DE69805781D1 - Substituierte 4-arylmethylene-2-imino-2,3-dihydrothiazolen, ihre derivaten, und ihre pharmazeutische verwendung - Google Patents
Substituierte 4-arylmethylene-2-imino-2,3-dihydrothiazolen, ihre derivaten, und ihre pharmazeutische verwendungInfo
- Publication number
- DE69805781D1 DE69805781D1 DE69805781T DE69805781T DE69805781D1 DE 69805781 D1 DE69805781 D1 DE 69805781D1 DE 69805781 T DE69805781 T DE 69805781T DE 69805781 T DE69805781 T DE 69805781T DE 69805781 D1 DE69805781 D1 DE 69805781D1
- Authority
- DE
- Germany
- Prior art keywords
- carbon atoms
- optionally substituted
- group
- group containing
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000005002 aryl methyl group Chemical group 0.000 abstract 1
- -1 benzo[b]thiophenyl Chemical group 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000004090 neuroprotective agent Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9705428.2A GB9705428D0 (en) | 1997-03-15 | 1997-03-15 | Therapeutic agents |
| PCT/EP1998/001358 WO1998041528A1 (en) | 1997-03-15 | 1998-03-09 | Substituted 4-arylmethylene-2-imino-2,3-dihydrothiazoles and derivatives and their pharmaceutical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69805781D1 true DE69805781D1 (de) | 2002-07-11 |
Family
ID=10809320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69805781T Expired - Lifetime DE69805781D1 (de) | 1997-03-15 | 1998-03-09 | Substituierte 4-arylmethylene-2-imino-2,3-dihydrothiazolen, ihre derivaten, und ihre pharmazeutische verwendung |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6187802B1 (de) |
| EP (1) | EP0970090B1 (de) |
| JP (1) | JP2001515501A (de) |
| KR (1) | KR20000076190A (de) |
| CN (1) | CN1255136A (de) |
| AT (1) | ATE218573T1 (de) |
| AU (1) | AU6728898A (de) |
| BG (1) | BG103754A (de) |
| BR (1) | BR9808254A (de) |
| CA (1) | CA2283438A1 (de) |
| DE (1) | DE69805781D1 (de) |
| GB (1) | GB9705428D0 (de) |
| HU (1) | HUP0001508A3 (de) |
| ID (1) | ID22636A (de) |
| IL (1) | IL131515A0 (de) |
| NO (1) | NO994452D0 (de) |
| NZ (1) | NZ337378A (de) |
| PL (1) | PL335696A1 (de) |
| SK (1) | SK122099A3 (de) |
| TR (1) | TR199902291T2 (de) |
| WO (1) | WO1998041528A1 (de) |
| ZA (1) | ZA982134B (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19856965A1 (de) * | 1998-12-10 | 2000-06-15 | Bayer Ag | Substituierte 2-Imino-thiazoline |
| US6803387B1 (en) | 1999-03-19 | 2004-10-12 | Abbott Gmbh & Co. Kg | Treatment of neuropathic pain or fibromyalgia |
| US6365632B1 (en) | 1999-03-19 | 2002-04-02 | Knoll Pharmaceuticals Company | Treatment of orthostatic hypotension |
| AU3894500A (en) | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Prevention of cardiovascular disease |
| AU3757200A (en) | 1999-03-19 | 2000-10-09 | Knoll Gmbh | Treatment of pulmonary hypertension |
| WO2000056310A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Treatment of chronic fatigue syndrome |
| WO2000056309A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Method of treating sexual dysfunction |
| WO2000056321A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Treatment of hyperactivity disorders |
| AU3895400A (en) | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Control of metabolism |
| GB9911881D0 (en) * | 1999-05-21 | 1999-07-21 | Knoll Ag | Therapeutic agents |
| GB9911863D0 (en) * | 1999-05-21 | 1999-07-21 | Knoll Ag | Therapeutic agents |
| FR2796643B1 (fr) * | 1999-07-22 | 2005-04-29 | Sod Conseils Rech Applic | Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique |
| GB0005789D0 (en) * | 2000-03-11 | 2000-05-03 | Knoll Ag | Therapeutic agents |
| AU2002314744A1 (en) | 2001-04-17 | 2002-10-28 | Sepracor, Inc. | Thiazole and other heterocyclic ligands and use thereof |
| IL162408A0 (en) * | 2001-12-11 | 2005-11-20 | Univ Virginia | Use of pramipexole to treat amyotrophic lateral scelrosis |
| US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
| US6743797B2 (en) | 2002-02-22 | 2004-06-01 | Chantest, Inc. | Methods for treating cardiac arrhythmia |
| US7211407B2 (en) * | 2003-07-15 | 2007-05-01 | Chan Test, Inc. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
| US20050054010A1 (en) * | 2003-07-15 | 2005-03-10 | Brown Arthur M. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
| US20050208595A1 (en) * | 2004-03-19 | 2005-09-22 | Brown Arthur M | High throughput assay systems and methods for identifying agents that alter expression of cellular proteins |
| ES2334061T3 (es) * | 2005-08-15 | 2010-03-04 | University Of Virginia Patent Foundation | Neurorrestauracion con pramipexol r(+). |
| RU2430913C2 (ru) * | 2006-01-06 | 2011-10-10 | Сепракор Инк. | Циклоалкиламины в качестве ингибиторов повторного поглощения моноамина |
| KR100752757B1 (ko) * | 2006-04-05 | 2007-08-29 | 한국과학기술연구원 | 2-페닐이미노-1,3-티아졸린을 포함하는 미백 조성물 |
| WO2007121188A2 (en) * | 2006-04-10 | 2007-10-25 | Knopp Neurosciences, Inc. | Compositions and methods of using r(+) pramipexole |
| US8518926B2 (en) * | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| PL2026803T3 (pl) | 2006-05-16 | 2012-05-31 | Knopp Neurosciences Inc | Kompozycje R(+) i S(-) pramipeksolu i sposoby ich zastosowania |
| US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| CA2681110A1 (en) | 2007-03-14 | 2008-09-18 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
| CN102186350A (zh) * | 2008-08-19 | 2011-09-14 | 诺普神经科学股份有限公司 | 使用(r)-普拉克索的组合物与方法 |
| KR101049935B1 (ko) * | 2008-12-03 | 2011-07-15 | 한국과학기술연구원 | 신규한 티아졸린계 화합물 및 이를 포함하는 ｔ-형 칼슘 채널 저해제 |
| AU2010262970A1 (en) * | 2009-06-19 | 2012-01-12 | Knopp Neurosciences, Inc. | Compositions and methods for treating amyotrophic lateral sclerosis |
| US9512096B2 (en) | 2011-12-22 | 2016-12-06 | Knopp Biosciences, LLP | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| ES2858500T3 (es) | 2013-07-12 | 2021-09-30 | Knopp Biosciences Llc | Tratamiento de niveles elevados de eosinófilos y/o basófilos |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| WO2015023786A1 (en) | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
| AU2014306597B2 (en) | 2013-08-13 | 2018-05-17 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4347248A (en) * | 1981-03-23 | 1982-08-31 | American Cyanamid Company | 2,3-Disubstituted-thiazolo[3,2-a]pyrimidines |
| FR2612187B1 (fr) * | 1987-03-12 | 1989-07-21 | Sanofi Sa | Derives du thiazole actifs sur le systeme cholinergique, leur procede de preparation et compositions pharmaceutiques en contenant |
| US5232921A (en) * | 1987-03-12 | 1993-08-03 | Sanofi | Thiazole derivatives active on the cholinergic system, process for obtention and pharmaceutical compositions |
| US5463069A (en) * | 1992-12-04 | 1995-10-31 | Sumitomo Chemical Company, Limited | Process of producing 2-iminothiazoline derivatives and process of producing their intermediates |
| US5521145A (en) * | 1994-04-04 | 1996-05-28 | Sumitomo Chemical Company, Ltd. | Iminothiazoline derivatives and herbicides containing them as active ingredients |
| GB9513467D0 (en) | 1995-07-01 | 1995-09-06 | Knoll Ag | Therapeutic agents |
-
1997
- 1997-03-15 GB GBGB9705428.2A patent/GB9705428D0/en active Pending
-
1998
- 1998-03-09 SK SK1220-99A patent/SK122099A3/sk unknown
- 1998-03-09 WO PCT/EP1998/001358 patent/WO1998041528A1/en not_active Application Discontinuation
- 1998-03-09 ID IDW991023A patent/ID22636A/id unknown
- 1998-03-09 AU AU67288/98A patent/AU6728898A/en not_active Abandoned
- 1998-03-09 NZ NZ337378A patent/NZ337378A/xx unknown
- 1998-03-09 US US09/380,967 patent/US6187802B1/en not_active Expired - Fee Related
- 1998-03-09 DE DE69805781T patent/DE69805781D1/de not_active Expired - Lifetime
- 1998-03-09 AT AT98912459T patent/ATE218573T1/de not_active IP Right Cessation
- 1998-03-09 BR BR9808254-0A patent/BR9808254A/pt not_active IP Right Cessation
- 1998-03-09 KR KR1019997008284A patent/KR20000076190A/ko not_active Application Discontinuation
- 1998-03-09 PL PL98335696A patent/PL335696A1/xx unknown
- 1998-03-09 CA CA002283438A patent/CA2283438A1/en not_active Abandoned
- 1998-03-09 TR TR1999/02291T patent/TR199902291T2/xx unknown
- 1998-03-09 CN CN98804891A patent/CN1255136A/zh active Pending
- 1998-03-09 HU HU0001508A patent/HUP0001508A3/hu unknown
- 1998-03-09 JP JP54009198A patent/JP2001515501A/ja active Pending
- 1998-03-09 IL IL13151598A patent/IL131515A0/xx unknown
- 1998-03-09 EP EP98912459A patent/EP0970090B1/de not_active Expired - Lifetime
- 1998-03-13 ZA ZA9802134A patent/ZA982134B/xx unknown
-
1999
- 1999-09-14 NO NO994452A patent/NO994452D0/no unknown
- 1999-09-24 BG BG103754A patent/BG103754A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK122099A3 (en) | 2000-05-16 |
| TR199902291T2 (xx) | 1999-12-21 |
| PL335696A1 (en) | 2000-05-08 |
| WO1998041528A1 (en) | 1998-09-24 |
| BG103754A (bg) | 2000-06-30 |
| EP0970090B1 (de) | 2002-06-05 |
| ATE218573T1 (de) | 2002-06-15 |
| KR20000076190A (ko) | 2000-12-26 |
| JP2001515501A (ja) | 2001-09-18 |
| ZA982134B (en) | 1999-09-13 |
| HUP0001508A3 (en) | 2003-01-28 |
| AU6728898A (en) | 1998-10-12 |
| BR9808254A (pt) | 2000-05-16 |
| NZ337378A (en) | 2001-01-26 |
| HUP0001508A2 (hu) | 2001-01-29 |
| EP0970090A1 (de) | 2000-01-12 |
| NO994452L (no) | 1999-09-14 |
| CA2283438A1 (en) | 1998-09-24 |
| CN1255136A (zh) | 2000-05-31 |
| NO994452D0 (no) | 1999-09-14 |
| US6187802B1 (en) | 2001-02-13 |
| ID22636A (id) | 1999-12-02 |
| IL131515A0 (en) | 2001-01-28 |
| GB9705428D0 (en) | 1997-04-30 |
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