BRPI0603401A - sistema de liberação de substáncia ativa e seu emprego - Google Patents

sistema de liberação de substáncia ativa e seu emprego

Info

Publication number
BRPI0603401A
BRPI0603401A BRPI0603401-2A BRPI0603401A BRPI0603401A BR PI0603401 A BRPI0603401 A BR PI0603401A BR PI0603401 A BRPI0603401 A BR PI0603401A BR PI0603401 A BRPI0603401 A BR PI0603401A
Authority
BR
Brazil
Prior art keywords
release system
active substance
substance release
polymethyl methacrylate
local active
Prior art date
Application number
BRPI0603401-2A
Other languages
English (en)
Inventor
Klaus-Dieter Kuehn
Sebastian Vogt
Original Assignee
Heraeus Kulzer Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heraeus Kulzer Gmbh filed Critical Heraeus Kulzer Gmbh
Publication of BRPI0603401A publication Critical patent/BRPI0603401A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

SISTEMA DE LIBERAçãO DE SUBSTáNCIA A presente invenção refere-se a m sistema de liberação local de substância ativa que consiste de corpos em formas de esferas qe são construídos por metacrilato de polimetila ou co-acrilato de metila de metacrilato de polimetila e opcionalmente dóxido de zircónio e/ou sulfato de bário e uma substância, ativa farmacêutica, que contêm pelo menos um compósto hemostipticamente estável até pelo menos 120<198>, de preferência um sal de cálcio.O sistema de liberação local de substância ativa é preparado como produto medicional ou como medicamento.
BRPI0603401-2A 2005-08-25 2006-08-24 sistema de liberação de substáncia ativa e seu emprego BRPI0603401A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005040429A DE102005040429A1 (de) 2005-08-25 2005-08-25 Wirkstofffreisetzungssystem und seine Verwendung

Publications (1)

Publication Number Publication Date
BRPI0603401A true BRPI0603401A (pt) 2007-05-22

Family

ID=37434235

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0603401-2A BRPI0603401A (pt) 2005-08-25 2006-08-24 sistema de liberação de substáncia ativa e seu emprego

Country Status (8)

Country Link
US (2) US20070053986A1 (pt)
EP (1) EP1757272A3 (pt)
JP (1) JP2007056021A (pt)
CN (1) CN1919210B (pt)
AU (1) AU2006203203B2 (pt)
BR (1) BRPI0603401A (pt)
CA (1) CA2551975C (pt)
DE (1) DE102005040429A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007063613B4 (de) * 2007-04-24 2010-01-07 Heraeus Kulzer Gmbh Verwendung eines Spacer-Polymethylmethacrylat-Knochenzement
EP1985317B1 (de) * 2007-04-24 2013-06-05 Heraeus Kulzer GmbH Spacer-Polymethylmethacrylat-Knochenzement
NZ594513A (en) 2009-03-04 2013-10-25 Orexo Ab Abuse resistant formulation
CN102421419B (zh) 2009-05-08 2016-05-04 奥瑞克索股份公司 用于持续药物传递的包含地聚合物粘合剂的组合物
NO2613784T3 (pt) 2010-09-07 2018-05-12

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2320373B2 (de) * 1973-04-21 1978-04-06 Merck Patent Gmbh, 6100 Darmstadt Antibioticahaltiges Mittel und seine Verwendung als chirurgisches Kunststoffmaterial
US4141864A (en) * 1974-03-15 1979-02-27 University Of Virginia Alumni Patents Foundation Osseous cement composition
DE2651441A1 (de) 1976-11-11 1978-05-24 Merck Patent Gmbh Antibioticahaltiges mittel und seine verwendung als chirurgisches kunststoffmaterial
DE2905878A1 (de) * 1979-02-16 1980-08-28 Merck Patent Gmbh Implantationsmaterialien und verfahren zu ihrer herstellung
CA1190855A (en) * 1980-09-03 1985-07-23 Rolf W. Pfirrmann Treatment of osteitis
DE3613213A1 (de) * 1986-04-18 1987-10-22 Merck Patent Gmbh Tricalciumphosphat fuer implantationsmaterialien
US5334626A (en) * 1992-07-28 1994-08-02 Zimmer, Inc. Bone cement composition and method of manufacture
CA2119090A1 (en) * 1993-03-26 1994-09-27 Wayne R. Gombotz Compositions for controlled release of biologically active tgf-.beta.
DE19606490A1 (de) 1996-02-22 1997-08-28 Merck Patent Gmbh Vorrichtung zur manuellen Herstellung von perlschnurförmigen pharmakahaltigen Implantaten
US20030064108A1 (en) * 1996-04-23 2003-04-03 Stefan Lukas Taste masked pharmaceutical compositions
US6309420B1 (en) * 1997-10-14 2001-10-30 Parallax Medical, Inc. Enhanced visibility materials for implantation in hard tissue
US5968999A (en) * 1997-10-28 1999-10-19 Charlotte-Mecklenburg Hospital Authority Bone cement compositions
US6482395B1 (en) * 1999-06-01 2002-11-19 Church & Dwight Co. Inc. Remineralizing-mineralizing oral products containing discrete cationic and anionic agglomerate components and method of use
US7001551B2 (en) * 2000-07-13 2006-02-21 Allograft Research Technologies, Inc. Method of forming a composite bone material implant
US9387094B2 (en) * 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
CN1259044C (zh) * 2001-03-30 2006-06-14 日清奥利友集团株式会社 骨代谢改善剂
DE10129845C2 (de) * 2001-06-15 2003-08-21 Bam Bundesanstalt Matforschung Verfahren zur Herstellung eines temporären Adhäsivs für Metall-Metall- und Metall-Keramik-Bindungen und Adhäsiv-Kit
KR20050009731A (ko) * 2002-06-06 2005-01-25 더 브리검 앤드 우먼즈 하스피털, 인크. 활성제를 전달하기 위한 비중합성 조혈 세포 응괴
AU2003272284B2 (en) * 2002-09-05 2009-03-05 Catherine G. Ambrose Antibiotic microspheres for treatment of infections and osteomyelitis
ATE424862T1 (de) * 2004-10-29 2009-03-15 Smith & Nephew Inc Bioabsorbierbare polymere mit kalziumkarbonat
US20060275223A1 (en) * 2005-06-02 2006-12-07 Burr James B Erythritol compositions for teeth and gums

Also Published As

Publication number Publication date
DE102005040429A1 (de) 2007-03-01
AU2006203203B2 (en) 2008-01-03
JP2007056021A (ja) 2007-03-08
CN1919210A (zh) 2007-02-28
CA2551975A1 (en) 2007-02-25
EP1757272A3 (de) 2007-05-23
CN1919210B (zh) 2011-05-18
CA2551975C (en) 2009-09-01
US20090280189A1 (en) 2009-11-12
AU2006203203A1 (en) 2007-03-15
US20070053986A1 (en) 2007-03-08
EP1757272A2 (de) 2007-02-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2268 DE 24/06/2014.