BRPI0612628B8 - 1-(2-amina-3-(alquil substituído)-3h-benzimidazolil)metil]-3-substituído-1,3-diidro-benzoimidazol-2-onas com atividade sobre vírus sincicial respiratório, seu processo de preparação e composição farmacêutica que os compreende - Google Patents
1-(2-amina-3-(alquil substituído)-3h-benzimidazolil)metil]-3-substituído-1,3-diidro-benzoimidazol-2-onas com atividade sobre vírus sincicial respiratório, seu processo de preparação e composição farmacêutica que os compreendeInfo
- Publication number
- BRPI0612628B8 BRPI0612628B8 BRPI0612628A BRPI0612628A BRPI0612628B8 BR PI0612628 B8 BRPI0612628 B8 BR PI0612628B8 BR PI0612628 A BRPI0612628 A BR PI0612628A BR PI0612628 A BRPI0612628 A BR PI0612628A BR PI0612628 B8 BRPI0612628 B8 BR PI0612628B8
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- 6alkyl
- benzoimidazol
- benzimidazolyl
- understands
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 241000725643 Respiratory syncytial virus Species 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 cyano, aminocarbonyl Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1-(2-amina-3-(alquil substituído)-3h-benzimidazolil)metil]-3-substituído-1,3-diidro-bernzoimidazol-2-onas com atividade sobre vírus sincicial respiratório. a presente invenção refere-se a inibidores de replicação de rsv de fórmula (i) (i) que podem ser representados por fórmula (i) seus sais e formas estereoquimicamente isoméricas, onde r é um radical de fórmula (a) ou (b); (a) (b) q é hidrogênio ou c1-6 alquila opcionalmente substituído por um heterociclo ou q é c1-6 alquila substituído por ambos um radical -or4 e um heterociclo; aik é c1-6 alcanodiila; x é o ou s; -a1=a=2-a3=a4 é -n=ch-ch=ch-, -ch=n-ch=ch-, -ch=ch-n=ch- ou -ch=ch-ch=n-; r1 é ar ou heterociclo; r2 é hidrogênio, c1-6 alquila, c1-6 alquila substituído, c3-7 cicloalquila; r3 é hidrogênio, c1-6 alquila, ciano, aminacarbonila, polihalo c1-6 alquila, c2-6 alquenila ou c2-6 alquinila; r4 é hidrogênio ou c1-6 alquila; ar é fenila ou fenila substituída; het é um heterociclo; composições farmacêuticas contendo compostos (i) e processos para preparação de compostos (i).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05076438 | 2005-06-20 | ||
| EP05076438.0 | 2005-06-20 | ||
| PCT/EP2006/063365 WO2006136561A1 (en) | 2005-06-20 | 2006-06-20 | 1- ( 2-amino-3- (substituted alkyl)-3h-benzimidazoiylmethyl) -3-subtituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0612628A2 BRPI0612628A2 (pt) | 2012-01-03 |
| BRPI0612628B1 BRPI0612628B1 (pt) | 2019-12-03 |
| BRPI0612628B8 true BRPI0612628B8 (pt) | 2021-05-25 |
Family
ID=35276402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0612628A BRPI0612628B8 (pt) | 2005-06-20 | 2006-06-20 | 1-(2-amina-3-(alquil substituído)-3h-benzimidazolil)metil]-3-substituído-1,3-diidro-benzoimidazol-2-onas com atividade sobre vírus sincicial respiratório, seu processo de preparação e composição farmacêutica que os compreende |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8034835B2 (pt) |
| EP (1) | EP1896473B1 (pt) |
| JP (1) | JP5078887B2 (pt) |
| CN (1) | CN101203517B (pt) |
| AT (1) | ATE529424T1 (pt) |
| AU (1) | AU2006260969B2 (pt) |
| BR (1) | BRPI0612628B8 (pt) |
| CA (1) | CA2612263C (pt) |
| MX (1) | MX2007016537A (pt) |
| RU (1) | RU2434000C2 (pt) |
| WO (1) | WO2006136561A1 (pt) |
| ZA (1) | ZA200711080B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007085357A1 (en) * | 2006-01-30 | 2007-08-02 | Euro-Celtique S.A. | Cyclourea compounds as calcium channel blockers |
| TWI650321B (zh) | 2011-10-14 | 2019-02-11 | 美商安比特生物科學公司 | 雜環化合物及其使用方法 |
| SG11201600977XA (en) | 2013-08-21 | 2016-03-30 | Alios Biopharma Inc | Antiviral compounds |
| MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
| JO3637B1 (ar) * | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
| US10881666B2 (en) | 2017-09-29 | 2021-01-05 | Enanta Pharmaceuticals, Inc. | Combination pharmaceutical agents as RSV inhibitors |
| TW201932470A (zh) | 2017-11-29 | 2019-08-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 具有抗ｒｓｖ活性之吡唑并嘧啶 |
| KR20200116099A (ko) | 2018-01-31 | 2020-10-08 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | Rsv에 대한 활성을 갖는 시클로알킬 치환 피라졸로피리미딘 |
| MA52348A (fr) | 2018-04-23 | 2021-03-03 | Janssen Sciences Ireland Unlimited Co | Composés hétéroaromatiques ayant une activité contre vrs |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2376785A1 (en) | 1999-06-28 | 2001-01-04 | Janssen Pharmaceutica N.V. | Benzimidazoles and imidazopyridines as respiratory syncytial virus replication inhibitors |
| SK18942001A3 (sk) | 1999-06-28 | 2002-10-08 | Janssen Pharmaceutica N. V. | Inhibítory replikácie respiračného syncytiálneho vírusu |
| UA74787C2 (en) | 1999-06-28 | 2006-02-15 | Janssen Pharmaceutica Nv | Respiratory syncytial virus replication inhibitors |
| US6489338B2 (en) | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
| AR046959A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
| BRPI0417811A (pt) * | 2003-12-18 | 2007-03-27 | Tibotec Pharm Ltd | aminobenzimidazóis e benzimidazóis como inibidores da replicação do vìrus sincicial respiratório |
-
2006
- 2006-06-20 RU RU2008102057/04A patent/RU2434000C2/ru active
- 2006-06-20 AT AT06763808T patent/ATE529424T1/de not_active IP Right Cessation
- 2006-06-20 EP EP06763808A patent/EP1896473B1/en active Active
- 2006-06-20 WO PCT/EP2006/063365 patent/WO2006136561A1/en active Application Filing
- 2006-06-20 US US11/993,109 patent/US8034835B2/en active Active
- 2006-06-20 CN CN2006800219722A patent/CN101203517B/zh active Active
- 2006-06-20 MX MX2007016537A patent/MX2007016537A/es active IP Right Grant
- 2006-06-20 AU AU2006260969A patent/AU2006260969B2/en not_active Ceased
- 2006-06-20 JP JP2008517487A patent/JP5078887B2/ja active Active
- 2006-06-20 BR BRPI0612628A patent/BRPI0612628B8/pt not_active IP Right Cessation
- 2006-06-20 CA CA2612263A patent/CA2612263C/en active Active
-
2007
- 2007-12-19 ZA ZA200711080A patent/ZA200711080B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006260969A1 (en) | 2006-12-28 |
| CN101203517B (zh) | 2011-07-06 |
| JP5078887B2 (ja) | 2012-11-21 |
| RU2434000C2 (ru) | 2011-11-20 |
| ZA200711080B (en) | 2009-03-25 |
| MX2007016537A (es) | 2008-03-06 |
| RU2008102057A (ru) | 2009-07-27 |
| ATE529424T1 (de) | 2011-11-15 |
| US8034835B2 (en) | 2011-10-11 |
| BRPI0612628B1 (pt) | 2019-12-03 |
| CN101203517A (zh) | 2008-06-18 |
| WO2006136561A1 (en) | 2006-12-28 |
| JP2008546738A (ja) | 2008-12-25 |
| CA2612263A1 (en) | 2006-12-28 |
| CA2612263C (en) | 2015-04-14 |
| EP1896473A1 (en) | 2008-03-12 |
| US20100183552A1 (en) | 2010-07-22 |
| EP1896473B1 (en) | 2011-10-19 |
| AU2006260969B2 (en) | 2011-11-17 |
| BRPI0612628A2 (pt) | 2012-01-03 |
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Owner name: JANSSEN R AND D IRELAND (IE) |
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| B25A | Requested transfer of rights approved |
Owner name: JANSSEN SCIENCES IRELAND UC (IE) |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
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