BRPI0513991A - composição para a promoção de relaxamento de músculo liso vascular - Google Patents
composição para a promoção de relaxamento de músculo liso vascularInfo
- Publication number
- BRPI0513991A BRPI0513991A BRPI0513991-0A BRPI0513991A BRPI0513991A BR PI0513991 A BRPI0513991 A BR PI0513991A BR PI0513991 A BRPI0513991 A BR PI0513991A BR PI0513991 A BRPI0513991 A BR PI0513991A
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- vasodilator
- active ingredient
- volatile
- saturated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
COMPOSIçãO PARA A PROMOçãO DE RELAXAMENTO DE MúSCULO LISO VASCULAR Uma composição para aplicação tópica a uma parte do corpo compreende um vasodilatador, por exemplo, trinitrato de gliceril, como ingrediente ativo dissolvido em uma mistura de solventes voláteis e não voláteis de diferentes capacidades de formação de solvato para o vasodilatador. O vasodilatador está presente na composição em uma concentração saturada ou levemente abaixo da saturação, pela qual a evaporação do solvente volátil em uso manterá o vasodilatador em concentrações saturadas ou supersaturadas no resíduo, assim o vasodilatador permanecerá saturado ou supersaturadono solvente restante e, uma vez que o ingrediente ativo passa através da pele e é absorvido na corrente sangüínea e assim torna-se esgotado na composição residual, a evaporação continuada do solvente volátil manterá o ingrediente ativo em um nível de saturação ou supersaturação na composição residual por toda a parte principal da fase de absorção, dessa forma maximizando os níveis de absorção porém em um nível de dosagem moderado.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0417675.6A GB0417675D0 (en) | 2004-08-09 | 2004-08-09 | Composition for promoting vascular smooth muscle relaxation |
| PCT/GB2005/003110 WO2006016139A1 (en) | 2004-08-09 | 2005-08-08 | Composition for promoting vascular smooth muscle relaxation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0513991A true BRPI0513991A (pt) | 2008-05-20 |
Family
ID=32982731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0513991-0A BRPI0513991A (pt) | 2004-08-09 | 2005-08-08 | composição para a promoção de relaxamento de músculo liso vascular |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8951553B2 (pt) |
| EP (1) | EP1786468B1 (pt) |
| JP (1) | JP2008509208A (pt) |
| KR (1) | KR101204397B1 (pt) |
| CN (1) | CN101022832A (pt) |
| AT (1) | ATE433761T1 (pt) |
| AU (1) | AU2005271049B2 (pt) |
| BR (1) | BRPI0513991A (pt) |
| CA (1) | CA2573386C (pt) |
| DE (1) | DE602005014999D1 (pt) |
| ES (1) | ES2328380T3 (pt) |
| GB (1) | GB0417675D0 (pt) |
| IL (1) | IL180577A0 (pt) |
| MX (1) | MX2007001639A (pt) |
| NO (1) | NO20070874L (pt) |
| NZ (1) | NZ552789A (pt) |
| RU (1) | RU2407519C2 (pt) |
| TW (1) | TWI371273B (pt) |
| WO (1) | WO2006016139A1 (pt) |
| ZA (1) | ZA200700193B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0602224D0 (en) * | 2006-02-03 | 2006-03-15 | Futura Medical Dev Ltd | Composition for promoting vascular smooth muscle relaxation |
| GB201713160D0 (en) * | 2017-08-16 | 2017-09-27 | Futura Medical Dev Ltd | Topical composition |
| CN109276565A (zh) * | 2018-10-19 | 2019-01-29 | 太阳雨林（厦门）生物医药有限公司 | 硝化甘油在制备治疗慢性肢体缺血性疾病药物中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4704119A (en) * | 1983-02-03 | 1987-11-03 | Alza Corporation | Method comprising transdermal and buccal treatment of angina |
| HU199678B (en) * | 1988-07-08 | 1990-03-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing aerosols containing nitroglicerol |
| US5370862A (en) * | 1990-06-13 | 1994-12-06 | Schwarz Pharma Ag | Pharmaceutical hydrophilic spray containing nitroglycerin for treating angina |
| DE4018919C2 (de) | 1990-06-13 | 1994-08-25 | Sanol Arznei Schwarz Gmbh | Nitroglycerin-Spray |
| DE4026072A1 (de) | 1990-08-17 | 1992-02-20 | Sanol Arznei Schwarz Gmbh | Nitroglycerinhaltiger, hydrophiler, waessriger pumpspray |
| WO1994002119A1 (en) | 1992-07-23 | 1994-02-03 | Hisamitsu Pharmaceutical Co., Inc. | Percutaneously administrable base composition and drug composition prepared therefrom |
| US5807569A (en) * | 1993-05-27 | 1998-09-15 | Smithkline Beecham P.L.C. | Topical composition |
| US5698589A (en) * | 1993-06-01 | 1997-12-16 | International Medical Innovations, Inc. | Water-based topical cream containing nitroglycerin and method of preparation and use thereof |
| GB9802078D0 (en) * | 1998-01-30 | 1998-03-25 | Futura Medical Limited | Preparation for treatment of erectile dysfunction |
-
2004
- 2004-08-09 GB GBGB0417675.6A patent/GB0417675D0/en not_active Ceased
-
2005
- 2005-08-08 MX MX2007001639A patent/MX2007001639A/es not_active Application Discontinuation
- 2005-08-08 AT AT05769661T patent/ATE433761T1/de not_active IP Right Cessation
- 2005-08-08 CN CNA200580027064XA patent/CN101022832A/zh active Pending
- 2005-08-08 US US11/659,815 patent/US8951553B2/en active Active
- 2005-08-08 EP EP05769661A patent/EP1786468B1/en not_active Not-in-force
- 2005-08-08 CA CA2573386A patent/CA2573386C/en not_active Expired - Fee Related
- 2005-08-08 KR KR1020077003116A patent/KR101204397B1/ko active IP Right Grant
- 2005-08-08 ES ES05769661T patent/ES2328380T3/es active Active
- 2005-08-08 DE DE602005014999T patent/DE602005014999D1/de active Active
- 2005-08-08 JP JP2007525343A patent/JP2008509208A/ja not_active Withdrawn
- 2005-08-08 ZA ZA200700193A patent/ZA200700193B/xx unknown
- 2005-08-08 NZ NZ552789A patent/NZ552789A/en not_active IP Right Cessation
- 2005-08-08 WO PCT/GB2005/003110 patent/WO2006016139A1/en active Application Filing
- 2005-08-08 RU RU2007106941/15A patent/RU2407519C2/ru not_active Application Discontinuation
- 2005-08-08 AU AU2005271049A patent/AU2005271049B2/en not_active Ceased
- 2005-08-08 BR BRPI0513991-0A patent/BRPI0513991A/pt not_active IP Right Cessation
- 2005-08-09 TW TW094126897A patent/TWI371273B/zh not_active IP Right Cessation
-
2007
- 2007-01-07 IL IL180577A patent/IL180577A0/en unknown
- 2007-02-15 NO NO20070874A patent/NO20070874L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1786468B1 (en) | 2009-06-17 |
| NO20070874L (no) | 2007-02-15 |
| ES2328380T3 (es) | 2009-11-12 |
| IL180577A0 (en) | 2007-06-03 |
| CA2573386A1 (en) | 2006-02-16 |
| AU2005271049A1 (en) | 2006-02-16 |
| KR101204397B1 (ko) | 2012-11-26 |
| US20080081058A1 (en) | 2008-04-03 |
| TWI371273B (en) | 2012-09-01 |
| CN101022832A (zh) | 2007-08-22 |
| RU2407519C2 (ru) | 2010-12-27 |
| DE602005014999D1 (de) | 2009-07-30 |
| WO2006016139A1 (en) | 2006-02-16 |
| TW200605874A (en) | 2006-02-16 |
| CA2573386C (en) | 2013-10-01 |
| ZA200700193B (en) | 2009-03-25 |
| ATE433761T1 (de) | 2009-07-15 |
| EP1786468A1 (en) | 2007-05-23 |
| KR20070054631A (ko) | 2007-05-29 |
| AU2005271049B2 (en) | 2011-08-04 |
| US8951553B2 (en) | 2015-02-10 |
| JP2008509208A (ja) | 2008-03-27 |
| MX2007001639A (es) | 2007-04-24 |
| NZ552789A (en) | 2010-12-24 |
| RU2007106941A (ru) | 2008-09-20 |
| GB0417675D0 (en) | 2004-09-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |