BRPI0617254A2 - "oligonucleotìdeo de filamento único, composição farmacêutica, métodos para estimular a atividade de tlr7 em uma célula que expressa tlr7, para estimular a atividade de tlr8 em uma célula que expressa tlr8, e, para estimular uma resposta imune em um paciente - Google Patents
"oligonucleotìdeo de filamento único, composição farmacêutica, métodos para estimular a atividade de tlr7 em uma célula que expressa tlr7, para estimular a atividade de tlr8 em uma célula que expressa tlr8, e, para estimular uma resposta imune em um paciente Download PDFInfo
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- BRPI0617254A2 BRPI0617254A2 BRPI0617254-7A BRPI0617254A BRPI0617254A2 BR PI0617254 A2 BRPI0617254 A2 BR PI0617254A2 BR PI0617254 A BRPI0617254 A BR PI0617254A BR PI0617254 A2 BRPI0617254 A2 BR PI0617254A2
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- Prior art keywords
- oligonucleotide
- virus
- tlr7
- cell
- nucleotide
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Landscapes
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| US60/751,917 | 2005-12-20 | ||
| PCT/EP2006/067334 WO2007042554A2 (en) | 2005-10-12 | 2006-10-12 | Methods and compositions for treating immune disorders |
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| DK2347775T3 (da) | 2005-12-13 | 2020-07-13 | Harvard College | Skabeloner til celletransplantation |
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| JP2010507361A (ja) | 2006-07-31 | 2010-03-11 | キュアバック ゲーエムベーハー | 具体的には免疫刺激剤/アジュバントとしての、一般式(I):GlXmGn、または一般式(II):ClXmCnで表される核酸 |
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| CN101541965A (zh) * | 2006-09-27 | 2009-09-23 | 科勒制药集团股份有限公司 | Tlr配体与抗病毒剂的组合物 |
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| US8349812B2 (en) * | 2007-11-06 | 2013-01-08 | Adiutide Pharmaceuticals Gmbh | Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties |
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| US10328133B2 (en) | 2008-02-13 | 2019-06-25 | President And Fellows Of Harvard College | Continuous cell programming devices |
| WO2010020590A1 (en) * | 2008-08-20 | 2010-02-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the response to anti-cancer treatment with an agonist of tlr7 or an agonist of tlr8 |
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| CA2801523C (en) | 2010-07-30 | 2021-08-03 | Curevac Gmbh | Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation |
| CN107648668B (zh) | 2010-10-06 | 2021-06-18 | 哈佛学院董事会 | 用于基于材料的细胞疗法的可注射的成孔水凝胶 |
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| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| WO2013113326A1 (en) | 2012-01-31 | 2013-08-08 | Curevac Gmbh | Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen |
| CN104244929B (zh) | 2012-04-16 | 2017-04-05 | 哈佛学院董事会 | 用于调节免疫反应的介孔二氧化硅组合物 |
| US9228184B2 (en) | 2012-09-29 | 2016-01-05 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| US9868955B2 (en) | 2012-09-29 | 2018-01-16 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| KR101441415B1 (ko) * | 2013-03-11 | 2014-09-24 | 국방과학연구소 | 신규한 siRNA, 이를 이용한 오소폭스바이러스에 대한 항바이러스 조성물 |
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| WO2015149944A2 (en) | 2014-04-01 | 2015-10-08 | Curevac Gmbh | Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant |
| US10682400B2 (en) | 2014-04-30 | 2020-06-16 | President And Fellows Of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| KR101643947B1 (ko) * | 2014-06-27 | 2016-07-29 | 건국대학교 산학협력단 | gHA1 단백질에 특이적으로 결합하는 RNA 앱타머 및 그를 포함하는 약학 조성물 |
| EP3250250A4 (en) | 2015-01-30 | 2019-05-22 | President and Fellows of Harvard College | PERITUMORAL AND INTRATUMORAL MATERIALS FOR CANCER THERAPY |
| JP7094533B2 (ja) | 2015-04-10 | 2022-07-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 免疫細胞捕捉デバイスおよびその製造および使用方法 |
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| EP3411475B1 (en) | 2016-02-06 | 2025-08-27 | President and Fellows of Harvard College | Recapitulating the hematopoietic niche to reconstitute immunity |
| CN115537372A (zh) | 2016-07-13 | 2022-12-30 | 哈佛学院院长等 | 抗原呈递细胞模拟支架及其制备和使用方法 |
| EP3493842A4 (en) | 2016-08-02 | 2020-07-29 | President and Fellows of Harvard College | BIOMATERIALS TO MODULATE IMMUNE RESPONSES |
| US20210155933A1 (en) * | 2017-08-31 | 2021-05-27 | Gilead Sciences, Inc. | Tlr-9 agonists for modulation of tumor microenvironment |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
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|---|---|---|---|---|
| US5683874A (en) * | 1991-03-27 | 1997-11-04 | Research Corporation Technologies, Inc. | Single-stranded circular oligonucleotides capable of forming a triplex with a target sequence |
| FR2814370B1 (fr) * | 2000-09-22 | 2004-08-20 | Centre Nat Rech Scient | Utilisation d'un complexe acide nucleique/pei pour le ciblage de cellules souches du cerveau |
| US8153141B2 (en) * | 2002-04-04 | 2012-04-10 | Coley Pharmaceutical Gmbh | Immunostimulatory G, U-containing oligoribonucleotides |
| TW200533750A (en) * | 2004-02-19 | 2005-10-16 | Coley Pharm Group Inc | Immunostimulatory viral RNA oligonucleotides |
| US20050197312A1 (en) * | 2004-03-03 | 2005-09-08 | Kevin Fitzgerald | Transcription factor RNA interference reagents and methods of use thereof |
| WO2006116458A2 (en) * | 2005-04-26 | 2006-11-02 | Coley Pharmaceutical Gmbh | Modified oligoribonucleotide analogs with enhances immunostimulatory activity |
-
2006
- 2006-10-12 EA EA200801045A patent/EA200801045A1/ru unknown
- 2006-10-12 BR BRPI0617254-7A patent/BRPI0617254A2/pt not_active IP Right Cessation
- 2006-10-12 US US12/088,752 patent/US20090169472A1/en not_active Abandoned
- 2006-10-12 AU AU2006301230A patent/AU2006301230A1/en not_active Abandoned
- 2006-10-12 CA CA002625488A patent/CA2625488A1/en not_active Abandoned
- 2006-10-12 JP JP2008535031A patent/JP2009511034A/ja active Pending
- 2006-10-12 EP EP06807200A patent/EP1937812A2/en not_active Withdrawn
- 2006-10-12 WO PCT/EP2006/067334 patent/WO2007042554A2/en not_active Ceased
- 2006-10-12 KR KR1020087011347A patent/KR20080065656A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007042554A2 (en) | 2007-04-19 |
| CA2625488A1 (en) | 2007-04-19 |
| AU2006301230A1 (en) | 2007-04-19 |
| KR20080065656A (ko) | 2008-07-14 |
| US20090169472A1 (en) | 2009-07-02 |
| JP2009511034A (ja) | 2009-03-19 |
| EA200801045A1 (ru) | 2008-10-30 |
| WO2007042554A3 (en) | 2007-07-05 |
| EP1937812A2 (en) | 2008-07-02 |
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