BRPI0516544A - composto, composição farmacêutica, método de aglutinação de receptores de canabinóides em um paciente e métodos para proteção, indução de apoptose e modulação do apetite - Google Patents

composto, composição farmacêutica, método de aglutinação de receptores de canabinóides em um paciente e métodos para proteção, indução de apoptose e modulação do apetite

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Publication number
BRPI0516544A
BRPI0516544A BRPI0516544-0A BRPI0516544A BRPI0516544A BR PI0516544 A BRPI0516544 A BR PI0516544A BR PI0516544 A BRPI0516544 A BR PI0516544A BR PI0516544 A BRPI0516544 A BR PI0516544A
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BR
Brazil
Prior art keywords
methods
disorders
patient
compound
protection
Prior art date
Application number
BRPI0516544-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Roland E Dolle
Karin Worm
Q Jean Zhou
Original Assignee
Adolor Corp
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Publication date
Application filed by Adolor Corp filed Critical Adolor Corp
Publication of BRPI0516544A publication Critical patent/BRPI0516544A/pt

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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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BRPI0516544-0A 2004-10-05 2005-10-04 composto, composição farmacêutica, método de aglutinação de receptores de canabinóides em um paciente e métodos para proteção, indução de apoptose e modulação do apetite BRPI0516544A (pt)

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US11/242,318 US7671052B2 (en) 2004-10-05 2005-10-03 Phenyl derivatives and methods of use
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Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
GB0427954D0 (en) * 2004-12-21 2005-01-26 Univ London Modulator
CA2654026A1 (en) * 2006-06-08 2007-12-13 Neurokey A/S Use of cannabinoid receptor agonists as hypothermia inducing drugs for the treatment of ischemia
WO2008109027A2 (en) * 2007-03-02 2008-09-12 University Of Tennessee Research Foundation, The Tri-aryl/heteroaroaromatic cannabinoids and use thereof
CN101815513B (zh) * 2007-08-07 2012-11-14 斯泰伦博斯大学 含有对乙酰氨基苯酚的眼用制剂
EP2211619A1 (en) * 2007-10-18 2010-08-04 Merck Sharp & Dohme Corp. Substituted 1,2,4-oxadiazoles and analogs thereof as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases
WO2009140078A1 (en) * 2008-05-16 2009-11-19 The Procter & Gamble Company Treatment of lower urinary tract dysfunction with cb2-receptor-selective agonists
KR20110130489A (ko) * 2009-03-23 2011-12-05 스미또모 가가꾸 가부시끼가이샤 시클로프로판카르복실산에스테르의 제조 방법
US9855225B2 (en) * 2011-08-18 2018-01-02 Temple University Office Of Technology Transfer Cannabinoid receptor treatments
CN103288684B (zh) * 2013-05-03 2014-12-10 西安交通大学 一种具有抗肿瘤活性的联苯脲化合物及其制备方法
US9585867B2 (en) 2015-08-06 2017-03-07 Charles Everett Ankner Cannabinod formulation for the sedation of a human or animal
US12364668B2 (en) 2017-11-15 2025-07-22 The Regents Of The University Of California Treatment of opioid use disorder, opioid withdrawal symptoms, and chronic pain
US12409131B2 (en) 2019-10-03 2025-09-09 Pike Therapeutics Usa, Inc. Transdermal delivery of dronabinol
CN114650809A (zh) 2019-10-03 2022-06-21 斯塔顿治疗公司 屈大麻酚的透皮递送
CA3155176A1 (en) 2019-10-11 2021-04-15 Pike Therapeutics, Inc., 1219014 B.C. Ltd. Transdermal compositions comprising cannabidiol (cbd) for use in the treatment of seizure disorders
US12016829B2 (en) 2019-10-11 2024-06-25 Pike Therapeutics Inc. Pharmaceutical composition and method for treating seizure disorders
CA3155181A1 (en) 2019-10-14 2021-04-22 Pike Therapeutics, Inc., 1219014 B.C. Ltd. Transdermal delivery of cannabidiol
US12268699B2 (en) 2019-10-14 2025-04-08 Pike Therapeutics Inc. Transdermal delivery of tetrahydrocannabinol
US12121617B2 (en) 2019-10-14 2024-10-22 Pike Therapeutics Inc. Transdermal delivery of cannabidiol
EP3838967A1 (en) * 2019-12-16 2021-06-23 Spago Nanomedical AB Immobilization of phenolic compounds
JP7687721B2 (ja) * 2020-12-25 2025-06-03 エムティックスバイオ カンパニ－ リミテッド 新規なアミノアルカン酸にビフェニル基を導入した誘導体化合物およびそれを含む抗炎症用組成物
EP4276092A4 (en) * 2021-01-06 2025-01-01 Chugai Seiyaku Kabushiki Kaisha Compound library

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663608A (en) * 1969-12-10 1972-05-16 Bristol Myers Co 1-phenyl-3-aminoalkyl-1,2,3,4-tetrahydronaphthalenes and the salts thereof
US4055664A (en) * 1975-02-10 1977-10-25 Armour Pharmaceutical Company Pharmaceutical preparations containing 4-(4-biphenylyl) butylamines and treatment of the animal organism therewith
DE3063585D1 (en) 1979-05-19 1983-07-07 Beecham Group Plc Chroman derivatives, processes for their preparation and pharmaceutical compositions containing them
JP2002363164A (ja) * 2001-04-06 2002-12-18 Mitsubishi Chemicals Corp ピラゾールカルボキサミド類、その中間体およびこれを有効成分とする有害生物防除剤
WO2003091189A1 (en) * 2002-04-25 2003-11-06 Virginia Commonwealth University Cannabinoids
US20040087590A1 (en) * 2002-08-23 2004-05-06 University Of Connecticut Novel biphenyl and biphenyl-like cannabinoids
ATE455096T1 (de) * 2002-11-19 2010-01-15 Galderma Res & Dev Biaromatische verbindungen die ppar-gamma rezeptoren aktivieren und deren anwendungen in kosmetischen oder pharmazeutischen zusammensetzungen
WO2004052846A1 (en) * 2002-12-06 2004-06-24 Bayer Healthcare Ag Tetrahydro-naphthalene derivatives
SE0300010D0 (sv) 2003-01-07 2003-01-07 Astrazeneca Ab Novel Compounds

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US20100168108A1 (en) 2010-07-01
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