BRPI0509467A - compostos macrocìclicos como inibidores de replicação viral - Google Patents
compostos macrocìclicos como inibidores de replicação viralInfo
- Publication number
- BRPI0509467A BRPI0509467A BRPI0509467-4A BRPI0509467A BRPI0509467A BR PI0509467 A BRPI0509467 A BR PI0509467A BR PI0509467 A BRPI0509467 A BR PI0509467A BR PI0509467 A BRPI0509467 A BR PI0509467A
- Authority
- BR
- Brazil
- Prior art keywords
- macrocyclic compounds
- methods
- viral replication
- replication inhibitors
- exposed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55816104P | 2004-03-30 | 2004-03-30 | |
US56241804P | 2004-04-14 | 2004-04-14 | |
US61238104P | 2004-09-22 | 2004-09-22 | |
US61246004P | 2004-09-22 | 2004-09-22 | |
PCT/US2005/010494 WO2005095403A2 (fr) | 2004-03-30 | 2005-03-29 | Composes macrocycliques inhibiteurs de replication virale |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0509467A true BRPI0509467A (pt) | 2007-09-11 |
Family
ID=35005653
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0509467-4A BRPI0509467A (pt) | 2004-03-30 | 2005-03-29 | compostos macrocìclicos como inibidores de replicação viral |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1749007A2 (fr) |
JP (1) | JP4950026B2 (fr) |
AP (1) | AP2006003763A0 (fr) |
AR (1) | AR050321A1 (fr) |
AU (1) | AU2005228894B9 (fr) |
BR (1) | BRPI0509467A (fr) |
CA (1) | CA2560897C (fr) |
CU (1) | CU23787B7 (fr) |
EA (1) | EA012389B1 (fr) |
EC (1) | ECSP066959A (fr) |
GE (1) | GEP20104926B (fr) |
IL (1) | IL177917A0 (fr) |
MA (1) | MA28548B1 (fr) |
NO (1) | NO20064933L (fr) |
NZ (1) | NZ549697A (fr) |
WO (1) | WO2005095403A2 (fr) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
CA2573271C (fr) | 2004-07-15 | 2015-10-06 | Amr Technology, Inc. | Tetrahydroisoquinolines a substitution aryle et heteroaryle et leur utilisation pour bloquer le recaptage de la norepinephrine, la dopamine et la serotonine |
US7323447B2 (en) | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2332963A3 (fr) * | 2005-03-08 | 2011-11-16 | Boehringer Ingelheim International Gmbh | Procédé pour la préparation de composés macrocycliques |
US7592336B2 (en) | 2005-05-10 | 2009-09-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7601686B2 (en) | 2005-07-11 | 2009-10-13 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7470664B2 (en) | 2005-07-20 | 2008-12-30 | Merck & Co., Inc. | HCV NS3 protease inhibitors |
BRPI0613962A2 (pt) | 2005-07-25 | 2009-03-24 | Intermune Inc | inibidores macrocìclicos inovadores de replicação de vìrus da hepatite c |
US7666834B2 (en) | 2005-07-29 | 2010-02-23 | Tibotec Pharmaceuticals Ltd. | Macrocyclic inhibitors of hepatitis C virus |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
US7772183B2 (en) | 2005-10-12 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7741281B2 (en) | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
DK1966130T3 (da) | 2005-12-23 | 2014-02-10 | Zealand Pharma As | Modificerede lysin-mimetiske forbindelser |
US7935670B2 (en) | 2006-07-11 | 2011-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7906619B2 (en) | 2006-07-13 | 2011-03-15 | Achillion Pharmaceuticals, Inc. | 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication |
US8343477B2 (en) | 2006-11-01 | 2013-01-01 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
US7772180B2 (en) | 2006-11-09 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7888464B2 (en) | 2006-11-16 | 2011-02-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
CN101568543B (zh) * | 2006-11-16 | 2012-06-06 | 百时美施贵宝公司 | 大环肽作为丙型肝炎病毒抑制剂 |
US8003604B2 (en) | 2006-11-16 | 2011-08-23 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7763584B2 (en) | 2006-11-16 | 2010-07-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2008079266A2 (fr) | 2006-12-21 | 2008-07-03 | Wyeth | Synthèse de composés de pyrrolidine |
CN101668538A (zh) * | 2007-01-08 | 2010-03-10 | 芬诺密克斯公司 | 大环类丙型肝炎蛋白酶抑制剂 |
WO2008096002A1 (fr) * | 2007-02-08 | 2008-08-14 | Tibotec Pharmaceuticals Ltd. | Phosphonates et amidophosphates macrocycliques inhibiteurs du vhc |
WO2008106130A2 (fr) | 2007-02-26 | 2008-09-04 | Achillion Pharmaceuticals, Inc. | Peptides substitués par une amine tertiaire utiles comme inhibiteurs de la réplication du virus de l'hépatite c |
US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
NZ581606A (en) | 2007-05-03 | 2012-06-29 | Intermune Inc | Novel macrocyclic inhibitors of hepatitis c virus replication |
TW200914013A (en) | 2007-06-29 | 2009-04-01 | Gilead Sciences Inc | Antiviral compounds |
AP2874A (en) | 2007-06-29 | 2014-03-31 | Gilead Sciences Inc | Antiviral compounds |
AR067180A1 (es) * | 2007-06-29 | 2009-09-30 | Gilead Sciences Inc | Compuestos antivirales |
SE531698C2 (sv) | 2007-07-12 | 2009-07-07 | Respiratorius Ab | Nya bronkdilaterande a,b-omättade amider |
TW201546079A (zh) | 2007-12-21 | 2015-12-16 | Celgene Avilomics Res Inc | Hcv蛋白酶抑制劑及其用途(一) |
CN101951770B (zh) | 2007-12-21 | 2014-12-31 | 阿维拉制药公司 | Hcv蛋白酶抑制剂和其用途 |
US8202996B2 (en) | 2007-12-21 | 2012-06-19 | Bristol-Myers Squibb Company | Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide |
US8309685B2 (en) | 2007-12-21 | 2012-11-13 | Celgene Avilomics Research, Inc. | HCV protease inhibitors and uses thereof |
US8293705B2 (en) | 2007-12-21 | 2012-10-23 | Avila Therapeutics, Inc. | HCV protease inhibitors and uses thereof |
WO2009080836A2 (fr) * | 2007-12-24 | 2009-07-02 | Tibotec Pharmaceuticals Ltd. | Indoles macrocycliques comme inhibiteurs du virus de l'hépatite c |
BRPI0909205A2 (pt) * | 2008-04-11 | 2015-08-11 | Hoffmann La Roche | Complexos de rutênio como catalizadores para reações de metátese |
US8163921B2 (en) | 2008-04-16 | 2012-04-24 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2300491B1 (fr) | 2008-05-29 | 2016-01-06 | Bristol-Myers Squibb Company | Inhibiteurs du virus de l hépatite c |
US7964560B2 (en) | 2008-05-29 | 2011-06-21 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
KR101647520B1 (ko) * | 2008-08-07 | 2016-08-10 | 에프. 호프만-라 로슈 아게 | 거대환식 화합물의 제조 방법 |
US8207341B2 (en) | 2008-09-04 | 2012-06-26 | Bristol-Myers Squibb Company | Process or synthesizing substituted isoquinolines |
UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
JP5539363B2 (ja) | 2008-09-17 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | インターフェロンおよびリバビリンとのhcvns3プロテアーゼ阻害剤の組合せ |
US8044087B2 (en) | 2008-09-29 | 2011-10-25 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8563505B2 (en) | 2008-09-29 | 2013-10-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2010068760A2 (fr) | 2008-12-10 | 2010-06-17 | Achillion Pharmaceuticals, Inc. | Nouveaux peptides 4-amino-4-oxobutanoyl utiles en tant qu'inhibiteurs de la réplication virale |
US8283310B2 (en) | 2008-12-15 | 2012-10-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
NZ593648A (en) | 2008-12-23 | 2013-09-27 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
EA201100851A1 (ru) | 2008-12-23 | 2012-04-30 | Фармассет, Инк. | Аналоги нуклеозидов |
CL2009002206A1 (es) | 2008-12-23 | 2011-08-26 | Gilead Pharmasset Llc | Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales. |
CA2898529C (fr) | 2009-02-27 | 2017-10-17 | Peter Jozef Maria Van Remoortere | Sel de sodium amorphe de l'inhibiteur tmc435 du vhc |
WO2010118078A1 (fr) | 2009-04-08 | 2010-10-14 | Idenix Pharmaceuticals, Inc. | Inhibiteurs macrocycliques de la sérine protéase |
WO2010132437A1 (fr) | 2009-05-12 | 2010-11-18 | Albany Molecular Research, Inc. | Aryle, hétéroaryle et tétrahydroisoquinolines à hétérocycle substitué et leur utilisation |
KR20120023072A (ko) | 2009-05-12 | 2012-03-12 | 브리스톨-마이어스 스큅 컴퍼니 | (S)-7-(〔1,2,4〕트리아졸〔1,5-a〕피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린의 결정형 및 이의 용도 |
AU2010247763B2 (en) | 2009-05-12 | 2015-12-24 | Albany Molecular Research, Inc. | 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof |
TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
US8232246B2 (en) | 2009-06-30 | 2012-07-31 | Abbott Laboratories | Anti-viral compounds |
PT2451438E (pt) | 2009-07-07 | 2014-03-26 | Boehringer Ingelheim Int | Composição farmacêutica para um inibidor de protease viral da hepatite c |
WO2011017389A1 (fr) | 2009-08-05 | 2011-02-10 | Idenix Pharmaceuticals, Inc. | Inhibiteurs macrocycliques de la sérine protéase macrocyclique utiles contre les infections virales, en particulier le virus de lhépatite c |
US20110129444A1 (en) * | 2009-09-28 | 2011-06-02 | Intermune, Inc | Novel macrocyclic inhibitors of hepatitis c virus replication |
NZ598465A (en) | 2009-10-30 | 2013-10-25 | Boehringer Ingelheim Int | Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin |
US8785487B2 (en) | 2010-01-25 | 2014-07-22 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
EP2609923B1 (fr) | 2010-03-31 | 2017-05-24 | Gilead Pharmasset LLC | Procede de crystallisation de (s)-isopropyl 2-(((s)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate |
BR112012024884A2 (pt) | 2010-03-31 | 2016-10-18 | Gilead Pharmasset Llc | síntese estereosseletiva de ativos contendo fósforo |
EP2455068A1 (fr) * | 2010-11-09 | 2012-05-23 | F. Hoffmann-La Roche AG | Composition pharmaceutique pour le traitement d'infections par VHC |
TW201238950A (en) | 2010-11-15 | 2012-10-01 | Abbott Lab | NAMPT and rock inhibitors |
AR084044A1 (es) | 2010-11-30 | 2013-04-17 | Pharmasset Inc | Compuestos 2’-espiro-nucleosidos |
EP2658859A4 (fr) | 2010-12-30 | 2014-07-30 | Enanta Pharm Inc | Inhibiteurs macrocycliques de sérine protéase d'hépatite c |
MX2013007698A (es) | 2010-12-30 | 2013-08-15 | Abbvie Inc | Inhibidores de serina proteasa de hepatitis c macrociclicos de fenantridina. |
US9353100B2 (en) | 2011-02-10 | 2016-05-31 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections |
US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
CA2874953A1 (fr) | 2012-06-12 | 2013-12-19 | Abbvie Inc. | Derives de pyridinone et de pyridazinone |
RS55592B1 (sr) | 2012-10-19 | 2017-06-30 | Bristol Myers Squibb Co | 9-metil supstituisani heksadekahidrociklopropa(e)pirolo(1,2-a)(1,4)diazaciklopentadecinil karbamat derivati kao nestrukturalni 3 (ns3) proteazni inhibitori za lečenje infekcijavirusom hepatitisa c |
US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2014071007A1 (fr) | 2012-11-02 | 2014-05-08 | Bristol-Myers Squibb Company | Inhibiteurs du virus de l'hépatite c |
WO2014070964A1 (fr) | 2012-11-02 | 2014-05-08 | Bristol-Myers Squibb Company | Inhibiteurs du virus de l'hépatite c |
EP2914614B1 (fr) | 2012-11-05 | 2017-08-16 | Bristol-Myers Squibb Company | Inhibiteurs du virus de l'hépatite c |
WO2014137869A1 (fr) | 2013-03-07 | 2014-09-12 | Bristol-Myers Squibb Company | Inhibiteurs du virus de l'hépatite c |
EP2970195B1 (fr) | 2013-03-14 | 2017-08-02 | Achillion Pharmaceuticals, Inc. | Processus de production de sovaprevir |
MX2015013020A (es) | 2013-03-15 | 2016-06-10 | Achillion Pharmaceuticals Inc | Polimorfos de sovaprevir y metodos de fabricacion de los mismos. |
US9006423B2 (en) | 2013-03-15 | 2015-04-14 | Achillion Pharmaceuticals Inc. | Process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof |
US9085607B2 (en) | 2013-03-15 | 2015-07-21 | Achillion Pharmaceuticals, Inc. | ACH-0142684 sodium salt polymorph, composition including the same, and method of manufacture thereof |
ES2792503T3 (es) | 2013-08-27 | 2020-11-11 | Gilead Pharmasset Llc | Formulación combinada de dos compuestos antivirales |
WO2015103490A1 (fr) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Formes galéniques antivirales solides |
JP6989864B2 (ja) | 2017-05-05 | 2022-02-03 | ジーランド ファーマ,アー/エス | ギャップ結合細胞間コミュニケーションモジュレータ及び糖尿病性眼疾患の治療のためのそれらの使用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
AR022061A1 (es) * | 1998-08-10 | 2002-09-04 | Boehringer Ingelheim Ca Ltd | Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos. |
UA74546C2 (en) * | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
US6608027B1 (en) * | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
WO2002060926A2 (fr) * | 2000-11-20 | 2002-08-08 | Bristol-Myers Squibb Company | Inhibiteurs du virus de l'hepatite c |
US6867185B2 (en) * | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
CA2369711A1 (fr) * | 2002-01-30 | 2003-07-30 | Boehringer Ingelheim (Canada) Ltd. | Peptides macrocycliques qui agissent contre le virus de l'hepatite c |
CA2370396A1 (fr) * | 2002-02-01 | 2003-08-01 | Boehringer Ingelheim (Canada) Ltd. | Tri-peptides inhibiteur de l'hepatite c |
CA2369970A1 (fr) * | 2002-02-01 | 2003-08-01 | Boehringer Ingelheim (Canada) Ltd. | Tri-peptides inhibiteur de l'hepatite c |
US6828301B2 (en) * | 2002-02-07 | 2004-12-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for hepatitis C viral protease inhibitors |
MY140680A (en) * | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
EP1506000B9 (fr) * | 2002-05-20 | 2011-08-31 | Bristol-Myers Squibb Company | Sulfamides heterocycliques en tant qu'inhibiteurs du virus de l'hepatite c |
EP2407470A3 (fr) * | 2003-10-14 | 2015-06-10 | F. Hoffmann-La Roche Ltd. | Acylsulfonamides et acides carboxyliques macrocycliques utilisés en tant qu'inhibiteurs de la réplication du virus de l'hépatite C |
ATE461209T1 (de) * | 2004-01-30 | 2010-04-15 | Medivir Ab | Hcv ns-3 serine protease inhibitoren |
-
2005
- 2005-03-29 EA EA200601467A patent/EA012389B1/ru not_active IP Right Cessation
- 2005-03-29 NZ NZ549697A patent/NZ549697A/en not_active IP Right Cessation
- 2005-03-29 AU AU2005228894A patent/AU2005228894B9/en not_active Ceased
- 2005-03-29 EP EP05757750A patent/EP1749007A2/fr not_active Withdrawn
- 2005-03-29 WO PCT/US2005/010494 patent/WO2005095403A2/fr active Application Filing
- 2005-03-29 GE GEAP20059674A patent/GEP20104926B/en unknown
- 2005-03-29 CA CA2560897A patent/CA2560897C/fr not_active Expired - Fee Related
- 2005-03-29 JP JP2007506466A patent/JP4950026B2/ja not_active Expired - Fee Related
- 2005-03-29 AP AP2006003763A patent/AP2006003763A0/xx unknown
- 2005-03-29 BR BRPI0509467-4A patent/BRPI0509467A/pt not_active IP Right Cessation
- 2005-03-30 AR ARP050101257A patent/AR050321A1/es not_active Application Discontinuation
-
2006
- 2006-09-06 IL IL177917A patent/IL177917A0/en unknown
- 2006-10-20 MA MA29407A patent/MA28548B1/fr unknown
- 2006-10-27 NO NO20064933A patent/NO20064933L/no not_active Application Discontinuation
- 2006-10-27 EC EC2006006959A patent/ECSP066959A/es unknown
-
2009
- 2009-12-08 CU CU20090209A patent/CU23787B7/es active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
AP2006003763A0 (en) | 2006-10-31 |
ECSP066959A (es) | 2006-12-20 |
NO20064933L (no) | 2006-12-15 |
AU2005228894A1 (en) | 2005-10-13 |
WO2005095403A3 (fr) | 2005-12-01 |
EA200601467A1 (ru) | 2007-06-29 |
IL177917A0 (en) | 2006-12-31 |
CA2560897C (fr) | 2012-06-12 |
EP1749007A2 (fr) | 2007-02-07 |
GEP20104926B (en) | 2010-03-25 |
MA28548B1 (fr) | 2007-04-03 |
AU2005228894B9 (en) | 2011-10-13 |
AR050321A1 (es) | 2006-10-18 |
JP2007531749A (ja) | 2007-11-08 |
CU23787B7 (es) | 2012-03-15 |
CU20090209A7 (es) | 2011-04-26 |
NZ549697A (en) | 2009-12-24 |
WO2005095403A2 (fr) | 2005-10-13 |
EA012389B1 (ru) | 2009-10-30 |
CA2560897A1 (fr) | 2005-10-13 |
JP4950026B2 (ja) | 2012-06-13 |
AU2005228894B2 (en) | 2011-08-25 |
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