BRPI0512944A - agentes terapêuticos para o tratamento de patologias relacionadas com hmgb1 - Google Patents
agentes terapêuticos para o tratamento de patologias relacionadas com hmgb1Info
- Publication number
- BRPI0512944A BRPI0512944A BRPI0512944-3A BRPI0512944A BRPI0512944A BR PI0512944 A BRPI0512944 A BR PI0512944A BR PI0512944 A BRPI0512944 A BR PI0512944A BR PI0512944 A BRPI0512944 A BR PI0512944A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- hmgb1
- therapeutic agents
- related conditions
- nucleic acid
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000055207 HMGB1 Human genes 0.000 abstract 1
- 108700010013 HMGB1 Proteins 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C12N2310/3181—Peptide nucleic acid, PNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/52—Physical structure branched
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58467804P | 2004-07-02 | 2004-07-02 | |
| US64658605P | 2005-01-26 | 2005-01-26 | |
| PCT/EP2005/007198 WO2006002971A2 (en) | 2004-07-02 | 2005-07-04 | Nucleic acids for the treatment of hmgb1-related pathologies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0512944A true BRPI0512944A (pt) | 2008-04-15 |
Family
ID=35106975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0512944-3A BRPI0512944A (pt) | 2004-07-02 | 2005-07-04 | agentes terapêuticos para o tratamento de patologias relacionadas com hmgb1 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20080305073A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1768677B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2008504335A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE399014T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005259381A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0512944A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2572519A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE602005007746D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1768677T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2306195T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL179828A0 (cg-RX-API-DMAC7.html) |
| PL (1) | PL1768677T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1768677E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006002971A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006017647A1 (en) | 2004-08-03 | 2006-02-16 | Transtech Pharma, Inc. | Rage fusion proteins and methods of use |
| US20100172909A1 (en) * | 2005-10-24 | 2010-07-08 | Masahiro Nishibori | Cerebral edema suppressant |
| EA015657B1 (ru) * | 2006-02-09 | 2011-10-31 | Транстек Фарма, Инк. | Слитые белки rage и способы применения |
| JP3882090B1 (ja) * | 2006-05-19 | 2007-02-14 | 国立大学法人 岡山大学 | 脳血管攣縮抑制剤 |
| US20100056608A1 (en) * | 2006-11-17 | 2010-03-04 | Clinical Gene Networks Ab | Methods for screening and treatment involving the genes gypc, agpat3, agl, pvrl2, hmgb 3, hsdl2 and/or ldb2 |
| CN101589309A (zh) * | 2006-11-17 | 2009-11-25 | 临床基因网络公司 | 涉及基因gypc、agpat3、agl、pvrl2、hmgb3、hsdl2和/或ldb2的筛选和治疗方法 |
| US8927510B2 (en) | 2008-05-16 | 2015-01-06 | Children's Medical Center Corporation | Compositions and methods for inhibition of retroviruses |
| AU2009256906A1 (en) * | 2008-06-11 | 2009-12-17 | Bionucleon S.R.L. | Inhibition of HRP-3 using modified oligonucleotides |
| CN102209897B (zh) | 2008-09-11 | 2015-04-29 | 巴斯德研究院 | 通过调节hiv-1复制和顽固存在的hmgb1依赖性触发来监测和抑制人免疫缺陷病毒感染 |
| US20120165244A1 (en) * | 2008-10-30 | 2012-06-28 | Hua-Lin Wu | Methods for binding lewis y antigen |
| MX2011006456A (es) | 2008-12-22 | 2011-10-11 | Creabilis S A | Sintesis de conjugados de polimero de compuestos de indolocarbazola. |
| RU2011142230A (ru) | 2009-04-20 | 2013-05-27 | Пфайзер Инк. | Контроль гликозилирования белка и композиции и способы, касающиеся этого |
| GB0911569D0 (en) * | 2009-07-03 | 2009-08-12 | Ulive Entpr Ltd | Method for the detection of organ or tissue injury |
| JP5467313B2 (ja) * | 2009-09-28 | 2014-04-09 | 国立大学法人 岡山大学 | アテローム動脈硬化抑制剤 |
| US8975019B2 (en) * | 2009-10-19 | 2015-03-10 | University Of Massachusetts | Deducing exon connectivity by RNA-templated DNA ligation/sequencing |
| EP2617426B1 (en) * | 2010-09-17 | 2016-08-10 | Japan Science and Technology Agency | Inhibitor of hmgb protein-mediated immune response activation |
| US20140378531A1 (en) * | 2012-02-01 | 2014-12-25 | New York University | Inhibition of pattern recognition receptors in pancreatic cancer treatment using tlr inhibitors |
| JP6624542B2 (ja) * | 2015-02-05 | 2019-12-25 | 国立大学法人広島大学 | ヒトｈｍｇｂ１結合剤およびヒトｈｍｇｂ１除去装置 |
| WO2018175301A1 (en) | 2017-03-20 | 2018-09-27 | Sienna Biopharmaceuticals, Inc. | Polymer conjugate of montesanib with reduced exposure |
| WO2018175340A1 (en) | 2017-03-20 | 2018-09-27 | Sienna Biopharmaceuticals, Inc. | Reduced exposure conjugates modulating therapeutic targets |
| WO2018175315A1 (en) | 2017-03-20 | 2018-09-27 | Sienna Biopharmaceuticals, Inc. | Polymer conjugates of staurosporine derivatives having reduced exposure |
| WO2018175302A1 (en) | 2017-03-20 | 2018-09-27 | Sienna Biopharmaceuticals, Inc. | Polymer conjugates targeting c-src with reduced exposure |
| EP3621657A1 (en) | 2017-05-10 | 2020-03-18 | Sienna Biopharmaceuticals, Inc. | Uses of polymer conjugates of indolocarbazole compounds with reduced exposure |
| CN111304202B (zh) * | 2020-02-26 | 2023-03-28 | 西安交通大学 | 一种用于识别且增强hmgb1生物学活性的核酸适配子及其应用 |
| CN114957440A (zh) * | 2022-05-26 | 2022-08-30 | 江苏大学 | 一种重组HMGB1 A Box蛋白及其获取方法与应用 |
| JP2025521607A (ja) * | 2022-06-23 | 2025-07-10 | ザ ジェイ． デビッド グラッドストーン インスティテューツ、 ア テスタメンタリー トラスト エスタブリッシュド アンダー ザ ウィル オブ ジェイ． デビッド グラッドストーン | アルツハイマー病を含むａｐｏｅ４－関連タウオパチーの治療のためのｈｍｇｂ１阻害剤 |
| CN114807150B (zh) * | 2022-06-28 | 2022-10-14 | 中国科学院基础医学与肿瘤研究所(筹) | 靶向和拮抗hmgb1分子的核酸适体 |
| AU2023308977A1 (en) | 2022-07-19 | 2025-03-06 | Rampart Bioscience, Inc. | Non-immunogenic circular, non-viral dna vectors |
| CN115774004B (zh) * | 2022-08-19 | 2024-07-05 | 四川大学华西医院 | 二氧化锆@量子点复合微球在制备检测hmgb1的荧光探针中的用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0672188B1 (en) * | 1992-10-14 | 2003-12-10 | NeXstar Pharmaceuticals, Inc. | Method for selecting nucleic acids on the basis of structure |
| ITMI20010562A1 (it) * | 2001-03-16 | 2002-09-16 | Marco E Bianchi | Inibitori o antagonisti della proteina hmg1 per il trattamento di disordini vascolari |
| WO2004046345A2 (en) * | 2002-11-20 | 2004-06-03 | Critical Therapeutics, Inc. | Use of hmgb fragments as anti-inflammatory agents |
-
2005
- 2005-07-04 WO PCT/EP2005/007198 patent/WO2006002971A2/en not_active Ceased
- 2005-07-04 BR BRPI0512944-3A patent/BRPI0512944A/pt not_active IP Right Cessation
- 2005-07-04 DE DE602005007746T patent/DE602005007746D1/de not_active Revoked
- 2005-07-04 DK DK05773148T patent/DK1768677T3/da active
- 2005-07-04 ES ES05773148T patent/ES2306195T3/es not_active Expired - Lifetime
- 2005-07-04 CA CA002572519A patent/CA2572519A1/en not_active Abandoned
- 2005-07-04 US US11/631,328 patent/US20080305073A1/en not_active Abandoned
- 2005-07-04 PL PL05773148T patent/PL1768677T3/pl unknown
- 2005-07-04 PT PT05773148T patent/PT1768677E/pt unknown
- 2005-07-04 AT AT05773148T patent/ATE399014T1/de not_active IP Right Cessation
- 2005-07-04 JP JP2007518555A patent/JP2008504335A/ja active Pending
- 2005-07-04 AU AU2005259381A patent/AU2005259381A1/en not_active Abandoned
- 2005-07-04 EP EP05773148A patent/EP1768677B1/en not_active Revoked
-
2006
- 2006-12-04 IL IL179828A patent/IL179828A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006002971A3 (en) | 2006-04-20 |
| IL179828A0 (en) | 2008-03-20 |
| ES2306195T3 (es) | 2008-11-01 |
| AU2005259381A1 (en) | 2006-01-12 |
| EP1768677A2 (en) | 2007-04-04 |
| PT1768677E (pt) | 2008-10-06 |
| US20080305073A1 (en) | 2008-12-11 |
| ATE399014T1 (de) | 2008-07-15 |
| PL1768677T3 (pl) | 2009-01-30 |
| DK1768677T3 (da) | 2008-10-20 |
| EP1768677B1 (en) | 2008-06-25 |
| WO2006002971A2 (en) | 2006-01-12 |
| CA2572519A1 (en) | 2006-01-12 |
| DE602005007746D1 (de) | 2008-08-07 |
| JP2008504335A (ja) | 2008-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |