BRPI0617222A2 - derivados de diacilindazol como inibidores de lipase e fosfolipase - Google Patents

derivados de diacilindazol como inibidores de lipase e fosfolipase Download PDF

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Publication number
BRPI0617222A2
BRPI0617222A2 BRPI0617222-9A BRPI0617222A BRPI0617222A2 BR PI0617222 A2 BRPI0617222 A2 BR PI0617222A2 BR PI0617222 A BRPI0617222 A BR PI0617222A BR PI0617222 A2 BRPI0617222 A2 BR PI0617222A2
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Brazil
Prior art keywords
alkyl
formula
compounds
heterocycle
phenyl
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Application number
BRPI0617222-9A
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English (en)
Portuguese (pt)
Inventor
Gerhard Zoller
Stefan Petry
Gunter Muller
Hubert Heuer
Norbert Tennagels
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Sanofi Aventis
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Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0617222A2 publication Critical patent/BRPI0617222A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
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  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Urology & Nephrology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI0617222-9A 2005-10-12 2006-10-04 derivados de diacilindazol como inibidores de lipase e fosfolipase BRPI0617222A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005048897A DE102005048897A1 (de) 2005-10-12 2005-10-12 Diacylindazol-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005048897.8 2005-10-12
PCT/EP2006/009577 WO2007042178A1 (de) 2005-10-12 2006-10-04 Diacylindazol-derivate als inhibitoren von lipasen und phospholipasen

Publications (1)

Publication Number Publication Date
BRPI0617222A2 true BRPI0617222A2 (pt) 2011-07-19

Family

ID=37813518

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0617222-9A BRPI0617222A2 (pt) 2005-10-12 2006-10-04 derivados de diacilindazol como inibidores de lipase e fosfolipase

Country Status (18)

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US (2) US7772268B2 (US20070167479A1-20070719-C00034.png)
EP (1) EP1937648B1 (US20070167479A1-20070719-C00034.png)
JP (1) JP2009511517A (US20070167479A1-20070719-C00034.png)
KR (1) KR20080048062A (US20070167479A1-20070719-C00034.png)
CN (1) CN101282939A (US20070167479A1-20070719-C00034.png)
AR (1) AR056686A1 (US20070167479A1-20070719-C00034.png)
AU (1) AU2006301591A1 (US20070167479A1-20070719-C00034.png)
BR (1) BRPI0617222A2 (US20070167479A1-20070719-C00034.png)
CA (1) CA2625546A1 (US20070167479A1-20070719-C00034.png)
DE (1) DE102005048897A1 (US20070167479A1-20070719-C00034.png)
IL (1) IL190672A0 (US20070167479A1-20070719-C00034.png)
MA (1) MA29856B1 (US20070167479A1-20070719-C00034.png)
NO (1) NO20081878L (US20070167479A1-20070719-C00034.png)
RU (1) RU2008114360A (US20070167479A1-20070719-C00034.png)
TW (1) TW200728285A (US20070167479A1-20070719-C00034.png)
UY (1) UY29853A1 (US20070167479A1-20070719-C00034.png)
WO (1) WO2007042178A1 (US20070167479A1-20070719-C00034.png)
ZA (1) ZA200802105B (US20070167479A1-20070719-C00034.png)

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EP2002835A1 (en) 2007-06-04 2008-12-17 GenKyo Tex Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
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EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
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WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
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WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
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US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
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TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
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US20080287448A1 (en) 2008-11-20
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EP1937648A1 (de) 2008-07-02
US8357698B2 (en) 2013-01-22
EP1937648B1 (de) 2014-11-26
KR20080048062A (ko) 2008-05-30
ZA200802105B (en) 2009-09-30
UY29853A1 (es) 2007-05-31
WO2007042178A1 (de) 2007-04-19
AU2006301591A1 (en) 2007-04-19
AR056686A1 (es) 2007-10-17
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