BRPI0407479A - Compostos heterocìclicos úteis como ativadores de nurr-1 - Google Patents
Compostos heterocìclicos úteis como ativadores de nurr-1Info
- Publication number
- BRPI0407479A BRPI0407479A BR0407479-3A BRPI0407479A BRPI0407479A BR PI0407479 A BRPI0407479 A BR PI0407479A BR PI0407479 A BRPI0407479 A BR PI0407479A BR PI0407479 A BRPI0407479 A BR PI0407479A
- Authority
- BR
- Brazil
- Prior art keywords
- alkoxy
- alkylamino
- alkyl
- hydroxy
- nurr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"COMPOSTOS HETEROCìCLICOS úTEIS COMO ATIVADORES DE NURR-1". A presente invenção refere-se a um composto da fórmula I; na qual R~ 1~, é hidróxi, C~ 1-4~ alcóxi, amina, C~ 1-4~ alquil - amino, di C~ 1-4~ alquilamino, benzilóxi ou C~ 2-7~ alcanoíla; R~ 2~ é C~ 1-4~ alquila, C~ 1-4~ alcóxi, C~ 1-4~ alcóxi C~ 1-4~ alcóxi, CF~ 3~, halogênio, C~ 1-4~ alquilamino, di- C~ 1-4~ alquilamino, di- C~ 1-4~ alquilamino di- C~ 1-4~ alcóxi, ou N-C~ 1-4~ alcóxi C~ 1-4~ alquil-N-C~ 1-4~ alquilamino, N-C~ 1-4~ alquil-piperazinila, morfolinila, pirrolidinil- C~ 1-4~ alcóxi, em que os radicais C~ 1-4~ alquila em R~ 2~ são ainda substituídos de modo opcional por C~ 1-4~ alquila, halogênio, ciano, amino, alcóxi ou alquiltio; X é N ou O; Yé N, O ou CH; Z é N ou CH, e W é N ou CH; contanto que (a) R~ 1~, não seja hidróxi ou C~ 1-4~ alcóxi quando R~ 2~ for CF~ 3~, X seja O, Y seja CH, Z seja N e W seja CH; (b) R~ 1~ não seja hidróxi ou C~ 1-4~ alcóxi quando R~ 2~ for CF~ 3~, ou cloro, X for N, Y for O, Z for CH e W for CH; (c) R~ 1~ não seja hidróxi, quando R~ 2~ for CF~ 3~, X for O, Y for N, Z for CH e W for CH e (d) X e Y não sejam ao mesmo tempo O; os sais dos mesmos, as preparações dos mesmos, o uso dos mesmos e composições farmacêuticas que contêm os mesmos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0303503.7A GB0303503D0 (en) | 2003-02-14 | 2003-02-14 | Organic compounds |
| PCT/EP2004/001372 WO2004072050A1 (en) | 2003-02-14 | 2004-02-13 | Heterocyclic compounds useful as nurr-1 activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0407479A true BRPI0407479A (pt) | 2006-02-07 |
Family
ID=9953078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0407479-3A BRPI0407479A (pt) | 2003-02-14 | 2004-02-13 | Compostos heterocìclicos úteis como ativadores de nurr-1 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7432293B2 (pt) |
| EP (1) | EP1597243A1 (pt) |
| JP (1) | JP2006517564A (pt) |
| CN (2) | CN101665469A (pt) |
| AR (1) | AR043168A1 (pt) |
| AU (1) | AU2004212151B2 (pt) |
| BR (1) | BRPI0407479A (pt) |
| CA (1) | CA2515847A1 (pt) |
| GB (1) | GB0303503D0 (pt) |
| MX (1) | MXPA05008584A (pt) |
| PE (1) | PE20050193A1 (pt) |
| PL (1) | PL376754A1 (pt) |
| TW (1) | TW200502225A (pt) |
| WO (1) | WO2004072050A1 (pt) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200508298B (en) | 2003-04-11 | 2007-01-31 | Ptc Therapeutics Inc | 1,2,4-oxadiazole benzoic acid compounds |
| EP1799659A1 (en) * | 2004-10-13 | 2007-06-27 | PTC Therapeutics, Inc. | Compounds for nonsense suppression, and methods for their use |
| US8716321B2 (en) | 2005-04-08 | 2014-05-06 | Ptc Therapeutics, Inc. | Methods for dosing an orally active 1,2,4-oxadiazole |
| AU2006239418A1 (en) | 2005-04-26 | 2006-11-02 | Neurosearch A/S | Novel oxadiazole derivatives and their medical use |
| MX2008012515A (es) | 2006-03-30 | 2008-11-19 | Ptc Therapeutics Inc | Metodos para la produccion de proteina funcional a partir de adn que tiene una mutacion sin sentido y el tratamiento de trastornos asociados con la misma. |
| FR2903105A1 (fr) | 2006-07-03 | 2008-01-04 | Sanofi Aventis Sa | Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique |
| FR2903107B1 (fr) | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2903108B1 (fr) * | 2006-07-03 | 2008-08-29 | Sanofi Aventis Sa | Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique. |
| NZ598012A (en) | 2006-09-08 | 2013-08-30 | Ptc Therapeutics Inc | Processes for the preparation of 1,2,4-oxadiazole benzoic acids |
| FR2906250B1 (fr) * | 2006-09-22 | 2008-10-31 | Sanofi Aventis Sa | Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique |
| CL2007002743A1 (es) | 2006-09-25 | 2008-07-11 | Pct Therapeutics Inc Soc Organ | Forma cristalina del acido 3-[5-(2-fluorofenil)-[1,2,4]oxadiazol-3-il]-benzoico; composicion farmaceutica que comprende a dicha forma cristalina; y su uso para modular la terminacion prematura de traslado o decaimiento de marn, tales como carcicoma. |
| WO2008130370A1 (en) | 2006-09-25 | 2008-10-30 | Ptc Therapeutics, Inc. | Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, compositions thereof and the use for nonsense suppression |
| SI2073805T1 (sl) * | 2006-10-12 | 2015-10-30 | Ptc Therapeutics, Inc. | Postopki za odmerjanje peroralno aktivnega 1,2,4-oksadiazola za zdravljenje supresije nesmiselnih mutacij |
| WO2009029632A1 (en) | 2007-08-27 | 2009-03-05 | Helicon Therapeutics, Inc. | Therapeutic isoxazole compounds |
| PT2307381T (pt) | 2008-06-09 | 2021-03-15 | Univ Muenchen Ludwig Maximilians | Novas drogas para inibir a agregação de proteínas envolvidas em doenças relacionadas com a agregação de proteínas e/ou doenças neurodegenerativas |
| CN102076670B (zh) * | 2008-06-24 | 2013-05-22 | Irm责任有限公司 | 调节g蛋白偶联受体的化合物和方法 |
| FR2933609B1 (fr) | 2008-07-10 | 2010-08-27 | Fournier Lab Sa | Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson. |
| WO2011009484A1 (en) * | 2009-07-22 | 2011-01-27 | Novartis Ag | Arylpyrazoles and arylisoxazoles and their use as pkd modulators |
| FR2950053B1 (fr) | 2009-09-11 | 2014-08-01 | Fournier Lab Sa | Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
| FR2955110A1 (fr) * | 2010-01-08 | 2011-07-15 | Fournier Lab Sa | Nouveaux derives de type pyrrolopyridine benzoique |
| KR101829086B1 (ko) * | 2010-10-14 | 2018-02-13 | 다이이찌 산쿄 가부시키가이샤 | 아실벤젠 유도체 |
| AR098311A1 (es) | 2013-11-05 | 2016-05-26 | Bayer Cropscience Ag | Compuestos para el control de artrópodos |
| TWI695717B (zh) | 2014-03-06 | 2020-06-11 | 美商 Ptc 治療公司 | １,２,４-二唑苯甲酸之鹽及醫藥組合物 |
| JP2018531975A (ja) | 2015-10-30 | 2018-11-01 | ピーティーシー セラピューティクス，インコーポレーテッド | てんかんの治療方法 |
| AU2018265584B2 (en) | 2017-05-12 | 2023-09-28 | Ludwig-Maximilians-Universität München | Phenyl-heterocycle-phenyl derivatives for use in the treatment or prevention of melanoma |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04295470A (ja) * | 1991-03-22 | 1992-10-20 | Wakamoto Pharmaceut Co Ltd | モノアミンオキシダーゼ−ｂ酵素阻害活性を有する１，２，４−オキサジアゾール誘導体及びその製造法 |
| WO1997003967A1 (en) * | 1995-07-22 | 1997-02-06 | Rhone-Poulenc Rorer Limited | Substituted aromatic compounds and their pharmaceutical use |
| DE19620041A1 (de) * | 1996-05-17 | 1998-01-29 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
| DE19643037A1 (de) * | 1996-10-18 | 1998-04-23 | Boehringer Ingelheim Kg | Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
| IT1300055B1 (it) * | 1998-04-17 | 2000-04-05 | Boehringer Ingelheim Italia | Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici |
| WO2000001679A1 (fr) * | 1998-07-01 | 2000-01-13 | Takeda Chemical Industries, Ltd. | Regulateurs du recepteur associe aux retinoides |
| JP2000080086A (ja) * | 1998-07-01 | 2000-03-21 | Takeda Chem Ind Ltd | レチノイド関連受容体機能調節剤 |
| ATE257827T1 (de) * | 1999-07-21 | 2004-01-15 | Hoffmann La Roche | Triazolderivate |
| BR0013427A (pt) * | 1999-08-19 | 2002-07-30 | Nps Pharma Inc | Compostos heteropolicìclicos e seus usos como antagonistas no receptor de glutamato metabotrópico |
| PL369598A1 (en) * | 2001-02-21 | 2005-05-02 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| US7223791B2 (en) * | 2001-06-26 | 2007-05-29 | Takeda Pharmaceutical Company Limited | Function regulator for retinoid relative receptor |
-
2003
- 2003-02-14 GB GBGB0303503.7A patent/GB0303503D0/en not_active Ceased
-
2004
- 2004-02-12 PE PE2004000155A patent/PE20050193A1/es not_active Application Discontinuation
- 2004-02-12 AR ARP040100440A patent/AR043168A1/es unknown
- 2004-02-13 AU AU2004212151A patent/AU2004212151B2/en not_active Ceased
- 2004-02-13 PL PL376754A patent/PL376754A1/pl not_active Application Discontinuation
- 2004-02-13 EP EP04710812A patent/EP1597243A1/en not_active Withdrawn
- 2004-02-13 CA CA002515847A patent/CA2515847A1/en not_active Abandoned
- 2004-02-13 CN CN200910004889A patent/CN101665469A/zh active Pending
- 2004-02-13 BR BR0407479-3A patent/BRPI0407479A/pt not_active IP Right Cessation
- 2004-02-13 JP JP2006501839A patent/JP2006517564A/ja active Pending
- 2004-02-13 WO PCT/EP2004/001372 patent/WO2004072050A1/en active Application Filing
- 2004-02-13 US US10/545,245 patent/US7432293B2/en not_active Expired - Fee Related
- 2004-02-13 MX MXPA05008584A patent/MXPA05008584A/es active IP Right Grant
- 2004-02-13 CN CNB2004800038107A patent/CN100475795C/zh not_active Expired - Fee Related
- 2004-02-13 TW TW093103501A patent/TW200502225A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006517564A (ja) | 2006-07-27 |
| WO2004072050A1 (en) | 2004-08-26 |
| TW200502225A (en) | 2005-01-16 |
| AU2004212151B2 (en) | 2008-09-04 |
| GB0303503D0 (en) | 2003-03-19 |
| US7432293B2 (en) | 2008-10-07 |
| AR043168A1 (es) | 2005-07-20 |
| US20060089365A1 (en) | 2006-04-27 |
| CN100475795C (zh) | 2009-04-08 |
| AU2004212151A1 (en) | 2004-08-26 |
| MXPA05008584A (es) | 2005-11-04 |
| EP1597243A1 (en) | 2005-11-23 |
| CA2515847A1 (en) | 2004-08-26 |
| PE20050193A1 (es) | 2005-04-11 |
| CN101665469A (zh) | 2010-03-10 |
| CN1747942A (zh) | 2006-03-15 |
| PL376754A1 (pl) | 2006-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |