CA2644721A1 - Use of inhibitors of jun n-terminal kinases to treat glaucoma - Google Patents
Use of inhibitors of jun n-terminal kinases to treat glaucoma Download PDFInfo
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- CA2644721A1 CA2644721A1 CA002644721A CA2644721A CA2644721A1 CA 2644721 A1 CA2644721 A1 CA 2644721A1 CA 002644721 A CA002644721 A CA 002644721A CA 2644721 A CA2644721 A CA 2644721A CA 2644721 A1 CA2644721 A1 CA 2644721A1
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- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/394,893 US7803824B2 (en) | 2004-10-29 | 2006-03-31 | Use of inhibitors of Jun N-terminal kinases to treat glaucoma |
| US11/394,893 | 2006-03-31 | ||
| PCT/US2007/063961 WO2007117849A2 (en) | 2006-03-31 | 2007-03-14 | Use of inhibitors of jun n-terminal kinases to treat glaucoma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2644721A1 true CA2644721A1 (en) | 2007-10-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002644721A Abandoned CA2644721A1 (en) | 2006-03-31 | 2007-03-14 | Use of inhibitors of jun n-terminal kinases to treat glaucoma |
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| Country | Link |
|---|---|
| US (3) | US7803824B2 (enExample) |
| EP (1) | EP2004158A2 (enExample) |
| JP (1) | JP5241033B2 (enExample) |
| KR (1) | KR20080108503A (enExample) |
| CN (1) | CN101415407B (enExample) |
| AR (1) | AR060222A1 (enExample) |
| AU (1) | AU2007235111B2 (enExample) |
| BR (1) | BRPI0710099A2 (enExample) |
| CA (1) | CA2644721A1 (enExample) |
| MX (1) | MX2008011319A (enExample) |
| TW (1) | TWI419694B (enExample) |
| WO (1) | WO2007117849A2 (enExample) |
| ZA (1) | ZA200807667B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7803824B2 (en) * | 2004-10-29 | 2010-09-28 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases to treat glaucoma |
| US20060094753A1 (en) * | 2004-10-29 | 2006-05-04 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases |
| US20090202524A1 (en) * | 2007-10-31 | 2009-08-13 | Alcon Research, Ltd. | Pai-1 expression and activity inhibitors for the treatment of ocular disorders |
| US20100056609A1 (en) * | 2008-08-26 | 2010-03-04 | Washington University | Methods and compositions for inhibition of axonal degeneration by modulation of the dlk/jnk pathway |
| WO2010151638A1 (en) * | 2009-06-25 | 2010-12-29 | Medical College Of Georgia Research Institute, Inc. | Jnk inhibitors for use in treating spinal muscular atrophy |
| JP2014511391A (ja) * | 2011-03-07 | 2014-05-15 | フォンダッツィオーネ・テレソン | Ｔｆｅｂリン酸化阻害剤およびその使用 |
| AU2014301631A1 (en) * | 2013-06-26 | 2015-08-27 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of various diseases |
| AU2015281361A1 (en) * | 2014-06-26 | 2016-11-17 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of various diseases |
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| WO1997040847A1 (en) * | 1996-04-26 | 1997-11-06 | University Of Ottawa | Therapeutic and drug screening methods for the treatment and prevention of neuronal disease |
| KR20010083884A (ko) | 1998-10-13 | 2001-09-03 | 세파론, 인코포레이티드 | 눈 질환 치료제 |
| ATE253062T1 (de) | 1998-12-17 | 2003-11-15 | Hoffmann La Roche | 4- und 5-alkynyloxindole sowie 4- und 5- alkenyloxindole |
| EP1175399B1 (en) | 1999-04-23 | 2009-03-11 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) |
| CZ2002534A3 (cs) | 1999-08-13 | 2002-07-17 | Vertex Pharmaceuticals Incorporated | Inhibitory protein-kináz, farmaceutické prostředky, které je obsahují, a jejich pouľití |
| US20040072888A1 (en) * | 1999-08-19 | 2004-04-15 | Bennett Brydon L. | Methods for treating inflammatory conditions or inhibiting JNK |
| CN1304375C (zh) | 1999-08-19 | 2007-03-14 | 信号药品公司 | 用作jnk抑制剂的吡唑并蒽酮及其衍生物和它们的组合物 |
| EP1088815A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonyl amino acid derivatives |
| EP1088822A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonyl hydrazide derivatives |
| EP1088821A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonamide derivatives |
| EP1110957A1 (en) | 1999-12-24 | 2001-06-27 | Applied Research Systems ARS Holding N.V. | Benzazole derivatives and their use as JNK modulators |
| EP1289523A1 (en) | 2000-06-01 | 2003-03-12 | Merck & Co., Inc. | Use of (di-substituted-phenyl)-pyrimidinyl-imidazole derivatives as jnk-inhibitors |
| EP1193256A1 (en) | 2000-09-27 | 2002-04-03 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins |
| US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
| CA2437248A1 (en) | 2001-02-02 | 2002-08-15 | Takeda Chemical Industries, Ltd. | Jnk inhibitor |
| GB0108770D0 (en) | 2001-04-06 | 2001-05-30 | Eisai London Res Lab Ltd | Inhibitors |
| CN1300116C (zh) | 2001-04-16 | 2007-02-14 | 卫材株式会社 | 1h－吲唑化合物 |
| WO2003018020A1 (en) | 2001-08-23 | 2003-03-06 | Takeda Chemical Industries, Ltd. | Jnk inhibitors |
| WO2003024967A2 (en) | 2001-09-19 | 2003-03-27 | Aventis Pharma S.A. | Indolizines as kinase protein inhibitors |
| JP2003129190A (ja) | 2001-10-19 | 2003-05-08 | Sumitomo Metal Ind Ltd | マルテンサイト系ステンレス鋼およびその製造方法 |
| US20030138819A1 (en) | 2001-10-26 | 2003-07-24 | Haiqing Gong | Method for detecting disease |
| ATE465153T1 (de) * | 2002-02-28 | 2010-05-15 | Eisai R&D Man Co Ltd | Neue indazolverbindungen mit kondensiertem ring |
| KR20040104566A (ko) * | 2002-04-30 | 2004-12-10 | 알콘, 인코퍼레이티드 | 안압 저하 및 녹내장성 망막병증/시신경병증 치료를 위한특유의 수단으로서의 결합 조직 성장 인자 (ｃｔｇｆ)의활성 및/또는 발현 조절, 저해, 또는 변조제 |
| US7465736B2 (en) | 2002-06-14 | 2008-12-16 | Laboratoires Serono S.A. | Azole methylidene cyanide derivatives and their use as protein kinase modulators |
| CA2497977A1 (en) * | 2002-09-20 | 2004-04-01 | Alcon, Inc. | Use of cytokine synthesis inhibitors for the treatment of dry eye disorders |
| US20040092568A1 (en) * | 2002-10-31 | 2004-05-13 | Zeldis Jerome B. | Methods for the treatment, prevention and management of macular degeneration |
| US20060094753A1 (en) * | 2004-10-29 | 2006-05-04 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases for the treatment of glaucomatous retinopathy and ocular diseases |
| US7803824B2 (en) * | 2004-10-29 | 2010-09-28 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases to treat glaucoma |
| US20060275797A1 (en) * | 2005-03-21 | 2006-12-07 | Alcon Manufacturing, Ltd. | Use of agents which inhibit connective tissue growth factor (CTGF) binding and signaling via the TrkA/p75NTR receptor complex for the prevention and treatment of CTGF-mediated ocular disorders |
-
2006
- 2006-03-31 US US11/394,893 patent/US7803824B2/en not_active Expired - Fee Related
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2007
- 2007-03-14 EP EP07758510A patent/EP2004158A2/en not_active Withdrawn
- 2007-03-14 BR BRPI0710099-0A patent/BRPI0710099A2/pt not_active IP Right Cessation
- 2007-03-14 MX MX2008011319A patent/MX2008011319A/es active IP Right Grant
- 2007-03-14 KR KR1020087023895A patent/KR20080108503A/ko not_active Ceased
- 2007-03-14 JP JP2009503137A patent/JP5241033B2/ja not_active Expired - Fee Related
- 2007-03-14 CN CN2007800116928A patent/CN101415407B/zh not_active Expired - Fee Related
- 2007-03-14 ZA ZA200807667A patent/ZA200807667B/xx unknown
- 2007-03-14 AU AU2007235111A patent/AU2007235111B2/en not_active Ceased
- 2007-03-14 WO PCT/US2007/063961 patent/WO2007117849A2/en not_active Ceased
- 2007-03-14 CA CA002644721A patent/CA2644721A1/en not_active Abandoned
- 2007-03-19 TW TW096109322A patent/TWI419694B/zh not_active IP Right Cessation
- 2007-03-29 AR ARP070101334A patent/AR060222A1/es not_active Application Discontinuation
-
2010
- 2010-08-18 US US12/858,739 patent/US20100311716A1/en not_active Abandoned
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2011
- 2011-09-14 US US13/232,410 patent/US20120004274A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0710099A2 (pt) | 2011-08-02 |
| US20120004274A1 (en) | 2012-01-05 |
| US20100311716A1 (en) | 2010-12-09 |
| TWI419694B (zh) | 2013-12-21 |
| ZA200807667B (en) | 2010-07-28 |
| EP2004158A2 (en) | 2008-12-24 |
| WO2007117849A2 (en) | 2007-10-18 |
| TW200744601A (en) | 2007-12-16 |
| KR20080108503A (ko) | 2008-12-15 |
| AR060222A1 (es) | 2008-06-04 |
| AU2007235111A1 (en) | 2007-10-18 |
| JP2009532373A (ja) | 2009-09-10 |
| AU2007235111B2 (en) | 2012-03-22 |
| US20060172991A1 (en) | 2006-08-03 |
| CN101415407A (zh) | 2009-04-22 |
| JP5241033B2 (ja) | 2013-07-17 |
| CN101415407B (zh) | 2011-05-11 |
| US7803824B2 (en) | 2010-09-28 |
| MX2008011319A (es) | 2008-09-19 |
| WO2007117849A3 (en) | 2008-04-10 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20140826 |