BRPI0710099A2 - uso de inibidores de quìnases jun n-terminais para tratar glaucoma - Google Patents
uso de inibidores de quìnases jun n-terminais para tratar glaucoma Download PDFInfo
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/394,893 | 2006-03-31 | ||
| US11/394,893 US7803824B2 (en) | 2004-10-29 | 2006-03-31 | Use of inhibitors of Jun N-terminal kinases to treat glaucoma |
| PCT/US2007/063961 WO2007117849A2 (en) | 2006-03-31 | 2007-03-14 | Use of inhibitors of jun n-terminal kinases to treat glaucoma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0710099A2 true BRPI0710099A2 (pt) | 2011-08-02 |
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|---|---|---|---|
| BRPI0710099-0A BRPI0710099A2 (pt) | 2006-03-31 | 2007-03-14 | uso de inibidores de quìnases jun n-terminais para tratar glaucoma |
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| Country | Link |
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| EP (1) | EP2004158A2 (enExample) |
| JP (1) | JP5241033B2 (enExample) |
| KR (1) | KR20080108503A (enExample) |
| CN (1) | CN101415407B (enExample) |
| AR (1) | AR060222A1 (enExample) |
| AU (1) | AU2007235111B2 (enExample) |
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| TW (1) | TWI419694B (enExample) |
| WO (1) | WO2007117849A2 (enExample) |
| ZA (1) | ZA200807667B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060094753A1 (en) * | 2004-10-29 | 2006-05-04 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases |
| US7803824B2 (en) * | 2004-10-29 | 2010-09-28 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases to treat glaucoma |
| US20090202524A1 (en) * | 2007-10-31 | 2009-08-13 | Alcon Research, Ltd. | Pai-1 expression and activity inhibitors for the treatment of ocular disorders |
| US20100056609A1 (en) * | 2008-08-26 | 2010-03-04 | Washington University | Methods and compositions for inhibition of axonal degeneration by modulation of the dlk/jnk pathway |
| US20120077753A1 (en) * | 2009-06-25 | 2012-03-29 | Laxman Gangwani | Jnk inhibitors for use in treating spinal muscular atrophy |
| KR20130131461A (ko) * | 2011-03-07 | 2013-12-03 | 폰다지오네 텔레톤 | Tfeb 변종 및 그의 용도 |
| EA201501080A1 (ru) * | 2013-06-26 | 2016-07-29 | Ксижен Инфлемейшн Лтд. | Новое применение обладающих способностью проникать в клетку пептидных ингибиторов пути трансдукции сигнала jnk для лечения различных заболеваний |
| EP3160489B9 (en) * | 2014-06-26 | 2023-10-04 | Xigen Inflammation Ltd. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of cystitis |
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| WO1997040847A1 (en) * | 1996-04-26 | 1997-11-06 | University Of Ottawa | Therapeutic and drug screening methods for the treatment and prevention of neuronal disease |
| CN1323208A (zh) | 1998-10-13 | 2001-11-21 | 协和发酵工业株式会社 | 眼病治疗剂 |
| WO2000035906A2 (en) | 1998-12-17 | 2000-06-22 | F. Hoffmann-La Roche Ag | 4- and 5-alkynyloxindoles and 4- and 5-alkenyloxindoles |
| DE60041763D1 (de) | 1999-04-23 | 2009-04-23 | Vertex Pharma | Inhibitoren von c-jun n-terminal kinasen (jnk) |
| DE60039616D1 (de) | 1999-08-13 | 2008-09-04 | Vertex Pharma | INHIBITOREN DER c-JUN N-TERMINALEN KINASE (JNK) UND ANDERE PROTEIN-KINASEN |
| KR20080028516A (ko) | 1999-08-19 | 2008-03-31 | 시그널 파머슈티컬스 인크 | Ｊｎｋ억제제로서의 피라졸로안트론과 그 유도체 및 이를함유하는 조성물 |
| US20040072888A1 (en) * | 1999-08-19 | 2004-04-15 | Bennett Brydon L. | Methods for treating inflammatory conditions or inhibiting JNK |
| EP1088821A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonamide derivatives |
| EP1088822A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonyl hydrazide derivatives |
| EP1088815A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonyl amino acid derivatives |
| EP1110957A1 (en) | 1999-12-24 | 2001-06-27 | Applied Research Systems ARS Holding N.V. | Benzazole derivatives and their use as JNK modulators |
| EP1289523A1 (en) | 2000-06-01 | 2003-03-12 | Merck & Co., Inc. | Use of (di-substituted-phenyl)-pyrimidinyl-imidazole derivatives as jnk-inhibitors |
| EP1193256A1 (en) | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins |
| US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
| WO2002062792A1 (en) | 2001-02-02 | 2002-08-15 | Takeda Chemical Industries, Ltd. | Jnk inhibitor |
| GB0108770D0 (en) | 2001-04-06 | 2001-05-30 | Eisai London Res Lab Ltd | Inhibitors |
| WO2002083648A1 (fr) | 2001-04-16 | 2002-10-24 | Eisai Co., Ltd. | Nouveau compose a base de 1h-indazole |
| EP1426050A4 (en) | 2001-08-23 | 2005-05-25 | Takeda Pharmaceutical | JNK INHIBITORS |
| CN100391958C (zh) | 2001-09-19 | 2008-06-04 | 安万特医药股份有限公司 | 化合物 |
| JP2003129190A (ja) | 2001-10-19 | 2003-05-08 | Sumitomo Metal Ind Ltd | マルテンサイト系ステンレス鋼およびその製造方法 |
| US20030138819A1 (en) | 2001-10-26 | 2003-07-24 | Haiqing Gong | Method for detecting disease |
| US7390797B2 (en) * | 2002-02-28 | 2008-06-24 | Eisai Co., Ltd. | Fused indazole compounds |
| EP1497420A4 (en) * | 2002-04-30 | 2005-04-27 | Alcon Inc | AGENTS THAT REGULATE, RESTRICT OR MODULATE THE ACTIVITY AND / OR EXPRESSION OF BIND WEAVE GROWTH FACTOR (CTGF) AS UNIQUE MEDICAMENTS BOTH TO REDUCE EYESPRINTS AND TREAT GLACCOMPETOSIS RETINOPATHIES / OPTIC NEUROPATHIES |
| US7465736B2 (en) | 2002-06-14 | 2008-12-16 | Laboratoires Serono S.A. | Azole methylidene cyanide derivatives and their use as protein kinase modulators |
| JP2006502183A (ja) * | 2002-09-20 | 2006-01-19 | アルコン，インコーポレイテッド | ドライアイ障害の処置のためのサイトカイン合成インヒビターの使用 |
| US20040092568A1 (en) * | 2002-10-31 | 2004-05-13 | Zeldis Jerome B. | Methods for the treatment, prevention and management of macular degeneration |
| US20060094753A1 (en) | 2004-10-29 | 2006-05-04 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases |
| US7803824B2 (en) * | 2004-10-29 | 2010-09-28 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases to treat glaucoma |
| US20060275797A1 (en) * | 2005-03-21 | 2006-12-07 | Alcon Manufacturing, Ltd. | Use of agents which inhibit connective tissue growth factor (CTGF) binding and signaling via the TrkA/p75NTR receptor complex for the prevention and treatment of CTGF-mediated ocular disorders |
-
2006
- 2006-03-31 US US11/394,893 patent/US7803824B2/en not_active Expired - Fee Related
-
2007
- 2007-03-14 KR KR1020087023895A patent/KR20080108503A/ko not_active Ceased
- 2007-03-14 CA CA002644721A patent/CA2644721A1/en not_active Abandoned
- 2007-03-14 AU AU2007235111A patent/AU2007235111B2/en not_active Ceased
- 2007-03-14 CN CN2007800116928A patent/CN101415407B/zh not_active Expired - Fee Related
- 2007-03-14 MX MX2008011319A patent/MX2008011319A/es active IP Right Grant
- 2007-03-14 WO PCT/US2007/063961 patent/WO2007117849A2/en not_active Ceased
- 2007-03-14 BR BRPI0710099-0A patent/BRPI0710099A2/pt not_active IP Right Cessation
- 2007-03-14 JP JP2009503137A patent/JP5241033B2/ja not_active Expired - Fee Related
- 2007-03-14 ZA ZA200807667A patent/ZA200807667B/xx unknown
- 2007-03-14 EP EP07758510A patent/EP2004158A2/en not_active Withdrawn
- 2007-03-19 TW TW096109322A patent/TWI419694B/zh not_active IP Right Cessation
- 2007-03-29 AR ARP070101334A patent/AR060222A1/es not_active Application Discontinuation
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2010
- 2010-08-18 US US12/858,739 patent/US20100311716A1/en not_active Abandoned
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2011
- 2011-09-14 US US13/232,410 patent/US20120004274A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009532373A (ja) | 2009-09-10 |
| WO2007117849A2 (en) | 2007-10-18 |
| TWI419694B (zh) | 2013-12-21 |
| MX2008011319A (es) | 2008-09-19 |
| AR060222A1 (es) | 2008-06-04 |
| WO2007117849A3 (en) | 2008-04-10 |
| AU2007235111B2 (en) | 2012-03-22 |
| KR20080108503A (ko) | 2008-12-15 |
| AU2007235111A1 (en) | 2007-10-18 |
| US20060172991A1 (en) | 2006-08-03 |
| US20100311716A1 (en) | 2010-12-09 |
| CN101415407A (zh) | 2009-04-22 |
| JP5241033B2 (ja) | 2013-07-17 |
| EP2004158A2 (en) | 2008-12-24 |
| CA2644721A1 (en) | 2007-10-18 |
| TW200744601A (en) | 2007-12-16 |
| CN101415407B (zh) | 2011-05-11 |
| ZA200807667B (en) | 2010-07-28 |
| US7803824B2 (en) | 2010-09-28 |
| US20120004274A1 (en) | 2012-01-05 |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2368 DE 24-05-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |