BRPI0720641A8 - Sequência de dna artificial com função líder otimizada em sua 5' (5'-utr) para a expressão intensificada de proteínas heterólogas em plantas - Google Patents

Sequência de dna artificial com função líder otimizada em sua 5' (5'-utr) para a expressão intensificada de proteínas heterólogas em plantas

Info

Publication number
BRPI0720641A8
BRPI0720641A8 BRPI0720641A BRPI0720641A BRPI0720641A8 BR PI0720641 A8 BRPI0720641 A8 BR PI0720641A8 BR PI0720641 A BRPI0720641 A BR PI0720641A BR PI0720641 A BRPI0720641 A BR PI0720641A BR PI0720641 A8 BRPI0720641 A8 BR PI0720641A8
Authority
BR
Brazil
Prior art keywords
utr
plants
dna sequence
heterologous proteins
enhanced expression
Prior art date
Application number
BRPI0720641A
Other languages
English (en)
Inventor
Marchetti Stefano
De Amicis Francesca
Patti Tamara
Original Assignee
Rodina Holding S A
Univ Degli Studi Udine
Adienne Pharma & Biotech Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rodina Holding S A, Univ Degli Studi Udine, Adienne Pharma & Biotech Sa filed Critical Rodina Holding S A
Publication of BRPI0720641A2 publication Critical patent/BRPI0720641A2/pt
Publication of BRPI0720641A8 publication Critical patent/BRPI0720641A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
    • A01H6/46—Gramineae or Poaceae, e.g. ryegrass, rice, wheat or maize
    • A01H6/4636—Oryza sp. [rice]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease

Abstract

SEQÜÊNCIA DE DNA ARTIFICIAL COM FUNÇÃO LÍDER OTIMIZADA EM SUA 5' (5'-UTR) PARA A EXPRESSÃO INTENSIFICADA DE PROTEÍNAS HETERÓLOGAS EM PLANTAS. Uma seqüência nucleotídica líder 5'-UTR compreende elementos favoráveis à expressão gênica, tais como elementos trinucleotídicos CAA repetidos em combinação com elementos dinucleotídicos CT repetidos.
BRPI0720641A 2006-12-29 2007-12-27 Sequência de dna artificial com função líder otimizada em sua 5' (5'-utr) para a expressão intensificada de proteínas heterólogas em plantas BRPI0720641A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000280A ITUD20060280A1 (it) 2006-12-29 2006-12-29 Sequenza artificiale di dna evente funzione di leader in 5' (5'-utr) ottimizzata per la sovraespressione di proteine eterologhe in pianta
PCT/EP2007/064590 WO2008080954A1 (en) 2006-12-29 2007-12-27 Artificial dna sequence with optimized leader function in 5' (5'-utr) for the improved expression of heterologous proteins in plants

Publications (2)

Publication Number Publication Date
BRPI0720641A2 BRPI0720641A2 (pt) 2014-03-18
BRPI0720641A8 true BRPI0720641A8 (pt) 2017-12-19

Family

ID=39205172

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0720641A BRPI0720641A8 (pt) 2006-12-29 2007-12-27 Sequência de dna artificial com função líder otimizada em sua 5' (5'-utr) para a expressão intensificada de proteínas heterólogas em plantas

Country Status (18)

Country Link
US (1) US9085775B2 (pt)
EP (1) EP2118291B1 (pt)
JP (2) JP2010514432A (pt)
KR (1) KR101596229B1 (pt)
CN (1) CN101617048B (pt)
AU (1) AU2007341217A1 (pt)
BR (1) BRPI0720641A8 (pt)
CA (1) CA2674170C (pt)
CY (1) CY1116649T1 (pt)
DK (1) DK2118291T3 (pt)
ES (1) ES2546184T3 (pt)
HU (1) HUE027484T2 (pt)
IT (1) ITUD20060280A1 (pt)
NZ (1) NZ578518A (pt)
PL (1) PL2118291T3 (pt)
PT (1) PT2118291E (pt)
RU (1) RU2009129091A (pt)
WO (1) WO2008080954A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITUD20080055A1 (it) * 2008-03-13 2009-09-14 Transactiva S R L Procedimento per la produzione di una proteina umana in pianta, in particolare un enzima lisosomiale umano ricombinante in endosperma di cereali
KR101703540B1 (ko) * 2012-06-04 2017-02-08 대한민국 3'' 영역의 염기 변이를 통한 전체 단백질의 발현 조절 방법
ITUD20130002A1 (it) * 2013-01-16 2014-07-17 Transactiva S R L Sequenza artificiale di dna avente funzione di leader in 5' (5'-utr) ottimizzata per la sovraespressione di proteine ricombinanti in pianta e metodo per la produzione di proteine ricombinanti in pianta
CN111349692B (zh) * 2013-06-25 2023-10-13 C.威特沃 进行聚合酶链式反应的方法及其相关应用
IT201700042052A1 (it) * 2017-04-14 2018-10-14 Transactiva S R L Vettore di espressione e metodo per la produzione di una proteina umana in pianta, in particolare un anticorpo ricombinante in endosperma di cereale

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8613481D0 (en) * 1986-06-04 1986-07-09 Diatech Ltd Translation of mrna
GB9206016D0 (en) * 1992-03-19 1992-04-29 Sandoz Ltd Improvements in or relating to organic compounds
US5362865A (en) 1993-09-02 1994-11-08 Monsanto Company Enhanced expression in plants using non-translated leader sequences
GB9515941D0 (en) * 1995-08-03 1995-10-04 Zeneca Ltd DNA constructs
JP3761628B2 (ja) 1995-07-14 2006-03-29 住友化学株式会社 植物プロモーターおよびその利用
GB9516241D0 (en) 1995-08-08 1995-10-11 Zeneca Ltd Dna constructs
ZA9811228B (en) 1997-12-12 1999-06-14 Mogen Int New constitutive plant promoters
US6376747B1 (en) 1999-08-27 2002-04-23 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Canada Plant-derived map kinase kinase
FR2815969B1 (fr) * 2000-10-30 2004-12-10 Aventis Cropscience Sa Plantes tolerantes aux herbicides par contournement de voie metabolique
KR100474115B1 (ko) 2001-06-01 2005-03-08 대한민국 유전자변형식물에 대한 ｐｃｒ 검정용 프라이머
US7517689B2 (en) 2004-07-09 2009-04-14 Donald Danforth Plant Science Center Methods and compositions for regulating gene expression in plant cells
US7847064B2 (en) 2004-07-09 2010-12-07 Donald Danforth Plant Science Center Methods and compositions for regulating gene expression in plant cells
US8065093B2 (en) * 2004-10-06 2011-11-22 Agency For Science, Technology, And Research Methods, systems, and compositions for classification, prognosis, and diagnosis of cancers

Also Published As

Publication number Publication date
CA2674170A1 (en) 2008-07-10
JP5913434B2 (ja) 2016-04-27
US20110041222A1 (en) 2011-02-17
HUE027484T2 (en) 2016-09-28
WO2008080954A1 (en) 2008-07-10
CY1116649T1 (el) 2017-03-15
KR101596229B1 (ko) 2016-03-07
US9085775B2 (en) 2015-07-21
KR20090102825A (ko) 2009-09-30
JP2010514432A (ja) 2010-05-06
PL2118291T3 (pl) 2015-11-30
ITUD20060280A1 (it) 2008-06-30
PT2118291E (pt) 2015-09-24
CN101617048A (zh) 2009-12-30
CN101617048B (zh) 2012-11-07
DK2118291T3 (en) 2015-08-31
EP2118291B1 (en) 2015-06-03
BRPI0720641A2 (pt) 2014-03-18
AU2007341217A1 (en) 2008-07-10
ES2546184T3 (es) 2015-09-21
NZ578518A (en) 2012-08-31
RU2009129091A (ru) 2011-02-10
CA2674170C (en) 2019-03-12
EP2118291A1 (en) 2009-11-18
JP2014221040A (ja) 2014-11-27

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: RODINA HOLDING S.A. (CH)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B25D Requested change of name of applicant approved

Owner name: ADIENNE PHARMA AND BIOTECH SA (CH)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 13A ANUIDADE.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2611 DE 19-01-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.