BRPI0506879A - derivados de 1,4-diazabiciclo[3.2.1] octanocarboxamida, seu preparo e sua aplicação em terapêutica - Google Patents

derivados de 1,4-diazabiciclo[3.2.1] octanocarboxamida, seu preparo e sua aplicação em terapêutica

Info

Publication number
BRPI0506879A
BRPI0506879A BRPI0506879-7A BRPI0506879A BRPI0506879A BR PI0506879 A BRPI0506879 A BR PI0506879A BR PI0506879 A BRPI0506879 A BR PI0506879A BR PI0506879 A BRPI0506879 A BR PI0506879A
Authority
BR
Brazil
Prior art keywords
alkyl
alpha
definitions
diazabicyclo
diazacyclo
Prior art date
Application number
BRPI0506879-7A
Other languages
English (en)
Inventor
Frederic Galli
Odile Leclerc
Alistair Lochead
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0506879A publication Critical patent/BRPI0506879A/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

"DERIVADOS DE 1,4-DIAZABICICLO¢3.2.1!OCTANOCARBOXAMIDA, SEU PREPARO E SUA APLICAçãO EM TERAPêUTICA". A presente invenção refere-se a compostos correspondentes à fórmula geral (I), na qual X representa N ou um grupo de fórmula C-R~ 2~,P, Q, R e W representam, cada um, N ou um grupo de fórmula geral C-R~ 3~, R~ 1~ representa H ou um alquila, R~ 2~ representa um alquila, R~ 3~ representa H ou um halogênio, ou um grupo alquila, alcóxi, nitro, amino, trifluorometila,, ciano, ou de fórmula geral -NR~ 4~R~ 5~, -NR~ 4~C(=O)R~ 5~, NR~ 4~C(=O)NR~ 5~R~ 6~, -NR~ 4~C(=O)OR~ 5~, NR~ 4~S(-O)~ 2~NR~ 5~R~ 6~ -OR~ 4~, -OC(=O)R~ 4~, -OC(=O)OR~ 4~, -OC(=O)ONR~ 4~R~ 5~, -OC(=O)SR~ 4~, -C(=O)OR~ 4~, C(=O)R~ 4~, -C(=O)NR~ 4~R~ 5~, SR~ 4~, -S(=O)R~ 4~, -S(=O)~ 2~R~ 4~, -S(=O)~ 2~NR~ 4~R~ 6~, ou um heterociclo, R~ 4~ R~ 5~ e R~ 6~ representam, cada um, H ou alquila, alcenila, alcinila, cicloalquila, cicloalquialquila, cicloalcenila, ou heterocicloalquila ou arila. Aplicação em terapêutica.
BRPI0506879-7A 2004-01-16 2005-01-07 derivados de 1,4-diazabiciclo[3.2.1] octanocarboxamida, seu preparo e sua aplicação em terapêutica BRPI0506879A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0400390A FR2865208B1 (fr) 2004-01-16 2004-01-16 Derives de 1,4-diazabicyclo[3.2.1]octanecarboxmique, leur preparation et leur application en therapeutique
PCT/FR2005/000027 WO2005077955A1 (fr) 2004-01-16 2005-01-07 Derives de 1,4-diazabicyclo[3.2.1]octanecarboxamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
BRPI0506879A true BRPI0506879A (pt) 2007-06-12

Family

ID=34707894

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0506879-7A BRPI0506879A (pt) 2004-01-16 2005-01-07 derivados de 1,4-diazabiciclo[3.2.1] octanocarboxamida, seu preparo e sua aplicação em terapêutica

Country Status (27)

Country Link
US (1) US7589201B2 (pt)
EP (1) EP1709052B1 (pt)
JP (1) JP4781279B2 (pt)
KR (1) KR101146445B1 (pt)
CN (1) CN1946726B (pt)
AT (1) ATE507228T1 (pt)
AU (1) AU2005212867B2 (pt)
BR (1) BRPI0506879A (pt)
CA (1) CA2549954C (pt)
CY (1) CY1111707T1 (pt)
DE (1) DE602005027659D1 (pt)
DK (1) DK1709052T3 (pt)
ES (1) ES2365141T3 (pt)
FR (1) FR2865208B1 (pt)
HK (1) HK1105632A1 (pt)
HR (1) HRP20110538T1 (pt)
IL (1) IL176702A (pt)
MA (1) MA28238A1 (pt)
NO (1) NO20063666L (pt)
NZ (1) NZ548046A (pt)
PL (1) PL1709052T3 (pt)
PT (1) PT1709052E (pt)
RS (1) RS51910B (pt)
RU (1) RU2361873C2 (pt)
SI (1) SI1709052T1 (pt)
WO (1) WO2005077955A1 (pt)
ZA (1) ZA200605823B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005243147A1 (en) * 2004-05-07 2005-11-24 Memory Pharmaceuticals Corporation 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
JP2008507518A (ja) 2004-07-22 2008-03-13 ピーティーシー セラピューティクス,インコーポレーテッド C型肝炎を治療するためのチエノピリジン
WO2006124897A2 (en) * 2005-05-13 2006-11-23 Lexicon Genetics Incorporated Methods and compositions for improving cognition
JP2009506036A (ja) * 2005-08-24 2009-02-12 レキシコン・ファーマシューティカルズ・インコーポレーテッド ピロロピリジン、ピロロピリミジンおよびピラゾロピリジン化合物、それらを含む組成物、ならびにそれらの使用方法
AR079980A1 (es) * 2010-01-13 2012-03-07 Sanofi Aventis Derivados de oxazolopirimidina sustituida en 2,5,7
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9420521D0 (en) * 1994-10-12 1994-11-30 Smithkline Beecham Plc Novel compounds
GB9803411D0 (en) * 1998-02-18 1998-04-15 Smithkline Beecham Plc Novel compounds
FR2809730B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo Derives de 1,4-diazabicyclo[3.2.2] nonanebenzoxazole, -benzothiazole et -benzimidazole, leur preparation et leur application therapeutique
WO2003044018A1 (en) * 2001-11-19 2003-05-30 Neurogen Corporation 1h-pyrrolo[3,2-b]pyridine-3-carboxylic acid amides
US6673811B1 (en) * 2001-11-19 2004-01-06 Neurogen Corporation 1H-pyrrolo [3,2-b] pyridine-3-carboxylic acid amines as GABAA receptor ligands
SE0202465D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab New compounds
FR2845388B1 (fr) * 2002-10-08 2004-11-12 Sanofi Synthelabo Derives de 1,4-diazabicyclo[3.2.2]nonanecarboxamides, leur preparation et leur application en therapeutique
US7456171B2 (en) * 2002-10-08 2008-11-25 Sanofi-Aventis 1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof
TW200529860A (en) * 2003-12-22 2005-09-16 Astrazeneca Ab Nicotinic acetylcholine receptor ligands

Also Published As

Publication number Publication date
CA2549954A1 (fr) 2005-08-25
CN1946726A (zh) 2007-04-11
PL1709052T3 (pl) 2011-09-30
RU2006129633A (ru) 2008-02-27
AU2005212867B2 (en) 2011-05-12
CY1111707T1 (el) 2015-10-07
JP4781279B2 (ja) 2011-09-28
HK1105632A1 (en) 2008-02-22
KR101146445B1 (ko) 2012-05-18
RU2361873C2 (ru) 2009-07-20
IL176702A (en) 2011-07-31
NO20063666L (no) 2006-10-11
AU2005212867A1 (en) 2005-08-25
US7589201B2 (en) 2009-09-15
ES2365141T3 (es) 2011-09-23
KR20070017990A (ko) 2007-02-13
FR2865208B1 (fr) 2009-01-16
EP1709052A1 (fr) 2006-10-11
DK1709052T3 (da) 2011-08-15
WO2005077955A1 (fr) 2005-08-25
CA2549954C (fr) 2013-04-23
NZ548046A (en) 2009-12-24
JP2007517838A (ja) 2007-07-05
PT1709052E (pt) 2011-07-20
ATE507228T1 (de) 2011-05-15
MA28238A1 (fr) 2006-10-02
CN1946726B (zh) 2011-08-31
ZA200605823B (en) 2008-01-08
HRP20110538T1 (hr) 2011-08-31
EP1709052B1 (fr) 2011-04-27
IL176702A0 (en) 2006-10-31
RS51910B (en) 2012-02-29
US20070155749A1 (en) 2007-07-05
SI1709052T1 (sl) 2011-08-31
DE602005027659D1 (de) 2011-06-09
FR2865208A1 (fr) 2005-07-22

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements