BRPI0511429A - proteìna de ligação à fibronectina (fnb) isolada, alterada de staphylococcal aureus (s. aureus); fnb isolada, alterada; composição imunogênica; método para imunizar um vertebrado contra s. aureus; vetor de expressão; célula hospedeira recombinante; método para produzir uma fnb alterada; método para induzir uma resposta imunológica em um vertebrado; proteìna isolada, alterada de ligação à fibronectina (fnb) de staphylococcal aureus (s. aureus); e molécula isolada de ácido nucléico que codifica uma fnb alterada de s. aureus - Google Patents
proteìna de ligação à fibronectina (fnb) isolada, alterada de staphylococcal aureus (s. aureus); fnb isolada, alterada; composição imunogênica; método para imunizar um vertebrado contra s. aureus; vetor de expressão; célula hospedeira recombinante; método para produzir uma fnb alterada; método para induzir uma resposta imunológica em um vertebrado; proteìna isolada, alterada de ligação à fibronectina (fnb) de staphylococcal aureus (s. aureus); e molécula isolada de ácido nucléico que codifica uma fnb alterada de s. aureusInfo
- Publication number
- BRPI0511429A BRPI0511429A BRPI0511429-2A BRPI0511429A BRPI0511429A BR PI0511429 A BRPI0511429 A BR PI0511429A BR PI0511429 A BRPI0511429 A BR PI0511429A BR PI0511429 A BRPI0511429 A BR PI0511429A
- Authority
- BR
- Brazil
- Prior art keywords
- aureus
- fnb
- altered
- isolated
- binding protein
- Prior art date
Links
- 101000815632 Streptococcus suis (strain 05ZYH33) Rqc2 homolog RqcH Proteins 0.000 title abstract 4
- 241000251539 Vertebrata <Metazoa> Species 0.000 title abstract 4
- 102000036072 fibronectin binding proteins Human genes 0.000 title abstract 4
- 230000002163 immunogen Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000013604 expression vector Substances 0.000 title abstract 2
- 230000028993 immune response Effects 0.000 title abstract 2
- 230000003053 immunization Effects 0.000 title abstract 2
- 230000001939 inductive effect Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000016359 Fibronectins Human genes 0.000 abstract 3
- 108010067306 Fibronectins Proteins 0.000 abstract 3
- 102000009123 Fibrin Human genes 0.000 abstract 2
- 108010073385 Fibrin Proteins 0.000 abstract 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 2
- 229950003499 fibrin Drugs 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PROTEìNA DE LIGAçãO à FIBRONECTINA (FNB) ISOLADA, ALTERADA DE STAPHYLOCOCCAL AUREUS (S. AUREUS); FNB ISOLADA, ALTERADA; COMPOSIçãO IMUNOGêNICA; MéTODO PARA IMUNIZAR UM VERTEBRADO CONTRA S. AUREUS; VETOR DE EXPRESSãO; CéLULA HOSPEDEIRA RECOMBINANTE; MéTODO PARA PRODUZIR UMA FNB ALTERADA; MéTODO PARA INDUZIR UMA RESPOSTA IMUNOLóGICA EM UM VERTEBRADO; PROTEINA ISOLADA, ALTERADA DE LIGAçãO à FIBRONECTINA (FNB) DE STAPHYLQCOCCAL AUREUS 3. AUREUS); E MOLéCULA ISOLADA DE áCIDO NUCLéICO QUE CODIFICA UMA FNB ALTERADA DE 3. AUREUS Descreve-se uma proteína (Fnb) isolada, alterada de 3. aureus que apresenta, pelo menos, uma mutação em um aminoácido selecionado a partir de resíduos correspondentes a Glnl03, Glnl05, Lysl57, Lys503, Lys620, Lys702, Lys762, Gln783 e Gln830 da FnbA da cepa ATCC49S525 de S. aureus. A substituição destes resíduos reativos dentro da proteína de ligação à fibronectina torna esta proteína menos capaz que a Fnb do tipo selvagem de ligação covalentemente cruzada com a fibronectina e a fibrina. A proteína alterada de ligação à fibronectina interfere efetivamente com a adesão de S. aureus à fibronectina e à fibrina e, conseqüentemente, uma composição imunogênica que compreende tal Fnb alterada exibe propriedades imunogênicas aperfeiçoadas e é mais segura para usar.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57372404P | 2004-05-21 | 2004-05-21 | |
| PCT/US2005/017186 WO2005116064A2 (en) | 2004-05-21 | 2005-05-17 | Altered fibronectin-binding protein of staphylococcus aureus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0511429A true BRPI0511429A (pt) | 2007-12-11 |
Family
ID=35219346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0511429-2A BRPI0511429A (pt) | 2004-05-21 | 2005-05-17 | proteìna de ligação à fibronectina (fnb) isolada, alterada de staphylococcal aureus (s. aureus); fnb isolada, alterada; composição imunogênica; método para imunizar um vertebrado contra s. aureus; vetor de expressão; célula hospedeira recombinante; método para produzir uma fnb alterada; método para induzir uma resposta imunológica em um vertebrado; proteìna isolada, alterada de ligação à fibronectina (fnb) de staphylococcal aureus (s. aureus); e molécula isolada de ácido nucléico que codifica uma fnb alterada de s. aureus |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7771731B2 (pt) |
| EP (2) | EP2301957A3 (pt) |
| JP (2) | JP2008502363A (pt) |
| KR (1) | KR20070029708A (pt) |
| CN (1) | CN1953991A (pt) |
| AR (1) | AR049182A1 (pt) |
| AU (1) | AU2005247910A1 (pt) |
| BR (1) | BRPI0511429A (pt) |
| CA (1) | CA2562037A1 (pt) |
| IL (1) | IL179282A0 (pt) |
| MX (1) | MXPA06013448A (pt) |
| TW (1) | TW200540182A (pt) |
| WO (1) | WO2005116064A2 (pt) |
| ZA (1) | ZA200609647B (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030224476A1 (en) * | 2002-03-01 | 2003-12-04 | Szu-Yi Chou | Method of producing transglutaminase reactive compound |
| EP2129473B1 (en) | 2007-03-28 | 2019-07-03 | Medtronic ATS Medical, Inc. | Method for inhibiting platelet interaction with biomaterial surfaces |
| CN101177451B (zh) * | 2007-11-02 | 2010-07-21 | 山东省农业科学院奶牛研究中心 | 金黄色葡萄球菌粘附素功能肽及其编码序列 |
| JP5709527B2 (ja) | 2008-01-31 | 2015-04-30 | ザ プロボスト フェローズ アンドスカラーズ オブ ザ カレッジ オブ ザ ホーリー アンド アンディバイデッドトリニティー オブ クイーン エリザベス ニア ダブリン | 微生物感染症の治療 |
| CA2768485C (en) | 2009-07-16 | 2018-12-04 | Timothy Foster | Treatment of staphylococci infections using recombinant fibrinogen binding protein clumping factor a |
| GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| EP2714971A4 (en) * | 2011-05-23 | 2015-01-21 | Phylogica Ltd | METHOD FOR DETERMINING, IDENTIFYING AND INSULATING CELL-PENETRATING PEPTIDES |
| CN103012568B (zh) * | 2012-09-29 | 2015-02-04 | 重庆原伦生物科技有限公司 | 耐甲氧西林金黄色葡萄球菌(MRSA)疫苗重组蛋白FnbA1及制备方法和应用 |
| US9908064B2 (en) | 2015-02-06 | 2018-03-06 | Leidos, Inc. | Portable fluidic platform for rapid cell-free production of protein biologics |
| CN105384800B (zh) * | 2015-12-07 | 2019-01-25 | 黑龙江八一农垦大学 | 金黄色葡萄球菌taf融合蛋白制备方法及其应用 |
| EP3257862A1 (en) * | 2016-06-16 | 2017-12-20 | ETH Zürich | Fibronectin-binding peptides for use in tumor or fibrosis diagnosis and therapy |
| CN106177932A (zh) * | 2016-07-03 | 2016-12-07 | 查文娟 | 一种耐甲氧西林金黄色葡萄球菌的疫苗 |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| CA3104859A1 (en) | 2018-07-03 | 2020-01-09 | Leidos, Inc. | Materials and methods for cell-free expression of vaccine epitope concatemers |
| CN111423516B (zh) * | 2020-04-01 | 2022-02-11 | 广州佰斯伦医疗器械有限公司 | 一种蛋白及其在创口修复及抑菌中的应用 |
| CN112795611B (zh) * | 2021-01-25 | 2023-04-28 | 昆明生物制造研究院有限公司 | 一种不可溶性蛋白制备核桃蛋白多肽的方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US5571514A (en) | 1987-06-01 | 1996-11-05 | Alfa Laval Ab | Fibronectin binding protein as well as its preparation |
| US5320951A (en) | 1987-06-01 | 1994-06-14 | Hoeoek Magnus | Fibronectin binding protein as well as its preparation |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| SE8901687D0 (sv) * | 1989-05-11 | 1989-05-11 | Alfa Laval Agri Int | Fibronectin binding protein as well as its preparation |
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| IL101715A (en) | 1991-05-02 | 2005-06-19 | Amgen Inc | Recombinant dna-derived cholera toxin subunit analogs |
| WO1993013302A1 (de) | 1991-12-23 | 1993-07-08 | Michael Zoche | Motor mit einer vorrichtung zur entölung |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6630455B1 (en) | 1995-01-13 | 2003-10-07 | Vanderbilt University | Methods for inducing mucosal immune responses |
| EP0971740B1 (en) * | 1997-01-21 | 2009-08-19 | THE TEXAS A&M UNIVERSITY SYSTEM | Fibronectin binding protein derived peptides which do not bind to fibronectin, antibodies thereto, and therapeutic uses |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| IL142231A0 (en) | 1998-09-30 | 2002-03-10 | American Cyanamid Co | Mutant cholera holotoxin as an adjuvant |
| WO2002098369A2 (en) | 2001-06-07 | 2002-12-12 | Wyeth Holdings Corporation | Mutant forms of cholera holotoxin as an adjuvant |
| ATE451386T1 (de) | 2001-06-07 | 2009-12-15 | Wyeth Corp | Mutantenformen von cholera holotoxin als adjuvans |
-
2005
- 2005-05-17 MX MXPA06013448A patent/MXPA06013448A/es active IP Right Grant
- 2005-05-17 BR BRPI0511429-2A patent/BRPI0511429A/pt not_active IP Right Cessation
- 2005-05-17 KR KR1020067024028A patent/KR20070029708A/ko not_active Application Discontinuation
- 2005-05-17 CN CNA2005800154390A patent/CN1953991A/zh active Pending
- 2005-05-17 EP EP10182756A patent/EP2301957A3/en not_active Withdrawn
- 2005-05-17 WO PCT/US2005/017186 patent/WO2005116064A2/en not_active Application Discontinuation
- 2005-05-17 JP JP2007527357A patent/JP2008502363A/ja active Pending
- 2005-05-17 AU AU2005247910A patent/AU2005247910A1/en not_active Abandoned
- 2005-05-17 EP EP05753026A patent/EP1749024A2/en not_active Withdrawn
- 2005-05-17 US US11/596,953 patent/US7771731B2/en not_active Expired - Fee Related
- 2005-05-17 CA CA002562037A patent/CA2562037A1/en not_active Abandoned
- 2005-05-19 TW TW094116382A patent/TW200540182A/zh unknown
- 2005-05-20 AR ARP050102090A patent/AR049182A1/es unknown
-
2006
- 2006-11-14 IL IL179282A patent/IL179282A0/en unknown
- 2006-11-20 ZA ZA200609647A patent/ZA200609647B/xx unknown
-
2010
- 2010-09-13 JP JP2010204962A patent/JP2010279391A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| IL179282A0 (en) | 2007-03-08 |
| EP2301957A3 (en) | 2011-05-18 |
| US20070218075A1 (en) | 2007-09-20 |
| JP2010279391A (ja) | 2010-12-16 |
| CN1953991A (zh) | 2007-04-25 |
| EP2301957A2 (en) | 2011-03-30 |
| CA2562037A1 (en) | 2005-12-08 |
| ZA200609647B (en) | 2010-02-24 |
| JP2008502363A (ja) | 2008-01-31 |
| WO2005116064A3 (en) | 2006-01-26 |
| AU2005247910A1 (en) | 2005-12-08 |
| KR20070029708A (ko) | 2007-03-14 |
| EP1749024A2 (en) | 2007-02-07 |
| US7771731B2 (en) | 2010-08-10 |
| WO2005116064A2 (en) | 2005-12-08 |
| TW200540182A (en) | 2005-12-16 |
| MXPA06013448A (es) | 2007-01-23 |
| AR049182A1 (es) | 2006-07-05 |
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| Date | Code | Title | Description |
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| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: PARA QUE A PETICAO NO 20090072586/RJ DE 28.07.09 SEJA ATENDIDA, APRESENTAR PROCURACAO ORIGINAL, OUCOPIA AUTENTICADA, DANDO PODERES PARA DESISTIR DO PEDIDO. |
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| B15G | Petition not considered as such [chapter 15.7 patent gazette] |
Free format text: REFERENTE A PETICAO NO 20090072586/RJ DE 28.07.2009, DE ACORDO COM O ARTIGO 219, INCISO II DA LPI 9279/96. |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2135 DE 06/12/2011. |