BRPI0520102A2 - composiÇço aquosa para armazenagem de hemÁcias suspensço de hemÁcias, mÉtodo de preservaÇço de hemÁcias ou glàbulos vermelhos do sangue ("red blood cells" - rbc`s) durante um perÍodo de armazenagem, mÉtodo para aperfeiÇoamento da manutenÇço de membrana de hemÁcias ou glàbulos vermelhos do sangue ("red blood cells" - rbc) e supressço de apoptose de rbc`s durante um perÍodo de armazenagem, mÉtodo para reduÇço de fragilidade de hemÁcias (rbc`s) e supressço de hemàlise de rbc`s durante um perÍodo de armazenagem, mÉtodo para aumentar a viabilidade de hemÁcias (rbc`s), mÉtodo de preservaÇço de hamÁcias (rbc`s) durante um perÍodo de armazenagem, combinaÇço, e composiÇço aquosa - Google Patents

composiÇço aquosa para armazenagem de hemÁcias suspensço de hemÁcias, mÉtodo de preservaÇço de hemÁcias ou glàbulos vermelhos do sangue ("red blood cells" - rbc`s) durante um perÍodo de armazenagem, mÉtodo para aperfeiÇoamento da manutenÇço de membrana de hemÁcias ou glàbulos vermelhos do sangue ("red blood cells" - rbc) e supressço de apoptose de rbc`s durante um perÍodo de armazenagem, mÉtodo para reduÇço de fragilidade de hemÁcias (rbc`s) e supressço de hemàlise de rbc`s durante um perÍodo de armazenagem, mÉtodo para aumentar a viabilidade de hemÁcias (rbc`s), mÉtodo de preservaÇço de hamÁcias (rbc`s) durante um perÍodo de armazenagem, combinaÇço, e composiÇço aquosa

Info

Publication number
BRPI0520102A2
BRPI0520102A2 BRPI0520102-0A BRPI0520102A BRPI0520102A2 BR PI0520102 A2 BRPI0520102 A2 BR PI0520102A2 BR PI0520102 A BRPI0520102 A BR PI0520102A BR PI0520102 A2 BRPI0520102 A2 BR PI0520102A2
Authority
BR
Brazil
Prior art keywords
rbc
red blood
red
during
cell
Prior art date
Application number
BRPI0520102-0A
Other languages
English (en)
Inventor
John R Hess
Original Assignee
Univ Cincinnati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cincinnati filed Critical Univ Cincinnati
Publication of BRPI0520102A2 publication Critical patent/BRPI0520102A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

COMPOSIÇçO AQUOSA PARA ARMAZENAGEM DE HEMÁCIAS, SUSPENSçO DE HEMÁCIAS, MÉTODO DE PRESERVAÇçO DE HEMÁCIAS OU GLàBULOS VERMELHOS DO SANGUE ("RED BLOOD CELLS" - RBC'S) DURANTE UM PERÍODO DE ARMAZENAGEM, MÉTODO PARA APERFEIÇOAMENTO DA MANUTENÇçO DE MEMBRANA DE HEMÁCIAS OU GLàBULOS VERMELHOS DO SANGUE ("RED BLOOD CELLS" - RBC) E SUPRESSçO DE APOPTOSE DE RBC'S DURANTE UM PERÍODO DE ARMAZENAGEM, MÉTODO PARA REDUÇçO DE FRAGILIDADE DE HEMÁCIAS (RBC'S) E SUPRESSçO DE HEMàLISE DE RBC'S DURANTE UM PERÍODO DE ARMAZENAGEM, MÉTODO PARA AUMENTAR A VIABILIDADE DE HEMÁCIAS (RBC'S), MÉTODO DE PRESERVAÇçO DE HEMÁCIAS (RBC'S) DURANTE UM PERÍODO DE ARMAZENAGEM, COMBINAÇçO, E COMPOSIÇçO AQUOSA. A presente invenção propõe uma composição aquosa para armazenagem de glóbulos vermelhos do sangue consistindo essencialmente em: adenina; dextrose; pelo menos um açúcar procetor de membrana não metabolizável; e um sistema de tampão de pH especificamente definido. Também são providos métodos aperfeiçoados de preservação de glób;los vermelhos do sangue e métodos para aumentar a viabilidade, a retenção de membrana, e a recuperabilidade ccm simultânea supressão de apoptose, hemólise, e eliminação pós-infusão de glóbulos vermelhos do sangue armazenados que utilizam as novas composições.
BRPI0520102-0A 2005-02-17 2005-02-17 composiÇço aquosa para armazenagem de hemÁcias suspensço de hemÁcias, mÉtodo de preservaÇço de hemÁcias ou glàbulos vermelhos do sangue ("red blood cells" - rbc`s) durante um perÍodo de armazenagem, mÉtodo para aperfeiÇoamento da manutenÇço de membrana de hemÁcias ou glàbulos vermelhos do sangue ("red blood cells" - rbc) e supressço de apoptose de rbc`s durante um perÍodo de armazenagem, mÉtodo para reduÇço de fragilidade de hemÁcias (rbc`s) e supressço de hemàlise de rbc`s durante um perÍodo de armazenagem, mÉtodo para aumentar a viabilidade de hemÁcias (rbc`s), mÉtodo de preservaÇço de hamÁcias (rbc`s) durante um perÍodo de armazenagem, combinaÇço, e composiÇço aquosa BRPI0520102A2 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2005/005004 WO2006088455A1 (en) 2005-02-17 2005-02-17 Compositions and methods for the storage of red blood cells

Publications (1)

Publication Number Publication Date
BRPI0520102A2 true BRPI0520102A2 (pt) 2009-04-22

Family

ID=35735111

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0520102-0A BRPI0520102A2 (pt) 2005-02-17 2005-02-17 composiÇço aquosa para armazenagem de hemÁcias suspensço de hemÁcias, mÉtodo de preservaÇço de hemÁcias ou glàbulos vermelhos do sangue ("red blood cells" - rbc`s) durante um perÍodo de armazenagem, mÉtodo para aperfeiÇoamento da manutenÇço de membrana de hemÁcias ou glàbulos vermelhos do sangue ("red blood cells" - rbc) e supressço de apoptose de rbc`s durante um perÍodo de armazenagem, mÉtodo para reduÇço de fragilidade de hemÁcias (rbc`s) e supressço de hemàlise de rbc`s durante um perÍodo de armazenagem, mÉtodo para aumentar a viabilidade de hemÁcias (rbc`s), mÉtodo de preservaÇço de hamÁcias (rbc`s) durante um perÍodo de armazenagem, combinaÇço, e composiÇço aquosa

Country Status (9)

Country Link
EP (2) EP2420140A1 (pt)
JP (1) JP2008529550A (pt)
CN (1) CN101166420B (pt)
AU (1) AU2005327576C1 (pt)
BR (1) BRPI0520102A2 (pt)
CA (1) CA2598366C (pt)
EA (1) EA024520B1 (pt)
MX (1) MX2007009885A (pt)
WO (1) WO2006088455A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8835104B2 (en) 2007-12-20 2014-09-16 Fenwal, Inc. Medium and methods for the storage of platelets
US8871434B2 (en) 2008-03-21 2014-10-28 Fenwal, Inc. Red blood cell storage medium for extended storage
US8968992B2 (en) 2008-03-21 2015-03-03 Fenwal, Inc. Red blood cell storage medium for extended storage
US12089589B2 (en) 2009-10-12 2024-09-17 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
EP2490751B1 (en) 2009-10-23 2016-11-09 Fenwal, Inc. Methods and systems for providing red blood cell products with reduced plasma
US20110229871A1 (en) 2010-02-16 2011-09-22 Ericson Daniel G Nucleoside-containing compositions and methods for treating red blood cells
EP2536416B1 (en) * 2010-02-16 2018-06-13 Viacell, LLC Arginine-containing storage and/or rejuvenating compositions and methods for storing or rejuvenating red blood cells
EP4091645A1 (en) * 2010-08-25 2022-11-23 Hemanext Inc. Method for enhancing red blood cell quality and survival during storage
CN101965829B (zh) * 2010-09-30 2012-11-28 中国人民解放军第三军医大学野战外科研究所 一种冷冻保存红细胞的方法
JP5859558B2 (ja) 2010-11-05 2016-02-10 ニュー・ヘルス・サイエンシーズ・インコーポレイテッドＮｅｗ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． 赤血球の照射及び嫌気性保存
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
JP2014518547A (ja) 2011-04-07 2014-07-31 フェンウォール、インコーポレイテッド 削減された残存血漿容積を有する血小板濃縮物を提供するための自動化方法とシステムおよびそのような血小板濃縮物のための貯蔵媒体
EP4074395B1 (en) 2011-08-10 2024-01-24 Hemanext Inc. Integrated leukocyte, oxygen and/or co2 depletion, and plasma separation filter device
EP2887800A4 (en) * 2012-08-22 2016-07-27 Haemonetics Corp CONTAINER FOR BLOOD CONSERVATION CONTAINING AN AQUEOUS COMPOSITION FOR THE PRESERVATION OF RED GLOBLES
WO2014134503A1 (en) 2013-02-28 2014-09-04 New Health Sciences, Inc. Gas depletion and gas addition devices for blood treatment
WO2014162435A1 (ja) * 2013-04-01 2014-10-09 テルモ株式会社 赤血球保存液、保存液収納容器、赤血球保存液の製造方法および血液バッグシステム
KR102701691B1 (ko) 2015-03-10 2024-08-30 헤마넥스트 인코포레이티드 산소 감소 1회용 키트, 장치 및 이의 사용 방법
CN104830830A (zh) * 2015-03-25 2015-08-12 厦门艾德生物医药科技有限公司 一种用于保护游离dna的血液抗凝剂及其应用
CN107847395B (zh) 2015-04-23 2021-10-15 新健康科学股份有限公司 厌氧血液储存容器
BR122021024410B1 (pt) 2015-05-18 2022-05-03 Hemanext Inc Métodos para gerenciar um banco de sangue e para prover fornecimento de produtos de sangue total armazenados para medicina de transfusão
IL303240A (en) 2016-05-27 2023-07-01 Hemanext Inc Anaerobic blood storage and pathogen inactivation method
CN107873696B (zh) * 2017-11-14 2020-12-11 上海市血液中心 一种熊科动物红细胞保存液及其应用
CN113812395A (zh) * 2021-09-24 2021-12-21 合肥天一生物技术研究所有限责任公司 一种红细胞保存液
CN117426372A (zh) * 2023-12-20 2024-01-23 中国人民解放军军事科学院军事医学研究院 一种保护红细胞的组合物、制备方法及应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150085A (en) 1998-09-16 2000-11-21 The United States Of America As Represented By The Secretary Of The Army Prolonged storage of red blood cells and composition
US6447987B1 (en) * 1978-09-09 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Prolonged storage of red blood cells
US4961928A (en) * 1986-03-19 1990-10-09 American Red Cross Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets
US5250303A (en) * 1989-10-06 1993-10-05 The American National Red Cross Procedure for storing red cells with prolonged maintenance of cellular concentrations of ATP and 2,3 DPG
CA2071833C (en) * 1990-11-07 1998-11-03 Jean-Marc Payrat Red blood cell storage solution
US5789151A (en) * 1997-05-15 1998-08-04 The Regents Of The University Of California Prolonged cold storage of red blood cells by oxygen removal and additive usage
US20030124504A1 (en) * 2001-11-16 2003-07-03 Bitensky Mark W. Additive solution for blood preservation

Also Published As

Publication number Publication date
EA200701660A1 (ru) 2008-02-28
CN101166420B (zh) 2015-08-19
WO2006088455A1 (en) 2006-08-24
EA024520B1 (ru) 2016-09-30
AU2005327576C1 (en) 2012-04-12
AU2005327576A1 (en) 2006-08-24
JP2008529550A (ja) 2008-08-07
AU2005327576B2 (en) 2011-08-25
CA2598366A1 (en) 2006-08-24
MX2007009885A (es) 2007-12-11
CN101166420A (zh) 2008-04-23
EP2420140A1 (en) 2012-02-22
CA2598366C (en) 2014-06-03
EP1863342A1 (en) 2007-12-12

Similar Documents

Publication Publication Date Title
BRPI0520102A2 (pt) composiÇço aquosa para armazenagem de hemÁcias suspensço de hemÁcias, mÉtodo de preservaÇço de hemÁcias ou glàbulos vermelhos do sangue ("red blood cells" - rbc`s) durante um perÍodo de armazenagem, mÉtodo para aperfeiÇoamento da manutenÇço de membrana de hemÁcias ou glàbulos vermelhos do sangue ("red blood cells" - rbc) e supressço de apoptose de rbc`s durante um perÍodo de armazenagem, mÉtodo para reduÇço de fragilidade de hemÁcias (rbc`s) e supressço de hemàlise de rbc`s durante um perÍodo de armazenagem, mÉtodo para aumentar a viabilidade de hemÁcias (rbc`s), mÉtodo de preservaÇço de hamÁcias (rbc`s) durante um perÍodo de armazenagem, combinaÇço, e composiÇço aquosa
US6365338B1 (en) Organ preservative solution containing trehalose, anti-oxidant, cations and an energy source
Bejaoui et al. Emerging concepts in liver graft preservation
CN109769797B (zh) 一种器官保存液
JP2001523225A (ja) 血液製剤の改良された貯蔵および保存法
US11570982B2 (en) Systems and methods for natural cryoprotectants for preservation of cells
US11730676B2 (en) Blood storage container containing aqueous composition for the storage of red blood cells
CN111296412B (zh) 一种无血清低dmso细胞冻存液及其应用
BR112015015090A2 (pt) processos para preservar a função de tecido ou de órgão e para preparar formulação para a mesma e kit respectivo
Hu et al. The effect of Laminaria japonic polysaccharide on sperm characteristics and biochemical parameters in cryopreserved boar sperm
CN109362708A (zh) 一种干细胞冷冻剂及其应用
BR0301159A (pt) Solução protetora para prevenção de danos isquêmicos
Hu et al. Effect of Gynostemma Pentaphyllum Polysaccharide on boar spermatozoa quality following freezing–thawing
US20170251660A1 (en) Nucleoside-containing compositions and methods for treating red blood cells
Cao et al. Testing Rhodiola sachalinensis saccharide as cryoprotectant for bovine spermatozoa
Třeška et al. Can ischemia-reperfusion syndrome in transplanted kidneys procured from non–heart-beating donors be influenced by adding selenium into the reperfusion solution? an experimental study
Cordeiro et al. Cryopreservation of adventitious roots of Cleome rosea Vahl (Cleomaceae) using a vitrification technique and assessment of genetic stability
Arreguín et al. Attenuation of oxidant damage in the postconditioned heart involves non‐enzymatic response and partial catalytic protection
US11589574B2 (en) Compositions and methods for transport and preservation of biological material
SG159556A1 (en) Compositions and methods for the storage of red blood cells
JP6777865B2 (ja) 臓器又は組織の保存剤及び臓器又は組織の保存方法
JP4590041B2 (ja) 臓器保存剤
Polyak et al. Comparison of Vasosol and University of Wisconsin solutions on early kidney function after 24 hours of cold ischemia in a canine autotransplantation model
Hosgood et al. Cold ischaemic injury in kidney transplantation
Gulevsky et al. Energy metabolism of packed white cells after cryopreservation and rehabilitation in a medium containing a cord blood low-molecular fraction

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: A01N 1/00 (2006.01), A01N 1/02 (2006.01)

B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B08E Application fees: payment of additional fee required [chapter 8.5 patent gazette]

Free format text: COMPLEMENTAR A RETRIBUICAO DA 3A E 14A ANUIDADES DE ACORDO COM A TABELA VIGENTE, REFERENTE A GUIA DE RETRIBUICAO GRUS 0000220706559727 E 29409161801643139, RESPECTIVAMENTE.