BRPI0415541B8 - uso de uma molécula inibidora de angiogênese, composição terapêutica para tratametno de câncer, e uso do anticorpo h33, produzido pelo hibridoma 13h33 - Google Patents

uso de uma molécula inibidora de angiogênese, composição terapêutica para tratametno de câncer, e uso do anticorpo h33, produzido pelo hibridoma 13h33

Info

Publication number
BRPI0415541B8
BRPI0415541B8 BRPI0415541A BRPI0415541A BRPI0415541B8 BR PI0415541 B8 BRPI0415541 B8 BR PI0415541B8 BR PI0415541 A BRPI0415541 A BR PI0415541A BR PI0415541 A BRPI0415541 A BR PI0415541A BR PI0415541 B8 BRPI0415541 B8 BR PI0415541B8
Authority
BR
Brazil
Prior art keywords
molecules
angiogenesis
jam
produced
hybridoma
Prior art date
Application number
BRPI0415541A
Other languages
English (en)
Inventor
A Imhof Beat
Aurrand-Lions Michel
Original Assignee
Laboratoires Serono S A
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/738,123 external-priority patent/US7642341B2/en
Application filed by Laboratoires Serono S A, Merck Serono Sa filed Critical Laboratoires Serono S A
Publication of BRPI0415541A publication Critical patent/BRPI0415541A/pt
Publication of BRPI0415541B1 publication Critical patent/BRPI0415541B1/pt
Publication of BRPI0415541B8 publication Critical patent/BRPI0415541B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

molécula inibidora de angiogênese, uso de uma molécula inibidora de angiogênese, composição terapêutica para tratamento de câncer, composição para diagnóstico destinada ao diagnóstico de câncer, uso do anticorpo h33, produzido pelo hibridoma 13h33, fragmento do anticorpo h33 conforme produzido pelo hibridoma 13h33, derivado do anticorpo h33 produzido pelo hibridoma 13h33, e uso de um fragmento ou derivado do anticorpo h33. a presente invenção refere-se a moléculas inibidoras de angiogênese que consistem no anticorpo monoclonal h33 ou fragmentos ou derivados do mesmo, refere-se a seu uso no tratamento de câncer, particularmente no tratamento de tumores sólidos, e refere-se a composições terapêuticas e de diagnóstico que compreendem essas moléculas. a invenção refere-se particularmente a derivados humanizados de h33 ou anticorpos monoclonais humanos possuindo a especificidade do h33.
BRPI0415541A 2003-11-19 2004-11-19 uso de uma molécula inibidora de angiogênese, composição terapêutica para tratametno de câncer, e uso do anticorpo h33, produzido pelo hibridoma 13h33 BRPI0415541B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03026629A EP1533617A1 (en) 2003-11-19 2003-11-19 Angiogenesis inhibiting molecules, their selection, production and their use in the treatment and diagnosis of cancer
US10/738,123 US7642341B2 (en) 2003-12-18 2003-12-18 Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer
PCT/EP2004/013247 WO2005050213A1 (en) 2003-11-19 2004-11-19 Angiogenesis inhibiting molecules and their use in the treatment and diagnosis of cancer

Publications (3)

Publication Number Publication Date
BRPI0415541A BRPI0415541A (pt) 2006-12-26
BRPI0415541B1 BRPI0415541B1 (pt) 2018-11-27
BRPI0415541B8 true BRPI0415541B8 (pt) 2021-05-25

Family

ID=34621557

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415541A BRPI0415541B8 (pt) 2003-11-19 2004-11-19 uso de uma molécula inibidora de angiogênese, composição terapêutica para tratametno de câncer, e uso do anticorpo h33, produzido pelo hibridoma 13h33

Country Status (19)

Country Link
US (1) US7790863B2 (pt)
EP (2) EP1533617A1 (pt)
JP (1) JP2007515159A (pt)
KR (1) KR101135834B1 (pt)
CN (1) CN1890567B (pt)
AT (1) ATE493657T1 (pt)
AU (1) AU2004291989B2 (pt)
BR (1) BRPI0415541B8 (pt)
CA (1) CA2546406C (pt)
DE (1) DE602004030819D1 (pt)
EA (1) EA009037B1 (pt)
ES (1) ES2358905T3 (pt)
HK (1) HK1097908A1 (pt)
IL (1) IL175686A (pt)
MX (1) MXPA06005523A (pt)
NO (1) NO20062793L (pt)
SG (1) SG148190A1 (pt)
WO (1) WO2005050213A1 (pt)
ZA (1) ZA200603069B (pt)

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US7642341B2 (en) 2003-12-18 2010-01-05 Merck Serono S.A. Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer
US8007797B2 (en) 2006-09-28 2011-08-30 Merck Serono S.A. Junctional adhesion molecule-C (JAM-C) binding compounds and methods of their use
EP2626435B1 (en) 2008-03-21 2016-06-01 MDxHealth S.A. Detection and prognosis of cervical cancer
EP2401383B1 (en) 2009-02-27 2013-09-18 Novartis AG Methods for selecting eukaryotic cells expressing a heterologous protein
US9107936B2 (en) 2011-02-02 2015-08-18 Institut National De La Sante Et De La Recherche Medicale (Inserm) Antagonists of GRASP55 for use as a medicament
WO2012160031A1 (en) * 2011-05-24 2012-11-29 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for prognosing solid tumor outcome
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Also Published As

Publication number Publication date
US20070202110A1 (en) 2007-08-30
WO2005050213A1 (en) 2005-06-02
EP1685405B1 (en) 2010-12-29
NO20062793L (no) 2006-08-18
JP2007515159A (ja) 2007-06-14
ES2358905T3 (es) 2011-05-16
CA2546406A1 (en) 2005-06-02
IL175686A0 (en) 2006-09-05
SG148190A1 (en) 2008-12-31
AU2004291989A1 (en) 2005-06-02
CA2546406C (en) 2013-04-09
DE602004030819D1 (de) 2011-02-10
EP1533617A1 (en) 2005-05-25
BRPI0415541B1 (pt) 2018-11-27
CN1890567A (zh) 2007-01-03
HK1097908A1 (en) 2007-07-06
BRPI0415541A (pt) 2006-12-26
EA009037B1 (ru) 2007-10-26
MXPA06005523A (es) 2006-12-14
EP1685405A1 (en) 2006-08-02
KR20060130562A (ko) 2006-12-19
US7790863B2 (en) 2010-09-07
IL175686A (en) 2012-02-29
AU2004291989B2 (en) 2009-08-06
EA200600995A1 (ru) 2006-10-27
KR101135834B1 (ko) 2012-04-16
CN1890567B (zh) 2012-12-12
ATE493657T1 (de) 2011-01-15
ZA200603069B (en) 2007-09-26

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
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Owner name: MERCK SERONO S.A. (CH)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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B09A Decision: intention to grant [chapter 9.1 patent gazette]
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