BRPI0410269A - derivados de fenoxazinona como substratos de enzima e uso dos mesmos como indicador na detecção de microorganismos com atividade peptidase - Google Patents

derivados de fenoxazinona como substratos de enzima e uso dos mesmos como indicador na detecção de microorganismos com atividade peptidase

Info

Publication number
BRPI0410269A
BRPI0410269A BRPI0410269-0A BRPI0410269A BRPI0410269A BR PI0410269 A BRPI0410269 A BR PI0410269A BR PI0410269 A BRPI0410269 A BR PI0410269A BR PI0410269 A BRPI0410269 A BR PI0410269A
Authority
BR
Brazil
Prior art keywords
ring
sulfo
halo
alkyl
hydrogen
Prior art date
Application number
BRPI0410269-0A
Other languages
English (en)
Inventor
Arthur James
John Perry
Annette Rigby
Stephen Stanforth
Original Assignee
Biomerieux Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomerieux Sa filed Critical Biomerieux Sa
Publication of BRPI0410269A publication Critical patent/BRPI0410269A/pt
Publication of BRPI0410269B1 publication Critical patent/BRPI0410269B1/pt
Publication of BRPI0410269B8 publication Critical patent/BRPI0410269B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/38—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

"DERIVADOS DE FENOXAZINONA COMO SUBSTRATOS DE ENZIMA E USO DOS MESMOS COMO INDICADOR NA DETECçãO DE MICROORGANISMOS COM ATIVIDADE PEPTIDASE". A presente invenção refere-se a novos substratos enzimáticos com a seguinte fórmula geral: onde R~ 1~, R~ 2~, R~ 3~, R~ 4~, R~ 5~,R~ 6~, A e X são como definidos na reivindicação 1, os meios de reação compreendendo os mesmos e uso dos mesmos para detecção e/ou identificação e/ou quantificação de microorganismos expressando pelo menos uma atividade peptidase.
BRPI0410269A 2003-05-13 2004-05-13 substrato enzimático cromogênico, uso do mesmo, meio de cultura e/ou revelação, processo para a detecção e/ou identificação e/ou quantificação de microorganismos expressando pelo menos uma atividade peptidase, processo para diferenciação, entre bactérias, entre aquelas pertencendo a micróbios gram-positivos ou gram-negativos e processo para diferenciação de levedura BRPI0410269B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0305719 2003-05-13
FR0305719A FR2854893B1 (fr) 2003-05-13 2003-05-13 Nouveaux substrats enzymatiques derives de phenoxazinone et leur utilisation comme revelateur dans la detection de microorganismes a activite peptidase
PCT/FR2004/050193 WO2004101536A1 (fr) 2003-05-13 2004-05-13 Nouveaux substrats enzymatiques derives de phenoxazinone et leur utilisation comme revelateur dans la detection de microorganismes a activite peptidase

Publications (3)

Publication Number Publication Date
BRPI0410269A true BRPI0410269A (pt) 2006-05-16
BRPI0410269B1 BRPI0410269B1 (pt) 2015-06-09
BRPI0410269B8 BRPI0410269B8 (pt) 2021-07-27

Family

ID=33306314

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410269A BRPI0410269B8 (pt) 2003-05-13 2004-05-13 substrato enzimático cromogênico, uso do mesmo, meio de cultura e/ou revelação, processo para a detecção e/ou identificação e/ou quantificação de microorganismos expressando pelo menos uma atividade peptidase, processo para diferenciação, entre bactérias, entre aquelas pertencendo a micróbios gram-positivos ou gram-negativos e processo para diferenciação de levedura

Country Status (10)

Country Link
US (2) US7420054B2 (pt)
EP (1) EP1625117B1 (pt)
JP (1) JP4515456B2 (pt)
CN (1) CN100372841C (pt)
AT (1) ATE383350T1 (pt)
BR (1) BRPI0410269B8 (pt)
DE (1) DE602004011210T2 (pt)
ES (1) ES2298788T3 (pt)
FR (1) FR2854893B1 (pt)
WO (1) WO2004101536A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2854893B1 (fr) * 2003-05-13 2006-07-07 Biomerieux Sa Nouveaux substrats enzymatiques derives de phenoxazinone et leur utilisation comme revelateur dans la detection de microorganismes a activite peptidase
FR2875242B1 (fr) * 2004-09-10 2006-11-17 Biomerieux Sa Nouveaux substrats enzymatiques derives de phenoxazinone et leur utilisation comme revelateur dans la detection de microorganismes a activite peptidase
FR2897874B1 (fr) * 2006-02-28 2013-11-15 Biomerieux Sa Procede pour l'identification d'au moins deux groupes de microorganismes
CN103820373B (zh) * 2014-03-19 2017-06-20 中国检验检疫科学研究院 用于分离和检测阴沟肠杆菌的显色培养基
CN109608414B (zh) * 2018-12-26 2020-09-29 山东师范大学 检测过氧亚硝酸根的荧光探针及其制备方法和应用
CN114773329B (zh) * 2022-04-15 2023-04-14 山东第一医科大学(山东省医学科学院) 吩噁嗪酮吡啶鎓盐类化合物及其制备方法和应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3411574A1 (de) * 1984-03-29 1985-10-10 Boehringer Mannheim Gmbh, 6800 Mannheim Glycoside von resorufin-derivaten, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der aktivitaet von glycosidasen
DE3629175A1 (de) * 1986-08-28 1988-03-17 Behringwerke Ag Chromogene verbindungen, verfahren zu deren herstellung und ihre verwendung
DE3644401A1 (de) * 1986-12-24 1988-07-07 Boehringer Mannheim Gmbh Neue hydrolase-substrate
FR2653447B1 (fr) * 1989-10-20 1991-12-27 Bio Merieux Procede et reactifs pour la detection de micro-organismes.
FR2659982B1 (fr) * 1990-03-23 1995-10-20 Serbio Utilisation de substrats chromogenes dans la determination de candida.
FR2671561B1 (fr) * 1991-01-16 1993-03-26 Bio Merieux Procede et milieu d'identification de bacteries du genre listeria.
FR2713240B1 (fr) 1993-12-02 1996-03-01 Bio Merieux Milieu nutritif pour la culture de microorganismes.
FR2751663B1 (fr) 1996-07-29 1998-10-02 Bio Merieux Procede de mise en evidence d'une activite enzymatique de microorganismes
US6235493B1 (en) * 1997-08-06 2001-05-22 The Regents Of The University Of California Amino acid substituted-cresyl violet, synthetic fluorogenic substrates for the analysis of agents in individual in vivo cells or tissue
FR2767535B1 (fr) 1997-08-20 2000-02-04 Bio Merieux Milieux de culture et d'identification specifique de differentes especes de candida et procedes d'analyse
FR2774097B1 (fr) 1998-01-28 2000-09-29 Bio Merieux Utilisation de derives d'indolamine dans la detection d'une activite de peptidase ou dans la detection de micro-organismes
JP4414515B2 (ja) * 1999-08-30 2010-02-10 三菱化学メディエンス株式会社 微生物の鑑別方法
FR2801903B1 (fr) * 1999-12-06 2004-01-30 Biomerieux Sa Nouveaux substrats enzymatiques pour la detection de pseudomonas aeruginosa, compositions les contenant et procede de detection de cette espece
JP2002010799A (ja) * 2000-06-29 2002-01-15 Kikkoman Corp 細菌検査培地
FR2854893B1 (fr) * 2003-05-13 2006-07-07 Biomerieux Sa Nouveaux substrats enzymatiques derives de phenoxazinone et leur utilisation comme revelateur dans la detection de microorganismes a activite peptidase

Also Published As

Publication number Publication date
CN100372841C (zh) 2008-03-05
US20080286820A1 (en) 2008-11-20
US7420054B2 (en) 2008-09-02
FR2854893B1 (fr) 2006-07-07
BRPI0410269B8 (pt) 2021-07-27
US20060121551A1 (en) 2006-06-08
EP1625117B1 (fr) 2008-01-09
ATE383350T1 (de) 2008-01-15
DE602004011210D1 (de) 2008-02-21
EP1625117A1 (fr) 2006-02-15
CN1788005A (zh) 2006-06-14
ES2298788T3 (es) 2008-05-16
BRPI0410269B1 (pt) 2015-06-09
JP2007501018A (ja) 2007-01-25
US7695930B2 (en) 2010-04-13
WO2004101536A1 (fr) 2004-11-25
DE602004011210T2 (de) 2009-02-12
FR2854893A1 (fr) 2004-11-19
JP4515456B2 (ja) 2010-07-28

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/06/2015, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/05/2004, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 19A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2722 DE 07-03-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.