PE20060495A1 - 4-(2,4-dicloro-5-metoxifenil)amino-6-metoxi-7-{[5-(amino-sustituido) metil]-3-furil}-3-quinolincarbonitrilos como inhibidores de quinasa - Google Patents

4-(2,4-dicloro-5-metoxifenil)amino-6-metoxi-7-{[5-(amino-sustituido) metil]-3-furil}-3-quinolincarbonitrilos como inhibidores de quinasa

Info

Publication number
PE20060495A1
PE20060495A1 PE2005000938A PE2005000938A PE20060495A1 PE 20060495 A1 PE20060495 A1 PE 20060495A1 PE 2005000938 A PE2005000938 A PE 2005000938A PE 2005000938 A PE2005000938 A PE 2005000938A PE 20060495 A1 PE20060495 A1 PE 20060495A1
Authority
PE
Peru
Prior art keywords
amino
dichloro
metoxyphenyl
metoxy
furyl
Prior art date
Application number
PE2005000938A
Other languages
English (en)
Inventor
Diane Harris Boschelli
Asaf Alimardanov
Jay Thomas Afragola
Biqi Wu
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20060495A1 publication Critical patent/PE20060495A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 Y R2 SON CADA UNO H, ALQUILO C1-C6, ALQUENILO C2-C6, ARILO, ENTRE OTROS O PUEDEN FORMAR JUNTO CON EL NITROGENO AL QUE ESTAN UNIDOS UN ANILLO HETEROCICLICO. SON COMPUESTOS PREFERIDOS: 4-[(2,4-DICLORO-5-METOXIFENIL)AMINO]-6-METOXI-7-{5-[4-METILPIPERAZIN-1-IL)METIL]-3-FURIL}-3-QUINOLINCARBONITRILO; 4-[(2,4-DICLORO-5-METOXIFENIL)AMINO]-6-METOXI-7-(5-{[4-(1-METILPIPERIDIN-4-IL)PIPERAZIN-1-IL]METIL}-3-FURIL)QUINOLIN-3-CARBONITRILO; 4-[(2,4-DICLORO-5-METOXIFENIL)AMINO]-6-METOXI-7-(5-{[4-(2,4-DIMETOXIFENIL)PIPERAZIN-1-IL]METIL}-3-FURIL)-3-QUINOLINCARBONITRILO. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE LAS QUINASAS DE PROTEINA UTILES EN EL TRATAMIENTO DE CANCER, ARTRITIS REUMATOIDE, ENFERMEDAD RENAL POLIQUISTICA, ENTRE OTROS
PE2005000938A 2004-08-16 2005-08-12 4-(2,4-dicloro-5-metoxifenil)amino-6-metoxi-7-{[5-(amino-sustituido) metil]-3-furil}-3-quinolincarbonitrilos como inhibidores de quinasa PE20060495A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60182504P 2004-08-16 2004-08-16

Publications (1)

Publication Number Publication Date
PE20060495A1 true PE20060495A1 (es) 2006-07-14

Family

ID=35395715

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000938A PE20060495A1 (es) 2004-08-16 2005-08-12 4-(2,4-dicloro-5-metoxifenil)amino-6-metoxi-7-{[5-(amino-sustituido) metil]-3-furil}-3-quinolincarbonitrilos como inhibidores de quinasa

Country Status (6)

Country Link
US (1) US7479561B2 (es)
AR (1) AR053409A1 (es)
GT (1) GT200500219A (es)
PE (1) PE20060495A1 (es)
TW (1) TW200612944A (es)
WO (1) WO2006023395A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200829555A (en) * 2006-11-10 2008-07-16 Astrazeneca Ab Chemical compounds
WO2008064004A2 (en) * 2006-11-16 2008-05-29 Wyeth 4-anilino-3-quinolinecarbonitriles for the treatment of acute myelogenous leukemia (aml)
US20080119463A1 (en) * 2006-11-16 2008-05-22 Wyeth 4-Anilino-3-quinolinecarbonitriles for the treatment of acute myelogenous leukemia (AML)
CN104797267A (zh) 2012-06-26 2015-07-22 德玛医药 使用卫康醇、二乙酰二脱水卫矛醇、二溴卫矛醇或类似物或其衍生物治疗具有基因多型性或ahi1失调或突变患者的抗酪氨酸激酶抑制剂的恶性肿瘤的方法
CN103848785B (zh) * 2012-12-04 2016-07-13 上海医药集团股份有限公司 一类氘代3-氰基喹啉类化合物、其药用组合物、制备方法及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6521618B2 (en) * 2000-03-28 2003-02-18 Wyeth 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
AR035851A1 (es) * 2000-03-28 2004-07-21 Wyeth Corp 3-cianoquinolinas, 3-ciano-1,6-naftiridinas y 3-ciano-1,7-naftiridinas como inhibidoras de proteina quinasas
US6961765B2 (en) * 2000-04-06 2005-11-01 Bbx Technologies, Inc. System and method for real time monitoring and control of networked computers
KR20060066733A (ko) 2003-08-19 2006-06-16 와이어쓰 홀딩스 코포레이션 4-아미노-3-퀴놀린카보니트릴의 제조방법

Also Published As

Publication number Publication date
GT200500219A (es) 2006-03-07
US20060035930A1 (en) 2006-02-16
WO2006023395A2 (en) 2006-03-02
WO2006023395A3 (en) 2006-06-08
US7479561B2 (en) 2009-01-20
TW200612944A (en) 2006-05-01
AR053409A1 (es) 2007-05-09

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