BR9808254A - Compostos, uso e processo para a preparação dos mesmos, composição farmacêutica, e, processo para tratamento da depressão, ansiedade, doença de parkinson, obesidade, desordens cognitivas, doenças repentinas, desordens neurológicas e de neuroproteção para proteger contra condições tais como derrame cerebral em seres humanos. - Google Patents
Compostos, uso e processo para a preparação dos mesmos, composição farmacêutica, e, processo para tratamento da depressão, ansiedade, doença de parkinson, obesidade, desordens cognitivas, doenças repentinas, desordens neurológicas e de neuroproteção para proteger contra condições tais como derrame cerebral em seres humanos.Info
- Publication number
- BR9808254A BR9808254A BR9808254-0A BR9808254A BR9808254A BR 9808254 A BR9808254 A BR 9808254A BR 9808254 A BR9808254 A BR 9808254A BR 9808254 A BR9808254 A BR 9808254A
- Authority
- BR
- Brazil
- Prior art keywords
- carbon atoms
- compounds
- optionally substituted
- disorders
- anxiety
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 208000019901 Anxiety disease Diseases 0.000 title abstract 3
- 208000008589 Obesity Diseases 0.000 title abstract 3
- 208000018737 Parkinson disease Diseases 0.000 title abstract 3
- 230000036506 anxiety Effects 0.000 title abstract 3
- 208000010877 cognitive disease Diseases 0.000 title abstract 3
- 235000020824 obesity Nutrition 0.000 title abstract 3
- 241000282414 Homo sapiens Species 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000000926 neurological effect Effects 0.000 title 1
- 230000000324 neuroprotective effect Effects 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 238000011282 treatment Methods 0.000 abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- 208000020401 Depressive disease Diseases 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005002 aryl methyl group Chemical group 0.000 abstract 1
- -1 benzo [b] thiophenyl Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000004090 neuroprotective agent Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"COMPOSTOS, USO E PROCESSO PARA A PREPARAçãO DOS MESMOS, COMPOSIçãO FARMACêUTICA, E, PROCESSO PARA TRATAMENTO DA DEPRESSãO, ANSIEDADE, DOENçA DE PARKINSON, OBESIDADE, DESORDENS COGNITIVAS, DOENçAS REPENTINAS, DESORDENS NEUROLóGICAS E DE NEUROPROTEçãO PARA PROTEGER CONTRA CONDIçõES TAIS COMO DERRAME CEREBRAL EM SERES HUMANOS". São descritos compostos de fórmula (I): incluindo seus sais farmaceuticamente aceitáveis na forma de enanciómeros individuais, racematos, ou outras misturas de enanciómeros, em que Ar é fenila, naftila ou benzo[b]tiofenila, cada um dos quais pode ser opcionalmente substituído; R~ 1~ e R~ 2~, que podem ser os mesmos ou diferentes, independentemente são a) H, b) um grupo alquila contendo de 1 a 6 átomos de carbono, c) um grupo alquenila contendo de 3 a 6 átomos de carbono, d) um grupo cicloalquila contendo de 3 a 7 átomos de carbono, e) um grupo cicloalquilmetila em que o anel contém de 3 a 7 átomos de carbono, f) um grupo arila ou heteroarila opcionalmente substituído, g) um grupo arilalquila ou heteroarilalquila cada um opcionalmente substituído; ou R~ 1~ e R~ 2~ formam uma cadeia de alquileno opcionalmente substituída por um ou mais grupos de alquila cada um contendo de 1 a 3 átomos de carbono, tal que, juntamente com os átomos a que eles são ligados, eles formam um anel de 5 ou 6 membros; R~ 3~ é a) H, b) um grupo arila ou heteroarila cada um opcionalmente substituído, c) um grupo arilmetila opcionalmente substituído; ou d) um grupo alcoxialquila contendo de 3 a 6 átomos de carbono; e R~ 4~ e R~ 5~, que podem ser os mesmos ou diferentes, independentemente são um grupo alquila contendo de 1 a 3 átomos de carbono, ou R~ 4~ e R~ 5~ juntamente com o átomo a qual eles são ligados formam um anel ciclo alquila contendo de 3 a 6 átomos de carbono; processos para preparar tais compostos; composições contendo tais compostos e seu uso no tratamento de depressão, ansiedade, doença de Parkinson, obesidade, desordens cognitivas, doenças repentinas, desordens neurológicas e como agentes neuroprotetores.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9705428.2A GB9705428D0 (en) | 1997-03-15 | 1997-03-15 | Therapeutic agents |
| PCT/EP1998/001358 WO1998041528A1 (en) | 1997-03-15 | 1998-03-09 | Substituted 4-arylmethylene-2-imino-2,3-dihydrothiazoles and derivatives and their pharmaceutical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9808254A true BR9808254A (pt) | 2000-05-16 |
Family
ID=10809320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9808254-0A BR9808254A (pt) | 1997-03-15 | 1998-03-09 | Compostos, uso e processo para a preparação dos mesmos, composição farmacêutica, e, processo para tratamento da depressão, ansiedade, doença de parkinson, obesidade, desordens cognitivas, doenças repentinas, desordens neurológicas e de neuroproteção para proteger contra condições tais como derrame cerebral em seres humanos. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6187802B1 (pt) |
| EP (1) | EP0970090B1 (pt) |
| JP (1) | JP2001515501A (pt) |
| KR (1) | KR20000076190A (pt) |
| CN (1) | CN1255136A (pt) |
| AT (1) | ATE218573T1 (pt) |
| AU (1) | AU6728898A (pt) |
| BG (1) | BG103754A (pt) |
| BR (1) | BR9808254A (pt) |
| CA (1) | CA2283438A1 (pt) |
| DE (1) | DE69805781D1 (pt) |
| GB (1) | GB9705428D0 (pt) |
| HU (1) | HUP0001508A3 (pt) |
| ID (1) | ID22636A (pt) |
| IL (1) | IL131515A0 (pt) |
| NO (1) | NO994452D0 (pt) |
| NZ (1) | NZ337378A (pt) |
| PL (1) | PL335696A1 (pt) |
| SK (1) | SK122099A3 (pt) |
| TR (1) | TR199902291T2 (pt) |
| WO (1) | WO1998041528A1 (pt) |
| ZA (1) | ZA982134B (pt) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19856965A1 (de) * | 1998-12-10 | 2000-06-15 | Bayer Ag | Substituierte 2-Imino-thiazoline |
| WO2000056308A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Prevention of cardiovascular disease |
| AU3760600A (en) | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Treatment of orthostatic hypotension |
| US6803387B1 (en) | 1999-03-19 | 2004-10-12 | Abbott Gmbh & Co. Kg | Treatment of neuropathic pain or fibromyalgia |
| JP2002539250A (ja) | 1999-03-19 | 2002-11-19 | クノール・ゲー・エム・ベー・ハー | 肺高血圧症の治療 |
| US6441046B1 (en) | 1999-03-19 | 2002-08-27 | Abbott Gmbh & Co. Kg | Control of metabolism |
| AU3899100A (en) | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Treatment of hyperactivity disorders |
| US6376554B1 (en) | 1999-03-19 | 2002-04-23 | Knoll Pharmaceutical Company | Method of treating sexual dysfunction |
| US6376551B1 (en) | 1999-03-19 | 2002-04-23 | Knoll Pharmaceutical Company | Treatment of chronic fatigue syndrome |
| GB9911881D0 (en) * | 1999-05-21 | 1999-07-21 | Knoll Ag | Therapeutic agents |
| GB9911863D0 (en) * | 1999-05-21 | 1999-07-21 | Knoll Ag | Therapeutic agents |
| FR2796643B1 (fr) * | 1999-07-22 | 2005-04-29 | Sod Conseils Rech Applic | Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique |
| GB0005789D0 (en) | 2000-03-11 | 2000-05-03 | Knoll Ag | Therapeutic agents |
| US6699866B2 (en) | 2001-04-17 | 2004-03-02 | Sepracor Inc. | Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof |
| US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
| PT1453505E (pt) * | 2001-12-11 | 2010-12-16 | Univ Virginia | Utilização de pramipexol para tratamento da esclerose lateral amiotrófica |
| US6743797B2 (en) * | 2002-02-22 | 2004-06-01 | Chantest, Inc. | Methods for treating cardiac arrhythmia |
| US20050054010A1 (en) * | 2003-07-15 | 2005-03-10 | Brown Arthur M. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
| US7211407B2 (en) * | 2003-07-15 | 2007-05-01 | Chan Test, Inc. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
| US20050208595A1 (en) * | 2004-03-19 | 2005-09-22 | Brown Arthur M | High throughput assay systems and methods for identifying agents that alter expression of cellular proteins |
| EP1917014B1 (en) * | 2005-08-15 | 2009-10-07 | University Of Virginia Patent Foundation | Neurorestoration with r(+) pramipexole |
| NZ569630A (en) * | 2006-01-06 | 2011-09-30 | Sepracor Inc | Cycloalkylamines as monoamine reuptake inhibitors |
| KR100752757B1 (ko) * | 2006-04-05 | 2007-08-29 | 한국과학기술연구원 | 2-페닐이미노-1,3-티아졸린을 포함하는 미백 조성물 |
| US20070259930A1 (en) * | 2006-04-10 | 2007-11-08 | Knopp Neurosciences, Inc. | Compositions and methods of using r(+) pramipexole |
| US8518926B2 (en) * | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| WO2007137071A2 (en) | 2006-05-16 | 2007-11-29 | Knopp Neurosciences, Inc. | Compositions of r(+) and s(-) pramipexole and methods of using the same |
| US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| CN101715443A (zh) | 2007-03-14 | 2010-05-26 | 诺普神经科学股份有限公司 | 手性纯化的取代的苯并噻唑二胺的合成 |
| US20110190356A1 (en) * | 2008-08-19 | 2011-08-04 | Knopp Neurosciences Inc. | Compositions and Methods of Using (R)- Pramipexole |
| KR101049935B1 (ko) * | 2008-12-03 | 2011-07-15 | 한국과학기술연구원 | 신규한 티아졸린계 화합물 및 이를 포함하는 ｔ-형 칼슘 채널 저해제 |
| JP2012530723A (ja) * | 2009-06-19 | 2012-12-06 | ノップ ニューロサイエンシーズ、インク． | 筋萎縮性側索硬化症を治療するための組成物及び方法 |
| WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| US10828284B2 (en) | 2013-07-12 | 2020-11-10 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| CA2921378A1 (en) | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
| AU2014306597B2 (en) | 2013-08-13 | 2018-05-17 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4347248A (en) | 1981-03-23 | 1982-08-31 | American Cyanamid Company | 2,3-Disubstituted-thiazolo[3,2-a]pyrimidines |
| US5232921A (en) | 1987-03-12 | 1993-08-03 | Sanofi | Thiazole derivatives active on the cholinergic system, process for obtention and pharmaceutical compositions |
| FR2612187B1 (fr) * | 1987-03-12 | 1989-07-21 | Sanofi Sa | Derives du thiazole actifs sur le systeme cholinergique, leur procede de preparation et compositions pharmaceutiques en contenant |
| US5463069A (en) | 1992-12-04 | 1995-10-31 | Sumitomo Chemical Company, Limited | Process of producing 2-iminothiazoline derivatives and process of producing their intermediates |
| US5521145A (en) | 1994-04-04 | 1996-05-28 | Sumitomo Chemical Company, Ltd. | Iminothiazoline derivatives and herbicides containing them as active ingredients |
| GB9513467D0 (en) * | 1995-07-01 | 1995-09-06 | Knoll Ag | Therapeutic agents |
-
1997
- 1997-03-15 GB GBGB9705428.2A patent/GB9705428D0/en active Pending
-
1998
- 1998-03-09 EP EP98912459A patent/EP0970090B1/en not_active Expired - Lifetime
- 1998-03-09 HU HU0001508A patent/HUP0001508A3/hu unknown
- 1998-03-09 PL PL98335696A patent/PL335696A1/xx unknown
- 1998-03-09 NZ NZ337378A patent/NZ337378A/xx unknown
- 1998-03-09 CA CA002283438A patent/CA2283438A1/en not_active Abandoned
- 1998-03-09 AT AT98912459T patent/ATE218573T1/de not_active IP Right Cessation
- 1998-03-09 WO PCT/EP1998/001358 patent/WO1998041528A1/en not_active Application Discontinuation
- 1998-03-09 KR KR1019997008284A patent/KR20000076190A/ko not_active Application Discontinuation
- 1998-03-09 US US09/380,967 patent/US6187802B1/en not_active Expired - Fee Related
- 1998-03-09 IL IL13151598A patent/IL131515A0/xx unknown
- 1998-03-09 DE DE69805781T patent/DE69805781D1/de not_active Expired - Lifetime
- 1998-03-09 JP JP54009198A patent/JP2001515501A/ja active Pending
- 1998-03-09 BR BR9808254-0A patent/BR9808254A/pt not_active IP Right Cessation
- 1998-03-09 TR TR1999/02291T patent/TR199902291T2/xx unknown
- 1998-03-09 AU AU67288/98A patent/AU6728898A/en not_active Abandoned
- 1998-03-09 ID IDW991023A patent/ID22636A/id unknown
- 1998-03-09 SK SK1220-99A patent/SK122099A3/sk unknown
- 1998-03-09 CN CN98804891A patent/CN1255136A/zh active Pending
- 1998-03-13 ZA ZA9802134A patent/ZA982134B/xx unknown
-
1999
- 1999-09-14 NO NO994452A patent/NO994452D0/no unknown
- 1999-09-24 BG BG103754A patent/BG103754A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU6728898A (en) | 1998-10-12 |
| JP2001515501A (ja) | 2001-09-18 |
| GB9705428D0 (en) | 1997-04-30 |
| WO1998041528A1 (en) | 1998-09-24 |
| DE69805781D1 (de) | 2002-07-11 |
| IL131515A0 (en) | 2001-01-28 |
| ZA982134B (en) | 1999-09-13 |
| KR20000076190A (ko) | 2000-12-26 |
| NO994452L (no) | 1999-09-14 |
| ATE218573T1 (de) | 2002-06-15 |
| CN1255136A (zh) | 2000-05-31 |
| HUP0001508A3 (en) | 2003-01-28 |
| CA2283438A1 (en) | 1998-09-24 |
| BG103754A (bg) | 2000-06-30 |
| EP0970090B1 (en) | 2002-06-05 |
| SK122099A3 (en) | 2000-05-16 |
| US6187802B1 (en) | 2001-02-13 |
| ID22636A (id) | 1999-12-02 |
| TR199902291T2 (xx) | 1999-12-21 |
| EP0970090A1 (en) | 2000-01-12 |
| PL335696A1 (en) | 2000-05-08 |
| NZ337378A (en) | 2001-01-26 |
| HUP0001508A2 (hu) | 2001-01-29 |
| NO994452D0 (no) | 1999-09-14 |
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