BR9808254A - Compostos, uso e processo para a preparação dos mesmos, composição farmacêutica, e, processo para tratamento da depressão, ansiedade, doença de parkinson, obesidade, desordens cognitivas, doenças repentinas, desordens neurológicas e de neuroproteção para proteger contra condições tais como derrame cerebral em seres humanos. - Google Patents

Compostos, uso e processo para a preparação dos mesmos, composição farmacêutica, e, processo para tratamento da depressão, ansiedade, doença de parkinson, obesidade, desordens cognitivas, doenças repentinas, desordens neurológicas e de neuroproteção para proteger contra condições tais como derrame cerebral em seres humanos.

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Publication number
BR9808254A
BR9808254A BR9808254-0A BR9808254A BR9808254A BR 9808254 A BR9808254 A BR 9808254A BR 9808254 A BR9808254 A BR 9808254A BR 9808254 A BR9808254 A BR 9808254A
Authority
BR
Brazil
Prior art keywords
carbon atoms
compounds
optionally substituted
disorders
anxiety
Prior art date
Application number
BR9808254-0A
Other languages
English (en)
Inventor
Sharon Crawford Cheetham
Frank Kerrigan
Colin Gerhart Pryce Jones
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Publication of BR9808254A publication Critical patent/BR9808254A/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/42Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"COMPOSTOS, USO E PROCESSO PARA A PREPARAçãO DOS MESMOS, COMPOSIçãO FARMACêUTICA, E, PROCESSO PARA TRATAMENTO DA DEPRESSãO, ANSIEDADE, DOENçA DE PARKINSON, OBESIDADE, DESORDENS COGNITIVAS, DOENçAS REPENTINAS, DESORDENS NEUROLóGICAS E DE NEUROPROTEçãO PARA PROTEGER CONTRA CONDIçõES TAIS COMO DERRAME CEREBRAL EM SERES HUMANOS". São descritos compostos de fórmula (I): incluindo seus sais farmaceuticamente aceitáveis na forma de enanciómeros individuais, racematos, ou outras misturas de enanciómeros, em que Ar é fenila, naftila ou benzo[b]tiofenila, cada um dos quais pode ser opcionalmente substituído; R~ 1~ e R~ 2~, que podem ser os mesmos ou diferentes, independentemente são a) H, b) um grupo alquila contendo de 1 a 6 átomos de carbono, c) um grupo alquenila contendo de 3 a 6 átomos de carbono, d) um grupo cicloalquila contendo de 3 a 7 átomos de carbono, e) um grupo cicloalquilmetila em que o anel contém de 3 a 7 átomos de carbono, f) um grupo arila ou heteroarila opcionalmente substituído, g) um grupo arilalquila ou heteroarilalquila cada um opcionalmente substituído; ou R~ 1~ e R~ 2~ formam uma cadeia de alquileno opcionalmente substituída por um ou mais grupos de alquila cada um contendo de 1 a 3 átomos de carbono, tal que, juntamente com os átomos a que eles são ligados, eles formam um anel de 5 ou 6 membros; R~ 3~ é a) H, b) um grupo arila ou heteroarila cada um opcionalmente substituído, c) um grupo arilmetila opcionalmente substituído; ou d) um grupo alcoxialquila contendo de 3 a 6 átomos de carbono; e R~ 4~ e R~ 5~, que podem ser os mesmos ou diferentes, independentemente são um grupo alquila contendo de 1 a 3 átomos de carbono, ou R~ 4~ e R~ 5~ juntamente com o átomo a qual eles são ligados formam um anel ciclo alquila contendo de 3 a 6 átomos de carbono; processos para preparar tais compostos; composições contendo tais compostos e seu uso no tratamento de depressão, ansiedade, doença de Parkinson, obesidade, desordens cognitivas, doenças repentinas, desordens neurológicas e como agentes neuroprotetores.
BR9808254-0A 1997-03-15 1998-03-09 Compostos, uso e processo para a preparação dos mesmos, composição farmacêutica, e, processo para tratamento da depressão, ansiedade, doença de parkinson, obesidade, desordens cognitivas, doenças repentinas, desordens neurológicas e de neuroproteção para proteger contra condições tais como derrame cerebral em seres humanos. BR9808254A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9705428.2A GB9705428D0 (en) 1997-03-15 1997-03-15 Therapeutic agents
PCT/EP1998/001358 WO1998041528A1 (en) 1997-03-15 1998-03-09 Substituted 4-arylmethylene-2-imino-2,3-dihydrothiazoles and derivatives and their pharmaceutical use

Publications (1)

Publication Number Publication Date
BR9808254A true BR9808254A (pt) 2000-05-16

Family

ID=10809320

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9808254-0A BR9808254A (pt) 1997-03-15 1998-03-09 Compostos, uso e processo para a preparação dos mesmos, composição farmacêutica, e, processo para tratamento da depressão, ansiedade, doença de parkinson, obesidade, desordens cognitivas, doenças repentinas, desordens neurológicas e de neuroproteção para proteger contra condições tais como derrame cerebral em seres humanos.

Country Status (22)

Country Link
US (1) US6187802B1 (pt)
EP (1) EP0970090B1 (pt)
JP (1) JP2001515501A (pt)
KR (1) KR20000076190A (pt)
CN (1) CN1255136A (pt)
AT (1) ATE218573T1 (pt)
AU (1) AU6728898A (pt)
BG (1) BG103754A (pt)
BR (1) BR9808254A (pt)
CA (1) CA2283438A1 (pt)
DE (1) DE69805781D1 (pt)
GB (1) GB9705428D0 (pt)
HU (1) HUP0001508A3 (pt)
ID (1) ID22636A (pt)
IL (1) IL131515A0 (pt)
NO (1) NO994452L (pt)
NZ (1) NZ337378A (pt)
PL (1) PL335696A1 (pt)
SK (1) SK122099A3 (pt)
TR (1) TR199902291T2 (pt)
WO (1) WO1998041528A1 (pt)
ZA (1) ZA982134B (pt)

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WO2000056321A1 (en) 1999-03-19 2000-09-28 Knoll Pharmaceutical Company Treatment of hyperactivity disorders
US6365632B1 (en) 1999-03-19 2002-04-02 Knoll Pharmaceuticals Company Treatment of orthostatic hypotension
AU3895300A (en) 1999-03-19 2000-10-09 Knoll Pharmaceutical Company Treatment of chronic fatigue syndrome
AU3895400A (en) 1999-03-19 2000-10-09 Knoll Pharmaceutical Company Control of metabolism
EP1162964A1 (en) 1999-03-19 2001-12-19 Knoll GmbH Treatment of pulmonary hypertension
AU3894500A (en) 1999-03-19 2000-10-09 Knoll Pharmaceutical Company Prevention of cardiovascular disease
WO2000056309A1 (en) 1999-03-19 2000-09-28 Knoll Pharmaceutical Company Method of treating sexual dysfunction
US6803387B1 (en) 1999-03-19 2004-10-12 Abbott Gmbh & Co. Kg Treatment of neuropathic pain or fibromyalgia
GB9911863D0 (en) * 1999-05-21 1999-07-21 Knoll Ag Therapeutic agents
GB9911881D0 (en) * 1999-05-21 1999-07-21 Knoll Ag Therapeutic agents
FR2796643B1 (fr) * 1999-07-22 2005-04-29 Sod Conseils Rech Applic Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique
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US9512096B2 (en) 2011-12-22 2016-12-06 Knopp Biosciences, LLP Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
ES2858500T3 (es) 2013-07-12 2021-09-30 Knopp Biosciences Llc Tratamiento de niveles elevados de eosinófilos y/o basófilos
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HUE055850T2 (hu) 2013-08-13 2022-01-28 Knopp Biosciences Llc Készítmények és módszerek a krónikus urticaria (csalánkiütés) kezelésére
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Also Published As

Publication number Publication date
CN1255136A (zh) 2000-05-31
AU6728898A (en) 1998-10-12
GB9705428D0 (en) 1997-04-30
TR199902291T2 (xx) 1999-12-21
SK122099A3 (en) 2000-05-16
KR20000076190A (ko) 2000-12-26
ID22636A (id) 1999-12-02
JP2001515501A (ja) 2001-09-18
DE69805781D1 (de) 2002-07-11
NZ337378A (en) 2001-01-26
HUP0001508A2 (hu) 2001-01-29
CA2283438A1 (en) 1998-09-24
PL335696A1 (en) 2000-05-08
NO994452D0 (no) 1999-09-14
ATE218573T1 (de) 2002-06-15
US6187802B1 (en) 2001-02-13
BG103754A (bg) 2000-06-30
IL131515A0 (en) 2001-01-28
HUP0001508A3 (en) 2003-01-28
ZA982134B (en) 1999-09-13
NO994452L (no) 1999-09-14
EP0970090B1 (en) 2002-06-05
WO1998041528A1 (en) 1998-09-24
EP0970090A1 (en) 2000-01-12

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