BRPI0610411A2 - uso de 17-alilamino-17-demetoxigeldanamicina (17-aag) ou 17-aminogeldanamicina (17-ag) ou um pró-fármaco tanto de 17-aag ou 17-ag, bem como uma formulação farmacêutica - Google Patents

uso de 17-alilamino-17-demetoxigeldanamicina (17-aag) ou 17-aminogeldanamicina (17-ag) ou um pró-fármaco tanto de 17-aag ou 17-ag, bem como uma formulação farmacêutica Download PDF

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Publication number
BRPI0610411A2
BRPI0610411A2 BRPI0610411-8A BRPI0610411A BRPI0610411A2 BR PI0610411 A2 BRPI0610411 A2 BR PI0610411A2 BR PI0610411 A BRPI0610411 A BR PI0610411A BR PI0610411 A2 BRPI0610411 A2 BR PI0610411A2
Authority
BR
Brazil
Prior art keywords
aag
dose
administered
subject
cmax
Prior art date
Application number
BRPI0610411-8A
Other languages
English (en)
Portuguese (pt)
Inventor
Robert Johnson
Alison Hannah
Gillian Cropp
Yiqing Zhou
J Sherrill
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Publication of BRPI0610411A2 publication Critical patent/BRPI0610411A2/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0610411-8A 2005-04-29 2006-04-26 uso de 17-alilamino-17-demetoxigeldanamicina (17-aag) ou 17-aminogeldanamicina (17-ag) ou um pró-fármaco tanto de 17-aag ou 17-ag, bem como uma formulação farmacêutica BRPI0610411A2 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US67644905P 2005-04-29 2005-04-29
US60/676,449 2005-04-29
US68094405P 2005-05-12 2005-05-12
US60/680,944 2005-05-12
US72170705P 2005-09-28 2005-09-28
US60/721,707 2005-09-28
US74920005P 2005-12-09 2005-12-09
US60/749,200 2005-12-09
PCT/US2006/016043 WO2006118953A2 (en) 2005-04-29 2006-04-26 Method of treating multiple myeloma using 17-aag of 17-ag of a prodrug of either

Publications (1)

Publication Number Publication Date
BRPI0610411A2 true BRPI0610411A2 (pt) 2010-06-22

Family

ID=37308498

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0610411-8A BRPI0610411A2 (pt) 2005-04-29 2006-04-26 uso de 17-alilamino-17-demetoxigeldanamicina (17-aag) ou 17-aminogeldanamicina (17-ag) ou um pró-fármaco tanto de 17-aag ou 17-ag, bem como uma formulação farmacêutica

Country Status (12)

Country Link
US (1) US7691392B2 (cg-RX-API-DMAC7.html)
EP (1) EP1874296A4 (cg-RX-API-DMAC7.html)
JP (1) JP2008539265A (cg-RX-API-DMAC7.html)
KR (1) KR20080000682A (cg-RX-API-DMAC7.html)
CN (1) CN101175489A (cg-RX-API-DMAC7.html)
AU (1) AU2006242540A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0610411A2 (cg-RX-API-DMAC7.html)
CA (1) CA2604473A1 (cg-RX-API-DMAC7.html)
IL (1) IL186292A0 (cg-RX-API-DMAC7.html)
MX (1) MX2007013494A (cg-RX-API-DMAC7.html)
RU (1) RU2007144195A (cg-RX-API-DMAC7.html)
WO (1) WO2006118953A2 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090197852A9 (en) * 2001-08-06 2009-08-06 Johnson Robert G Jr Method of treating breast cancer using 17-AAG or 17-AG or a prodrug of either in combination with a HER2 inhibitor
PE20081506A1 (es) 2006-12-12 2008-12-09 Infinity Discovery Inc Formulaciones de ansamicina
US9511046B2 (en) * 2013-01-11 2016-12-06 Abraxis Bioscience, Llc Methods of treating pancreatic cancer
CN110917190B (zh) * 2019-11-29 2022-12-23 中国人民解放军军事科学院军事医学研究院 一种抑制阿片类镇痛药物不良反应的制剂及其应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261989A (en) * 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
ES2148223T3 (es) * 1992-03-23 2000-10-16 Univ Georgetown Taxol encapsulado en liposomas y metodo para su uso.
US5387584A (en) * 1993-04-07 1995-02-07 Pfizer Inc. Bicyclic ansamycins
WO1994026254A1 (en) 1993-05-17 1994-11-24 The Liposome Company, Inc. Incorporation of taxol into liposomes and gels
US5415869A (en) * 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
US5932566A (en) * 1994-06-16 1999-08-03 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
WO1996009713A1 (en) * 1994-09-22 1996-03-28 Glenayre Electronics, Inc. Synchronized paging system
US5662883A (en) * 1995-01-10 1997-09-02 Nanosystems L.L.C. Microprecipitation of micro-nanoparticulate pharmaceutical agents
US5534270A (en) * 1995-02-09 1996-07-09 Nanosystems Llc Method of preparing stable drug nanoparticles
US5510118A (en) * 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US6682758B1 (en) * 1998-12-22 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Water-insoluble drug delivery system
MXPA01011981A (es) 1999-05-24 2003-09-04 Sonus Pharma Inc Vehiculo de emulsion para farmacos poco solubles.
GB9918429D0 (en) 1999-08-04 1999-10-06 Novartis Ag Organic compounds
TW200408407A (en) * 2001-11-30 2004-06-01 Dana Farber Cancer Inst Inc Methods and compositions for modulating the immune system and uses thereof
US20060014730A1 (en) 2002-04-10 2006-01-19 Conforma Therapeutics Corporation Ansamycin formulations and methods for producing and using same
JP2005535626A (ja) * 2002-06-24 2005-11-24 リサーチ ディベロップメント ファンデーション クルクミンによるヒト多発性骨髄腫の治療
CA2518836A1 (en) 2003-03-13 2004-09-30 Conforma Therapeutics Corporation Drug formulations having long and medium chain triglycerides
US20050043233A1 (en) * 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
US7282493B2 (en) * 2003-12-23 2007-10-16 Infinity Pharmaceuticals, Inc. Analogs of benzoquinone-containing ansamycins and methods of use thereof
US20050256097A1 (en) * 2004-05-11 2005-11-17 Kosan Biosciences, Inc. Pharmaceutical solution formulations containing 17-AAG
US20070249540A1 (en) 2004-05-24 2007-10-25 Adonia Papathanassiu Methods for Inhibiting Proteasome and Heat Shock Protein 90
WO2006034147A2 (en) 2004-09-16 2006-03-30 Abraxis Bioscience, Inc. Compositions and methods for the preparation and administration of poorly water soluble drugs
US20060067953A1 (en) * 2004-09-29 2006-03-30 Conforma Therapeutics Corporation Oral pharmaceutical formulations and methods for producing and using same
EP1853238A4 (en) 2005-02-28 2008-07-23 Kosan Biosciences Inc PHARMACEUTICAL FORMULATIONS WITH 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN
AU2006226861B2 (en) * 2005-03-22 2012-08-16 Dana-Farber Cancer Institute, Inc. Treatment of protein degradation disorders
AU2006242446A1 (en) * 2005-04-29 2006-11-09 Kosan Biosciences Incorporated Method of treating multiple myeloma using 17-AAG or 17-AG or a prodrug of either in combination with a proteasome inhibitor

Also Published As

Publication number Publication date
AU2006242540A1 (en) 2006-11-09
WO2006118953A3 (en) 2007-12-06
US20060252739A1 (en) 2006-11-09
MX2007013494A (es) 2008-01-24
RU2007144195A (ru) 2009-06-10
CA2604473A1 (en) 2006-11-09
JP2008539265A (ja) 2008-11-13
EP1874296A4 (en) 2010-06-30
EP1874296A2 (en) 2008-01-09
IL186292A0 (en) 2008-08-07
US7691392B2 (en) 2010-04-06
CN101175489A (zh) 2008-05-07
KR20080000682A (ko) 2008-01-02
WO2006118953A2 (en) 2006-11-09

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A. E 7A. ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2210 DE 14/05/2013.