BRPI0417220A - processo de purificação de beta interferon humano - Google Patents

processo de purificação de beta interferon humano

Info

Publication number
BRPI0417220A
BRPI0417220A BRPI0417220-5A BRPI0417220A BRPI0417220A BR PI0417220 A BRPI0417220 A BR PI0417220A BR PI0417220 A BRPI0417220 A BR PI0417220A BR PI0417220 A BRPI0417220 A BR PI0417220A
Authority
BR
Brazil
Prior art keywords
beta interferon
human beta
interferon
purification process
affinity chromatography
Prior art date
Application number
BRPI0417220-5A
Other languages
English (en)
Inventor
Ji Sook Park
Jong Sang Chung
Min Ji Baek
Jee Won Ahn
Ki Wan Kim
Hyung Ki Park
Dong Eok Lee
Myung Suk Oh
Original Assignee
Cj Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cj Corp filed Critical Cj Corp
Publication of BRPI0417220A publication Critical patent/BRPI0417220A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"PROCESSO DE PURIFICAçãO DE BETA INTERFERON HUMANO". é proporcionado um processo de purificação do beta interferon humano a partir de uma cultura que contém beta interferon humano recombinante realizando cromatografia por afinidade e cromatografia líquida em fase reversa de alto desempenho (RP-HPLC), em que a cromatografia por afinidade inclui: adsorver a cultura que contém beta interferon numa coluna de cromatografia por afinidade equilibrada, seguida de lavagem com uma solução tampão equilibrada; lavar a coluna com uma solução tampão de lavagem A de pH 6,5-7,5 contendo 30-60% em peso de propilenoglicol e uma solução tampão de lavagem B de pH 6,5-7,5 contendo 30-60% em peso de propilenoglicol e NaC1 1-2M; é eluir uma fração contendo beta interferon com uma solução tampão de pH 6,5-7,5 contendo 40-60% em peso de propileno e NaC1 1-2M.
BRPI0417220-5A 2003-12-04 2004-12-04 processo de purificação de beta interferon humano BRPI0417220A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2003-0087552A KR100524871B1 (ko) 2003-12-04 2003-12-04 인터페론 베타의 정제방법
PCT/KR2004/003179 WO2005054288A1 (en) 2003-12-04 2004-12-04 Process for purifying interferon beta

Publications (1)

Publication Number Publication Date
BRPI0417220A true BRPI0417220A (pt) 2007-02-21

Family

ID=36647277

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417220-5A BRPI0417220A (pt) 2003-12-04 2004-12-04 processo de purificação de beta interferon humano

Country Status (14)

Country Link
US (1) US7780960B2 (pt)
EP (1) EP1697411B1 (pt)
JP (1) JP2007530447A (pt)
KR (1) KR100524871B1 (pt)
CN (1) CN100462370C (pt)
AT (1) ATE521712T1 (pt)
AU (1) AU2004295265B2 (pt)
BR (1) BRPI0417220A (pt)
CA (1) CA2548160C (pt)
ES (1) ES2369911T3 (pt)
MX (1) MXPA06006357A (pt)
PL (1) PL1697411T3 (pt)
RU (1) RU2346003C2 (pt)
WO (1) WO2005054288A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005335900B2 (en) * 2005-08-26 2012-03-29 Ares Trading S.A. Process for the preparation of glycosylated interferon beta
KR100848600B1 (ko) * 2007-02-28 2008-07-28 인하대학교 산학협력단 완충용액을 이용한 재조합 단백질 대량생산 방법
CN114573679A (zh) * 2022-03-29 2022-06-03 深圳科兴药业有限公司 分离重组人干扰素α1b异构体的纯化方法
CN114814000A (zh) * 2022-03-30 2022-07-29 深圳科兴药业有限公司 重组人干扰素的含量检测方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5564799A (en) * 1978-11-07 1980-05-15 Toray Ind Inc Multi-stage concentration and purification of interferon originated from human fibroblast
US4289689A (en) * 1980-03-14 1981-09-15 Hoffmann-La Roche Inc. Preparation of homogeneous human fibroblast interferon
US4278661A (en) * 1979-10-12 1981-07-14 E. I. Du Pont De Nemours And Company Purification of interferon
NL7907791A (nl) * 1979-10-23 1981-04-27 Stichting Rega V Z W Werkwijze voor het zuiveren van interferon.
JPS58201794A (ja) * 1982-05-17 1983-11-24 Toray Ind Inc ヒトインターフェロンβの濃縮精製法
US4966843A (en) * 1982-11-01 1990-10-30 Cetus Corporation Expression of interferon genes in Chinese hamster ovary cells
US4483849A (en) * 1983-01-07 1984-11-20 Carter William A Stabilization and purification of interferon with propylene glycol, resulting in a non-toxic product
US4658017A (en) * 1984-02-14 1987-04-14 Health Research, Inc. (Roswell Park Division) Method for the large scale purification of human fibroblast interferon
US4808523A (en) * 1984-11-07 1989-02-28 Yeda Research And Development Co., Ltd. Constitutive production of human IFN-β1 by mammalian cells transformed by the IFN-β1 gene fused to an SV40 early promoter
FR2617763B1 (fr) 1987-07-07 1989-12-01 Essilor Int Procede de fabrication de lentille de contact en un polymere proteique naturel, par moulage avant reticulation
IT1222427B (it) * 1987-07-31 1990-09-05 Sclavo Spa Procedimento per la purificazione di interferone
DE4128319A1 (de) * 1991-08-27 1993-03-04 Bioferon Biochem Substanz Neues rekombinantes human-ifn-beta, verfahren zu dessen herstellung und dieses enthaltende pharmazeutische zubereitungen
EP0551535A1 (en) * 1992-01-13 1993-07-21 SCLAVO S.p.A. Process for the purification of recombinant human beta interferon, beta interferon thus purified, and pharmaceutical compositions which contain them
US7144574B2 (en) 1999-08-27 2006-12-05 Maxygen Aps Interferon β variants and conjugates

Also Published As

Publication number Publication date
US7780960B2 (en) 2010-08-24
EP1697411A1 (en) 2006-09-06
ES2369911T3 (es) 2011-12-09
AU2004295265B2 (en) 2009-01-08
MXPA06006357A (es) 2006-08-23
KR100524871B1 (ko) 2005-10-31
CN1902225A (zh) 2007-01-24
EP1697411A4 (en) 2008-08-27
CA2548160C (en) 2011-06-07
PL1697411T3 (pl) 2011-12-30
EP1697411B1 (en) 2011-08-24
ATE521712T1 (de) 2011-09-15
US20070093649A1 (en) 2007-04-26
JP2007530447A (ja) 2007-11-01
CN100462370C (zh) 2009-02-18
CA2548160A1 (en) 2005-06-16
RU2346003C2 (ru) 2009-02-10
WO2005054288A1 (en) 2005-06-16
RU2006123539A (ru) 2008-01-10
KR20050054209A (ko) 2005-06-10
AU2004295265A1 (en) 2005-06-16

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: CJ CHEILJEDANG CORPORATION (KR)

Free format text: TRANSFERIDO DE: CJ CORPORATION

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.