ATE218573T1 - Substituierte 4-arylmethylene-2-imino-2,3- dihydrothiazolen, ihre derivaten, und ihre pharmazeutische verwendung - Google Patents
Substituierte 4-arylmethylene-2-imino-2,3- dihydrothiazolen, ihre derivaten, und ihre pharmazeutische verwendungInfo
- Publication number
- ATE218573T1 ATE218573T1 AT98912459T AT98912459T ATE218573T1 AT E218573 T1 ATE218573 T1 AT E218573T1 AT 98912459 T AT98912459 T AT 98912459T AT 98912459 T AT98912459 T AT 98912459T AT E218573 T1 ATE218573 T1 AT E218573T1
- Authority
- AT
- Austria
- Prior art keywords
- carbon atoms
- optionally substituted
- group
- group containing
- compounds
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000005002 aryl methyl group Chemical group 0.000 abstract 1
- -1 benzo[b]thiophenyl Chemical group 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000004090 neuroprotective agent Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9705428.2A GB9705428D0 (en) | 1997-03-15 | 1997-03-15 | Therapeutic agents |
| PCT/EP1998/001358 WO1998041528A1 (en) | 1997-03-15 | 1998-03-09 | Substituted 4-arylmethylene-2-imino-2,3-dihydrothiazoles and derivatives and their pharmaceutical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE218573T1 true ATE218573T1 (de) | 2002-06-15 |
Family
ID=10809320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98912459T ATE218573T1 (de) | 1997-03-15 | 1998-03-09 | Substituierte 4-arylmethylene-2-imino-2,3- dihydrothiazolen, ihre derivaten, und ihre pharmazeutische verwendung |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6187802B1 (de) |
| EP (1) | EP0970090B1 (de) |
| JP (1) | JP2001515501A (de) |
| KR (1) | KR20000076190A (de) |
| CN (1) | CN1255136A (de) |
| AT (1) | ATE218573T1 (de) |
| AU (1) | AU6728898A (de) |
| BG (1) | BG103754A (de) |
| BR (1) | BR9808254A (de) |
| CA (1) | CA2283438A1 (de) |
| DE (1) | DE69805781D1 (de) |
| GB (1) | GB9705428D0 (de) |
| HU (1) | HUP0001508A3 (de) |
| ID (1) | ID22636A (de) |
| IL (1) | IL131515A0 (de) |
| NO (1) | NO994452L (de) |
| NZ (1) | NZ337378A (de) |
| PL (1) | PL335696A1 (de) |
| SK (1) | SK122099A3 (de) |
| TR (1) | TR199902291T2 (de) |
| WO (1) | WO1998041528A1 (de) |
| ZA (1) | ZA982134B (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19856965A1 (de) * | 1998-12-10 | 2000-06-15 | Bayer Ag | Substituierte 2-Imino-thiazoline |
| WO2000056310A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Treatment of chronic fatigue syndrome |
| WO2000056319A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Treatment of orthostatic hypotension |
| WO2000056308A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Prevention of cardiovascular disease |
| WO2000056309A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Method of treating sexual dysfunction |
| WO2000056311A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Control of metabolism |
| AU3899100A (en) | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Treatment of hyperactivity disorders |
| AU3757200A (en) | 1999-03-19 | 2000-10-09 | Knoll Gmbh | Treatment of pulmonary hypertension |
| US6803387B1 (en) | 1999-03-19 | 2004-10-12 | Abbott Gmbh & Co. Kg | Treatment of neuropathic pain or fibromyalgia |
| GB9911863D0 (en) * | 1999-05-21 | 1999-07-21 | Knoll Ag | Therapeutic agents |
| GB9911881D0 (en) * | 1999-05-21 | 1999-07-21 | Knoll Ag | Therapeutic agents |
| FR2796643B1 (fr) * | 1999-07-22 | 2005-04-29 | Sod Conseils Rech Applic | Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique |
| GB0005789D0 (en) * | 2000-03-11 | 2000-05-03 | Knoll Ag | Therapeutic agents |
| WO2002083863A2 (en) | 2001-04-17 | 2002-10-24 | Sepracor, Inc. | Thiazole and other heterocyclic ligands and use thereof |
| US7157480B2 (en) * | 2001-12-11 | 2007-01-02 | University Of Virginia Patent Foundation | Use of pramipexole to treat amyotrophic lateral sclerosis |
| US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
| US6743797B2 (en) * | 2002-02-22 | 2004-06-01 | Chantest, Inc. | Methods for treating cardiac arrhythmia |
| US20050054010A1 (en) * | 2003-07-15 | 2005-03-10 | Brown Arthur M. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
| US7211407B2 (en) * | 2003-07-15 | 2007-05-01 | Chan Test, Inc. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
| US20050208595A1 (en) * | 2004-03-19 | 2005-09-22 | Brown Arthur M | High throughput assay systems and methods for identifying agents that alter expression of cellular proteins |
| JP2009504748A (ja) * | 2005-08-15 | 2009-02-05 | ユニバーシティ オブ バージニア パテント ファウンデーション | Ｒ（＋）プラミペキソールを用いた神経回復 |
| CA2636324C (en) * | 2006-01-06 | 2012-03-20 | Sepracor Inc. | Cycloalkylamines as monoamine reuptake inhibitors |
| KR100752757B1 (ko) * | 2006-04-05 | 2007-08-29 | 한국과학기술연구원 | 2-페닐이미노-1,3-티아졸린을 포함하는 미백 조성물 |
| US20070259930A1 (en) * | 2006-04-10 | 2007-11-08 | Knopp Neurosciences, Inc. | Compositions and methods of using r(+) pramipexole |
| US8518926B2 (en) * | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| DK2026803T3 (da) * | 2006-05-16 | 2012-04-16 | Knopp Neurosciences Inc | Sammensætninger af R(+) og S(-) pramipexol og fremgangsmåder til anvendelse heraf |
| US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| AU2008224844B2 (en) * | 2007-03-14 | 2012-08-09 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
| JP2012500283A (ja) | 2008-08-19 | 2012-01-05 | ノップ ニューロサイエンシーズ、インク． | （ｒ）−プラミペキソールを使用した組成物並びにその方法 |
| KR101049935B1 (ko) * | 2008-12-03 | 2011-07-15 | 한국과학기술연구원 | 신규한 티아졸린계 화합물 및 이를 포함하는 ｔ-형 칼슘 채널 저해제 |
| EP2442655A4 (de) * | 2009-06-19 | 2013-04-03 | Knopp Neurosciences Inc | Zusammensetzungen und verfahren zur behandlung von amyotropher lateralsklerose (als) |
| WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| SI3838271T1 (sl) | 2013-07-12 | 2025-12-31 | Areteia Therapeutics, Inc. | Zdravljenje povišanih ravni eozinofilcev in/ali bazofilcev |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| PT3033081T (pt) | 2013-08-13 | 2021-06-01 | Knopp Biosciences Llc | Composições e métodos para o tratamento da urticária crónica |
| AU2014306683B2 (en) | 2013-08-13 | 2017-10-12 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4347248A (en) | 1981-03-23 | 1982-08-31 | American Cyanamid Company | 2,3-Disubstituted-thiazolo[3,2-a]pyrimidines |
| FR2612187B1 (fr) * | 1987-03-12 | 1989-07-21 | Sanofi Sa | Derives du thiazole actifs sur le systeme cholinergique, leur procede de preparation et compositions pharmaceutiques en contenant |
| US5232921A (en) | 1987-03-12 | 1993-08-03 | Sanofi | Thiazole derivatives active on the cholinergic system, process for obtention and pharmaceutical compositions |
| DE69305828T2 (de) | 1992-12-04 | 1997-06-12 | Sumitomo Chemical Co., Ltd., Osaka | Verfahren zur Herstellung von 2-Iminothiazolin-Derivaten und Verfahren zur Herstellung ihrer Zwischenprodukte |
| CN1113242A (zh) | 1994-04-04 | 1995-12-13 | 住友化学工业株式会社 | 亚氨基噻唑啉衍生物及含有它们作为活性成分的除草剂 |
| GB9513467D0 (en) | 1995-07-01 | 1995-09-06 | Knoll Ag | Therapeutic agents |
-
1997
- 1997-03-15 GB GBGB9705428.2A patent/GB9705428D0/en active Pending
-
1998
- 1998-03-09 CN CN98804891A patent/CN1255136A/zh active Pending
- 1998-03-09 PL PL98335696A patent/PL335696A1/xx unknown
- 1998-03-09 SK SK1220-99A patent/SK122099A3/sk unknown
- 1998-03-09 AU AU67288/98A patent/AU6728898A/en not_active Abandoned
- 1998-03-09 WO PCT/EP1998/001358 patent/WO1998041528A1/en not_active Ceased
- 1998-03-09 IL IL13151598A patent/IL131515A0/xx unknown
- 1998-03-09 JP JP54009198A patent/JP2001515501A/ja active Pending
- 1998-03-09 TR TR1999/02291T patent/TR199902291T2/xx unknown
- 1998-03-09 NZ NZ337378A patent/NZ337378A/xx unknown
- 1998-03-09 EP EP98912459A patent/EP0970090B1/de not_active Expired - Lifetime
- 1998-03-09 BR BR9808254-0A patent/BR9808254A/pt not_active IP Right Cessation
- 1998-03-09 AT AT98912459T patent/ATE218573T1/de not_active IP Right Cessation
- 1998-03-09 US US09/380,967 patent/US6187802B1/en not_active Expired - Fee Related
- 1998-03-09 ID IDW991023A patent/ID22636A/id unknown
- 1998-03-09 HU HU0001508A patent/HUP0001508A3/hu unknown
- 1998-03-09 DE DE69805781T patent/DE69805781D1/de not_active Expired - Lifetime
- 1998-03-09 CA CA002283438A patent/CA2283438A1/en not_active Abandoned
- 1998-03-09 KR KR1019997008284A patent/KR20000076190A/ko not_active Withdrawn
- 1998-03-13 ZA ZA9802134A patent/ZA982134B/xx unknown
-
1999
- 1999-09-14 NO NO994452A patent/NO994452L/no unknown
- 1999-09-24 BG BG103754A patent/BG103754A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0970090A1 (de) | 2000-01-12 |
| SK122099A3 (en) | 2000-05-16 |
| CN1255136A (zh) | 2000-05-31 |
| KR20000076190A (ko) | 2000-12-26 |
| WO1998041528A1 (en) | 1998-09-24 |
| HUP0001508A2 (hu) | 2001-01-29 |
| US6187802B1 (en) | 2001-02-13 |
| NO994452D0 (no) | 1999-09-14 |
| CA2283438A1 (en) | 1998-09-24 |
| PL335696A1 (en) | 2000-05-08 |
| BG103754A (bg) | 2000-06-30 |
| JP2001515501A (ja) | 2001-09-18 |
| AU6728898A (en) | 1998-10-12 |
| EP0970090B1 (de) | 2002-06-05 |
| BR9808254A (pt) | 2000-05-16 |
| TR199902291T2 (xx) | 1999-12-21 |
| ID22636A (id) | 1999-12-02 |
| GB9705428D0 (en) | 1997-04-30 |
| IL131515A0 (en) | 2001-01-28 |
| NO994452L (no) | 1999-09-14 |
| NZ337378A (en) | 2001-01-26 |
| HUP0001508A3 (en) | 2003-01-28 |
| ZA982134B (en) | 1999-09-13 |
| DE69805781D1 (de) | 2002-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69805781D1 (de) | Substituierte 4-arylmethylene-2-imino-2,3-dihydrothiazolen, ihre derivaten, und ihre pharmazeutische verwendung | |
| BG104561A (en) | Aryl fused azapolycyclic compounds | |
| NZ338016A (en) | Novel 2-(iminomethyl)amino-phenyl derivatives, preparation, application as medicines and pharmaceutical compositions containing same | |
| ATE160341T1 (de) | Benzolsulfonamid-derivate und verfahren zur herstellung | |
| HUP0302167A2 (hu) | Metabotropikus glutamát receptor antagonista hatású kinolinszármazékok, a vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra | |
| GEP20022676B (en) | 4-Phenyl-Pyridine Derivatives, Method for Their Production and Their Use for Treatment of Disorders Caused by Antagonist of NK-1 Receptors | |
| DE69819891D1 (de) | Spiro chinuclidin-derivate, ihre herstellung und verwendung | |
| CA2269994A1 (en) | 7-hetero-bicyclo¬2.2.1|-heptanes | |
| NZ516599A (en) | 2-arylimino-2,3-dihydrothiazoles, and their use thereof as somatostatin receptor ligands | |
| DE69505968D1 (de) | Azolidindion-derivate und ihre anwendung als antihyperglykämika | |
| DE69316067D1 (de) | Arzneimittel zur Verwendung bei der Behandlung von Parkinsonismus | |
| IL158343A (en) | Dopamine glycoconjugate compounds, pharmaceutical compositions comprising them, processes for their preparation and use thereof in the manufacture of medicaments and as medicaments for treating parkinson's disease | |
| MY133474A (en) | Aryl fused azapolycyclic compounds | |
| CA2316388A1 (en) | Tetrahydrobenzindole derivative | |
| MY110773A (en) | 1-arylcycloalky1 sulphides, sulphoxides and sulphones, processes for their preparation, and their use in the treatment of depression, anxiety and parkinson''s disease. | |
| DE69837334D1 (de) | Heterozyclische verbindungen, ihr herstellungsverfahren und diese enthaltende pharmazeutische zusammensetzungen | |
| WO1999021848A3 (en) | Novel 1-(n'-(arylalkylaminoalkyl))aminoisoindoles; a new class of dopamine receptor subtype specific ligands | |
| HUP9904594A2 (hu) | Piperazinoszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| DE68911006D1 (de) | Pharmakologisch-aktive Alkylthiobenzimidazol-Derivate und Verfahren zu deren Herstellung. | |
| MX9703671A (es) | Compuesto de aminometil arilo y ligandos selectivos del subtipo de receptor de la dopamina. | |
| DE69624459D1 (de) | Kondensierte indan-derivate und ihre salze | |
| DE69626624D1 (de) | Medikamente gegen trhombocytopenie | |
| ATE311182T1 (de) | Benzopyranderivate zur behandlung von perihperer gefässerkrankung | |
| ATE108444T1 (de) | 3-isoxazolonderivate, ihre herstellung und ihre anwendung in der therapeutik. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |