BRPI0616982B8 - uso de oligouronato, composição farmacêutica inalável e aplicador de spray - Google Patents

uso de oligouronato, composição farmacêutica inalável e aplicador de spray

Info

Publication number
BRPI0616982B8
BRPI0616982B8 BRPI0616982A BRPI0616982A BRPI0616982B8 BR PI0616982 B8 BRPI0616982 B8 BR PI0616982B8 BR PI0616982 A BRPI0616982 A BR PI0616982A BR PI0616982 A BRPI0616982 A BR PI0616982A BR PI0616982 B8 BRPI0616982 B8 BR PI0616982B8
Authority
BR
Brazil
Prior art keywords
oligouronate
pharmaceutical composition
spray applicator
inhalable pharmaceutical
human
Prior art date
Application number
BRPI0616982A
Other languages
English (en)
Inventor
Taylor Catherine
Ingar Draget Kurt
Asmund Smidsrod Olav
Original Assignee
Ntnu Tech Transfer As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35429950&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0616982(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ntnu Tech Transfer As filed Critical Ntnu Tech Transfer As
Publication of BRPI0616982A2 publication Critical patent/BRPI0616982A2/pt
Publication of BRPI0616982B1 publication Critical patent/BRPI0616982B1/pt
Publication of BRPI0616982B8 publication Critical patent/BRPI0616982B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

tratamento com oligouronato. a presente invenção refere-se a um método para tratamento de um ser humano ou não humano para combater a hiperviscosidade mucosal no trato respiratório, em que o método compreende a aplicação em uma superfície mucosal no dito trato no dito sujeito de uma quantidade eficaz de um oligouronato fisiologicamente tolerável.
BRPI0616982A 2005-10-06 2006-10-06 uso de oligouronato, composição farmacêutica inalável e aplicador de spray BRPI0616982B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0520375A GB2430881B (en) 2005-10-06 2005-10-06 Oligoelectrolyte polyols for the treatment of mucosal hyperviscosity
GB0520375.7 2005-10-06
PCT/GB2006/003720 WO2007039754A1 (en) 2005-10-06 2006-10-06 Use of oligouronates for treating mucus hyperviscosity

Publications (3)

Publication Number Publication Date
BRPI0616982A2 BRPI0616982A2 (pt) 2011-07-05
BRPI0616982B1 BRPI0616982B1 (pt) 2020-05-05
BRPI0616982B8 true BRPI0616982B8 (pt) 2021-05-25

Family

ID=35429950

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0616982A BRPI0616982B8 (pt) 2005-10-06 2006-10-06 uso de oligouronato, composição farmacêutica inalável e aplicador de spray

Country Status (15)

Country Link
US (2) US8754063B2 (pt)
EP (4) EP3403657B1 (pt)
JP (1) JP5313677B2 (pt)
KR (1) KR101144576B1 (pt)
CN (1) CN101325973B (pt)
AU (1) AU2006298544B2 (pt)
BR (1) BRPI0616982B8 (pt)
CA (1) CA2624568C (pt)
DK (3) DK1942938T3 (pt)
EA (1) EA015436B1 (pt)
ES (3) ES2390974T3 (pt)
GB (1) GB2430881B (pt)
HK (1) HK1125855A1 (pt)
PL (1) PL3403657T3 (pt)
WO (2) WO2007039760A2 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2430881B (en) 2005-10-06 2010-10-13 Ntnu Technology Transfer As Oligoelectrolyte polyols for the treatment of mucosal hyperviscosity
GB0707096D0 (en) * 2007-04-12 2007-05-23 Ntnu Technology Transfer As Method
RU2527894C2 (ru) 2007-11-27 2014-09-10 Альгифарма ИПР АС Использование альгинатных олигомеров в борьбе с биопленками
GB0904942D0 (en) 2009-03-23 2009-05-06 Ntnu Technology Transfer As Composition
GB0904941D0 (en) 2009-03-23 2009-05-06 Ntnu Technology Transfer As Composition
GB0909529D0 (en) 2009-06-03 2009-07-15 Algipharma Ipr As Alginate oligomers for the inhibition of microbial adherence to surfaces
GB0909557D0 (en) 2009-06-03 2009-07-15 Algipharma Ipr As Anti-microbial alginate oligomers
JP5202764B2 (ja) 2009-06-03 2013-06-05 アルギファルマ エーエス 細菌における多剤耐性の克服に使用されるアルギネートオリゴマー
GB201116010D0 (en) 2011-09-15 2011-10-26 Algipharma As Use of alginate oligomers to enhance the effects of antifungal agents
WO2015017316A2 (en) * 2013-08-01 2015-02-05 Abbott Nicholas L Methods and compositions for modifying mucous membranes
GB201322777D0 (en) 2013-12-20 2014-02-05 Algipharma As Use of alginate oligomers as blood anticoagulants
EP3086847A1 (en) * 2013-12-23 2016-11-02 Norwegian University of Science and Technology (NTNU) Uses of oligouronates in cancer treatment
CA2940560A1 (en) * 2014-02-28 2015-09-03 Algipharma As Use of alginate oligomers in the treatment of cystic fibrosis and other conditions associated with defective cftr ion channel function
FR3024358B1 (fr) * 2014-08-01 2017-11-10 Soc De Courtage Et De Diffusion Codif Int Compositions cosmetiques et complements alimentaires neuro-protecteurs comprenant de l'oligoalginate ayant un degre de polymerisation de 10 pour lutter contre le vieillissement de la peau.
GB201415381D0 (en) 2014-08-29 2014-10-15 Algipharma As Inhalable powder formulations of alginate oligomers
GB201504878D0 (en) * 2015-03-23 2015-05-06 Algipharma As Use of alginate oligomers and CFTR modulators in the treatment of conditions associated with CFTR dysfuntion
GB201517639D0 (en) 2015-10-06 2015-11-18 Algipharma As Use of alginate oligomers to treat or prevent microbial overgrowth in the intestinal tract
GB201812473D0 (en) 2018-07-31 2018-09-12 Algipharma As Method for the qualitative and quantitative detection of alginate oligomers in body fluids
GB201908639D0 (en) 2019-06-17 2019-07-31 Algipharma Ipr As Use of alginate oligomers in the anticoagulation therapy of subjects at risk of blood clots which have an abnormally dense microstructure
CN115005447B (zh) * 2022-06-16 2024-02-06 青岛海关技术中心 低聚古罗糖醛酸在制备抗疲劳产品中的应用
EP4393472A1 (en) * 2022-12-27 2024-07-03 Abbas Mirshafiey Mannuronate, guluronate and gulumannuronate tablet, capsule or ampoule formulation and method for its preparation
WO2024141760A1 (en) 2022-12-30 2024-07-04 Algipharma As Compositions and methods to increase the systemic bioavailability of a polypeptide therapeutic agent undergoing oral administration

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL297511A (pt) * 1956-12-20
FR7576M (pt) * 1968-03-27 1970-01-05
HU172831B (hu) * 1976-03-31 1978-12-28 Egyt Gyogyszervegyeszeti Gyar Sposob poluchenija kompleksov oligo- i poligalakturonnyk kislot s ionami zhiznenno vazhnykh metallov
JPS6176413A (ja) 1984-09-21 1986-04-18 Junzo Sunamoto 吸水性高分子によりカプセル化されたリポソ−ムの製造法
DD268865A1 (de) * 1987-01-16 1989-06-14 Adw Ddr Verfahren zur herstellung eines pharmazeutischen praeparates
US4898852A (en) * 1987-06-02 1990-02-06 Walsh William E Cyclopolgalcturonic acid composition and treatment
US4855128A (en) 1988-01-14 1989-08-08 Warner-Lambert Company Saccharide inhibition of dental plaque
JP2641472B2 (ja) 1988-01-30 1997-08-13 日本レダリー株式会社 感染症治療剤
JPH05502863A (ja) 1989-12-05 1993-05-20 トランセル・コーポレイション 生体内適用および埋め込み用コーティング組成物同種グルロン酸―アルギン酸塩およびその使用方法
US5459054A (en) * 1989-12-05 1995-10-17 Neocrin Company Cells encapsulated in alginate containing a high content of a- l- guluronic acid
AU7221691A (en) 1990-01-23 1991-08-21 Terje Espevik Mannuronic acid containing alginate wound healing composition and method
US5166137A (en) * 1991-03-27 1992-11-24 Nobipols Forskningsstiftelse Guluronic acid polymers and use of same for inhibition of cytokine production
US5952308A (en) * 1991-07-29 1999-09-14 Pola Chemical Industries Inc. Mineral absorption promoting agent
US5460957A (en) * 1992-04-28 1995-10-24 Maruha Corporation Calcium alginate oligosaccharide and method for producing the same from potassium or sodium alginate
HU213872B (en) 1993-09-08 1997-11-28 Mta Koezponti Kemiai Kutato In Oligo- and polygalacturonate mixed complex, pharmaceutical and food compositions containing them, further process for preparing these compounds
DE4330773A1 (de) * 1993-09-10 1995-03-16 Laevosan Gmbh & Co Kg Blockierung der Anlagerung von Keimen an menschliche Zellen
JP2828391B2 (ja) * 1993-10-29 1998-11-25 東燃株式会社 オリゴ糖を表面に有するリポソーム
AUPM322393A0 (en) 1993-12-24 1994-01-27 Austin Research Institute, The Mucin carbohydrate compounds and their use in immunotherapy
US5795587A (en) * 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
WO1997014785A2 (en) * 1995-10-19 1997-04-24 Advanced Reproduction Technologies, Inc. Methods and compositions to improve germ cell and embryo survival and function
JP3512553B2 (ja) * 1996-01-30 2004-03-29 ポーラ化成工業株式会社 便秘抑制剤及びそれを含有する組成物
FR2747045B1 (fr) * 1996-04-05 1998-06-26 Hooreman Michel Nouveau medicament optimisant la viscosite des mucus et ameliorant le fonctionnement de l'intestin
NO305441B1 (no) * 1996-07-12 1999-05-31 Norsk Hydro As Anvendelse av G-blokk polysakkarider
EP0963196B1 (en) 1996-09-27 2005-01-19 Jagotec Ag Hyaluronic drug delivery system
NO305033B1 (no) * 1997-05-09 1999-03-22 Algipharma As Fremgangsmate for fremstilling av uronsyreblokker fra alginat
US6339075B1 (en) * 1997-06-30 2002-01-15 The University Of British Columbia Use of dextran and other polysaccharides to improve mucus clearance
KR100219918B1 (ko) 1997-07-03 1999-09-01 김윤 대장선택적 약물전달용 조성물
JP3932679B2 (ja) 1998-07-21 2007-06-20 セイコーエプソン株式会社 ポリグルロン酸の製造法
US6290987B1 (en) 1998-09-27 2001-09-18 Generex Pharmaceuticals, Inc. Mixed liposome pharmaceutical formulation with amphiphiles and phospholipids
EP1212047A2 (en) * 1999-08-26 2002-06-12 The Governors Of The University Of Alberta Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto
US20040224922A1 (en) * 1999-08-26 2004-11-11 Malcolm King Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto
US6458387B1 (en) 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
US7785625B2 (en) * 2000-01-14 2010-08-31 Lg Life Sciences, Limited Lipophilic-coated microparticle containing a protein drug and formulation comprising same
KR100501584B1 (ko) * 2000-02-03 2005-07-18 (주)케이비피 저분자 폴리만유로네이트의 제조방법, 혈청지질개선제로서의 이의 신규 용도 및 이를 함유하는 기능성식품 및 건강 보조 식품
DE10006989A1 (de) * 2000-02-16 2001-08-23 Nutricia Nv Antiadhäsive Kohlenhydratmischung
HU230315B1 (hu) 2000-03-07 2016-01-28 Rush-Presbyterian-St. Luke's Medical Center Összetételek és eljárások patogén mikrobák és spermatozoák csapdázására
AU4445201A (en) 2000-03-30 2001-10-08 Generex Pharmaceuticals Inc. Method for administering insulin to the buccal region
DE10019076A1 (de) * 2000-04-06 2001-10-18 Lang Christine Verwendung von Polygalakturoniden als Lebensmittelzusatzstoffe
JP2002338493A (ja) 2000-10-23 2002-11-27 Genaera Corp ムチン合成インヒビター
DE10057976B4 (de) 2000-11-22 2005-02-03 Südzucker AG Mannheim/Ochsenfurt Verfahren zur Herstellung von Pektinhydrolyseprodukten
US6440314B1 (en) * 2001-01-03 2002-08-27 Vulcan Chemical Technologies, Inc. Method for destroying chlorite in solution
ITMI20010347A1 (it) 2001-02-21 2002-08-21 Grisotech S A Complessi di immunoglobuline e polisaccaridi per assorbimento orale etrans-mucosale
US6610331B1 (en) * 2002-05-30 2003-08-26 Scott M. Sweazy Fertility kit
JP2005145885A (ja) 2003-11-14 2005-06-09 Japan Science & Technology Agency アルギン酸オリゴマーからなる免疫機構賦活剤
ES2398318T3 (es) 2004-03-12 2013-03-15 Biodel, Inc. Composiciones de suministro de fármacos de acción rápida
ATE537263T1 (de) * 2004-06-07 2011-12-15 Protiva Biotherapeutics Inc Kationische lipide und verwendungsverfahren
JP2006028041A (ja) 2004-07-13 2006-02-02 Ltt Bio-Pharma Co Ltd 核酸含有ナノ粒子
EP1714660A1 (en) * 2005-04-21 2006-10-25 N.V. Nutricia Uronic acid and probiotics
US7621036B2 (en) 2005-06-21 2009-11-24 Cardiomems, Inc. Method of manufacturing implantable wireless sensor for in vivo pressure measurement
EP1745705A1 (en) 2005-07-20 2007-01-24 N.V. Nutricia Process for preparing uronic acid oligosaccharides by extrusion
GB2430881B (en) 2005-10-06 2010-10-13 Ntnu Technology Transfer As Oligoelectrolyte polyols for the treatment of mucosal hyperviscosity
CN101312736B (zh) 2005-10-21 2013-03-20 生命细胞产品有限公司 包囊体系
GB0707096D0 (en) 2007-04-12 2007-05-23 Ntnu Technology Transfer As Method
US20110130444A1 (en) 2007-05-04 2011-06-02 Stefan Moisyadi Methods and compositions for targeted delivery of gene therapeutic vectors
US8389768B2 (en) 2008-05-19 2013-03-05 The University Of North Carolina At Chapel Hill Methods and compositions comprising novel cationic lipids

Also Published As

Publication number Publication date
HK1125855A1 (en) 2009-08-21
US20090156549A1 (en) 2009-06-18
EP3403657B1 (en) 2021-12-08
CN101325973A (zh) 2008-12-17
GB0520375D0 (en) 2005-11-16
US8673878B2 (en) 2014-03-18
KR101144576B1 (ko) 2012-05-09
EP1942938A1 (en) 2008-07-16
WO2007039760A3 (en) 2007-08-09
KR20080080491A (ko) 2008-09-04
ES2390974T3 (es) 2012-11-20
EP1954315A2 (en) 2008-08-13
DK3403657T3 (da) 2022-02-28
JP5313677B2 (ja) 2013-10-09
EP2311497A1 (en) 2011-04-20
DK1942938T3 (da) 2012-09-17
DK2311497T3 (en) 2018-10-22
EP3403657A1 (en) 2018-11-21
CA2624568C (en) 2014-04-08
WO2007039760A2 (en) 2007-04-12
JP2009511455A (ja) 2009-03-19
GB2430881A (en) 2007-04-11
AU2006298544A1 (en) 2007-04-12
PL3403657T3 (pl) 2022-03-21
BRPI0616982B1 (pt) 2020-05-05
AU2006298544B2 (en) 2012-07-05
WO2007039754A1 (en) 2007-04-12
EP2311497B1 (en) 2018-07-11
EP1942938B1 (en) 2012-07-04
US8754063B2 (en) 2014-06-17
ES2688971T3 (es) 2018-11-07
US20090010914A1 (en) 2009-01-08
ES2907875T3 (es) 2022-04-26
EA015436B1 (ru) 2011-08-30
EA200801033A1 (ru) 2008-10-30
CN101325973B (zh) 2013-02-13
BRPI0616982A2 (pt) 2011-07-05
GB2430881B (en) 2010-10-13
CA2624568A1 (en) 2007-04-12

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