPECTIVELY |
| GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| WO2001056557A2 (en) | 2000-02-05 | 2001-08-09 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of erk |
| CN1362953A (zh) | 2000-02-05 | 2002-08-07 | 沃泰克斯药物股份有限公司 | 用作erk抑制剂的吡唑组合物 |
| BR0109188A (pt) | 2000-03-15 | 2003-03-18 | Warner Lambert Co | Diarilaminas 5-amida substituìdas como inibidores de mex |
| TWI310684B (en) | 2000-03-27 | 2009-06-11 | Bristol Myers Squibb Co | Synergistic pharmaceutical kits for treating cancer |
| US20050009876A1 (en) * | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
| US7211594B2 (en) * | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
| US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| DE60128709T2 (de) | 2000-09-15 | 2007-12-27 | Vertex Pharmaceuticals Inc., Cambridge | Triazol-verbindungen als protein-kinase-inhibitoren |
| ATE335737T1 (de) | 2000-09-15 | 2006-09-15 | Vertex Pharma | Isoxazole und ihre verwendung als erk-inhibitoren |
| ES2279837T3 (es) * | 2000-11-20 | 2007-09-01 | Scios Inc. | Inhibidores de tipo piperidina/piperazina de la quinasa p38. |
| BR0116493A (pt) * | 2000-12-21 | 2003-09-30 | Vertex Pharma | Compostos de pirazol úteis como inibidores de proteìna cinase |
| MY130778A (en) | 2001-02-09 | 2007-07-31 | Vertex Pharma | Heterocyclic inhibitiors of erk2 and uses thereof |
| DE60234510D1 (de) * | 2001-04-16 | 2010-01-07 | Eisai R&D Man Co Ltd | 1h-indazolverbindungen die jnk hemmen |
| AU2002305260A1 (en) | 2001-04-27 | 2002-11-11 | Vertex Pharmaceuticals Incorporated | Pyrazole derived kinase inhibitors |
| US6962936B2 (en) | 2001-04-27 | 2005-11-08 | Vertex Pharmaceuticals Incorporated | Triazole-derived kinase inhibitors and uses thereof |
| WO2003011854A1 (en) | 2001-08-03 | 2003-02-13 | Vertex Pharmaceuticals Incorporated | Pyrazole-derived kinase inhibitors and uses thereof |
| ATE392421T1 (de) | 2001-08-03 | 2008-05-15 | Vertex Pharma | Von pyrazol abgeleitete kinaseinhibitoren und deren verwendung |
| US7253199B2 (en) | 2001-10-23 | 2007-08-07 | Applied Research Systems Ars Holding N.V. | Azole derivatives and pharmaceutical compositions containing them |
| US20030187026A1 (en) * | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| EP1506189A1 (en) | 2002-04-26 | 2005-02-16 | Vertex Pharmaceuticals Incorporated | Pyrrole derivatives as inhibitors of erk2 and uses thereof |
| WO2003099212A2 (en) | 2002-05-24 | 2003-12-04 | The University Of Utah Research Foundation | Mitogen activated protein kinase inhibitor compositions for lymphoma therapy |
| IL164209A0 (en) * | 2002-05-31 | 2005-12-18 | Eisai Co Ltd | Pyrazole derivatives and pharmaceutical compositions containing the same |
| US7205308B2 (en) | 2002-09-04 | 2007-04-17 | Schering Corporation | Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7196092B2 (en) | 2002-09-04 | 2007-03-27 | Schering Corporation | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| AR041291A1 (es) | 2002-09-19 | 2005-05-11 | Schering Corp | Imidazopiridinas como inhibidores de quinasa dependientes de ciclina |
| AU2004221881A1 (en) | 2003-03-13 | 2004-09-30 | Vertex Pharmaceuticals Incorporated | Compositions useful as protein kinase inhibitors |
| GB2400101A (en) | 2003-03-28 | 2004-10-06 | Biofocus Discovery Ltd | Compounds capable of binding to the active site of protein kinases |
| WO2005002673A1 (en) | 2003-07-03 | 2005-01-13 | Astex Therapeutics Limited | Raf kinase inhibitors |
| US20050107386A1 (en) * | 2003-11-19 | 2005-05-19 | Rama Krishna Narla | Methods of treating diseases and disorders by targeting multiple kinases |
| WO2005063258A1 (en) | 2003-12-22 | 2005-07-14 | Gilead Sciences, Inc. | Kinase inhibitor phosphonate conjugates |
| JP2007530595A (ja) | 2004-03-26 | 2007-11-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｅｒｋ２のピリジンインヒビターおよびそれらの使用 |
| EP1756082A1 (en) | 2004-04-13 | 2007-02-28 | Astex Therapeutics Limited | 5-morpholinylmethylthiophenyl pharmaceutial compounds as p38 map kinase modulators |
| CN1976919A (zh) | 2004-05-14 | 2007-06-06 | 沃泰克斯药物股份有限公司 | 作为erk蛋白激酶抑制剂的吡咯化合物、它们的合成和中间体 |
| DE602005015319D1 (de) | 2004-05-14 | 2009-08-20 | Vertex Pharma | Prodrugs von als erk-proteinkinase-inhibitoren wirkenden pyrrolylpyrimidinen |
| WO2006040569A1 (en) | 2004-10-14 | 2006-04-20 | Astex Therapeutics Limited | Thiophene amide compounds for use in the treatment or prophylaxis of cancers |
| WO2006071644A1 (en) | 2004-12-23 | 2006-07-06 | Vertex Pharmaceuticals Incorporated | Selective inhibitors of erk protein kinases and uses therof |
| CN100377868C (zh) * | 2005-03-24 | 2008-04-02 | 中国科学院物理研究所 | 用于磁性/非磁性/磁性多层薄膜的核心复合膜及其用途 |
| WO2006136008A1 (en) | 2005-05-24 | 2006-12-28 | University Health Network | Salicylic acid hydrazones as inhibitors of the erk mapkinase pathway and for the treatment of cancer |
| US8217042B2 (en) * | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
| US8546404B2 (en) * | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
| BRPI0619823B8 (pt) * | 2005-12-13 | 2021-05-25 | Merck Sharp & Dohme | compostos que são inibidores de erk |
| JP2009528280A (ja) * | 2006-02-16 | 2009-08-06 | シェーリング コーポレイション | Ｅｒｋインヒビターとしてのピロリジン誘導体 |
| EP2260869A3 (en) * | 2006-04-20 | 2011-03-23 | Takeda Pharmaceutical Company Limited | Pharmaceutical product |
| US7601852B2 (en) * | 2006-05-11 | 2009-10-13 | Kosan Biosciences Incorporated | Macrocyclic kinase inhibitors |
| MX2009000285A (es) * | 2006-06-30 | 2009-06-08 | Schering Corp | Piperidinas sustituidas que incrementan la actividad de p53 y usos de las mismas. |
| US7671832B2 (en) * | 2006-07-10 | 2010-03-02 | Philips Lumileds Lighting Company, Llc | Multi-colored LED backlight with color-compensated clusters near edge |
| JP5347202B2 (ja) | 2007-03-28 | 2013-11-20 | ファーマサイクリックス，インク． | ブルトンチロシンキナーゼインヒビター |
| AU2008262412A1 (en) * | 2007-06-05 | 2008-12-18 | Merck Sharp & Dohme Corp. | Polycyclic indazole derivatives and their use as ERK inhibitors for the treatment of cancer |
| CN101790526A (zh) | 2007-06-08 | 2010-07-28 | 雅培制药有限公司 | 用作激酶抑制剂的5-杂芳基取代的吲唑化合物 |
| EP2170893A1 (en) | 2007-06-18 | 2010-04-07 | Schering Corporation | Heterocyclic compounds and use thereof as erk inhibitors |
| CA2774769A1 (en) | 2009-09-30 | 2011-04-07 | Schering Corporation | Novel compounds that are erk inhibitors |
-
2009
- 2009-02-19 JP JP2010547732A patent/JP5276676B2/ja not_active Expired - Fee Related
- 2009-02-19 CN CN200980113870.7A patent/CN102015693B/zh not_active Expired - Fee Related
- 2009-02-19 MY MYPI20103904 patent/MY152271A/en unknown
- 2009-02-19 CA CA2714479A patent/CA2714479A1/en not_active Abandoned
- 2009-02-19 NZ NZ587504A patent/NZ587504A/xx not_active IP Right Cessation
- 2009-02-19 AU AU2009215534A patent/AU2009215534B8/en not_active Ceased
- 2009-02-19 US US12/918,099 patent/US8716483B2/en active Active
- 2009-02-19 SG SG2013013206A patent/SG188179A1/en unknown
- 2009-02-19 EP EP09712601.5A patent/EP2260031B1/en active Active
- 2009-02-19 ES ES09712601.5T patent/ES2556353T3/es active Active
- 2009-02-19 WO PCT/US2009/034447 patent/WO2009105500A1/en active Application Filing
- 2009-02-19 KR KR1020107020896A patent/KR20100117123A/ko not_active Ceased
- 2009-02-19 BR BRPI0908120A patent/BRPI0908120A8/pt not_active IP Right Cessation
- 2009-02-19 MX MX2010009268A patent/MX2010009268A/es active IP Right Grant
- 2009-02-19 RU RU2010138635/04A patent/RU2525389C2/ru not_active IP Right Cessation
- 2009-02-20 PE PE2009000250A patent/PE20091491A1/es active IP Right Grant
- 2009-02-20 TW TW098105537A patent/TWI398441B/zh not_active IP Right Cessation
- 2009-02-20 CL CL2009000394A patent/CL2009000394A1/es unknown
- 2009-02-20 AR ARP090100604A patent/AR070460A1/es active IP Right Grant
-
2010
- 2010-08-10 IL IL207530A patent/IL207530A/en active IP Right Grant
- 2010-08-18 ZA ZA2010/05909A patent/ZA201005909B/en unknown
- 2010-08-20 EC EC2010010415A patent/ECSP10010415A/es unknown
- 2010-09-21 CO CO10116702A patent/CO6300939A2/es active IP Right Grant
-
2014
- 2014-01-17 ZA ZA2014/00396A patent/ZA201400396B/en unknown
Also Published As
Similar Documents
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B25D | Requested change of name of applicant approved |
Owner name: MERCK SHARP AND DOHME CORP. (US) |
|
| B25G | Requested change of headquarter approved |
Owner name: MERCK SHARP AND DOHME CORP. (US) |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |