BRPI0307976B8 - processo para a ligação seletiva de uma forma anormal agregativa de uma proteína, e, processo ou ensaio quanto à presença de uma forma agregativa anormal de uma proteína de uma amostra - Google Patents
processo para a ligação seletiva de uma forma anormal agregativa de uma proteína, e, processo ou ensaio quanto à presença de uma forma agregativa anormal de uma proteína de uma amostraInfo
- Publication number
- BRPI0307976B8 BRPI0307976B8 BRPI0307976A BRPI0307976A BRPI0307976B8 BR PI0307976 B8 BRPI0307976 B8 BR PI0307976B8 BR PI0307976 A BRPI0307976 A BR PI0307976A BR PI0307976 A BRPI0307976 A BR PI0307976A BR PI0307976 B8 BRPI0307976 B8 BR PI0307976B8
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- abnormal
- aggregative
- assay
- sample
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/968—Plasmin, i.e. fibrinolysin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Materials For Medical Uses (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
processo para a ligação seletiva de uma forma anormal agregativa de uma proteína, processo ou ensaio quanto à presença de uma forma agregativa anormal de uma proteína de uma amostra, e, agente de ligação. as formas agregativas infecciosas de proteínas, tais como prp, amilóide e tau, são ligadas seletivamente na presença da proteína de forma normal, empregando-se um agente de ligação poliônica, tal como sulfato de dextrano ou pentosano (aniônico), ou compostos de poliamina, tais como pdadmac (catiônico), sob condições de ligação seletiva, incluindo o uso de n-lauroil sarcosina em ph suavemente alcalino, e podem então ser ensaiadas.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0204797.5 | 2002-02-28 | ||
GB0204797A GB0204797D0 (en) | 2002-02-28 | 2002-02-28 | Selective binding of pathological forms of prion proteins |
GB0216808A GB0216808D0 (en) | 2002-07-18 | 2002-07-18 | Selective binding of pathological forms of prion proteins |
GB0216808.6 | 2002-07-18 | ||
GB0229614.3 | 2002-12-19 | ||
GB0229614A GB0229614D0 (en) | 2002-12-19 | 2002-12-19 | Selective binding of pathological forms of prion proteins |
PCT/GB2003/000858 WO2003073106A2 (en) | 2002-02-28 | 2003-02-28 | Binding of pathological forms of prion proteins |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0307976A2 BRPI0307976A2 (pt) | 2016-06-21 |
BRPI0307976B1 BRPI0307976B1 (pt) | 2017-12-19 |
BRPI0307976B8 true BRPI0307976B8 (pt) | 2021-07-27 |
Family
ID=27767735
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0307976A BRPI0307976B8 (pt) | 2002-02-28 | 2003-02-28 | processo para a ligação seletiva de uma forma anormal agregativa de uma proteína, e, processo ou ensaio quanto à presença de uma forma agregativa anormal de uma proteína de uma amostra |
Country Status (13)
Country | Link |
---|---|
US (2) | US7659076B2 (pt) |
EP (1) | EP1478931B2 (pt) |
JP (1) | JP4550425B2 (pt) |
CN (1) | CN100526884C (pt) |
AU (1) | AU2003214375B2 (pt) |
BR (1) | BRPI0307976B8 (pt) |
CA (1) | CA2477569C (pt) |
CO (1) | CO5611225A2 (pt) |
ES (1) | ES2564293T5 (pt) |
MX (1) | MXPA04008275A (pt) |
NZ (1) | NZ535276A (pt) |
RU (1) | RU2309410C2 (pt) |
WO (1) | WO2003073106A2 (pt) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070166741A1 (en) | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
EP1395833B1 (en) * | 2001-05-31 | 2013-02-27 | Adlyfe, Inc. | Misfolded protein sensor method |
US20050026165A1 (en) * | 2001-05-31 | 2005-02-03 | Cindy Orser | Detection of conformationally altered proteins and prions |
RU2309410C2 (ru) * | 2002-02-28 | 2007-10-27 | Майкроусенс Байофейдж Лимитед | Связывание патологических форм прионовых белков |
EP1380290A1 (en) | 2002-07-09 | 2004-01-14 | Universitair Medisch Centrum Utrecht | Cross-beta structure pathway and its therapeutic relevance |
JP4709149B2 (ja) | 2003-08-13 | 2011-06-22 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | プリオン特異的ペプチド試薬 |
US20060035242A1 (en) | 2004-08-13 | 2006-02-16 | Michelitsch Melissa D | Prion-specific peptide reagents |
DE10354207B8 (de) * | 2003-11-20 | 2006-06-14 | Priontype Gmbh & Co.Kg | Verfahren zum Nachweis von pathologisch veränderten Prion-Proteinen (PrPSc) und Kit zur Durchführung des Verfahrens |
FR2865280B1 (fr) * | 2004-01-20 | 2007-01-12 | Biomerieux Sa | Procede de detection de la prp utilisant une molecule ayant au moins une charge positive et/ou au moins une liaison osidique et un ligand autre qu'un ligand proteique |
MXPA06011402A (es) * | 2004-04-05 | 2007-03-12 | Idexx Lab Inc | Reactivos para pruebas de encefalopatia espongiforme transmisible y metodos de uso de los mismos. |
US20060057671A1 (en) * | 2004-09-10 | 2006-03-16 | Orser Cindy S | Immobilized probes and methods of detecting conformationally altered prion proteins |
WO2006076683A2 (en) * | 2005-01-13 | 2006-07-20 | Novartis Vaccines And Diagnostics Inc. | Isolation and detection of pathogenic prions |
AU2006204705C1 (en) * | 2005-01-13 | 2012-07-05 | Novartis Vaccines And Diagnostics, Inc. | ELISA assays using prion-specific peptide reagents |
EP1848830A4 (en) * | 2005-01-13 | 2009-05-06 | Novartis Vaccines & Diagnostic | ISOLATION OF PATHOGENIC PRIONS |
EP2386861A3 (en) * | 2005-07-13 | 2012-07-18 | Crossbeta Biosciences B.V. | Cross-ß structure binding compounds |
AU2006267174A1 (en) * | 2005-07-13 | 2007-01-18 | Crossbeta Biosciences B.V. | Adjuvation through cross-beta structure |
US8114832B2 (en) | 2005-07-13 | 2012-02-14 | Crossbeta Biosciences B.V. | Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition |
US20070015133A1 (en) * | 2005-07-13 | 2007-01-18 | Umc Utrecht Holding B.V. | Method for detecting and/or removing protein and/or peptide comprising a cross-beta structure from an aqueous solution comprising a protein |
FR2888937B1 (fr) * | 2005-07-21 | 2012-10-26 | Biomerieux Sa | Procede de detection des fcpa utilisant un agent d'agregation des fcpa et un agent de capture des agregats formes |
NZ566020A (en) | 2005-09-09 | 2012-08-31 | Novartis Ag | Prion-specific peptoid reagents |
HUE025489T2 (en) * | 2006-01-17 | 2016-04-28 | Somalogic Inc | Multiplexed analysis of test samples |
DE102006010647A1 (de) * | 2006-03-06 | 2007-09-13 | Latza, Reinhard, Dr.med. | Test zum Nachweis von pathologischen Prionen |
US7601506B2 (en) | 2006-07-28 | 2009-10-13 | Idexx Laboratories, Inc. | Identification of leucocytes bearing diagnostic markers for transmissible spongiform encephalopathies |
GB0701970D0 (en) | 2007-02-01 | 2007-03-14 | Wilson Stuart | Treatment of protein aggregation diseases |
CN101784559A (zh) * | 2007-04-18 | 2010-07-21 | 比奥克罗密克斯有限公司 | 使用共轭聚电解质结合病理形式的蛋白质 |
JP4246777B1 (ja) * | 2007-11-20 | 2009-04-02 | 森永乳業株式会社 | 異常型プリオン蛋白質結合剤および異常型プリオン蛋白質の検出方法 |
CN102083450A (zh) * | 2008-04-30 | 2011-06-01 | 诺华有限公司 | 致病性构象异构体的分析 |
US9072370B2 (en) * | 2008-06-19 | 2015-07-07 | Colgate-Palmolive Company | User health profiles derived from oral care implements |
CA2779846A1 (en) * | 2009-11-04 | 2011-05-12 | Novartis Ag | Positively charged species as binding reagents in the separation of protein aggregates from monomers |
JP2013032295A (ja) * | 2009-12-04 | 2013-02-14 | Kaneka Corp | タウ蛋白の吸着材および吸着除去システム |
EP2392342A1 (en) | 2010-06-04 | 2011-12-07 | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | Compositions for use in the treatment or diagnosis of prion diseases |
FR2973114A1 (fr) * | 2011-03-21 | 2012-09-28 | Ets Francais Du Sang | Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc |
ITMI20130112A1 (it) | 2013-01-24 | 2014-07-25 | Chemi Spa | Metodo di qualificazione di preparazioni di pentosan polifosfato, sue materie prime e processi di produzione |
EP3347490A1 (en) * | 2015-09-11 | 2018-07-18 | Corning Incorporated | Compositions and methods for nucleic acid purification from blood samples |
US11422128B2 (en) | 2016-04-13 | 2022-08-23 | Lsi Medience Corporation | Immunoassay employing sulfated polysaccharide |
CN109517166B (zh) * | 2018-10-25 | 2021-01-22 | 天津大学 | 疏水基团修饰的羧基端聚酰胺胺树状分子和制备方法及其抑制β淀粉样蛋白聚集的应用 |
US20230160912A1 (en) * | 2020-03-31 | 2023-05-25 | Fujirebio Inc. | Method for immunoassay of amyloid beta in blood, and kit for same |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
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DE3880647T2 (de) * | 1987-11-20 | 1993-11-18 | Kanegafuchi Chemical Ind | Sorbentmittel für Serum-Amyloid-Proteine. |
US5216127A (en) * | 1987-11-20 | 1993-06-01 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Adsorbent for serum amyloid protein |
US5429746A (en) † | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
DE69632056T2 (de) * | 1995-09-14 | 2004-12-30 | The Regents Of The University Of California, Oakland | Für natives prp-sc spezifische antikörper |
US6162931A (en) * | 1996-04-12 | 2000-12-19 | Molecular Probes, Inc. | Fluorinated xanthene derivatives |
US5808011A (en) * | 1996-07-01 | 1998-09-15 | Biopure Corporation | Method for chromatographic removal of prions |
US6221614B1 (en) * | 1997-02-21 | 2001-04-24 | The Regents Of The University Of California | Removal of prions from blood, plasma and other liquids |
US6419916B1 (en) | 1999-06-01 | 2002-07-16 | The Regents Of The University Of California | Assay for compounds which affect conformationally altered proteins |
US5977324A (en) * | 1998-02-20 | 1999-11-02 | The Regents Of The University Of California | Process for concentrating protein with disease-related conformation |
GB2335490B (en) * | 1998-03-20 | 2003-05-14 | Ortho Clinical Diagnostics | An assay surface that permits an analyte releasiing step |
US6150172A (en) † | 1999-01-08 | 2000-11-21 | The United States Of America As Represented By The Secretary Of Agriculture | Method and kit for extracting prion protein |
WO2000072851A1 (en) * | 1999-06-01 | 2000-12-07 | The Regents Of The University Of California | Method of sterilizing |
EP1216258A1 (en) | 1999-09-28 | 2002-06-26 | Universität Zürich | Factors having prion-binding activity in serum and plasma and agents to detect transmissible spongiform encephalopathitis |
WO2002000713A1 (en) * | 2000-06-26 | 2002-01-03 | Universität Zürich | Prion-binding activity in serum and plasma determined as plasminogen and fibrinogen |
JP2002056658A (ja) * | 2000-08-04 | 2002-02-22 | Pioneer Electronic Corp | メニュー選択装置 |
DE10107083C2 (de) * | 2001-02-13 | 2003-02-20 | Abdulgabar Salama | Pentosan Polysulfat als Ligand zum Nachweis von Prionen |
EP1448062A1 (en) * | 2001-04-17 | 2004-08-25 | ISTA S.p.A. | Detection and quantification of prion isoforms in neurodegenerative diseases using mass spectrometry |
RU2309410C2 (ru) | 2002-02-28 | 2007-10-27 | Майкроусенс Байофейдж Лимитед | Связывание патологических форм прионовых белков |
-
2003
- 2003-02-28 RU RU2004128924/15A patent/RU2309410C2/ru active
- 2003-02-28 NZ NZ535276A patent/NZ535276A/en not_active IP Right Cessation
- 2003-02-28 AU AU2003214375A patent/AU2003214375B2/en not_active Expired
- 2003-02-28 MX MXPA04008275A patent/MXPA04008275A/es active IP Right Grant
- 2003-02-28 US US10/506,131 patent/US7659076B2/en active Active
- 2003-02-28 WO PCT/GB2003/000858 patent/WO2003073106A2/en active Application Filing
- 2003-02-28 BR BRPI0307976A patent/BRPI0307976B8/pt not_active IP Right Cessation
- 2003-02-28 EP EP03709945.4A patent/EP1478931B2/en not_active Expired - Lifetime
- 2003-02-28 CA CA2477569A patent/CA2477569C/en not_active Expired - Lifetime
- 2003-02-28 CN CNB038066904A patent/CN100526884C/zh not_active Expired - Lifetime
- 2003-02-28 JP JP2003571742A patent/JP4550425B2/ja not_active Expired - Lifetime
- 2003-02-28 ES ES03709945T patent/ES2564293T5/es not_active Expired - Lifetime
-
2004
- 2004-09-27 CO CO04095972A patent/CO5611225A2/es not_active Application Discontinuation
-
2009
- 2009-12-22 US US12/644,283 patent/US8460885B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1478931B2 (en) | 2018-11-07 |
EP1478931B1 (en) | 2015-12-30 |
US20100184054A1 (en) | 2010-07-22 |
US7659076B2 (en) | 2010-02-09 |
JP2005519088A (ja) | 2005-06-30 |
CO5611225A2 (es) | 2006-02-28 |
US20050221404A1 (en) | 2005-10-06 |
CN1643381A (zh) | 2005-07-20 |
NZ535276A (en) | 2008-04-30 |
US8460885B2 (en) | 2013-06-11 |
AU2003214375B2 (en) | 2008-05-08 |
RU2004128924A (ru) | 2005-06-10 |
ES2564293T5 (es) | 2019-04-04 |
BRPI0307976A2 (pt) | 2016-06-21 |
WO2003073106A2 (en) | 2003-09-04 |
ES2564293T3 (es) | 2016-03-21 |
RU2309410C2 (ru) | 2007-10-27 |
CA2477569A1 (en) | 2003-09-04 |
CN100526884C (zh) | 2009-08-12 |
EP1478931A2 (en) | 2004-11-24 |
WO2003073106A3 (en) | 2004-01-08 |
BRPI0307976B1 (pt) | 2017-12-19 |
JP4550425B2 (ja) | 2010-09-22 |
CA2477569C (en) | 2013-09-24 |
AU2003214375A1 (en) | 2003-09-09 |
MXPA04008275A (es) | 2005-04-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/02/2003, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO |
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B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 20A ANUIDADE. |
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B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2711 DE 20-12-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |