BRPI0809978A2 - Dispositivos e métodos de dispensação de gotículas - Google Patents

Dispositivos e métodos de dispensação de gotículas

Info

Publication number
BRPI0809978A2
BRPI0809978A2 BRPI0809978-2A2A BRPI0809978A BRPI0809978A2 BR PI0809978 A2 BRPI0809978 A2 BR PI0809978A2 BR PI0809978 A BRPI0809978 A BR PI0809978A BR PI0809978 A2 BRPI0809978 A2 BR PI0809978A2
Authority
BR
Brazil
Prior art keywords
gothicle
methods
dispensing devices
dispensing
devices
Prior art date
Application number
BRPI0809978-2A2A
Other languages
English (en)
Portuguese (pt)
Inventor
Michael Pollack
Vamsee Pamula
Vijay Srinivasan
Original Assignee
Advanced Liquid Logic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Liquid Logic Inc filed Critical Advanced Liquid Logic Inc
Publication of BRPI0809978A2 publication Critical patent/BRPI0809978A2/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3031—Micromixers using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/088—Channel loops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Molecular Biology (AREA)
  • Electrochemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Coating Apparatus (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micromachines (AREA)
  • Jet Pumps And Other Pumps (AREA)
BRPI0809978-2A2A 2007-04-10 2008-04-10 Dispositivos e métodos de dispensação de gotículas BRPI0809978A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91089707P 2007-04-10 2007-04-10
US98020207P 2007-10-16 2007-10-16
PCT/US2008/059955 WO2008124846A2 (en) 2007-04-10 2008-04-10 Droplet dispensing device and methods

Publications (1)

Publication Number Publication Date
BRPI0809978A2 true BRPI0809978A2 (pt) 2014-10-07

Family

ID=39831590

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0809978-2A2A BRPI0809978A2 (pt) 2007-04-10 2008-04-10 Dispositivos e métodos de dispensação de gotículas

Country Status (9)

Country Link
US (2) US20100032293A1 (enExample)
EP (1) EP2132296A4 (enExample)
JP (1) JP2010524002A (enExample)
KR (1) KR20100016343A (enExample)
CN (1) CN101743304B (enExample)
AU (1) AU2008237017B2 (enExample)
BR (1) BRPI0809978A2 (enExample)
CA (1) CA2719549A1 (enExample)
WO (1) WO2008124846A2 (enExample)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1859330T3 (pl) 2005-01-28 2013-01-31 Univ Duke Urządzenia i sposoby manipulacji kropelkami na płytkach obwodów drukowanych
US20140193807A1 (en) 2006-04-18 2014-07-10 Advanced Liquid Logic, Inc. Bead manipulation techniques
US8716015B2 (en) 2006-04-18 2014-05-06 Advanced Liquid Logic, Inc. Manipulation of cells on a droplet actuator
US10078078B2 (en) 2006-04-18 2018-09-18 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US8658111B2 (en) * 2006-04-18 2014-02-25 Advanced Liquid Logic, Inc. Droplet actuators, modified fluids and methods
US8637324B2 (en) 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US7439014B2 (en) 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US8809068B2 (en) 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
US9675972B2 (en) 2006-05-09 2017-06-13 Advanced Liquid Logic, Inc. Method of concentrating beads in a droplet
US8685344B2 (en) 2007-01-22 2014-04-01 Advanced Liquid Logic, Inc. Surface assisted fluid loading and droplet dispensing
EP2111554B1 (en) 2007-02-09 2013-05-08 Advanced Liquid Logic, Inc. Droplet actuator devices and methods employing magnetic beads
WO2008101194A2 (en) 2007-02-15 2008-08-21 Advanced Liquid Logic, Inc. Capacitance detection in a droplet actuator
WO2009002920A1 (en) 2007-06-22 2008-12-31 Advanced Liquid Logic, Inc. Droplet-based nucleic acid amplification in a temperature gradient
AU2008293652B2 (en) * 2007-08-24 2013-02-21 Advanced Liquid Logic, Inc. Bead manipulations on a droplet actuator
US8702938B2 (en) 2007-09-04 2014-04-22 Advanced Liquid Logic, Inc. Droplet actuator with improved top substrate
US20100236928A1 (en) * 2007-10-17 2010-09-23 Advanced Liquid Logic, Inc. Multiplexed Detection Schemes for a Droplet Actuator
EP2237955A4 (en) * 2007-12-23 2016-04-20 Advanced Liquid Logic Inc DROPLET FORMATION ACTUATOR CONFIGURATIONS, AND METHODS OF PERFORMING DROPLET FORMING OPERATIONS
US8852952B2 (en) 2008-05-03 2014-10-07 Advanced Liquid Logic, Inc. Method of loading a droplet actuator
EP2286228B1 (en) 2008-05-16 2019-04-03 Advanced Liquid Logic, Inc. Droplet actuator devices and methods for manipulating beads
US8877512B2 (en) 2009-01-23 2014-11-04 Advanced Liquid Logic, Inc. Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator
US8926065B2 (en) 2009-08-14 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
FR2950544B1 (fr) 2009-09-29 2011-12-09 Ecole Polytech Circuit microfluidique
WO2011057197A2 (en) 2009-11-06 2011-05-12 Advanced Liquid Logic, Inc. Integrated droplet actuator for gel electrophoresis and molecular analysis
EP2516669B1 (en) 2009-12-21 2016-10-12 Advanced Liquid Logic, Inc. Enzyme assays on a droplet actuator
US8685325B2 (en) * 2010-03-09 2014-04-01 Sparkle Power Inc. Field-programmable lab-on-a-chip based on microelectrode array architecture
US9248450B2 (en) 2010-03-30 2016-02-02 Advanced Liquid Logic, Inc. Droplet operations platform
EP2567213B1 (en) 2010-05-05 2018-01-24 The Governing Council of the Universtiy of Toronto Method of processing dried samples using digital microfluidic device
US9011662B2 (en) 2010-06-30 2015-04-21 Advanced Liquid Logic, Inc. Droplet actuator assemblies and methods of making same
CA2833897C (en) 2011-05-09 2020-05-19 Advanced Liquid Logic, Inc. Microfluidic feedback using impedance detection
CA2833907A1 (en) 2011-05-10 2012-11-15 Advanced Liquid Logic, Inc. Enzyme concentration and assays
EP2729792A4 (en) 2011-07-06 2015-03-18 Advanced Liquid Logic Inc STORING REAGENTS ON A DROPLET HANDLING ACTUATOR
US8901043B2 (en) 2011-07-06 2014-12-02 Advanced Liquid Logic, Inc. Systems for and methods of hybrid pyrosequencing
US9513253B2 (en) 2011-07-11 2016-12-06 Advanced Liquid Logic, Inc. Droplet actuators and techniques for droplet-based enzymatic assays
US9446404B2 (en) 2011-07-25 2016-09-20 Advanced Liquid Logic, Inc. Droplet actuator apparatus and system
EP2776165A2 (en) 2011-11-07 2014-09-17 Illumina, Inc. Integrated sequencing apparatuses and methods of use
WO2013078216A1 (en) 2011-11-21 2013-05-30 Advanced Liquid Logic Inc Glucose-6-phosphate dehydrogenase assays
US8808519B2 (en) * 2011-12-14 2014-08-19 Hamilton Sundstrand Space Systems International Microfluidic device
US9223317B2 (en) 2012-06-14 2015-12-29 Advanced Liquid Logic, Inc. Droplet actuators that include molecular barrier coatings
CN104603595B (zh) 2012-06-27 2017-08-08 先进流体逻辑公司 用于减少气泡形成的技术和液滴致动器设计
WO2014062551A1 (en) * 2012-10-15 2014-04-24 Advanced Liquid Logic, Inc. Digital microfluidics cartridge and system for operating a flow cell
JP1628116S (enExample) 2012-10-24 2019-04-01
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
US9914785B2 (en) 2012-11-28 2018-03-13 Zymeworks Inc. Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
KR101340154B1 (ko) * 2012-12-11 2013-12-10 서강대학교산학협력단 액적 분리장치
WO2014108218A1 (en) * 2013-01-09 2014-07-17 Tecan Trading Ag Microfluidics systems with waste hollow
EP2951593B1 (en) 2013-01-31 2018-09-19 Luminex Corporation Fluid retention plates and analysis cartridges
WO2014150905A2 (en) 2013-03-15 2014-09-25 Genmark Diagnostics, Inc. Systems, methods, and apparatus for manipulating deformable fluid vessels
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
TWI510780B (zh) * 2014-03-20 2015-12-01 Univ Nat Chiao Tung 生物檢測設備及生物晶片
EP3831481B1 (en) 2014-11-11 2025-06-18 Roche Diagnostics GmbH Fluid sample processing cartridge
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
CN108026494A (zh) 2015-06-05 2018-05-11 米罗库鲁斯公司 限制蒸发和表面结垢的空气基质数字微流控装置和方法
CN208562324U (zh) 2015-06-05 2019-03-01 米罗库鲁斯公司 空气基质数字微流控(dmf)装置
US11325127B2 (en) 2016-01-20 2022-05-10 The Regents Of The University Of California Methods for fluid manipulation by electrodewetting
WO2018039281A1 (en) 2016-08-22 2018-03-01 Miroculus Inc. Feedback system for parallel droplet control in a digital microfluidic device
EP3516401B1 (en) 2016-09-19 2025-07-30 Roche Diagnostics GmbH Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
EP3311919B1 (en) * 2016-10-19 2021-04-14 Sharp Life Science (EU) Limited Fluid extraction from a microfluidic device
EP3563151A4 (en) 2016-12-28 2020-08-19 Miroculus Inc. DIGITAL MICROFLUIDIC DEVICES AND METHODS
WO2018187476A1 (en) 2017-04-04 2018-10-11 Miroculus Inc. Digital microfluidic apparatuses and methods for manipulating and processing encapsulated droplets
US10730048B2 (en) 2017-06-21 2020-08-04 Sharp Life Science (Eu) Limited EWOD device with holdback feature for fluid loading
WO2019023133A1 (en) 2017-07-24 2019-01-31 Miroculus Inc. DIGITAL MICROFLUIDIC SYSTEMS AND METHODS WITH INTEGRATED PLASMA COLLECTION DEVICE
WO2019046860A1 (en) 2017-09-01 2019-03-07 Miroculus Inc. DIGITAL MICROFLUIDIC DEVICES AND METHODS OF USE
WO2019099306A1 (en) * 2017-11-14 2019-05-23 Illumina, Inc. Droplet dispensing
US20190262829A1 (en) * 2018-02-28 2019-08-29 Volta Labs, Inc. Directing Motion of Droplets Using Differential Wetting
CN112469504B (zh) 2018-05-23 2024-08-16 米罗库鲁斯公司 对数字微流控中的蒸发的控制
CN112839700B (zh) * 2018-10-15 2023-05-02 伊英克公司 数字微流控输送装置
CN113543883A (zh) 2019-01-31 2021-10-22 米罗库鲁斯公司 非结垢组合物以及用于操控和处理包封的微滴的方法
EP3953041A4 (en) 2019-04-08 2023-01-25 Miroculus Inc. MULTI-CARTRIDGE DIGITAL MICROFLUID DEVICES AND METHODS OF USE
WO2020247506A1 (en) * 2019-06-03 2020-12-10 Abbott Laboratories Devices and methods for fluid actuation
WO2020247533A1 (en) * 2019-06-03 2020-12-10 Abbott Laboratories Devices and methods for sample analysis
WO2021016614A1 (en) 2019-07-25 2021-01-28 Miroculus Inc. Digital microfluidics devices and methods of use thereof
WO2021047533A1 (en) * 2019-09-10 2021-03-18 Bgi Shenzhen Co., Ltd. Operation of magnetic beads on microfluidics substrates
WO2021102134A1 (en) 2019-11-20 2021-05-27 E Ink Corporation Spatially variable hydrophobic layers for digital microfluidics
US11554374B2 (en) 2020-01-17 2023-01-17 Nuclera Nucleics Ltd. Spatially variable dielectric layers for digital microfluidics
US11946901B2 (en) 2020-01-27 2024-04-02 Nuclera Ltd Method for degassing liquid droplets by electrical actuation at higher temperatures
KR20220141862A (ko) 2020-02-18 2022-10-20 뉴클라 뉴클레익스 리미티드 전기습윤 장치 구동을 위한 적응형 게이트 구동
CN115135413A (zh) 2020-02-19 2022-09-30 核酸有限公司 用于EWoD阵列的高频AC驱动的锁存晶体管驱动
US11596946B2 (en) 2020-04-27 2023-03-07 Nuclera Nucleics Ltd. Segmented top plate for variable driving and short protection for digital microfluidics
TW202201003A (zh) 2020-05-28 2022-01-01 英商核酸有限公司 用於在高電極密度電子濕潤陣列上穩健多尺寸液體施配之空間與時間頸縮部
CN114669335B (zh) * 2020-12-24 2023-06-16 广东奥素液芯微纳科技有限公司 一种微液滴的生成方法与微液滴的应用方法
CN114669336B (zh) * 2020-12-24 2024-02-09 广东奥素液芯微纳科技有限公司 一种微液滴生成方法
CN114653410B (zh) * 2020-12-24 2023-07-14 广东奥素液芯微纳科技有限公司 一种微液滴生成方法及系统
CN112588332B (zh) * 2020-12-24 2023-02-10 广东奥素液芯微纳科技有限公司 一种微液滴生成方法和生成系统
EP4268957A4 (en) * 2020-12-24 2025-03-19 Foshan Acxel Boxin Tech Co., Ltd Microdroplet generation method and system
CN114054108A (zh) * 2021-11-05 2022-02-18 佛山奥素博新科技有限公司 一种微液滴快速生成方法
GB202203522D0 (en) * 2022-03-14 2022-04-27 Nuclera Nucleics Ltd Controlled reservoir filling
US11772093B2 (en) 2022-01-12 2023-10-03 Miroculus Inc. Methods of mechanical microfluidic manipulation
CN114870916B (zh) * 2022-05-06 2023-12-05 中新国际联合研究院 一种微流体液滴移动、剥离和分离剥离结构及方法
GB202211204D0 (en) * 2022-08-01 2022-09-14 Nuclera Nucleics Ltd A method of forming arrays of droplets

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2543320B1 (fr) * 1983-03-23 1986-01-31 Thomson Csf Dispositif indicateur a commande electrique de deplacement d'un fluide
US4879568A (en) * 1987-01-10 1989-11-07 Am International, Inc. Droplet deposition apparatus
US5181016A (en) * 1991-01-15 1993-01-19 The United States Of America As Represented By The United States Department Of Energy Micro-valve pump light valve display
US5486337A (en) * 1994-02-18 1996-01-23 General Atomics Device for electrostatic manipulation of droplets
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
US6063339A (en) * 1998-01-09 2000-05-16 Cartesian Technologies, Inc. Method and apparatus for high-speed dot array dispensing
GB9820755D0 (en) * 1998-09-23 1998-11-18 Xaar Technology Ltd Drop on demand ink jet printing apparatus
US6565727B1 (en) * 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
US6294063B1 (en) * 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US20020051971A1 (en) * 1999-05-21 2002-05-02 John R. Stuelpnagel Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6924792B1 (en) * 2000-03-10 2005-08-02 Richard V. Jessop Electrowetting and electrostatic screen display systems, colour displays and transmission means
US6773566B2 (en) * 2000-08-31 2004-08-10 Nanolytics, Inc. Electrostatic actuators for microfluidics and methods for using same
AU2001290879A1 (en) * 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
US7163612B2 (en) * 2001-11-26 2007-01-16 Keck Graduate Institute Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like
FR2841063B1 (fr) * 2002-06-18 2004-09-17 Commissariat Energie Atomique Dispositif de deplacement de petits volumes de liquide le long d'un micro-catenaire par des forces electrostatiques
FR2843048B1 (fr) * 2002-08-01 2004-09-24 Commissariat Energie Atomique Dispositif d'injection et de melange de micro-gouttes liquides.
US6911132B2 (en) * 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
US7329545B2 (en) * 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US6989234B2 (en) * 2002-09-24 2006-01-24 Duke University Method and apparatus for non-contact electrostatic actuation of droplets
US7547380B2 (en) * 2003-01-13 2009-06-16 North Carolina State University Droplet transportation devices and methods having a fluid surface
WO2005040228A2 (en) * 2003-10-24 2005-05-06 Adhesives Research, Inc. Disintegratable films for diagnostic devices
JP4773360B2 (ja) * 2003-11-17 2011-09-14 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 流体を操作するためのシステム
JP2007518991A (ja) * 2004-01-14 2007-07-12 ルミネックス・コーポレーション ダイナミックレンジを拡大する方法及びシステム
FR2866493B1 (fr) * 2004-02-16 2010-08-20 Commissariat Energie Atomique Dispositif de controle du deplacement d'une goutte entre deux ou plusieurs substrats solides
US7693666B2 (en) * 2004-07-07 2010-04-06 Rensselaer Polytechnic Institute Method, system, and program product for controlling chemical reactions in a digital microfluidic system
FR2872715B1 (fr) * 2004-07-08 2006-11-17 Commissariat Energie Atomique Microreacteur goutte
FR2872809B1 (fr) * 2004-07-09 2006-09-15 Commissariat Energie Atomique Methode d'adressage d'electrodes
FR2879946B1 (fr) * 2004-12-23 2007-02-09 Commissariat Energie Atomique Dispositif de dispense de gouttes
US7458661B2 (en) * 2005-01-25 2008-12-02 The Regents Of The University Of California Method and apparatus for promoting the complete transfer of liquid drops from a nozzle
PL1859330T3 (pl) * 2005-01-28 2013-01-31 Univ Duke Urządzenia i sposoby manipulacji kropelkami na płytkach obwodów drukowanych
EP1885885A4 (en) * 2005-05-11 2008-08-27 Nanolytics Inc METHOD OR DEVICE FOR CONDUCTING CHEMICAL OR BIOCHEMICAL REACTIONS AT MULTIPLE TEMPERATURES
JP2006317364A (ja) * 2005-05-16 2006-11-24 Hitachi High-Technologies Corp 分注装置
JP4500733B2 (ja) * 2005-05-30 2010-07-14 株式会社日立ハイテクノロジーズ 化学分析装置
JP2006329904A (ja) * 2005-05-30 2006-12-07 Hitachi High-Technologies Corp 液体搬送デバイス及び分析システム
JP4969060B2 (ja) * 2005-06-08 2012-07-04 株式会社日立ハイテクノロジーズ 自動分析装置
CN101252993A (zh) * 2005-06-16 2008-08-27 精华微技有限公司 利用液滴驱动、搅拌和蒸发的生物传感器检测
FR2887305B1 (fr) * 2005-06-17 2011-05-27 Commissariat Energie Atomique Dispositif de pompage par electromouillage et application aux mesures d'activite electrique
DE602005011870D1 (de) * 2005-07-01 2009-01-29 Commissariat Energie Atomique Hydrophobe oberflächenbeschichtung mit geringer benetzungshysterese, aufbringungsverfahren dafür, mikrokomponente und verwendung
FR2888912B1 (fr) * 2005-07-25 2007-08-24 Commissariat Energie Atomique Procede de commande d'une communication entre deux zones par electromouillage, dispositif comportant des zones isolables les unes des autres et procede de realisation d'un tel dispositif
US20070023292A1 (en) * 2005-07-26 2007-02-01 The Regents Of The University Of California Small object moving on printed circuit board
CA2623130C (en) * 2005-09-21 2018-01-09 Luminex Corporation Methods and systems for image data processing
FR2890875B1 (fr) * 2005-09-22 2008-02-22 Commissariat Energie Atomique Fabrication d'un systeme diphasique liquide/liquide ou gaz en micro-fluidique
US7344679B2 (en) * 2005-10-14 2008-03-18 International Business Machines Corporation Method and apparatus for point of care osmolarity testing
CN101351270A (zh) * 2005-10-22 2009-01-21 精华微技有限公司 从用于芯片微流控的液柱中抽取液滴
US8637317B2 (en) * 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Method of washing beads
WO2009140373A2 (en) * 2008-05-13 2009-11-19 Advanced Liquid Logic, Inc. Droplet actuator devices, systems, and methods
US7901947B2 (en) * 2006-04-18 2011-03-08 Advanced Liquid Logic, Inc. Droplet-based particle sorting
US7439014B2 (en) * 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US8658111B2 (en) * 2006-04-18 2014-02-25 Advanced Liquid Logic, Inc. Droplet actuators, modified fluids and methods
US7763471B2 (en) * 2006-04-18 2010-07-27 Advanced Liquid Logic, Inc. Method of electrowetting droplet operations for protein crystallization
WO2007123908A2 (en) * 2006-04-18 2007-11-01 Advanced Liquid Logic, Inc. Droplet-based multiwell operations
US8389297B2 (en) * 2006-04-18 2013-03-05 Duke University Droplet-based affinity assay device and system
US8716015B2 (en) * 2006-04-18 2014-05-06 Advanced Liquid Logic, Inc. Manipulation of cells on a droplet actuator
US7816121B2 (en) * 2006-04-18 2010-10-19 Advanced Liquid Logic, Inc. Droplet actuation system and method
US8041463B2 (en) * 2006-05-09 2011-10-18 Advanced Liquid Logic, Inc. Modular droplet actuator drive
US7822510B2 (en) * 2006-05-09 2010-10-26 Advanced Liquid Logic, Inc. Systems, methods, and products for graphically illustrating and controlling a droplet actuator
WO2008055256A2 (en) * 2006-11-02 2008-05-08 The Regents Of The University Of California Method and apparatus for real-time feedback control of electrical manipulation of droplets on chip
US8685344B2 (en) * 2007-01-22 2014-04-01 Advanced Liquid Logic, Inc. Surface assisted fluid loading and droplet dispensing
EP2111554B1 (en) * 2007-02-09 2013-05-08 Advanced Liquid Logic, Inc. Droplet actuator devices and methods employing magnetic beads
WO2008101194A2 (en) * 2007-02-15 2008-08-21 Advanced Liquid Logic, Inc. Capacitance detection in a droplet actuator
WO2008106678A1 (en) * 2007-03-01 2008-09-04 Advanced Liquid Logic, Inc. Droplet actuator structures
CN101663403B (zh) * 2007-03-05 2013-04-24 先进流体逻辑公司 基于微滴的过氧化氢测定
BRPI0808400A2 (pt) * 2007-03-13 2014-07-08 Advanced Liquid Logic Inc Dispositivos atuadores de gotículas, configurações, e métodos para aperfeiçoar a detecção da absorbância.
US8093062B2 (en) * 2007-03-22 2012-01-10 Theodore Winger Enzymatic assays using umbelliferone substrates with cyclodextrins in droplets in oil
EP2837692A1 (en) * 2007-03-22 2015-02-18 Advanced Liquid Logic, Inc. Enzymatic assays for a droplet actuator
WO2008116221A1 (en) * 2007-03-22 2008-09-25 Advanced Liquid Logic, Inc. Bead sorting on a droplet actuator
US8202686B2 (en) * 2007-03-22 2012-06-19 Advanced Liquid Logic, Inc. Enzyme assays for a droplet actuator
WO2008118831A2 (en) * 2007-03-23 2008-10-02 Advanced Liquid Logic, Inc. Droplet actuator loading and target concentration
EP2516669B1 (en) * 2009-12-21 2016-10-12 Advanced Liquid Logic, Inc. Enzyme assays on a droplet actuator

Also Published As

Publication number Publication date
AU2008237017A1 (en) 2008-10-16
AU2008237017B2 (en) 2013-10-24
EP2132296A4 (en) 2015-04-08
US20100032293A1 (en) 2010-02-11
US20150075985A1 (en) 2015-03-19
CN101743304A (zh) 2010-06-16
WO2008124846A2 (en) 2008-10-16
KR20100016343A (ko) 2010-02-12
JP2010524002A (ja) 2010-07-15
WO2008124846A3 (en) 2009-12-23
CA2719549A1 (en) 2008-10-16
EP2132296A2 (en) 2009-12-16
CN101743304B (zh) 2013-04-24

Similar Documents

Publication Publication Date Title
BRPI0809978A2 (pt) Dispositivos e métodos de dispensação de gotículas
DK2155299T3 (da) Afgivelsesindretning
BRPI0820379A2 (pt) Sistemas e métodos de dispensação de produto médico
BRPI0807225A2 (pt) Dispositivo e método endocirúrgico
BRPI0814324A2 (pt) Dispositivo
BRPI0822034A2 (pt) Dispositivo
BRPI0809511A2 (pt) Dispositivo de distribuição transdérmica de microagulha
BRPI0816907A2 (pt) Método e dispositivo
BRPI0810906A2 (pt) Dispositivo baseado em personalidade
BRPI0818466A2 (pt) dispositivo de exibição
ATE513131T1 (de) Streichvorrichtung
EP2192406A4 (en) Profiling apparatus
BRPI0811839A2 (pt) Dispositivo de exibição
DK2013109T3 (da) Forbedret distributionsapparat
BRPI0914151A2 (pt) distribuidor de medicamento e método
EP2191756A4 (en) SHOWER DEVICE
FI20075686A0 (fi) Konfigurointimenetelmä ja -laite
BRPI0811840A2 (pt) Dispositivo de exibição
BRPI0820320A2 (pt) Dispositivo distribuidor
DE502008001742D1 (de) Kabelbearbeitungseinrichtung
BRPI0715508A2 (pt) Dispositivos e métodos de plantio
DE502005004882D1 (de) Einmal-Spendevorrichtung
BRPI0820296A2 (pt) Dispositivo de exibição
DK2115708T3 (da) Dispenseringsanordning
BRPI0818836A2 (pt) Aparelho batente de extremidade e métodos

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL