ZA200905796B - Purinyl derivatives and their use as potassium channel modulators - Google Patents

Purinyl derivatives and their use as potassium channel modulators

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Publication number
ZA200905796B
ZA200905796B ZA200905796A ZA200905796A ZA200905796B ZA 200905796 B ZA200905796 B ZA 200905796B ZA 200905796 A ZA200905796 A ZA 200905796A ZA 200905796 A ZA200905796 A ZA 200905796A ZA 200905796 B ZA200905796 B ZA 200905796B
Authority
ZA
South Africa
Prior art keywords
potassium channel
channel modulators
purinyl derivatives
purinyl
derivatives
Prior art date
Application number
ZA200905796A
Other languages
English (en)
Inventor
Birgitte L Eriksen
Ulrik Svane Soerensen
Charlotte Hougaard
Dan Peters
Tina Holm Johansen
Palle Christophersen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of ZA200905796B publication Critical patent/ZA200905796B/xx

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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ZA200905796A 2007-03-28 2008-03-27 Purinyl derivatives and their use as potassium channel modulators ZA200905796B (en)

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DKPA200700482 2007-03-28

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US (2) US20120004246A1 (enExample)
EP (1) EP2402341B1 (enExample)
JP (5) JP5703432B2 (enExample)
KR (1) KR101564233B1 (enExample)
CN (1) CN101646669B (enExample)
BR (1) BRPI0808746B8 (enExample)
NZ (1) NZ579248A (enExample)
RU (1) RU2468026C2 (enExample)
UA (1) UA98482C2 (enExample)
ZA (1) ZA200905796B (enExample)

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EP2114916A2 (en) * 2007-02-02 2009-11-11 NeuroSearch A/S Pyridinyl-pyrazole derivatives and their use as potassium channel modulators
EP2142546B1 (en) 2007-03-28 2017-06-07 Saniona A/S Purinyl derivatives and their use as potassium channel modulators
JP5703432B2 (ja) * 2007-03-28 2015-04-22 ノイロサーチ アクティーゼルスカブ プリニル誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用
EP2203436A1 (en) 2007-09-17 2010-07-07 Neurosearch A/S Pyrazine derivatives and their use as potassium channel modulators
ES2533788T3 (es) * 2008-05-30 2015-04-14 Genentech, Inc. Compuestos inhibidores de PI3K de tipo purina y métodos de uso
EP2331527A1 (en) * 2008-09-02 2011-06-15 NeuroSearch A/S Pyrazolyl-pyrimidine derivatives and their use as potassium channel modulators
WO2010034706A1 (en) * 2008-09-26 2010-04-01 Neurosearch A/S Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators
US8268838B2 (en) * 2008-09-26 2012-09-18 Neurosearch A/S Substituted purinyl-pyrazole derivatives and their use as potassium channel modulators
WO2010112485A1 (en) 2009-04-01 2010-10-07 Neurosearch A/S SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS
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