BRPI0414916A - métodos para a preparação de compostos de sulfonamida de benzoxazol e intermediários dos mesmos - Google Patents
métodos para a preparação de compostos de sulfonamida de benzoxazol e intermediários dos mesmosInfo
- Publication number
- BRPI0414916A BRPI0414916A BRPI0414916-5A BRPI0414916A BRPI0414916A BR PI0414916 A BRPI0414916 A BR PI0414916A BR PI0414916 A BRPI0414916 A BR PI0414916A BR PI0414916 A BRPI0414916 A BR PI0414916A
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- sulfonamide compounds
- benzoxazole sulfonamide
- preparation
- intermediates
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- BBFZKZROAWKUCD-UHFFFAOYSA-N 1,3-benzoxazole-2-sulfonamide Chemical class C1=CC=C2OC(S(=O)(=O)N)=NC2=C1 BBFZKZROAWKUCD-UHFFFAOYSA-N 0.000 title abstract 4
- 239000000543 intermediate Substances 0.000 title abstract 4
- SDCCPSGJFZFNPB-UHFFFAOYSA-N 2-amino-3h-1,3-benzoxazole-2-sulfonamide Chemical class C1=CC=C2OC(N)(S(N)(=O)=O)NC2=C1 SDCCPSGJFZFNPB-UHFFFAOYSA-N 0.000 abstract 1
- CPMVNLAOBJLSFV-UHFFFAOYSA-N 2-sulfanyl-3h-1,3-benzoxazole-2-sulfonamide Chemical compound C1=CC=C2OC(S(=O)(=O)N)(S)NC2=C1 CPMVNLAOBJLSFV-UHFFFAOYSA-N 0.000 abstract 1
- 239000004030 hiv protease inhibitor Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03103630 | 2003-09-30 | ||
| US50799603P | 2003-10-02 | 2003-10-02 | |
| PCT/EP2004/052382 WO2005030739A1 (en) | 2003-09-30 | 2004-09-30 | Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0414916A true BRPI0414916A (pt) | 2006-11-07 |
Family
ID=34395298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0414916-5A BRPI0414916A (pt) | 2003-09-30 | 2004-09-30 | métodos para a preparação de compostos de sulfonamida de benzoxazol e intermediários dos mesmos |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20070123574A1 (https=) |
| EP (1) | EP1670773B1 (https=) |
| JP (1) | JP4919802B2 (https=) |
| KR (1) | KR101090102B1 (https=) |
| CN (1) | CN1860107B (https=) |
| AP (1) | AP1985A (https=) |
| AT (1) | ATE353323T1 (https=) |
| AU (1) | AU2004276017B2 (https=) |
| BR (1) | BRPI0414916A (https=) |
| CA (1) | CA2537877C (https=) |
| DE (1) | DE602004004674T2 (https=) |
| DK (1) | DK1670773T3 (https=) |
| EA (1) | EA011891B1 (https=) |
| ES (1) | ES2281828T3 (https=) |
| IL (1) | IL173891A0 (https=) |
| IN (1) | IN2012DN02301A (https=) |
| MX (1) | MXPA06003575A (https=) |
| NO (1) | NO20061951L (https=) |
| NZ (1) | NZ546279A (https=) |
| PL (1) | PL1670773T3 (https=) |
| PT (1) | PT1670773E (https=) |
| SI (1) | SI1670773T1 (https=) |
| WO (1) | WO2005030739A1 (https=) |
| ZA (1) | ZA200602603B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR053845A1 (es) * | 2005-04-15 | 2007-05-23 | Tibotec Pharm Ltd | 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450 |
| US8575186B2 (en) | 2009-10-05 | 2013-11-05 | Albany Molecular Research, Inc. | Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof |
| AU2012207335A1 (en) | 2011-01-19 | 2013-07-25 | Albany Molecular Research, Inc. | Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia |
| WO2014194519A1 (en) | 2013-06-07 | 2014-12-11 | Merck Sharp & Dohme Corp. | Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968942A (en) * | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| CN1530372A (zh) * | 1995-03-10 | 2004-09-22 | G.D.ɪ����˾ | 杂环羰基氨基酸羟乙氨基磺酰胺逆转录病毒蛋白酶抑制剂 |
| AU7722296A (en) * | 1995-11-15 | 1997-06-05 | G.D. Searle & Co. | Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| EP1208092B1 (en) * | 2000-04-07 | 2006-06-21 | Samsung Electronics Co., Ltd. | Sulfonamide derivative as a matrix metalloproteinase inhibitor |
| US6455738B1 (en) * | 2000-07-13 | 2002-09-24 | Rhodia Chimie | Process for the sulfonation of an aromatic compound |
| ES2275866T3 (es) * | 2001-02-14 | 2007-06-16 | Tibotec Pharmaceuticals Ltd. | 2-(aminosustituido)-benzotiazol-sulfonamidas de amplio esprecto inhibidoras de la proteasa de vih. |
| EA009590B1 (ru) * | 2001-05-11 | 2008-02-28 | Тиботек Фармасьютикалз Лтд. | 2-аминобензоксазолсульфонамидные ингибиторы вич-протеазы широкого спектра |
| TWI286476B (en) * | 2001-12-12 | 2007-09-11 | Tibotec Pharm Ltd | Combination of cytochrome P450 dependent protease inhibitors |
| MY142238A (en) * | 2002-03-12 | 2010-11-15 | Tibotec Pharm Ltd | Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors |
-
2004
- 2004-09-30 JP JP2006530265A patent/JP4919802B2/ja not_active Expired - Fee Related
- 2004-09-30 AU AU2004276017A patent/AU2004276017B2/en not_active Ceased
- 2004-09-30 BR BRPI0414916-5A patent/BRPI0414916A/pt not_active IP Right Cessation
- 2004-09-30 KR KR1020067005992A patent/KR101090102B1/ko not_active Expired - Fee Related
- 2004-09-30 ES ES04766869T patent/ES2281828T3/es not_active Expired - Lifetime
- 2004-09-30 AT AT04766869T patent/ATE353323T1/de active
- 2004-09-30 NZ NZ546279A patent/NZ546279A/en not_active IP Right Cessation
- 2004-09-30 WO PCT/EP2004/052382 patent/WO2005030739A1/en not_active Ceased
- 2004-09-30 AP AP2006003603A patent/AP1985A/xx active
- 2004-09-30 CN CN2004800280971A patent/CN1860107B/zh not_active Expired - Fee Related
- 2004-09-30 IN IN2301DEN2012 patent/IN2012DN02301A/en unknown
- 2004-09-30 CA CA2537877A patent/CA2537877C/en not_active Expired - Fee Related
- 2004-09-30 MX MXPA06003575A patent/MXPA06003575A/es active IP Right Grant
- 2004-09-30 EP EP04766869A patent/EP1670773B1/en not_active Expired - Lifetime
- 2004-09-30 DK DK04766869T patent/DK1670773T3/da active
- 2004-09-30 PT PT04766869T patent/PT1670773E/pt unknown
- 2004-09-30 SI SI200430265T patent/SI1670773T1/sl unknown
- 2004-09-30 PL PL04766869T patent/PL1670773T3/pl unknown
- 2004-09-30 US US10/574,157 patent/US20070123574A1/en not_active Abandoned
- 2004-09-30 EA EA200600699A patent/EA011891B1/ru not_active IP Right Cessation
- 2004-09-30 DE DE602004004674T patent/DE602004004674T2/de not_active Expired - Lifetime
-
2006
- 2006-02-22 IL IL173891A patent/IL173891A0/en not_active IP Right Cessation
- 2006-03-29 ZA ZA200602603A patent/ZA200602603B/xx unknown
- 2006-05-02 NO NO20061951A patent/NO20061951L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1670773A1 (en) | 2006-06-21 |
| CN1860107B (zh) | 2013-08-21 |
| DE602004004674T2 (de) | 2007-11-22 |
| AU2004276017A1 (en) | 2005-04-07 |
| PT1670773E (pt) | 2007-05-31 |
| CA2537877C (en) | 2015-03-17 |
| DE602004004674D1 (de) | 2007-03-22 |
| AU2004276017B2 (en) | 2010-08-19 |
| NZ546279A (en) | 2008-09-26 |
| KR101090102B1 (ko) | 2011-12-07 |
| EA011891B1 (ru) | 2009-06-30 |
| ZA200602603B (en) | 2008-05-28 |
| IL173891A0 (en) | 2006-07-05 |
| ES2281828T3 (es) | 2007-10-01 |
| JP4919802B2 (ja) | 2012-04-18 |
| EA200600699A1 (ru) | 2006-08-25 |
| MXPA06003575A (es) | 2006-06-05 |
| CA2537877A1 (en) | 2005-04-07 |
| AP1985A (en) | 2009-03-30 |
| WO2005030739A1 (en) | 2005-04-07 |
| AP2006003603A0 (en) | 2006-04-30 |
| JP2007507468A (ja) | 2007-03-29 |
| NO20061951L (no) | 2006-05-02 |
| CN1860107A (zh) | 2006-11-08 |
| IN2012DN02301A (https=) | 2015-08-14 |
| SI1670773T1 (sl) | 2007-06-30 |
| EP1670773B1 (en) | 2007-02-07 |
| KR20060092224A (ko) | 2006-08-22 |
| PL1670773T3 (pl) | 2007-06-29 |
| DK1670773T3 (da) | 2007-05-29 |
| ATE353323T1 (de) | 2007-02-15 |
| US20070123574A1 (en) | 2007-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: PARA INT.CL: C07D 263/58, C07D 413/12, C07D 417/12, A61P 31/18 Ipc: C07D 263/58 (2011.01) |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 12A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |