BRPI0410647A - derivados de amida de ácido 2,3,4,5-tetrahidrobenzo[f][1,4]oxazepina-5-carboxìlic o, proceso para preparar os mesmos, medicamentos e uso dos referidos derivados - Google Patents
derivados de amida de ácido 2,3,4,5-tetrahidrobenzo[f][1,4]oxazepina-5-carboxìlic o, proceso para preparar os mesmos, medicamentos e uso dos referidos derivadosInfo
- Publication number
- BRPI0410647A BRPI0410647A BRPI0410647-4A BRPI0410647A BRPI0410647A BR PI0410647 A BRPI0410647 A BR PI0410647A BR PI0410647 A BRPI0410647 A BR PI0410647A BR PI0410647 A BRPI0410647 A BR PI0410647A
- Authority
- BR
- Brazil
- Prior art keywords
- derivatives
- lower alkyl
- phenyl
- acid amide
- unsubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"DERIVADOS DE AMIDA DE áCIDO 2,3,4,5-TETRAHIDROBENZO¢F!¢1,4!OXAZEPINA-5-CARBOXìLIC O, PROCESSO PARA PREPARAR OS MESMOS, MEDICAMENTO E USO DOS REFERIDOS DERIVADOS". A presente invenção refere-se a derivados de benzoxazepinona de fórmula (I) em que R¬ 1¬ é hidrogênio, alcóxi inferior, halogênio ou -NR<39>R<39><39>; n é 1 ou 2; R<39>,R<39><39> são de modo independente um do outro hidrogênio ou alquila inferior; R¬ 2¬ é hidrogênio, alquila inferior, -(CH~ 2~)~ m~-cicloalquila, -(CH~ 2~)~ m~-fenila ou -(CH~ 2~)~ m~-O-alquila inferior; m é 0, 1 ou 2; R¬ 3¬ é alquila inferior, -(CH~ 2~)~ m~,-C(O)O-alquila inferior, cicloalquila ou -(CH~ 2~)~ m~-fenila, a qual é não substituída ou substituída por um ou dois substituintes, selecionados do grupo consistindo em halogênio ou alquila inferior; R¬ 4¬ é -(CH~ 2~)~ o~-fenila, o qual é não substituída ou substituída por um ou dois substituintes, selecionados do grupo consistindo em halogênio, trifluorometila, -NR<39>R<39><39>, nitro ou -SO~ 2~NH~ 2~, ou é - cicloalquila, não substituído ou substituída por fenila, ou é - (CR<39>R<39><39>)~ o~-heterociclila, selecionada do grupo definido na reivindicação 1 e o é 1 ou 2; e a sais de adição de ácido farmaceuticamente adequados dos mesmos. Estes compostos são bons inibidores da <sym>-secretase para o tratamento da doença de Alzheimer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03011040 | 2003-05-19 | ||
PCT/EP2004/005177 WO2004100958A1 (en) | 2003-05-19 | 2004-05-14 | 2, 3, 4, 5-tetrahydrobenzo[f][1, 4]oxazepine-5-carboxylic acid amide derivatives as gamma-secretase inhibitors for the treatment of alzheimer’s disease |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0410647A true BRPI0410647A (pt) | 2006-07-04 |
Family
ID=33442730
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0410647-4A BRPI0410647A (pt) | 2003-05-19 | 2004-05-14 | derivados de amida de ácido 2,3,4,5-tetrahidrobenzo[f][1,4]oxazepina-5-carboxìlic o, proceso para preparar os mesmos, medicamentos e uso dos referidos derivados |
Country Status (19)
Country | Link |
---|---|
US (1) | US7060698B2 (pt) |
EP (1) | EP1631296B1 (pt) |
JP (1) | JP4510021B2 (pt) |
KR (1) | KR100731368B1 (pt) |
CN (1) | CN1794997B (pt) |
AR (1) | AR044363A1 (pt) |
AT (1) | ATE360424T1 (pt) |
AU (1) | AU2004238037B2 (pt) |
BR (1) | BRPI0410647A (pt) |
CA (1) | CA2524640C (pt) |
CL (1) | CL2004001068A1 (pt) |
DE (1) | DE602004006118T2 (pt) |
ES (1) | ES2285458T3 (pt) |
MX (1) | MXPA05012368A (pt) |
MY (1) | MY143953A (pt) |
PL (1) | PL1631296T3 (pt) |
RU (1) | RU2332408C2 (pt) |
TW (1) | TWI290550B (pt) |
WO (1) | WO2004100958A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200502221A (en) | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
US7060698B2 (en) * | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
CA2589102C (en) | 2004-11-02 | 2013-08-13 | Northwestern University | Pyridazine compounds and methods for using the compounds to treat inflammatory diseases |
US7211573B2 (en) * | 2004-12-08 | 2007-05-01 | Hoffmann-La Roche Inc. | Malonamide derivatives |
WO2006065218A1 (en) * | 2004-12-14 | 2006-06-22 | Astrazeneca Ab | Novel molecular probes |
RU2318818C1 (ru) * | 2006-04-12 | 2008-03-10 | Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" | Азагетероциклы, комбинаторная библиотека, фокусированная библиотека, фармацевтическая композиция и способ получения (варианты) |
US8855099B2 (en) | 2007-03-19 | 2014-10-07 | Qualcomm Incorporated | Selective phase connection establishment |
FR2913886B1 (fr) | 2007-03-22 | 2012-03-02 | Guerbet Sa | Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer |
JP5275315B2 (ja) * | 2010-10-01 | 2013-08-28 | 学校法人近畿大学 | 新規化合物及びβ−セクレターゼ阻害剤 |
JP2014001142A (ja) * | 2010-10-05 | 2014-01-09 | Astellas Pharma Inc | シクロアルカン化合物 |
CA2818903C (en) * | 2010-12-14 | 2021-03-23 | Electrophoretics Limited | 5-(1,3-benzoxazol-2-yl)-4-(pyridin-4-yl)pyrimidin-2-amine and its use as a casein kinase 1delta inhibitor |
NO3175985T3 (pt) * | 2011-07-01 | 2018-04-28 | ||
WO2019173761A1 (en) | 2018-03-09 | 2019-09-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | C-abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965553A (en) * | 1996-06-20 | 1999-10-12 | Pfizer Inc. | Squalene synthetase inhibitors |
CA2274249A1 (en) * | 1996-12-06 | 1998-06-11 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1.beta. converting enzyme |
PL360243A1 (en) | 2000-06-23 | 2004-09-06 | Takeda Chemical Industries,Ltd | Benzoxazepinones and their use as squalene synthase inhibitors |
JP2002080468A (ja) * | 2000-06-23 | 2002-03-19 | Takeda Chem Ind Ltd | ベンゾオキサゼピン化合物 |
GB0025173D0 (en) | 2000-10-13 | 2000-11-29 | Merck Sharp & Dohme | Therapeutic agents |
US7060798B2 (en) * | 2002-05-13 | 2006-06-13 | State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University | Modified protein adhesives and lignocellulosic composites made from the adhesives |
US7060698B2 (en) * | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
-
2004
- 2004-05-03 US US10/838,054 patent/US7060698B2/en not_active Expired - Fee Related
- 2004-05-13 TW TW093113546A patent/TWI290550B/zh not_active IP Right Cessation
- 2004-05-14 EP EP04732944A patent/EP1631296B1/en not_active Expired - Lifetime
- 2004-05-14 CA CA2524640A patent/CA2524640C/en not_active Expired - Fee Related
- 2004-05-14 RU RU2005139529/04A patent/RU2332408C2/ru not_active IP Right Cessation
- 2004-05-14 AU AU2004238037A patent/AU2004238037B2/en not_active Ceased
- 2004-05-14 PL PL04732944T patent/PL1631296T3/pl unknown
- 2004-05-14 CN CN2004800140158A patent/CN1794997B/zh not_active Expired - Fee Related
- 2004-05-14 WO PCT/EP2004/005177 patent/WO2004100958A1/en active IP Right Grant
- 2004-05-14 AT AT04732944T patent/ATE360424T1/de active
- 2004-05-14 JP JP2006529815A patent/JP4510021B2/ja not_active Expired - Fee Related
- 2004-05-14 ES ES04732944T patent/ES2285458T3/es not_active Expired - Lifetime
- 2004-05-14 DE DE602004006118T patent/DE602004006118T2/de not_active Expired - Lifetime
- 2004-05-14 MX MXPA05012368A patent/MXPA05012368A/es active IP Right Grant
- 2004-05-14 KR KR1020057021910A patent/KR100731368B1/ko not_active IP Right Cessation
- 2004-05-14 BR BRPI0410647-4A patent/BRPI0410647A/pt not_active IP Right Cessation
- 2004-05-17 AR ARP040101685A patent/AR044363A1/es unknown
- 2004-05-17 CL CL200401068A patent/CL2004001068A1/es unknown
- 2004-05-18 MY MYPI20041936A patent/MY143953A/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2007501261A (ja) | 2007-01-25 |
ES2285458T3 (es) | 2007-11-16 |
MY143953A (en) | 2011-07-29 |
CA2524640C (en) | 2011-10-11 |
US20040235819A1 (en) | 2004-11-25 |
WO2004100958A1 (en) | 2004-11-25 |
KR100731368B1 (ko) | 2007-06-21 |
CN1794997A (zh) | 2006-06-28 |
TW200510355A (en) | 2005-03-16 |
RU2005139529A (ru) | 2006-08-10 |
ATE360424T1 (de) | 2007-05-15 |
DE602004006118D1 (de) | 2007-06-06 |
AR044363A1 (es) | 2005-09-07 |
KR20060003107A (ko) | 2006-01-09 |
CN1794997B (zh) | 2010-05-12 |
DE602004006118T2 (de) | 2008-01-03 |
RU2332408C2 (ru) | 2008-08-27 |
CA2524640A1 (en) | 2004-11-25 |
US7060698B2 (en) | 2006-06-13 |
EP1631296A1 (en) | 2006-03-08 |
PL1631296T3 (pl) | 2007-08-31 |
CL2004001068A1 (es) | 2005-04-15 |
TWI290550B (en) | 2007-12-01 |
AU2004238037A1 (en) | 2004-11-25 |
EP1631296B1 (en) | 2007-04-25 |
MXPA05012368A (es) | 2006-02-02 |
AU2004238037B2 (en) | 2009-11-26 |
JP4510021B2 (ja) | 2010-07-21 |
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Legal Events
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014. |