BRPI0413718A - ativadores de plasminogênio tendo uma capacidade reduzida de ligar lisina - Google Patents

ativadores de plasminogênio tendo uma capacidade reduzida de ligar lisina

Info

Publication number
BRPI0413718A
BRPI0413718A BRPI0413718-3A BRPI0413718A BRPI0413718A BR PI0413718 A BRPI0413718 A BR PI0413718A BR PI0413718 A BRPI0413718 A BR PI0413718A BR PI0413718 A BRPI0413718 A BR PI0413718A
Authority
BR
Brazil
Prior art keywords
reduced ability
plasminogen activators
bind lysine
lysine
bind
Prior art date
Application number
BRPI0413718-3A
Other languages
English (en)
Inventor
Wolfgang Soehngen
Oliver Kops
Vincent Ellis
Original Assignee
Paion Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paion Deutschland Gmbh filed Critical Paion Deutschland Gmbh
Publication of BRPI0413718A publication Critical patent/BRPI0413718A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"ATIVADORES DE PLASMINOGêNIO TENDO UMA CAPACIDADE REDUZIDA DE LIGAR LISINA". A presente invenção refere-se ao uso, para o tratamento de doença trombótica, de ativadores de plasminogênio que têm uma capacidade reduzida de ligar lisina.
BRPI0413718-3A 2003-09-12 2004-09-13 ativadores de plasminogênio tendo uma capacidade reduzida de ligar lisina BRPI0413718A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10342518A DE10342518A1 (de) 2003-09-12 2003-09-12 Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
PCT/EP2004/010220 WO2005026341A2 (de) 2003-09-12 2004-09-13 Plasminogen-aktivatoren mit verringerter lysin-bindungskapazität

Publications (1)

Publication Number Publication Date
BRPI0413718A true BRPI0413718A (pt) 2006-10-17

Family

ID=34305758

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413718-3A BRPI0413718A (pt) 2003-09-12 2004-09-13 ativadores de plasminogênio tendo uma capacidade reduzida de ligar lisina

Country Status (14)

Country Link
EP (2) EP2368984A1 (pt)
JP (1) JP2007505079A (pt)
CN (1) CN1849394A (pt)
AU (1) AU2004272731A1 (pt)
BR (1) BRPI0413718A (pt)
CA (1) CA2537696A1 (pt)
DE (1) DE10342518A1 (pt)
EA (2) EA200801861A1 (pt)
IL (1) IL173953A0 (pt)
MX (1) MXPA06002756A (pt)
NO (1) NO20061646L (pt)
NZ (1) NZ545825A (pt)
WO (1) WO2005026341A2 (pt)
ZA (1) ZA200602716B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8430749B2 (en) 2001-08-10 2013-04-30 Igt Dynamic casino tracking and optimization
US7946917B2 (en) 2001-08-10 2011-05-24 Igt Flexible loyalty points programs
DE10153601A1 (de) 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
DE10342518A1 (de) 2003-09-12 2005-05-12 Paion Gmbh Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
IL190184A0 (en) 2008-03-16 2009-02-11 Hadasit Med Res Service tPA MUTANT IN THE TREATMENT OF ACUTE BRAIN INJURY AND NEURODEGENERATIVE DISORDERS

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766075A (en) 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants
IE69054B1 (en) * 1988-07-20 1996-08-07 Schering Ag Vampire bat salivary plasminogen activators
DE3825253A1 (de) * 1988-07-25 1990-02-01 Boehringer Mannheim Gmbh T-pa-derivat und seine herstellung
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
AU642404B2 (en) 1989-02-13 1993-10-21 Schering Aktiengesellschaft Berlin Und Bergkamen Novel thrombolytic
US6008019A (en) 1989-02-13 1999-12-28 Schering Aktiengesellschaft Plasminogen activator from saliva of the vampire bat
JP3696617B2 (ja) * 1991-12-16 2005-09-21 ジェネンテク，インコーポレイテッド フィブリン特異性が改善されたｔ‐ＰＡ置換変異体
DE4423574A1 (de) * 1994-07-05 1996-01-11 Boehringer Mannheim Gmbh Nicht-glykosylierte Plasminogenaktivator-Derivate und ihre Verwendung bei erhöhtem Blutungsrisiko
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
PL1622639T3 (pl) * 2003-05-02 2013-06-28 Lundbeck H As Dożylne wstrzyknięcie nieneurotoksycznych aktywatorów plazminogenu do leczenia udaru mózgu
DE10342518A1 (de) 2003-09-12 2005-05-12 Paion Gmbh Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität

Also Published As

Publication number Publication date
AU2004272731A1 (en) 2005-03-24
JP2007505079A (ja) 2007-03-08
NO20061646L (no) 2006-04-11
ZA200602716B (en) 2007-07-25
EP1664293A2 (de) 2006-06-07
EA200801861A1 (ru) 2010-06-30
NZ545825A (en) 2009-08-28
MXPA06002756A (es) 2007-08-24
CA2537696A1 (en) 2005-03-24
EP2368984A1 (de) 2011-09-28
EA200600573A1 (ru) 2006-08-25
EA011156B1 (ru) 2009-02-27
CN1849394A (zh) 2006-10-18
DE10342518A1 (de) 2005-05-12
WO2005026341A2 (de) 2005-03-24
IL173953A0 (en) 2006-07-05
WO2005026341A3 (de) 2005-09-01

Similar Documents

Publication Publication Date Title
MA29369B1 (fr) Dosage fixe d'anticorps anti-her
BRPI0410503B8 (pt) composição tópica e uso da composição
UA94221C2 (en) Lipocalin protein
BR0211905A (pt) Dialdeìdos de rapamicina
UY29919A1 (es) Derivados sustituidos de 3,4-dihidroisoquinolin-1-amino-trifluoroacetato, sus composiciones farmacéuticas y aplicaciones
ECSP067043A (es) Derivados de pirrolotriazina útiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogénesis
BRPI0316438C1 (pt) uso de eritropoietina em doenças cardíacas
NO20041917L (no) Spesifikke midler som binder humant angiopoietin-2
DK1534335T3 (da) FcgammaRIIB-specifikke antistoffer og fremgangsmåder til anvendelse deraf
BR0211390A (pt) Tratamento de infecções da unha com no
PL1841743T3 (pl) Amidy kwasu 3-arylo-3-hydroksy-2-aminopropionowego, amidy kwasu 3-heteroarylo-3-hydroksy-2-aminopropionowego i powiązane związki o działaniu przeciwbólowym i/lub immunostymulacyjnym
ECSP077401A (es) Medicamentos que contienen compuestos de carbonilo y su uso
ECSP045081A (es) Derivados de 1,8-naftiridina y su uso para el tratamiento de la diabetes y trastornos relacionados
AR050254A1 (es) Intermediarios y procesos para preparar dichos intermediarios utiles en la fabricacion de pirrolotriazinas
BRPI0508051A (pt) derivados de heteroarilaminopirazol utilizáveis para o tratamento de diabetes
BRPI0513237A (pt) hidrolisados de proteìna para diminuição de pressão sanguìnea
CY1105880T1 (el) Χρηση μιας φαρμακευτικης συνθεσεως πepιεχουσης γαλακτικο οξυ ή γαλακτικη ριζα και καλιο για την αγωγη του εγκεφαλικου οιδηματος ή του τραυματισμου του εγκεφαλου
CL2007002384A1 (es) Uso de compuestos derivados de 2,5-dihidroxibenceno para el tratamiento de la psoriasis.
BR0308211A (pt) Cumarinas úteis como biomarcadores
BRPI0518290A2 (pt) processo para a fabricaÇço de um composto alquenil aromÁtico sob baixas condiÇÕes de processo de vapor-para-àleo
ECSP055584A (es) Proceso para la preparación de fibrinógeno
CY1110537T1 (el) Ενωσεις και μεθοδοι για την αγωγη της δυσλιπιδαιμιας
CL2007002380A1 (es) Uso de compuestos derivados de 2,5-dihidroxibenceno para el tratamiento terapeutico y/o profilactico de la queratosis actinica.
BR0107667A (pt) Composto de linezolida em forma de cristal que e farmaceuticamente útil como agente antibacteriano e método de preparação do mesmo
DE50112902D1 (de) Hautreinigungsmittel

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.