DE602004011210D1 - Neue phenoxazinonderivate als enzymsubstrate und deren verwendung als indikator beim nachweis von mikroorganismen mit peptidaseaktivität - Google Patents
Neue phenoxazinonderivate als enzymsubstrate und deren verwendung als indikator beim nachweis von mikroorganismen mit peptidaseaktivitätInfo
- Publication number
- DE602004011210D1 DE602004011210D1 DE602004011210T DE602004011210T DE602004011210D1 DE 602004011210 D1 DE602004011210 D1 DE 602004011210D1 DE 602004011210 T DE602004011210 T DE 602004011210T DE 602004011210 T DE602004011210 T DE 602004011210T DE 602004011210 D1 DE602004011210 D1 DE 602004011210D1
- Authority
- DE
- Germany
- Prior art keywords
- ring
- sulfo
- halo
- alkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 5
- 108090000790 Enzymes Proteins 0.000 title abstract 5
- 239000000758 substrate Substances 0.000 title abstract 4
- 230000000694 effects Effects 0.000 title abstract 3
- 102000035195 Peptidases Human genes 0.000 title abstract 2
- 108091005804 Peptidases Proteins 0.000 title abstract 2
- 244000005700 microbiome Species 0.000 title abstract 2
- 235000019833 protease Nutrition 0.000 title abstract 2
- TZMSYXZUNZXBOL-UHFFFAOYSA-N 10H-phenoxazine Chemical class C1=CC=C2NC3=CC=CC=C3OC2=C1 TZMSYXZUNZXBOL-UHFFFAOYSA-N 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 4
- 125000000332 coumarinyl group Chemical class O1C(=O)C(=CC2=CC=CC=C12)* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- QQEDYUHGZYMULN-UHFFFAOYSA-N 10h-phenoxazin-3-amine Chemical class C1=CC=C2OC3=CC(N)=CC=C3NC2=C1 QQEDYUHGZYMULN-UHFFFAOYSA-N 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 229940124530 sulfonamide Drugs 0.000 abstract 2
- 150000003456 sulfonamides Chemical class 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 abstract 1
- 240000002355 Celtis tournefortii var. glabrata Species 0.000 abstract 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- -1 bromo, chloro, benzoyl Chemical group 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 229960000956 coumarin Drugs 0.000 abstract 1
- 235000001671 coumarin Nutrition 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/38—[b, e]-condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0305719 | 2003-05-13 | ||
| FR0305719A FR2854893B1 (fr) | 2003-05-13 | 2003-05-13 | Nouveaux substrats enzymatiques derives de phenoxazinone et leur utilisation comme revelateur dans la detection de microorganismes a activite peptidase |
| PCT/FR2004/050193 WO2004101536A1 (fr) | 2003-05-13 | 2004-05-13 | Nouveaux substrats enzymatiques derives de phenoxazinone et leur utilisation comme revelateur dans la detection de microorganismes a activite peptidase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004011210D1 true DE602004011210D1 (de) | 2008-02-21 |
| DE602004011210T2 DE602004011210T2 (de) | 2009-02-12 |
Family
ID=33306314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004011210T Expired - Lifetime DE602004011210T2 (de) | 2003-05-13 | 2004-05-13 | Neue phenoxazinonderivate als enzymsubstrate und deren verwendung als indikator beim nachweis von mikroorganismen mit peptidaseaktivität |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7420054B2 (de) |
| EP (1) | EP1625117B1 (de) |
| JP (1) | JP4515456B2 (de) |
| CN (1) | CN100372841C (de) |
| AT (1) | ATE383350T1 (de) |
| BR (1) | BRPI0410269B8 (de) |
| DE (1) | DE602004011210T2 (de) |
| ES (1) | ES2298788T3 (de) |
| FR (1) | FR2854893B1 (de) |
| WO (1) | WO2004101536A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2854893B1 (fr) * | 2003-05-13 | 2006-07-07 | Biomerieux Sa | Nouveaux substrats enzymatiques derives de phenoxazinone et leur utilisation comme revelateur dans la detection de microorganismes a activite peptidase |
| FR2875242B1 (fr) * | 2004-09-10 | 2006-11-17 | Biomerieux Sa | Nouveaux substrats enzymatiques derives de phenoxazinone et leur utilisation comme revelateur dans la detection de microorganismes a activite peptidase |
| FR2897874B1 (fr) * | 2006-02-28 | 2013-11-15 | Biomerieux Sa | Procede pour l'identification d'au moins deux groupes de microorganismes |
| CN103820373B (zh) * | 2014-03-19 | 2017-06-20 | 中国检验检疫科学研究院 | 用于分离和检测阴沟肠杆菌的显色培养基 |
| CN109608414B (zh) * | 2018-12-26 | 2020-09-29 | 山东师范大学 | 检测过氧亚硝酸根的荧光探针及其制备方法和应用 |
| CN114773329B (zh) * | 2022-04-15 | 2023-04-14 | 山东第一医科大学(山东省医学科学院) | 吩噁嗪酮吡啶鎓盐类化合物及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3411574A1 (de) * | 1984-03-29 | 1985-10-10 | Boehringer Mannheim Gmbh, 6800 Mannheim | Glycoside von resorufin-derivaten, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der aktivitaet von glycosidasen |
| DE3629175A1 (de) * | 1986-08-28 | 1988-03-17 | Behringwerke Ag | Chromogene verbindungen, verfahren zu deren herstellung und ihre verwendung |
| DE3644401A1 (de) * | 1986-12-24 | 1988-07-07 | Boehringer Mannheim Gmbh | Neue hydrolase-substrate |
| FR2653447B1 (fr) * | 1989-10-20 | 1991-12-27 | Bio Merieux | Procede et reactifs pour la detection de micro-organismes. |
| FR2659982B1 (fr) * | 1990-03-23 | 1995-10-20 | Serbio | Utilisation de substrats chromogenes dans la determination de candida. |
| FR2671561B1 (fr) * | 1991-01-16 | 1993-03-26 | Bio Merieux | Procede et milieu d'identification de bacteries du genre listeria. |
| FR2713240B1 (fr) | 1993-12-02 | 1996-03-01 | Bio Merieux | Milieu nutritif pour la culture de microorganismes. |
| FR2751663B1 (fr) | 1996-07-29 | 1998-10-02 | Bio Merieux | Procede de mise en evidence d'une activite enzymatique de microorganismes |
| US6235493B1 (en) * | 1997-08-06 | 2001-05-22 | The Regents Of The University Of California | Amino acid substituted-cresyl violet, synthetic fluorogenic substrates for the analysis of agents in individual in vivo cells or tissue |
| FR2767535B1 (fr) | 1997-08-20 | 2000-02-04 | Bio Merieux | Milieux de culture et d'identification specifique de differentes especes de candida et procedes d'analyse |
| FR2774097B1 (fr) | 1998-01-28 | 2000-09-29 | Bio Merieux | Utilisation de derives d'indolamine dans la detection d'une activite de peptidase ou dans la detection de micro-organismes |
| JP4414515B2 (ja) * | 1999-08-30 | 2010-02-10 | 三菱化学メディエンス株式会社 | 微生物の鑑別方法 |
| FR2801903B1 (fr) * | 1999-12-06 | 2004-01-30 | Biomerieux Sa | Nouveaux substrats enzymatiques pour la detection de pseudomonas aeruginosa, compositions les contenant et procede de detection de cette espece |
| JP2002010799A (ja) * | 2000-06-29 | 2002-01-15 | Kikkoman Corp | 細菌検査培地 |
| FR2854893B1 (fr) * | 2003-05-13 | 2006-07-07 | Biomerieux Sa | Nouveaux substrats enzymatiques derives de phenoxazinone et leur utilisation comme revelateur dans la detection de microorganismes a activite peptidase |
-
2003
- 2003-05-13 FR FR0305719A patent/FR2854893B1/fr not_active Expired - Fee Related
-
2004
- 2004-05-13 EP EP04760775A patent/EP1625117B1/de not_active Expired - Lifetime
- 2004-05-13 AT AT04760775T patent/ATE383350T1/de not_active IP Right Cessation
- 2004-05-13 US US10/554,461 patent/US7420054B2/en active Active
- 2004-05-13 CN CNB2004800128762A patent/CN100372841C/zh not_active Expired - Fee Related
- 2004-05-13 ES ES04760775T patent/ES2298788T3/es not_active Expired - Lifetime
- 2004-05-13 WO PCT/FR2004/050193 patent/WO2004101536A1/fr active IP Right Grant
- 2004-05-13 DE DE602004011210T patent/DE602004011210T2/de not_active Expired - Lifetime
- 2004-05-13 JP JP2006530437A patent/JP4515456B2/ja not_active Expired - Fee Related
- 2004-05-13 BR BRPI0410269A patent/BRPI0410269B8/pt not_active IP Right Cessation
-
2008
- 2008-07-22 US US12/219,422 patent/US7695930B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN100372841C (zh) | 2008-03-05 |
| US20080286820A1 (en) | 2008-11-20 |
| US7420054B2 (en) | 2008-09-02 |
| FR2854893B1 (fr) | 2006-07-07 |
| BRPI0410269B8 (pt) | 2021-07-27 |
| US20060121551A1 (en) | 2006-06-08 |
| EP1625117B1 (de) | 2008-01-09 |
| ATE383350T1 (de) | 2008-01-15 |
| BRPI0410269A (pt) | 2006-05-16 |
| EP1625117A1 (de) | 2006-02-15 |
| CN1788005A (zh) | 2006-06-14 |
| ES2298788T3 (es) | 2008-05-16 |
| BRPI0410269B1 (pt) | 2015-06-09 |
| JP2007501018A (ja) | 2007-01-25 |
| US7695930B2 (en) | 2010-04-13 |
| WO2004101536A1 (fr) | 2004-11-25 |
| DE602004011210T2 (de) | 2009-02-12 |
| FR2854893A1 (fr) | 2004-11-19 |
| JP4515456B2 (ja) | 2010-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |