BRPI0608383A2 - método para produzir um derivado de ácido nicotìnico ou um seu sal - Google Patents

método para produzir um derivado de ácido nicotìnico ou um seu sal

Info

Publication number
BRPI0608383A2
BRPI0608383A2 BRPI0608383-8A BRPI0608383A BRPI0608383A2 BR PI0608383 A2 BRPI0608383 A2 BR PI0608383A2 BR PI0608383 A BRPI0608383 A BR PI0608383A BR PI0608383 A2 BRPI0608383 A2 BR PI0608383A2
Authority
BR
Brazil
Prior art keywords
salt
producing
nicotinic acid
acid derivative
group
Prior art date
Application number
BRPI0608383-8A
Other languages
English (en)
Inventor
Shigeyuki Nishimura
Fumio Kanamori
Masashi Hisamoto
Original Assignee
Ishihara Sangyo Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ishihara Sangyo Kaisha filed Critical Ishihara Sangyo Kaisha
Publication of BRPI0608383A2 publication Critical patent/BRPI0608383A2/pt
Publication of BRPI0608383B1 publication Critical patent/BRPI0608383B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

MéTODO PARA PRODUZIR UM DERIVADO DE áCIDO NICOTìNICO OU UM SEU SAL. A presente invenção refere-se a um método para produzir um jerivado do ácido nicotínico específico ou um seu sal. Um método para produzir um derivado do ácido nicotínico representado pela fórmula (I): onde cada um entre X^ 1^ e X^ 2^, que são independentes entre si, é um átomo de hidrogênio, um átomo de halogênio, um grupo alquila, um grupo alcóxi, um grupo halo-alquila, ou um grupo halo-alcóxi; R é um grupo alquila; e Hal é um átomo de cloro ou um átomo de bromo; ou um seu sal, método este que compreende reagir um composto representado pela fórmula (II): onde X^ 1^, X^ 2^ e R são como definidos acima, ou um seu sal, com um agente halogenante.
BRPI0608383A 2005-04-21 2006-04-20 método para produzir um derivado de ácido nicotínico ou um seu sal BRPI0608383B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005123899 2005-04-21
PCT/JP2006/308318 WO2006115171A1 (ja) 2005-04-21 2006-04-20 ニコチン酸誘導体又はその塩の製造方法

Publications (2)

Publication Number Publication Date
BRPI0608383A2 true BRPI0608383A2 (pt) 2009-12-29
BRPI0608383B1 BRPI0608383B1 (pt) 2015-12-29

Family

ID=37214789

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0608383A BRPI0608383B1 (pt) 2005-04-21 2006-04-20 método para produzir um derivado de ácido nicotínico ou um seu sal

Country Status (12)

Country Link
US (1) US8039633B2 (pt)
EP (1) EP1873145B1 (pt)
KR (1) KR101308227B1 (pt)
CN (1) CN101160288B (pt)
AU (1) AU2006240772B2 (pt)
BR (1) BRPI0608383B1 (pt)
DK (1) DK1873145T3 (pt)
ES (1) ES2392735T3 (pt)
IL (1) IL186564A (pt)
PL (1) PL1873145T3 (pt)
PT (1) PT1873145E (pt)
WO (1) WO2006115171A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10478498B2 (en) 2014-06-20 2019-11-19 Reform Biologics, Llc Excipient compounds for biopolymer formulations
KR102359436B1 (ko) 2015-06-05 2022-02-09 (주)아모레퍼시픽 메틸 2-프로필-6-(트리플루오로메틸) 니코티네이트의 제조방법
WO2023091370A1 (en) * 2021-11-16 2023-05-25 Comera Life Sciences, Inc. Excipient compounds for biopolymer formulations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3961065A (en) * 1973-05-04 1976-06-01 Pfizer Inc. Benzenesulfonylurea derivatives
US3879403A (en) * 1973-05-04 1975-04-22 Pfizer Benzenesulfonylurea derivatives
MX12896A (es) * 1987-09-04 1993-06-01 Pfizer Procedimiento para preparar un compuesto de espiro-heteroazolonas
US4980357A (en) * 1990-03-01 1990-12-25 Pfizer Inc. Azolidinedione derivatives
JP2859451B2 (ja) 1991-01-11 1999-02-17 太平洋セメント株式会社 Ｎ−フルオロピリジニウム塩の製造方法
JP3217848B2 (ja) 1992-03-25 2001-10-15 クミアイ化学工業株式会社 ピリジン誘導体及び除草剤

Also Published As

Publication number Publication date
DK1873145T3 (da) 2012-10-29
IL186564A (en) 2012-10-31
CN101160288A (zh) 2008-04-09
US8039633B2 (en) 2011-10-18
BRPI0608383B1 (pt) 2015-12-29
IL186564A0 (en) 2008-01-20
KR20070121787A (ko) 2007-12-27
ES2392735T3 (es) 2012-12-13
US20090054656A1 (en) 2009-02-26
CN101160288B (zh) 2012-04-11
PL1873145T3 (pl) 2013-02-28
EP1873145A1 (en) 2008-01-02
AU2006240772B2 (en) 2011-11-10
EP1873145A4 (en) 2010-01-13
WO2006115171A1 (ja) 2006-11-02
PT1873145E (pt) 2012-12-03
EP1873145B1 (en) 2012-10-10
KR101308227B1 (ko) 2013-09-13
AU2006240772A1 (en) 2006-11-02

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/04/2006, OBSERVADAS AS CONDICOES LEGAIS.