BRPI0509827B8 - nanopartículas pegiladas para transporte de moléculas biologicamente ativas, composição farmacêutica, liofilizato constituindo nanopartículas pegiladas e processo de preparação de nanopartículas pegiladas - Google Patents

nanopartículas pegiladas para transporte de moléculas biologicamente ativas, composição farmacêutica, liofilizato constituindo nanopartículas pegiladas e processo de preparação de nanopartículas pegiladas

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Publication number
BRPI0509827B8
BRPI0509827B8 BRPI0509827A BRPI0509827A BRPI0509827B8 BR PI0509827 B8 BRPI0509827 B8 BR PI0509827B8 BR PI0509827 A BRPI0509827 A BR PI0509827A BR PI0509827 A BRPI0509827 A BR PI0509827A BR PI0509827 B8 BRPI0509827 B8 BR PI0509827B8
Authority
BR
Brazil
Prior art keywords
pegylated nanoparticles
nanoparticles
biologically active
active molecules
lyophilizate
Prior art date
Application number
BRPI0509827A
Other languages
English (en)
Inventor
Manuel Irache Garreta Juan
Pavlova Yoncheva Krassimira
Original Assignee
Inst Cientifico Y Tecnologico De Navarra S A
Univ Navarra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Cientifico Y Tecnologico De Navarra S A, Univ Navarra filed Critical Inst Cientifico Y Tecnologico De Navarra S A
Publication of BRPI0509827A publication Critical patent/BRPI0509827A/pt
Publication of BRPI0509827B1 publication Critical patent/BRPI0509827B1/pt
Publication of BRPI0509827B8 publication Critical patent/BRPI0509827B8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6933—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained by reactions only involving carbon to carbon, e.g. poly(meth)acrylate, polystyrene, polyvinylpyrrolidone or polyvinylalcohol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/04—Anhydrides, e.g. cyclic anhydrides
    • C08F222/06—Maleic anhydride
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)

Abstract

nanopartículas pegiladas papa transporte de moléculas biologicamente ativas, composição farmacêutica, liofilizato constituindo nanopartículas pegiladas e processo de preparação de nanopartículas pegiladas, se refere a nanopartículas formando um polímero biodegradável, preferencialmente o éter de metil vinil e o copolímero anidrido maléico (pvm/ma) e um glicol de polietileno ou derivativos deste; estas nanopartículas são fáceis de produzir e fornecem excelentes características de bioadesão, dimensão e potencial zeta, sendo portanto adequadas para administração de moléculas ativas; a seleção do tipo de glicol de polietileno usado em sua produção permite modular apropriadamente as características destas nanopartículas, que podem ser usadas de forma vantajosa de acordo com o tipo de droga a ser transportada e/ou método de administração da formulação farmacêutica; a pegilação é realizada através da simples incubação por um curto período de tempo das duas macromoléculas em questão, sem precisar fazer uso de solventes orgânicos com alta toxicidade nem dos longos e trabalhosos processos de síntese orgânica; além disso, o processo de pegilação pode ser associado ao processo de encapsulamento de moléculas biologicamente ativas.
BRPI0509827A 2004-04-29 2005-04-28 nanopartículas pegiladas para transporte de moléculas biologicamente ativas, composição farmacêutica, liofilizato constituindo nanopartículas pegiladas e processo de preparação de nanopartículas pegiladas BRPI0509827B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ESP200401022 2004-04-29
ES200401022A ES2246694B1 (es) 2004-04-29 2004-04-29 Nanoparticulas pegiladas.
PCT/ES2005/000226 WO2005104648A2 (es) 2004-04-29 2005-04-28 Nanopartículas pegiladas

Publications (3)

Publication Number Publication Date
BRPI0509827A BRPI0509827A (pt) 2007-10-23
BRPI0509827B1 BRPI0509827B1 (pt) 2020-11-03
BRPI0509827B8 true BRPI0509827B8 (pt) 2021-05-25

Family

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Family Applications (1)

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BRPI0509827A BRPI0509827B8 (pt) 2004-04-29 2005-04-28 nanopartículas pegiladas para transporte de moléculas biologicamente ativas, composição farmacêutica, liofilizato constituindo nanopartículas pegiladas e processo de preparação de nanopartículas pegiladas

Country Status (13)

Country Link
US (1) US8628801B2 (pt)
EP (1) EP1752142B1 (pt)
JP (1) JP2007534729A (pt)
CN (1) CN1976688A (pt)
AT (1) ATE442841T1 (pt)
AU (1) AU2005237270B2 (pt)
BR (1) BRPI0509827B8 (pt)
CA (1) CA2564982C (pt)
DE (1) DE602005016674D1 (pt)
ES (2) ES2246694B1 (pt)
MX (1) MXPA06012583A (pt)
RU (1) RU2400215C2 (pt)
WO (1) WO2005104648A2 (pt)

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AU2005237270A1 (en) 2005-11-10
RU2400215C2 (ru) 2010-09-27
WO2005104648A3 (es) 2005-12-08
JP2007534729A (ja) 2007-11-29
ES2246694B1 (es) 2007-05-01
AU2005237270B2 (en) 2011-02-17
CA2564982C (en) 2015-04-21
EP1752142A2 (en) 2007-02-14
ATE442841T1 (de) 2009-10-15
BRPI0509827B1 (pt) 2020-11-03
EP1752142B1 (en) 2009-09-16
RU2006142100A (ru) 2008-06-20
ES2333659T3 (es) 2010-02-25
BRPI0509827A (pt) 2007-10-23
US8628801B2 (en) 2014-01-14
CN1976688A (zh) 2007-06-06
MXPA06012583A (es) 2007-03-21
US20080248125A1 (en) 2008-10-09
DE602005016674D1 (de) 2009-10-29
ES2246694A1 (es) 2006-02-16
CA2564982A1 (en) 2005-11-10

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