BRPI0408613A - revestimento antifúngico de unhas e método de uso - Google Patents

revestimento antifúngico de unhas e método de uso

Info

Publication number
BRPI0408613A
BRPI0408613A BRPI0408613-9A BRPI0408613A BRPI0408613A BR PI0408613 A BRPI0408613 A BR PI0408613A BR PI0408613 A BRPI0408613 A BR PI0408613A BR PI0408613 A BRPI0408613 A BR PI0408613A
Authority
BR
Brazil
Prior art keywords
fungicidal
composition
coat
amount
antifungal
Prior art date
Application number
BRPI0408613-9A
Other languages
English (en)
Inventor
Stanley W Kepka
Y Joseph Mo
Hang-Yong Wang
Mingqi Lu
William R Pfister
Original Assignee
Nexmed Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexmed Holdings Inc filed Critical Nexmed Holdings Inc
Publication of BRPI0408613A publication Critical patent/BRPI0408613A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A61Q3/02—Nail coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/806—Drug, bio-affecting and body treating compositions involving IgM
    • Y10S424/807—Monoclonal
    • Y10S424/808—Human

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

"REVESTIMENTO ANTIFúNGICO DE UNHAS E MéTODO DE USO". A presente invenção refere-se a uma composição antifúngica de revestimento de unhas de ação dupla e método de uso para melhorar ou prevenir a infecção fúngica nas unhas, e onicomicose, particularmente. As modalidades da composição na forma de um tipo de um revestimento e um tipo de dois revestimentos apropriados para regimes fungicidas diários são descritas. Uma composição antifúngica de revestimento de unhas preferida compreende uma quantidade fungicida eficaz de um agente antifúngico, uma quantidade melhoradora de permeação de um melhorador de permeação substancialmente não volátil, uma quantidade formadora de película de um polímero hidrofílico, e um veículo sólido farmaceuticamente aceitável. A composição provê um revestimento fungicida substancialmente solúvel em água em contato com uma unha infectada ou susceptível fungicamente.
BRPI0408613-9A 2003-03-21 2004-03-22 revestimento antifúngico de unhas e método de uso BRPI0408613A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45668403P 2003-03-21 2003-03-21
PCT/US2004/008618 WO2004084826A2 (en) 2003-03-21 2004-03-22 Antifungal nail coat and method of use

Publications (1)

Publication Number Publication Date
BRPI0408613A true BRPI0408613A (pt) 2006-03-07

Family

ID=33098141

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408613-9A BRPI0408613A (pt) 2003-03-21 2004-03-22 revestimento antifúngico de unhas e método de uso

Country Status (28)

Country Link
US (3) US7462362B2 (pt)
EP (2) EP2106805B1 (pt)
JP (1) JP4540667B2 (pt)
KR (1) KR101093990B1 (pt)
CN (2) CN102973420A (pt)
AT (2) ATE432087T1 (pt)
AU (1) AU2004224326B2 (pt)
BR (1) BRPI0408613A (pt)
CA (1) CA2519705C (pt)
CO (1) CO5640092A2 (pt)
CY (1) CY1111773T1 (pt)
DE (1) DE602004021253D1 (pt)
DK (2) DK1635770T3 (pt)
EC (1) ECSP056110A (pt)
ES (1) ES2366273T3 (pt)
HR (1) HRP20050918A2 (pt)
IL (1) IL170963A (pt)
IS (1) IS8078A (pt)
MA (1) MA27760A1 (pt)
MX (1) MXPA05010114A (pt)
NO (1) NO335895B1 (pt)
NZ (1) NZ542904A (pt)
PL (1) PL2106805T3 (pt)
RU (1) RU2358718C2 (pt)
SG (1) SG152065A1 (pt)
TN (1) TNSN05231A1 (pt)
WO (1) WO2004084826A2 (pt)
ZA (1) ZA200507972B (pt)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050238672A1 (en) * 2004-04-27 2005-10-27 Nimni Marcel E Antifungal drug delivery
AU2005314426A1 (en) * 2004-12-10 2006-06-15 Talima Therapeutics, Inc. Compositions and methods for treating conditions of the nail unit
US20060275230A1 (en) 2004-12-10 2006-12-07 Frank Kochinke Compositions and methods for treating conditions of the nail unit
EP1698336A1 (en) * 2005-03-01 2006-09-06 Ferrer Internacional, S.A. Antifungal compositions comprising Sertaconazole and either Hydrocortisone or an antibacterial agent
FR2892023B1 (fr) * 2005-10-14 2009-09-25 Galderma Sa Composition pharmaceutique a base d'amorolfine et d'agent filmogene hydrosoluble pour application ungueale et peri-ungueale
AU2006332425A1 (en) * 2006-01-02 2007-07-12 Tlt Medical Ltd. Pharmaceutical composition for the treatment of nail diseases
WO2007098591A2 (en) * 2006-03-02 2007-09-07 Nuvo Research Inc. Topical nail formulation
AU2006339841B2 (en) 2006-03-08 2012-08-30 Nihon Nohyaku Co., Ltd. Pharmaceutical composition for external use
AU2006339842B2 (en) 2006-03-08 2012-06-07 Nihon Nohyaku Co., Ltd. Pharmaceutical composition for external use
WO2007102243A1 (ja) 2006-03-08 2007-09-13 Nihon Nohyaku Co., Ltd. 外用の医薬組成物
JP5529539B2 (ja) 2007-09-05 2014-06-25 株式会社ポーラファルマ 医薬組成物
WO2009031644A1 (ja) 2007-09-05 2009-03-12 Pola Pharma Inc. 抗真菌医薬組成物
EP2191827B1 (en) 2007-09-05 2013-10-30 Pola Pharma Inc. Antifungal composition
US20090175810A1 (en) * 2008-01-03 2009-07-09 Gareth Winckle Compositions and methods for treating diseases of the nail
MX2011003568A (es) * 2008-10-03 2011-06-09 Nexmed Holdings Inc Composicion estabilizada para el tratamiento de psoriasis.
CN102256602A (zh) * 2008-10-21 2011-11-23 诺沃德米克斯国际有限公司 用于治疗上皮组织的组合物
WO2010047288A1 (en) 2008-10-24 2010-04-29 Semiconductor Energy Laboratory Co., Ltd. Method for manufacturing semiconductordevice
KR20230085223A (ko) * 2008-12-04 2023-06-13 충시 위 고투과력을 가진 조성물 및 이의 적용
US20100291182A1 (en) * 2009-01-21 2010-11-18 Arsenal Medical, Inc. Drug-Loaded Fibers
WO2010086732A1 (en) * 2009-01-30 2010-08-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Stable compositions for nail and skin treatment
JP2012516320A (ja) * 2009-01-30 2012-07-19 イッスム リサーチ デベロプメント カンパニー オブ ザ ヘブライ ユニバーシティ オブ エルサレム リミテッド 爪および皮膚を処置するための組成物
US9050271B2 (en) 2009-04-09 2015-06-09 Pola Pharma Inc. Antimycotic pharmaceutical composition
WO2010117089A2 (en) 2009-04-09 2010-10-14 Pola Pharma Inc. Antimycotic pharmaceutical composition
WO2011014850A2 (en) 2009-07-31 2011-02-03 Nuvo Research Inc. Topical eutectic-based formulations
US10420862B2 (en) 2009-08-24 2019-09-24 Aresenal AAA, LLC. In-situ forming foams for treatment of aneurysms
US9173817B2 (en) 2009-08-24 2015-11-03 Arsenal Medical, Inc. In situ forming hemostatic foam implants
US20110202016A1 (en) * 2009-08-24 2011-08-18 Arsenal Medical, Inc. Systems and methods relating to polymer foams
US9044580B2 (en) 2009-08-24 2015-06-02 Arsenal Medical, Inc. In-situ forming foams with outer layer
EP2470178B1 (en) 2009-08-25 2018-10-17 Pola Pharma Inc. Antimycotic pharmaceutical composition
US20120305017A1 (en) * 2009-11-02 2012-12-06 Shigeru Fukumoto Skin cosmetic kneaded composition and method for producing same, and method for using skin cosmetic kneaded composition
CN102770123A (zh) 2009-12-23 2012-11-07 纽沃研究股份有限公司 用于治疗甲癣的高渗透性特比萘芬制剂
RU2012153175A (ru) * 2010-05-04 2014-06-20 Нексмед Холдингс, Инк. Композиции терапевтических пептидов и способы
KR20130079382A (ko) 2010-05-04 2013-07-10 넥스메드 홀딩스 인코포레이티드 소분자 치료제의 조성물
US8039494B1 (en) 2010-07-08 2011-10-18 Dow Pharmaceutical Sciences, Inc. Compositions and methods for treating diseases of the nail
RU2432158C1 (ru) * 2010-07-28 2011-10-27 Закрытое акционерное общество "Институт прикладной нанотехнологии" Профилактический бактерицидный лак для обработки ногтей
JP6109075B2 (ja) * 2010-12-02 2017-04-05 ネクスメッド ホールディングス，インコーポレイテッド ２−（ｎ，ｎ−ジメチルアミノ）−プロピオン酸ドデシルの活性鏡像体
US8968626B2 (en) 2011-01-31 2015-03-03 Arsenal Medical, Inc. Electrospinning process for manufacture of multi-layered structures
US9034240B2 (en) 2011-01-31 2015-05-19 Arsenal Medical, Inc. Electrospinning process for fiber manufacture
US9194058B2 (en) 2011-01-31 2015-11-24 Arsenal Medical, Inc. Electrospinning process for manufacture of multi-layered structures
AU2012241018B2 (en) * 2011-04-08 2015-11-12 Pfizer Inc. Crystalline and non- crystalline forms of tofacitinib, and a pharmaceutical composition comprising tofacitinib and a penetration enhancer
EP2707007B1 (en) * 2011-05-11 2018-03-07 Veloce BioPharma LLC Antifungal compositions for the treatment of nails
CA2745320A1 (en) 2011-07-06 2013-01-06 Duoject Medical Systems Inc. Reconstitution device
US8993831B2 (en) 2011-11-01 2015-03-31 Arsenal Medical, Inc. Foam and delivery system for treatment of postpartum hemorrhage
CA2864910C (en) * 2012-02-17 2018-07-24 Joseph CAPRIOTTI Antifungal compositions for the treatment of skin and nails
CA2775393C (en) * 2012-05-02 2014-04-29 Samy Saad Topical non-aqueous pharmaceutical formulations
JP6132842B2 (ja) * 2012-07-30 2017-05-24 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 抗白癬菌症外用液剤
US20150209301A1 (en) 2012-07-30 2015-07-30 Nichiban Company Limited Patch for anti-dermatophytosis
US8900625B2 (en) * 2012-12-15 2014-12-02 Nexmed Holdings, Inc. Antimicrobial compounds and methods of use
US8697753B1 (en) 2013-02-07 2014-04-15 Polichem Sa Method of treating onychomycosis
CN105377355A (zh) 2013-03-14 2016-03-02 拇趾公司 治疗甲单元的感染、疾病或病症的方法
US20140271529A1 (en) * 2013-03-14 2014-09-18 Alc Therapeutics, Llc Antifungal compositions for the treatment of secondary skin and nail infections
GB201317005D0 (en) * 2013-09-25 2013-11-06 Blueberry Therapeutics Ltd Composition and methods of treatment
WO2015051183A1 (en) 2013-10-03 2015-04-09 Dow Pharmaceutical Sciences, Inc. Stabilized efinaconazole compositions
US10245257B2 (en) 2013-11-22 2019-04-02 Dow Pharmaceutical Sciences, Inc. Anti-infective methods, compositions, and devices
EP2952208A1 (en) * 2014-06-04 2015-12-09 Universidade de Santiago de Compostela Hydroalcoholic system for nail treatment
EP3190105A4 (en) 2014-08-13 2018-05-30 Meiji Seika Pharma Co., Ltd. Crystalline anti-trichophyton drug and method for producing same
MX2017009450A (es) 2015-01-20 2018-01-18 Veloce Biopharma Llc Composicion yodofora novedosa y metodos de uso.
JP6591100B1 (ja) * 2019-01-25 2019-10-16 ロート製薬株式会社 爪及び爪周り用医薬組成物
CN112791048B (zh) * 2020-12-31 2023-01-17 海南海神同洲制药有限公司 一种硝酸舍他康唑栓及其制备方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3069633D1 (en) 1979-08-22 1984-12-20 Sandoz Ag Propenylamines, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
DE3045914A1 (de) * 1980-12-05 1982-07-22 Bayer Ag, 5090 Leverkusen Antimykotische mittel mit hoher wirkstoff-freisetzung in form von elastischen fluessig-pflastern
US4406509A (en) * 1981-11-25 1983-09-27 E. I. Du Pont De Nemours & Co. Jack and plug electrical assembly
DE3544983A1 (de) 1985-12-19 1987-06-25 Hoechst Ag Antimykotisch wirksamer nagellack
US4861764A (en) 1986-11-17 1989-08-29 Macro Chem. Corp. Percutaneous absorption enhancers, compositions containing same and method of use
FR2613227B1 (fr) * 1987-04-01 1990-12-28 Oreal Compositions pharmaceutiques a base de nitrate de miconazole ou de nitrate d'econazole dans le traitement des infections fongiques des ongles
US5082866A (en) * 1988-06-01 1992-01-21 Odontex, Inc. Biodegradable absorption enhancers
US4980378A (en) 1988-06-01 1990-12-25 Odontex, Inc. Biodegradable absorption enhancers
FR2673537B1 (fr) * 1991-03-08 1993-06-11 Oreal Utilisation d'agents de penetration hydrophiles dans les compositions dermatologiques pour le traitement des onychomycoses, et compositions correspondantes.
HU219480B (hu) * 1991-05-23 2001-04-28 Novartis Ag. Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására
AU7977294A (en) * 1993-10-07 1995-05-01 Odontex, Inc. Absorption enhancers for topical pharmaceutical formulations
US6019988A (en) * 1996-11-18 2000-02-01 Bristol-Myers Squibb Company Methods and compositions for enhancing skin permeation of drugs using permeation enhancers, when drugs and/or permeation enhancers are unstable in combination during long-term storage
US6046244A (en) * 1997-11-05 2000-04-04 Nexmed Holdings, Inc. Topical compositions for prostaglandin E1 delivery
US6118020A (en) 1999-05-19 2000-09-12 Nexmed Holdings, Inc. Crystalline salts of dodecyl 2-(N,N-dimethylamino)-propionate
US6495124B1 (en) * 2000-02-14 2002-12-17 Macrochem Corporation Antifungal nail lacquer and method using same
ATE526917T1 (de) 2000-02-16 2011-10-15 Cpex Pharmaceuticals Inc Pharmazeutische zusammensetzung
US7074392B1 (en) * 2000-03-27 2006-07-11 Taro Pharmaceutical Industries Limited Controllled delivery system of antifungal and keratolytic agents for local treatment of fungal infections
WO2002002503A1 (en) * 2000-07-01 2002-01-10 Chemtech Research Incorporation Process for preparation of terbinafine and its hydrochloride as an antifungal agent
JP4899139B2 (ja) * 2000-08-10 2012-03-21 株式会社ポーラファルマ 抗真菌医薬組成物
JP2002068975A (ja) * 2000-08-25 2002-03-08 Pola Chem Ind Inc 抗真菌医薬組成物
JP4803511B2 (ja) * 2000-08-25 2011-10-26 株式会社ポーラファルマ 抗真菌医薬組成物
US6585963B1 (en) * 2001-02-15 2003-07-01 Watson Pharmaceuticals, Inc. Nail compositions and methods of administering same
US6846837B2 (en) * 2002-06-21 2005-01-25 Howard I. Maibach Topical administration of basic antifungal compositions to treat fungal infections of the nails

Also Published As

Publication number Publication date
IL170963A (en) 2010-12-30
JP4540667B2 (ja) 2010-09-08
TNSN05231A1 (fr) 2007-06-11
KR101093990B1 (ko) 2011-12-16
EP1635770A4 (en) 2007-12-26
EP2106805A1 (en) 2009-10-07
WO2004084826A2 (en) 2004-10-07
NO335895B1 (no) 2015-03-16
NZ542904A (en) 2009-04-30
SG152065A1 (en) 2009-05-29
ECSP056110A (es) 2006-03-01
RU2358718C2 (ru) 2009-06-20
DE602004021253D1 (de) 2009-07-09
EP1635770B1 (en) 2009-05-27
ZA200507972B (en) 2007-02-28
CA2519705C (en) 2013-07-02
ATE512672T1 (de) 2011-07-15
ES2366273T3 (es) 2011-10-18
ATE432087T1 (de) 2009-06-15
KR20060003868A (ko) 2006-01-11
US7462362B2 (en) 2008-12-09
EP2106805B1 (en) 2011-06-15
CY1111773T1 (el) 2015-10-07
EP1635770A2 (en) 2006-03-22
CN102973420A (zh) 2013-03-20
AU2004224326B2 (en) 2010-04-22
CA2519705A1 (en) 2004-10-07
WO2004084826A3 (en) 2004-11-04
CN1791378A (zh) 2006-06-21
RU2005132390A (ru) 2006-06-27
CO5640092A2 (es) 2006-05-31
PL2106805T3 (pl) 2011-10-31
AU2004224326A1 (en) 2004-10-07
IS8078A (is) 2005-10-18
HRP20050918A2 (en) 2006-12-31
MA27760A1 (fr) 2006-02-01
DK1635770T3 (da) 2009-08-03
NO20054830L (no) 2005-12-16
DK2106805T3 (da) 2011-08-15
MXPA05010114A (es) 2006-04-27
US20060067898A1 (en) 2006-03-30
NO20054830D0 (no) 2005-10-19
US20090099266A1 (en) 2009-04-16
JP2006520800A (ja) 2006-09-14
US20130323189A1 (en) 2013-12-05

Similar Documents

Publication Publication Date Title
BRPI0408613A (pt) revestimento antifúngico de unhas e método de uso
ATE238751T1 (de) Antimykotischer nagellack
BR0206885A (pt) Revestimentos de polìmeros de flúor coalescentes a baixas temperaturas
UA92901C2 (uk) Панель засклення (варіанти) та застосування верхнього покриваючого шару для неї
WO2003097091A3 (en) Glucan-based vaccines
DE60000103D1 (de) Eine wässrige polymerdispersion enthaltender nagellack
DE60326966D1 (de) Selbstvernetzbare wässrige beschichtungszusammensetzung
AU2001293005A1 (en) Polymerizable 1,1-disubstituted ethylene monomer formulation applicators, applicator tips, applicator kits and methods
DK1185401T3 (da) Isothiazolon/aminoxid træbeskyttelsesmidler
DE60326744D1 (de) Zahnbeschichtungsset
CA2428324A1 (en) Dentifrice composition comprising hydroxyethyl cellulose, an anhydrous humectant, a polyethylene glycol and an abrasive
WO2004006870A3 (de) Glitterstoffhaltige kosmetika
DE60129804D1 (de) Hydrophobierende mikro-emulsionen
EP1152014A4 (en) RESIN COMPOSITION
EP1028149A3 (en) Aqueous coating and method for film formation using the same
BR0212143A (pt) Composição para lavagem bucal para tratamento ou prevenção de infecção por bactérias ou fungos
FR2874320B1 (fr) Composition cosmetique comprenant comme agent antitranspirant un polymere hydrosoluble floculant ; procede de traitement de la transpiration
WO2004048421A3 (en) Branched cationic copolymers and methods for antimicrobial use
ATE322881T1 (de) Haarstyling zusammensetzung
TH45854A3 (th) สารผสมเคลือบเล็บโพลิอะคริลและโพลิยูรีเทน
TH44157A3 (th) สารผสมเคลือบเล็บ
TH41747A3 (th) สารผสมเคลือบเล็บ
WO2004054521A3 (en) Active topical skin protectants containing amines,polyalkenimines and/or derivatives
CY1116454T1 (el) Ενωσεις βιοκτονου βοριουχου φθαλιδιου

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2307 DE 24/03/2015.

B15K Others concerning applications: alteration of classification

Ipc: A61K 31/137 (2006.01), A61K 8/41 (2006.01), A61K 8