BRPI0808746B8 - derivado de purinila como modulador do canal de potássio, composição farmacêutica, e, uso de um derivado de purinila. - Google Patents

derivado de purinila como modulador do canal de potássio, composição farmacêutica, e, uso de um derivado de purinila.

Info

Publication number
BRPI0808746B8
BRPI0808746B8 BRPI0808746A BRPI0808746A BRPI0808746B8 BR PI0808746 B8 BRPI0808746 B8 BR PI0808746B8 BR PI0808746 A BRPI0808746 A BR PI0808746A BR PI0808746 A BRPI0808746 A BR PI0808746A BR PI0808746 B8 BRPI0808746 B8 BR PI0808746B8
Authority
BR
Brazil
Prior art keywords
purinyl
purinyl derivative
potassium channel
derivative
pharmaceutical composition
Prior art date
Application number
BRPI0808746A
Other languages
English (en)
Portuguese (pt)
Inventor
L Eriksen Birgitte
Hougaard Charlotte
Peters Dan
Christophersen Palle
Holm Johansen Tina
Svane Sorensen Ulrik
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Priority claimed from PCT/EP2008/053648 external-priority patent/WO2008116909A1/en
Publication of BRPI0808746A2 publication Critical patent/BRPI0808746A2/pt
Publication of BRPI0808746B1 publication Critical patent/BRPI0808746B1/pt
Publication of BRPI0808746B8 publication Critical patent/BRPI0808746B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms

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  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Pain & Pain Management (AREA)
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  • Reproductive Health (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
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BRPI0808746A 2007-03-28 2008-03-27 derivado de purinila como modulador do canal de potássio, composição farmacêutica, e, uso de um derivado de purinila. BRPI0808746B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200700482 2007-03-28
DKPA200700482 2007-03-28
PCT/EP2008/053648 WO2008116909A1 (en) 2007-03-28 2008-03-27 Purinyl derivatives and their use as potassium channel modulators

Publications (3)

Publication Number Publication Date
BRPI0808746A2 BRPI0808746A2 (pt) 2014-08-19
BRPI0808746B1 BRPI0808746B1 (pt) 2020-09-24
BRPI0808746B8 true BRPI0808746B8 (pt) 2021-05-25

Family

ID=41658005

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0808746A BRPI0808746B8 (pt) 2007-03-28 2008-03-27 derivado de purinila como modulador do canal de potássio, composição farmacêutica, e, uso de um derivado de purinila.

Country Status (10)

Country Link
US (2) US20100105705A1 (enExample)
EP (1) EP2402341B1 (enExample)
JP (5) JP2010522720A (enExample)
KR (1) KR101564233B1 (enExample)
CN (1) CN101646669B (enExample)
BR (1) BRPI0808746B8 (enExample)
NZ (1) NZ579248A (enExample)
RU (1) RU2468026C2 (enExample)
UA (1) UA98482C2 (enExample)
ZA (1) ZA200905796B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010517970A (ja) * 2007-02-02 2010-05-27 ノイロサーチ アクティーゼルスカブ ピリジニル−ピラゾール誘導体及びカリウムチャネル調節剤としてのそれらの使用
US20100105705A1 (en) * 2007-03-28 2010-04-29 Neurosearch A/S Purinyl derivatives and their use as potassium channel modulators
EP2142547A1 (en) * 2007-03-28 2010-01-13 NeuroSearch A/S Purinyl derivatives and their use as potassium channel modulators
WO2009037247A1 (en) 2007-09-17 2009-03-26 Neurosearch A/S Pyrazine derivatives and their use as potassium channel modulators
US8158624B2 (en) * 2008-05-30 2012-04-17 Genetech, Inc. Purine PI3K inhibitor compounds and methods of use
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