BRPI0514806A - composições e processo de microemulsão e emulsão sub-mìcron - Google Patents

composições e processo de microemulsão e emulsão sub-mìcron

Info

Publication number
BRPI0514806A
BRPI0514806A BRPI0514806-5A BRPI0514806A BRPI0514806A BR PI0514806 A BRPI0514806 A BR PI0514806A BR PI0514806 A BRPI0514806 A BR PI0514806A BR PI0514806 A BRPI0514806 A BR PI0514806A
Authority
BR
Brazil
Prior art keywords
microemulsion
emulsion
surfactant
water
sub
Prior art date
Application number
BRPI0514806-5A
Other languages
English (en)
Inventor
Maria Graziella Larm
Ronald Harding
Michael Johnston
Prema Vijayakumar
Phoebe Sun
Albert Zorko Abram
Original Assignee
Connetics Australia Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35999634&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0514806(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Connetics Australia Pty Ltd filed Critical Connetics Australia Pty Ltd
Publication of BRPI0514806A publication Critical patent/BRPI0514806A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/068—Microemulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Colloid Chemistry (AREA)

Abstract

COMPOSIçóES E PROCESSO DE MICROEMULSãO E EMULSãO SUB-MìCRON. A invenção fornece um processo para a preparação de uma composição em microemulsão ou emulsão sub-mícron de óleo em água, para distribuição dérmica de pelo menos um ingrediente farmaceuticamente ativo, sendo que o método inclui as etapas de: (a) misturar uma primeira parte que inclui pelo menos um do grupo que consiste em óleos animais, minerais ou vegetais, silanos, siloxanos, ésteres, ácidos graxos, gorduras, compostos halogenados ou álcoois alcoxilados; e um ou mais tensoativos lipofílicos, e uma segunda parte que inclui água e pelo menos um tensoativo hidrofílico, para atingir homogeneidade, (b) aquecer a mistura da etapa (a) até uma temperatura de união de fases na faixa entre 40 e 99<198>C, de preferência 45 a 95<198>C, mais preferivelmente 65 a 85<198>C, sob agitação contínua, para obter uma micro emulsão ou emulsão sub-mícron de óleo em água, (e) deixar que a dita micro emulsão ou emulsão sub-mícron resfrie, e (d) adicionar uma terceira parte à dita micro emulsão ou emulsão sub-mícron, em uma temperatura entre 2<198>C e a dita temperatura de união de fases, sendo que a dita terceira parte, caso necessário, é pré-misturada e aquecida até que os componentes sejam dissolvidos, e inclui pelo menos um componente selecionado no grupo que consiste em um composto não-tensoativo do tipo anfifílico, um tensoativo e água, desde que, quando a terceira parte inclui água, ela inclui também um composto não-tensoativo do tipo anfifílico e/ou um tensoativo. A temperatura de união de fases pode ser determinada visualmente pela obtenção da translucidez na composição ou por medições, tal como a condutividade, que tem um pico e depois se mantém em um plató enquanto a união de fases ocorre. Descobriu-se que se um composto não-tensoativo do tipo anfifílico, tal como um poliol, é adicionado à segunda parte, como seria o caso convencionalmente, não se forma uma micro emulsão ou emulsão sub-mícron, enquanto que adicionando à assim denominada terceira parte, a união de fases ocorre em uma temperatura mais baixa do que seria esperado, e além disso, esta fase parece auxiliar na manutenção das características da micro emulsão ou emulsão sub-mícron da formulação durante a estocagem em temperaturas normais.
BRPI0514806-5A 2004-08-31 2005-08-31 composições e processo de microemulsão e emulsão sub-mìcron BRPI0514806A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60627804P 2004-08-31 2004-08-31
US67072205P 2005-04-12 2005-04-12
PCT/AU2005/001321 WO2006024095A1 (en) 2004-08-31 2005-08-31 Microemulsion & sub-micron emulsion process & compositions

Publications (1)

Publication Number Publication Date
BRPI0514806A true BRPI0514806A (pt) 2008-06-24

Family

ID=35999634

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514806-5A BRPI0514806A (pt) 2004-08-31 2005-08-31 composições e processo de microemulsão e emulsão sub-mìcron

Country Status (15)

Country Link
US (1) US8460641B2 (pt)
EP (2) EP1796636B2 (pt)
JP (1) JP4972553B2 (pt)
KR (1) KR101243526B1 (pt)
AR (1) AR051197A1 (pt)
AU (1) AU2005279704B2 (pt)
BR (1) BRPI0514806A (pt)
CA (1) CA2578594C (pt)
ES (1) ES2429040T5 (pt)
HK (1) HK1110198A1 (pt)
IL (1) IL181632A (pt)
PL (1) PL1796636T5 (pt)
RU (1) RU2381023C2 (pt)
TW (1) TWI397427B (pt)
WO (1) WO2006024095A1 (pt)

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Also Published As

Publication number Publication date
WO2006024095A1 (en) 2006-03-09
US8460641B2 (en) 2013-06-11
EP1796636B2 (en) 2016-12-14
ES2429040T3 (es) 2013-11-12
CA2578594C (en) 2012-04-17
EP2438910A1 (en) 2012-04-11
AU2005279704A1 (en) 2006-03-09
WO2006024095A8 (en) 2007-04-19
EP1796636B1 (en) 2013-08-14
RU2007111706A (ru) 2008-10-10
HK1110198A1 (en) 2008-07-11
ES2429040T5 (es) 2017-06-13
JP4972553B2 (ja) 2012-07-11
KR20070069155A (ko) 2007-07-02
PL1796636T5 (pl) 2017-10-31
EP1796636A4 (en) 2011-03-02
CA2578594A1 (en) 2006-03-09
AU2005279704B2 (en) 2010-05-13
JP2008511550A (ja) 2008-04-17
IL181632A0 (en) 2007-07-04
EP1796636A1 (en) 2007-06-20
TW200624124A (en) 2006-07-16
PL1796636T3 (pl) 2014-01-31
IL181632A (en) 2015-01-29
KR101243526B1 (ko) 2013-03-20
TWI397427B (zh) 2013-06-01
US20060057168A1 (en) 2006-03-16
RU2381023C2 (ru) 2010-02-10
AR051197A1 (es) 2006-12-27

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