BRPI0706913A2 - vacina com base em levedura para induzir uma reação imune - Google Patents
vacina com base em levedura para induzir uma reação imune Download PDFInfo
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- BRPI0706913A2 BRPI0706913A2 BRPI0706913-8A BRPI0706913A BRPI0706913A2 BR PI0706913 A2 BRPI0706913 A2 BR PI0706913A2 BR PI0706913 A BRPI0706913 A BR PI0706913A BR PI0706913 A2 BRPI0706913 A2 BR PI0706913A2
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| US9463237B2 (en) * | 2011-01-31 | 2016-10-11 | Baxalta Incorporated | Recombinant viral vectors and methods for inducing a heterosubtypic immune response to influenza A viruses |
| AU2012214394B2 (en) | 2011-02-12 | 2016-08-11 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis B infection |
| PL2685995T3 (pl) * | 2011-03-17 | 2017-10-31 | Globeimmune Inc | Kompozycje immunoterapeutyczne drożdże-Brachyury |
| CN103732249A (zh) * | 2011-05-23 | 2014-04-16 | 威斯特解剖及生物研究所 | 含有经修饰腺病毒载体的流感疫苗 |
| SG195383A1 (en) * | 2011-06-14 | 2013-12-30 | Globeimmune Inc | Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection |
| WO2012177760A1 (en) * | 2011-06-20 | 2012-12-27 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Computationally optimized broadly reactive antigens for h1n1 influenza |
| EP2744918A4 (en) | 2011-08-17 | 2015-06-10 | Globeimmune Inc | IMMUNOTHERAPEUTIC YEAST MUC1 COMPOSITIONS AND USES THEREOF |
| ES2525205T3 (es) | 2011-11-09 | 2014-12-18 | Werner Lubitz | Vacuna para su uso en inmunoterapia tumoral |
| DE102011121069A1 (de) | 2011-12-13 | 2013-06-13 | Martin-Luther-Universität Halle-Wittenberg | Vakzinierung mittels rekombinanter Hefe durch Erzeugung einer protektiven humoralen Immunantwort gegen definierte Antigene |
| AU2013281221B2 (en) | 2012-06-26 | 2018-05-17 | Biodesix, Inc. | Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies |
| US9744193B2 (en) | 2012-09-06 | 2017-08-29 | Orbis Health Solutions Llc | Tumor lysate loaded particles |
| JP5954079B2 (ja) | 2012-09-25 | 2016-07-20 | ソニー株式会社 | 培養観察装置及び培養観察方法 |
| AU2013359469B2 (en) * | 2012-12-10 | 2019-05-16 | Seattle Biomedical Research Institute | Cell-free biofragment compositions and related systems, devices, and methods |
| CN105209063A (zh) * | 2013-03-15 | 2015-12-30 | 宾夕法尼亚大学理事会 | 具有抗原和作为佐剂的白细胞介素-23的疫苗 |
| CA2907560C (en) | 2013-03-19 | 2021-12-07 | Timothy C. Rodell | Yeast-based immunotherapy for chordoma |
| TWI626948B (zh) | 2013-03-26 | 2018-06-21 | 環球免疫公司 | 治療或預防人類免疫缺乏病毒感染之組合物及方法 |
| JP2014210747A (ja) * | 2013-04-19 | 2014-11-13 | アンジェスＭｇ株式会社 | 細胞性免疫誘導能が改善された経口ワクチン |
| US10226522B2 (en) * | 2013-08-30 | 2019-03-12 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of tuberculosis |
| CA3156357A1 (en) | 2014-01-06 | 2015-07-09 | The Trustees Of The University Of Pennsylvania | Pd1 and pdl1 antibodies and vaccine combinations and use of same for immunotherapy |
| AU2015227226B2 (en) | 2014-03-05 | 2017-10-05 | Orbis Health Solutions Llc | Vaccine delivery systems using yeast cell wall particles |
| US10799567B2 (en) * | 2014-04-11 | 2020-10-13 | Globeimmune, Inc. | Yeast-based immunotherapy and type I interferon sensitivity |
| CN105233302B (zh) * | 2014-07-10 | 2018-10-19 | 中国人民解放军军事医学科学院生物工程研究所 | 一种流感血凝素糖蛋白多聚物纳米颗粒的制备方法 |
| JP2018502922A (ja) | 2015-01-09 | 2018-02-01 | イーチュービクス コーポレイション | エボラウイルスワクチン接種のための方法および組成物 |
| US11020470B2 (en) * | 2015-04-13 | 2021-06-01 | The Regents Of The University Of Michigan | Virus-like particles |
| WO2017023840A1 (en) | 2015-08-03 | 2017-02-09 | Globeimmune, Inc. | Modified yeast-brachyury immunotherapeutic compositions |
| CA2995454A1 (en) * | 2015-08-11 | 2017-02-16 | Orbis Health Solutions Llc | Bacterial and viral vaccine strategy |
| GB2552441A (en) * | 2015-10-22 | 2018-01-31 | Royal Veterinary College | Methods |
| EP3195878A1 (en) | 2016-01-22 | 2017-07-26 | Werner Lubitz | Bacterial ghosts for the treatment of cancer |
| MX2018011491A (es) | 2016-03-24 | 2019-08-01 | Nantcell Inc | Disposiciones de secuencia y secuencias para presentacion de neoepitopos. |
| US11779637B2 (en) | 2017-04-24 | 2023-10-10 | Nantcell, Inc. | Targeted neoepitope vectors and methods therefor |
| CA3086456A1 (en) * | 2017-12-21 | 2019-06-27 | Kirin Holdings Kabushiki Kaisha | Cross-immunizing antigen vaccine and method for preparation thereof |
| DE102017012109A1 (de) * | 2017-12-27 | 2019-06-27 | Martin-Luther-Universität Halle-Wittenberg | Optimiertes Wirts-/Vektorsystem zur Erzeugung protektiver mono- und multivalenter subunit-Vakzine auf Basis der Hefe Kluyveromyces lactis |
| WO2019222073A1 (en) | 2018-05-15 | 2019-11-21 | Globeimmune, Inc. | Lysates of recombinant yeast for inducing cellular immune responses |
| CN111315407B (zh) * | 2018-09-11 | 2023-05-02 | 上海市公共卫生临床中心 | 一种广谱抗流感疫苗免疫原及其应用 |
| WO2020061203A1 (en) | 2018-09-21 | 2020-03-26 | Nantcell, Inc. | Methods and compositions for modulating myeloid-derived suppressor cells |
| CN114269374A (zh) * | 2019-05-21 | 2022-04-01 | 艾斯佩罗疫苗公司 | 基于酵母的口服疫苗接种 |
| EP4103722A4 (en) * | 2020-02-11 | 2024-05-22 | Cytonus Therapeutics, Inc. | RAPID VACCINE PLATFORM |
| US20210284716A1 (en) | 2020-03-11 | 2021-09-16 | Immunitybio, Inc. | ACE2-Fc Trap |
| US12285480B2 (en) | 2020-03-11 | 2025-04-29 | Nantcell, Inc. | Method of inducing immunity against SARS-CoV-2 using spike and nucleocapsid-ETSD immunogens delivered by RNA and replication-defective adenoviruses |
| US11857620B2 (en) | 2020-03-11 | 2024-01-02 | Immunitybio, Inc. | Method of inducing immunity against SARS-CoV-2 using spike (s) and nucleocapsid (N)-ETSD immunogens delivered by a replication-defective adenovirus |
| WO2021211691A1 (en) | 2020-04-14 | 2021-10-21 | Immunitybio, Inc. | Yeast lysate covid-19 vaccine |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830463A (en) * | 1993-07-07 | 1998-11-03 | University Technology Corporation | Yeast-based delivery vehicles |
| US5413914A (en) | 1993-07-07 | 1995-05-09 | The Regents Of The University Of Colorado | Yeast assay to identify inhibitors of dibasic amino acid processing endoproteases |
| AU1308495A (en) * | 1994-01-11 | 1995-08-01 | Rijksuniversiteit Gent | Influenza vaccine |
| US5691189A (en) * | 1994-01-19 | 1997-11-25 | Bristol-Myers Squibb Company | Saccharomyces cerevisiae expressing M2 protein of influenza A virus |
| US6696251B1 (en) * | 1996-05-31 | 2004-02-24 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| US20020044948A1 (en) * | 2000-03-15 | 2002-04-18 | Samir Khleif | Methods and compositions for co-stimulation of immunological responses to peptide antigens |
| WO2002000885A2 (en) * | 2000-06-23 | 2002-01-03 | American Cyanamid Company | Assembly of wild-type and chimeric influenza virus-like particles (vlps) |
| AU2002225681A1 (en) * | 2000-11-15 | 2002-05-27 | Globe Immune, Inc. | Yeast-dentritic cell vaccines and uses thereof |
| US20030008000A1 (en) * | 2001-03-08 | 2003-01-09 | Wong Jonathan P. | DNA vaccine using liposome-encapsulated plasmid DNA encoding for hemagglutinin protein of influenza virus |
| US20030202982A1 (en) * | 2001-08-15 | 2003-10-30 | Birkett Ashley J. | Influenza immunogen and vaccine |
| US7439042B2 (en) * | 2002-12-16 | 2008-10-21 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
| BR0316758A (pt) * | 2002-12-16 | 2005-10-25 | Globeimmune Inc | Vacinas baseadas em levedura como imunoterapia |
| US8592197B2 (en) * | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
| US20060024670A1 (en) * | 2004-05-18 | 2006-02-02 | Luke Catherine J | Influenza virus vaccine composition and methods of use |
| ES2375995T3 (es) | 2004-09-17 | 2012-03-08 | University Of Massachusetts | Composiciones y sus usos para deficiencias de enzima lisosomal. |
| TW200806316A (en) * | 2006-02-02 | 2008-02-01 | Globeimmune Inc | Yeast-based vaccine for inducing an immune response |
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- 2007-02-02 US US11/670,902 patent/US7736642B2/en not_active Expired - Fee Related
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2012
- 2012-11-29 JP JP2012260860A patent/JP2013075899A/ja active Pending
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2014
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Free format text: HOMOLOGADA A DESISTENCIA DO PEDIDO, SOLICITADA ATRAVES DA PETICAO ELETRONICA WBRJ NO 860150215948 DE 21/09/2015. |