ATE315395T1 - Pharmazeutische zusammensetzungen, die faropenem natrium und eine diamineacetat verbindung zur verbesserung der magen-darm trakt absorption enthalten - Google Patents
Pharmazeutische zusammensetzungen, die faropenem natrium und eine diamineacetat verbindung zur verbesserung der magen-darm trakt absorption enthaltenInfo
- Publication number
- ATE315395T1 ATE315395T1 AT00961049T AT00961049T ATE315395T1 AT E315395 T1 ATE315395 T1 AT E315395T1 AT 00961049 T AT00961049 T AT 00961049T AT 00961049 T AT00961049 T AT 00961049T AT E315395 T1 ATE315395 T1 AT E315395T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- gastrointestinal tract
- acetate compound
- improving gastrointestinal
- Prior art date
Links
- -1 DIAMINE ACETATE COMPOUND Chemical class 0.000 title abstract 2
- 238000010521 absorption reaction Methods 0.000 title 1
- MOGICMVNWAUWMK-HIXRZVNASA-L disodium;(5r,6s)-6-[(1r)-1-hydroxyethyl]-7-oxo-3-[(2r)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate;pentahydrate Chemical compound O.O.O.O.O.[Na+].[Na+].S([C@@H]1[C@H](C(N1C=1C([O-])=O)=O)[C@H](O)C)C=1[C@H]1CCCO1.S([C@@H]1[C@H](C(N1C=1C([O-])=O)=O)[C@H](O)C)C=1[C@H]1CCCO1 MOGICMVNWAUWMK-HIXRZVNASA-L 0.000 title 1
- 229960000379 faropenem Drugs 0.000 title 1
- 210000001035 gastrointestinal tract Anatomy 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 150000002961 penems Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26463799 | 1999-09-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE315395T1 true ATE315395T1 (de) | 2006-02-15 |
Family
ID=17406127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00961049T ATE315395T1 (de) | 1999-09-17 | 2000-09-18 | Pharmazeutische zusammensetzungen, die faropenem natrium und eine diamineacetat verbindung zur verbesserung der magen-darm trakt absorption enthalten |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6531508B1 (de) |
| EP (1) | EP1142573B1 (de) |
| JP (1) | JP4745573B2 (de) |
| KR (1) | KR20010101030A (de) |
| CN (1) | CN1198611C (de) |
| AT (1) | ATE315395T1 (de) |
| CA (1) | CA2351673A1 (de) |
| DE (1) | DE60025503T2 (de) |
| DK (1) | DK1142573T3 (de) |
| ES (1) | ES2256035T3 (de) |
| WO (1) | WO2001021175A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ECSP003699A (es) * | 1999-10-08 | 2002-04-23 | Smithkline Beecham Corp | Inhibidores de fab i |
| DE60230934D1 (de) * | 2001-04-06 | 2009-03-05 | Affinium Pharm Inc | Fab-i-inhibitoren |
| EP1575951B1 (de) | 2002-12-06 | 2014-06-25 | Debiopharm International SA | Heterozyclische verbindungen, verfahren zu deren herstellung und ihre verwendung als heilmittel |
| WO2004082586A2 (en) | 2003-03-17 | 2004-09-30 | Affinium Pharmaceuticals, Inc. | Phamaceutical compositions comprising inhibitors of fab i and further antibiotics |
| US20050069590A1 (en) * | 2003-09-30 | 2005-03-31 | Buehler Gail K. | Stable suspensions for medicinal dosages |
| US8450307B2 (en) | 2004-06-04 | 2013-05-28 | Affinium Pharmaceuticals, Inc. | Therapeutic agents, and methods of making and using the same |
| CA2880727C (en) * | 2005-08-31 | 2019-05-07 | Neil P. Desai | Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents |
| CA2632476A1 (en) * | 2005-12-05 | 2007-06-14 | Affinium Pharmaceuticals, Inc. | Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents |
| EP2687533B1 (de) | 2006-07-20 | 2017-07-19 | Debiopharm International SA | Acrylamidderivate als FAB-I-Hemmer |
| EP2046801A4 (de) * | 2006-07-28 | 2014-04-16 | Hetero Drugs Ltd | Feste freie faropenemsäure |
| CN101129381B (zh) * | 2006-08-25 | 2012-02-01 | 天津和美生物技术有限公司 | 含β-内酰胺类抗生素和离子螯合剂的抗生素复方 |
| WO2008098374A1 (en) * | 2007-02-16 | 2008-08-21 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab i inhibitors |
| US9169477B2 (en) | 2012-01-27 | 2015-10-27 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Compositions and methods for immunization against bacteria expressing a carbapenemase |
| KR101720885B1 (ko) | 2012-06-19 | 2017-03-28 | 데비오팜 인터네셔날 에스 에이 | (e)-n-메틸-n-((3-메틸벤조푸란-2-일)메틸)-3-(7-옥소-5,6,7,8-테트라히드로-1,8-나프티리딘-3-일)아크릴아미드의전구약물 유도체 |
| RS61312B1 (sr) | 2016-02-26 | 2021-02-26 | Debiopharm Int Sa | Lek za lečenje infekcija dijabetskog stopala |
| MY203711A (en) | 2019-02-14 | 2024-07-15 | Debiopharm Int Sa | Afabicin formulation, method for making the same and uses thereof |
| JP7418475B2 (ja) | 2019-06-14 | 2024-01-19 | デバイオファーム インターナショナル エス．エー． | バイオフィルムが関与する細菌感染症を治療するための医薬及びその使用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD29756A (de) * | ||||
| GB909365A (en) | 1960-04-28 | 1962-10-31 | Horner Frank W Ltd | Orally ingestible solid penicillin compositions |
| GB1061426A (en) | 1964-05-22 | 1967-03-15 | Olin Mathieson | Water-soluble penicillin composition |
| US4504485A (en) | 1983-04-04 | 1985-03-12 | Schering Corporation | 5R,6S,8R-6-(1-Hydroxyethyl)-2-(2-carbamoyloxyethylthio)-penem-3-carboxylic acid |
| JP2514249B2 (ja) | 1989-05-23 | 1996-07-10 | 帝人株式会社 | 安定化されたカルシトニン類医薬組成物 |
| DE69232598T2 (de) | 1991-02-01 | 2002-11-21 | Suntory Limited, Osaka | Verwendung von Cilastatin, Glutathione und N-acetyl-L-Cysteine zur Herstellung eines Arzneimittels zur Verbesserung der Resorption von Carbapenem oder Penem Antibiotika im Magen-Darm-Trakt |
| JPH0769887A (ja) | 1993-07-09 | 1995-03-14 | Takeda Chem Ind Ltd | ペネム化合物含有固形組成物、その製造法および剤 |
| JPH0812675A (ja) | 1994-06-30 | 1996-01-16 | Lederle Japan Ltd | ２−［（４−ハロゲン置換フェニル）チオ］−カルバペネム誘導体 |
| DE69922296T2 (de) | 1998-01-13 | 2005-10-27 | Daiichi Suntory Pharma Co., Ltd. | Antibakterille zusammensetzung zur topischen anwendung, enthaltend faropenem |
-
2000
- 2000-09-18 DE DE60025503T patent/DE60025503T2/de not_active Expired - Fee Related
- 2000-09-18 ES ES00961049T patent/ES2256035T3/es not_active Expired - Lifetime
- 2000-09-18 EP EP00961049A patent/EP1142573B1/de not_active Expired - Lifetime
- 2000-09-18 CN CNB008022372A patent/CN1198611C/zh not_active Expired - Fee Related
- 2000-09-18 AT AT00961049T patent/ATE315395T1/de not_active IP Right Cessation
- 2000-09-18 DK DK00961049T patent/DK1142573T3/da active
- 2000-09-18 US US09/856,094 patent/US6531508B1/en not_active Expired - Fee Related
- 2000-09-18 CA CA002351673A patent/CA2351673A1/en not_active Abandoned
- 2000-09-18 JP JP2001524601A patent/JP4745573B2/ja not_active Expired - Lifetime
- 2000-09-18 KR KR1020017006262A patent/KR20010101030A/ko not_active Abandoned
- 2000-09-18 WO PCT/JP2000/006346 patent/WO2001021175A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010101030A (ko) | 2001-11-14 |
| JP4745573B2 (ja) | 2011-08-10 |
| DE60025503D1 (de) | 2006-04-06 |
| CN1327385A (zh) | 2001-12-19 |
| CA2351673A1 (en) | 2001-03-29 |
| US6531508B1 (en) | 2003-03-11 |
| WO2001021175A1 (fr) | 2001-03-29 |
| DE60025503T2 (de) | 2006-09-07 |
| CN1198611C (zh) | 2005-04-27 |
| DK1142573T3 (da) | 2006-04-10 |
| EP1142573A1 (de) | 2001-10-10 |
| EP1142573B1 (de) | 2006-01-11 |
| EP1142573A4 (de) | 2002-07-24 |
| ES2256035T3 (es) | 2006-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1142573 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |