PL376754A1 - Związki heterocykliczne użyteczne jako aktywatory Nurr-1 - Google Patents
Związki heterocykliczne użyteczne jako aktywatory Nurr-1Info
- Publication number
- PL376754A1 PL376754A1 PL376754A PL37675404A PL376754A1 PL 376754 A1 PL376754 A1 PL 376754A1 PL 376754 A PL376754 A PL 376754A PL 37675404 A PL37675404 A PL 37675404A PL 376754 A1 PL376754 A1 PL 376754A1
- Authority
- PL
- Poland
- Prior art keywords
- nurr
- activators
- heterocyclic compounds
- compounds useful
- heterocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0303503.7A GB0303503D0 (en) | 2003-02-14 | 2003-02-14 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PL376754A1 true PL376754A1 (pl) | 2006-01-09 |
Family
ID=9953078
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL376754A PL376754A1 (pl) | 2003-02-14 | 2004-02-13 | Związki heterocykliczne użyteczne jako aktywatory Nurr-1 |
Country Status (14)
Country | Link |
---|---|
US (1) | US7432293B2 (pl) |
EP (1) | EP1597243A1 (pl) |
JP (1) | JP2006517564A (pl) |
CN (2) | CN101665469A (pl) |
AR (1) | AR043168A1 (pl) |
AU (1) | AU2004212151B2 (pl) |
BR (1) | BRPI0407479A (pl) |
CA (1) | CA2515847A1 (pl) |
GB (1) | GB0303503D0 (pl) |
MX (1) | MXPA05008584A (pl) |
PE (1) | PE20050193A1 (pl) |
PL (1) | PL376754A1 (pl) |
TW (1) | TW200502225A (pl) |
WO (1) | WO2004072050A1 (pl) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0409319B8 (pt) | 2003-04-11 | 2021-05-25 | Ptc Therapeutics Inc | composto, composição farmacêutica, forma de dosagem unitária, e, uso de um composto |
AU2005295727A1 (en) * | 2004-10-13 | 2006-04-27 | Ptc Therapeutics, Inc. | Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation-related diseases |
CA2603402C (en) | 2005-04-08 | 2017-10-31 | Ptc Therapeutics, Inc. | Compositions of an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy |
RU2007139255A (ru) | 2005-04-26 | 2009-06-10 | Ньюросерч А/С (DK) | Новые оксадиазольные производные и их медицинское применение |
BRPI0710213A2 (pt) | 2006-03-30 | 2011-04-12 | Ptc Therapeutics Inc | métodos para produzir uma quantidade efetiva de uma proteìna de transleitura funcional codificada por uma sequência de ácido nucleico que compreende uma mutação não-sentido e para tratar, controlar e/ou prevenir uma doença |
FR2903108B1 (fr) * | 2006-07-03 | 2008-08-29 | Sanofi Aventis Sa | Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique. |
FR2903107B1 (fr) | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
FR2903105A1 (fr) | 2006-07-03 | 2008-01-04 | Sanofi Aventis Sa | Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique |
CA2662749C (en) | 2006-09-08 | 2015-01-20 | Ptc Therapeutics, Inc. | Processes for the preparation of 1,2,4-oxadiazole benzoic acids |
FR2906250B1 (fr) * | 2006-09-22 | 2008-10-31 | Sanofi Aventis Sa | Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique |
EP2068871B1 (en) | 2006-09-25 | 2013-12-25 | PTC Therapeutics, Inc. | Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, compositions thereof and the use for nonsense suppression |
EP2076501B8 (en) * | 2006-09-25 | 2019-11-13 | PTC Therapeutics, Inc. | Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid |
SI2073805T1 (sl) * | 2006-10-12 | 2015-10-30 | Ptc Therapeutics, Inc. | Postopki za odmerjanje peroralno aktivnega 1,2,4-oksadiazola za zdravljenje supresije nesmiselnih mutacij |
MX2010002258A (es) | 2007-08-27 | 2010-04-22 | Helicon Therapeutics Inc | Compuestos terapeuticos de isoxazol. |
PL2684873T3 (pl) | 2008-06-09 | 2019-07-31 | Ludwig-Maximilians-Universität München | Leki do hamowania agregacji białek związanych z chorobami związanymi z agregacją białka i/lub chorobami neurodegeneracyjnymi |
EP2300442A2 (en) * | 2008-06-24 | 2011-03-30 | Irm Llc | Compounds and methods for modulating g protein-coupled receptors |
FR2933609B1 (fr) | 2008-07-10 | 2010-08-27 | Fournier Lab Sa | Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson. |
WO2011009484A1 (en) * | 2009-07-22 | 2011-01-27 | Novartis Ag | Arylpyrazoles and arylisoxazoles and their use as pkd modulators |
FR2950053B1 (fr) | 2009-09-11 | 2014-08-01 | Fournier Lab Sa | Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
FR2955110A1 (fr) * | 2010-01-08 | 2011-07-15 | Fournier Lab Sa | Nouveaux derives de type pyrrolopyridine benzoique |
CA2814628C (en) * | 2010-10-14 | 2015-06-16 | Daiichi Sankyo Company, Limited | Acylbenzene derivative |
EP3066083B1 (de) * | 2013-11-05 | 2019-10-30 | Bayer Animal Health GmbH | Neue verbindungen zur bekämpfung von arthropoden |
TWI695717B (zh) | 2014-03-06 | 2020-06-11 | 美商 Ptc 治療公司 | 1,2,4-二唑苯甲酸之鹽及醫藥組合物 |
CN108348527A (zh) | 2015-10-30 | 2018-07-31 | Ptc医疗公司 | 用于治疗癫痫的方法 |
WO2018206778A1 (en) | 2017-05-12 | 2018-11-15 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Phenyl-heterocycle-phenyl derivatives for use in the treatment or prevention of melanoma |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04295470A (ja) * | 1991-03-22 | 1992-10-20 | Wakamoto Pharmaceut Co Ltd | モノアミンオキシダーゼ−b酵素阻害活性を有する1,2,4−オキサジアゾール誘導体及びその製造法 |
AU6526896A (en) * | 1995-07-22 | 1997-02-18 | Rhone-Poulenc Rorer Limited | Substituted aromatic compounds and their pharmaceutical use |
DE19620041A1 (de) * | 1996-05-17 | 1998-01-29 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
DE19643037A1 (de) * | 1996-10-18 | 1998-04-23 | Boehringer Ingelheim Kg | Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
DE19816880A1 (de) | 1998-04-17 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue Diphenyl-substituierte 5-Ring-Heterocyclen, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
JP2000080086A (ja) * | 1998-07-01 | 2000-03-21 | Takeda Chem Ind Ltd | レチノイド関連受容体機能調節剤 |
BR9911752A (pt) * | 1998-07-01 | 2001-04-03 | Takeda Chemical Industries Ltd | Agente de regulagem da função do receptor relacionado com a retinóide, derivados de oxazol, de imidazol e de tiazol, composto, processo para regular uma função de receptor relacionado com a retinóide, e, uso de um derivado |
ATE257827T1 (de) * | 1999-07-21 | 2004-01-15 | Hoffmann La Roche | Triazolderivate |
UA75871C2 (en) * | 1999-08-19 | 2006-06-15 | Nps Pharma Inc | 1,2,4-oxadiazole derivatives and use thereof as antagonists at metabotropic glutamate receptors |
RU2319701C2 (ru) * | 2001-02-21 | 2008-03-20 | Астразенека Аб | ГЕТЕРОПОЛИЦИКЛИЧЕСКОЕ СОЕДИНЕНИЕ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ОБЛАДАЮЩАЯ АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ В ОТНОШЕНИИ МЕТАБОТРОПНЫХ ГЛЮТАМАТНЫХ РЕЦЕПТОРОВ mGluR ГРУППЫ I |
US7223791B2 (en) * | 2001-06-26 | 2007-05-29 | Takeda Pharmaceutical Company Limited | Function regulator for retinoid relative receptor |
-
2003
- 2003-02-14 GB GBGB0303503.7A patent/GB0303503D0/en not_active Ceased
-
2004
- 2004-02-12 PE PE2004000155A patent/PE20050193A1/es not_active Application Discontinuation
- 2004-02-12 AR ARP040100440A patent/AR043168A1/es unknown
- 2004-02-13 EP EP04710812A patent/EP1597243A1/en not_active Withdrawn
- 2004-02-13 AU AU2004212151A patent/AU2004212151B2/en not_active Ceased
- 2004-02-13 CN CN200910004889A patent/CN101665469A/zh active Pending
- 2004-02-13 JP JP2006501839A patent/JP2006517564A/ja active Pending
- 2004-02-13 WO PCT/EP2004/001372 patent/WO2004072050A1/en active Application Filing
- 2004-02-13 PL PL376754A patent/PL376754A1/pl not_active Application Discontinuation
- 2004-02-13 BR BR0407479-3A patent/BRPI0407479A/pt not_active IP Right Cessation
- 2004-02-13 CN CNB2004800038107A patent/CN100475795C/zh not_active Expired - Fee Related
- 2004-02-13 MX MXPA05008584A patent/MXPA05008584A/es active IP Right Grant
- 2004-02-13 US US10/545,245 patent/US7432293B2/en not_active Expired - Fee Related
- 2004-02-13 CA CA002515847A patent/CA2515847A1/en not_active Abandoned
- 2004-02-13 TW TW093103501A patent/TW200502225A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US7432293B2 (en) | 2008-10-07 |
BRPI0407479A (pt) | 2006-02-07 |
JP2006517564A (ja) | 2006-07-27 |
AU2004212151A1 (en) | 2004-08-26 |
AR043168A1 (es) | 2005-07-20 |
CN1747942A (zh) | 2006-03-15 |
TW200502225A (en) | 2005-01-16 |
CA2515847A1 (en) | 2004-08-26 |
AU2004212151B2 (en) | 2008-09-04 |
MXPA05008584A (es) | 2005-11-04 |
CN100475795C (zh) | 2009-04-08 |
WO2004072050A1 (en) | 2004-08-26 |
EP1597243A1 (en) | 2005-11-23 |
PE20050193A1 (es) | 2005-04-11 |
CN101665469A (zh) | 2010-03-10 |
GB0303503D0 (en) | 2003-03-19 |
US20060089365A1 (en) | 2006-04-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL376754A1 (pl) | Związki heterocykliczne użyteczne jako aktywatory Nurr-1 | |
IL174375A0 (en) | Novel heterocyclic compounds as hsp90-inhibitors | |
IL209082A0 (en) | Fushed heterocyclic compounds | |
PL377087A1 (pl) | Związki heterocykliczne | |
HK1091809A1 (en) | 3-alkylidenehydrazino substituted heteroaryl compounds as thrombopoietin receptor activators | |
EP1551801A4 (en) | NOVEL GAMMA-LACTAMES AS INHIBITORS OF BETA-SECRETASE | |
SG131944A1 (en) | N3-substituted imidazopyridine-derivatives as c-kit inhibitors | |
GB0304424D0 (en) | Novel compounds | |
EP1596860A4 (en) | NEW CONNECTIONS | |
EP1476425A4 (en) | Heterocyclic Aryl Sulphonamidocyclic Compounds | |
EP1648885A4 (en) | NEW CONNECTIONS | |
GB0305426D0 (en) | Novel compounds | |
GB0302431D0 (en) | Novel compounds | |
GB0302546D0 (en) | Novel compounds | |
GB0304809D0 (en) | Novel compounds | |
GB0403135D0 (en) | Chiral compounds | |
ZA200509643B (en) | 3-alkylidenehydrazino substituted heteroaryl compounds as thrombopoietin receptor activators | |
EP1635834A4 (en) | NEW COMPOUNDS | |
AU2003906640A0 (en) | Heterocyclic compounds | |
GB0305165D0 (en) | Novel compounds | |
GB0301955D0 (en) | Novel compounds | |
GB0305163D0 (en) | Novel compounds | |
GB0304811D0 (en) | Novel compounds | |
GB0305290D0 (en) | Novel compounds | |
GB0304803D0 (en) | Novel compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |